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List of works by Holger Wille

A Neuronal Culture System to Detect Prion Synaptotoxicity

scientific article

A novel Gerstmann-Sträussler-Scheinker disease mutation defines a precursor for amyloidogenic 8 kDa PrP fragments and reveals N-terminal structural changes shared by other GSS alleles.

scientific article published on 16 January 2018

A synthetic peptide initiates Gerstmann-Sträussler-Scheinker (GSS) disease in transgenic mice

scientific article published on January 2000

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro ⬇️

scientific article published on August 1, 1992

An easy method for bacterial expression and purification of wild-type and mutant superoxide dismutase 1 (SOD1).

scientific article published on 3 April 2017

Assembly of natural and recombinant prion protein into fibrils

scientific article published in June 2005

Bioluminescence Imaging of Neuroinflammation in Transgenic Mice After Peripheral Inoculation of Alpha-Synuclein Fibrils

scientific article published on 13 April 2017

Colloid formation by drugs in simulated intestinal fluid

scientific article

Combining molecular dynamics simulations and experimental analyses in protein misfolding

scientific article published on 01 January 2019

Comparing the Folds of Prions and Other Pathogenic Amyloids.

scientific article published on 4 May 2018

Conformational diversity of wild-type Tau fibrils specified by templated conformation change

scientific article published on 14 November 2008

Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains.

scientific article

Degradation of Fungal Prion HET-s(218-289) Induces Formation of a Generic Amyloid Fold ⬇️

scientific article published on May 15, 2012

Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency

scientific article published on 11 August 2017

Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation

scientific article published on 26 March 2020

Eight prion strains have PrPSc molecules with different conformations ⬇️

scientific article (publication date: October 1998)

Engineering a 2D protein-DNA crystal

scientific article

Evolutionary descent of prion genes from the ZIP family of metal ion transporters

scientific article

Family reunion--the ZIP/prion gene family

scientific article published on 14 December 2010

Full atomistic model of prion structure and conversion

scientific article published on 11 July 2019

Genes contributing to prion pathogenesis

scientific article

Homogeneous nanodiscs of native membranes formed by stilbene-maleic-acid copolymers

scientific article published on 11 August 2020

In vitro conversion and seeded fibrillization of posttranslationally modified prion protein

scientific article published in May 2011

Influence of water, fat, and glycerol on the mechanism of thermal prion inactivation

scientific article published on 18 September 2007

Microtubule-associated protein tau, paired helical filaments, and phosphorylation.

scientific article

Molecular properties of complexes formed between the prion protein and synthetic peptides ⬇️

scientific article published on July 25, 1997

Native nanodiscs formed by styrene-maleic acid copolymer derivatives help recover infectious prion multimers bound to brain-derived lipids

scientific article published on 01 May 2020

Neuroinvasion of α-Synuclein Prionoids after Intraperitoneal and Intraglossal Inoculation.

scientific article

Prion protein with a mutant N-terminal octarepeat region undergoes cobalamin-dependent assembly into high-molecular weight complexes

scientific article published on 07 March 2022

Prion uptake in the gut: identification of the first uptake and replication sites

scientific article (publication date: December 2011)

Protease-Resistant Prions Selectively Decrease Shadoo Protein ⬇️

scientific article published on November 17, 2011

Scrapie infectivity is independent of amyloid staining properties of the N-terminally truncated prion protein

scientific article published on June 2000

Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice

scientific article published on 27 April 2016

Self-assembling small molecules form nanofibrils that bind procaspase-3 to promote activation

scientific article

Self-assembly of recombinant prion protein of 106 residues

scientific article published on March 2000

Separation of scrapie prion infectivity from PrP amyloid polymers

scientific article

Significance of native PLGA nanoparticles in the treatment of Alzheimer's disease pathology

scientific article published in 2022

Small-molecule aggregates inhibit amyloid polymerization

scientific article published on 27 January 2008

Solid-state NMR studies of the secondary structure of a mutant prion protein fragment of 55 residues that induces neurodegeneration

scientific article

Somatostatin binds to the human amyloid β peptide and favors the formation of distinct oligomers

scientific article published on 26 June 2017

Structural studies of truncated forms of the prion protein PrP.

scientific article

Subcellular distribution of the prion protein in sickness and in health

scientific article

The CNS in inbred transgenic models of 4-repeat Tauopathy develops consistent tau seeding capacity yet focal and diverse patterns of protein deposition

scientific article published on 4 October 2017

The Detection of Infectious Prions: In Vitro Conversion Assays Change the (Folding) Landscape

scientific article published on 25 March 2016

The Structural Architecture of an Infectious Mammalian Prion Using Electron Cryomicroscopy

scientific article

The Structure of Mammalian Prions and Their Aggregates

scientific article published on 22 October 2016

The Structure of PrPSc Prions

scientific article published on 7 February 2018

The Structure of the Infectious Prion Protein and Its Propagation

scientific article published on 31 July 2017

The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer

scientific article

The chicken neural extracellular matrix molecule restrictin: similarity with EGF-, fibronectin type III-, and fibrinogen-like motifs

scientific article

The human brain somatostatin interactome: SST binds selectively to P-type family ATPases

scientific article published on 28 May 2019

The structure of human prions: from biology to structural models-considerations and pitfalls

scientific article

The structure of the infectious prion protein: experimental data and molecular models

scientific article

Toll-like receptor-mediated immune response inhibits prion propagation.

scientific article

α-Synuclein strains target distinct brain regions and cell types

scientific article published on 02 December 2019

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