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List of works by David E. Szymkowski

A Dictyostelium discoideum cDNA coding for a protein with homology to the rat ribosomal protein L7

scientific article published on July 1989

Allergic lung inflammation is mediated by soluble tumor necrosis factor (TNF) and attenuated by dominant-negative TNF biologics

scientific article published on 04 February 2011

Altered expression of oligodendrocyte and neuronal marker genes predicts the clinical onset of autoimmune encephalomyelitis and indicates the effectiveness of multiple sclerosis-directed therapeutics.

scientific article

An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts ⬇️

scientific article published on November 15, 1992

Antibody-mediated coengagement of FcγRIIb and B cell receptor complex suppresses humoral immunity in systemic lupus erythematosus

scientific article published on 28 February 2011

Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease

scientific article published on September 2006

Central but not systemic administration of XPro1595 is therapeutic following moderate spinal cord injury in mice

scientific article

Chemical genomics versus orthodox drug development

scientific article published on 01 February 2003

Cloning of the amino-terminal and 5'-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts

scientific article published on March 1998

Creating the next generation of protein therapeutics through rational drug design.

scientific article

Dominant-negative tumor necrosis factor protects from Mycobacterium bovis Bacillus Calmette Guérin (BCG) and endotoxin-induced liver injury without compromising host immunity to BCG and Mycobacterium tuberculosis

scientific article

Electron microscopy of DNA excision repair patches produced by human cell extracts

scientific article published on 01 May 1993

Harnessing Fc receptor biology in the design of therapeutic antibodies

scientific article published on 30 March 2016

Hippocampal TNFα Signaling Contributes to Seizure Generation in an Infection-Induced Mouse Model of Limbic Epilepsy

scientific article

Immune suppression in cynomolgus monkeys by XPro9523: an improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn

scientific article

Inactivation of TNF signaling by rationally designed dominant-negative TNF variants

scientific article

Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcgammaRIIb with Fc-engineered antibodies

scientific article

Inhibition of soluble tumor necrosis factor ameliorates synaptic alterations and Ca2+ dysregulation in aged rats

scientific journal article

Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination ⬇️

scientific article published on September 1, 2011

MUC17, a novel membrane-tethered mucin.

scientific article

Neutralization of membrane TNF, but not soluble TNF, is crucial for the treatment of experimental colitis

scientific article published in February 2013

Non-specific antiviral activity of antisense molecules targeted to the E1 region of human papillomavirus

scientific article published on December 2000

Nucleotide excision repair of DNA by mammalian cell extracts and purified proteins

scientific article published on 01 January 1993

Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.

scientific article published on 20 June 2002

Rational optimization of proteins as drugs: a new era of 'medicinal biology'.

scientific article published in May 2004

Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody

scientific article published on 16 January 2012

Roles of soluble and membrane TNF and related ligands in mycobacterial infections: effects of selective and non-selective TNF inhibitors during infection

scientific article published on January 2011

Soluble TNF mediates the transition from pulmonary inflammation to fibrosis

scientific article

Soluble TNF, but not membrane TNF, is critical in LPS-induced hepatitis

scientific article

Suppression of innate and adaptive B cell activation pathways by antibody coengagement of FcγRIIb and CD19.

scientific article

Suppression of mast cell degranulation through a dual-targeting tandem IgE-IgG Fc domain biologic engineered to bind with high affinity to FcγRIIb

scientific article published on 25 January 2012

Suppression of rheumatoid arthritis B cells by XmAb5871, an anti-CD19 antibody that coengages B cell antigen receptor complex and Fcγ receptor IIb inhibitory receptor

scientific article published in May 2014

Systemically administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia

scientific article

The TNF superfamily in 2009: new pathways, new indications, and new drugs

scientific article published on 28 October 2009

Timely lessons for target-based discovery of anti-inflammatory drugs

scientific article published on 01 January 2005

Too many targets, not enough target validation

scientific article published on 01 April 2001

Transmembrane TNF-α is sufficient for articular inflammation and hypernociception in a mouse model of gout

article

Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB.

scientific article published in September 2011

Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine

scientific article published on 21 July 2017

Tumour necrosis factor-mediated macrophage activation in the target organ is critical for clinical manifestation of uveitis ⬇️

scientific article published on May 1, 2012

Workshop Summary: Introduction to Rational Design of New Means for Therapeutic Modulation of Function of the TNF Family

scientific article published on 01 January 2011

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