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List of works by Martin Metz

041 Prevalence, characteristics and burden of pruritus in chronic dermatoses

scholarly article by T. Hawro published in October 2017

057 The role of substance P and its receptor NK1R in chronic prurigo: Results from a randomized, controlled trial with topical aprepitant

scholarly article by T. Ohanyan published in October 2017

A Role for Bax in the Regulation of Apoptosis in Mouse Mast Cells

A beneficial role for immunoglobulin E in host defense against honeybee venom

scientific article

A novel method to generate and culture human mast cells: Peripheral CD34+ stem cell-derived mast cells (PSCMCs).

scientific article published on 17 July 2014

A randomized trial of quilizumab in adults with refractory chronic spontaneous urticaria

scientific article published on 19 July 2016

Acquired cold urticaria symptoms can be safely prevented by ebastine.

scientific article

Aktuelles zur kutanen Neurobiologie von Pruritus

Anaphylaxis caused by mosquito allergy in systemic mastocytosis

scientific article published in October 2013

Anti-Immunoglobulin E Treatment of Patients with Recalcitrant Physical Urticaria

Anti-pruritic Effect of Sertaconazole 2% Cream in Atopic Dermatitis Subjects: A Prospective, Randomized, Double-blind, Vehicle-controlled, Multi-centre Clinical Trial of Efficacy, Safety and Local Tolerability

scientific article published on 3 November 2015

Antihistamine-resistant urticaria factitia successfully treated with anti-immunoglobulin E therapy

scientific article published in November 2010

Aprepitant in Anti-histamine-refractory Chronic Nodular Prurigo: A Multicentre, Randomized, Double-blind, Placebo-controlled, Cross-over, Phase-II trial (APREPRU)

scientific article published on 01 April 2019

Are we facing a change in the treatment of chronic pruritus?

scientific article published on 01 November 2019

Atopic dermatitis in children: management of pruritus ⬇️

scientific article published on November 1, 2012

Autoimmune chronic spontaneous urticaria: What we know and what we do not know

scholarly article by Pavel Kolkhir et al published June 2017 in The Journal of Allergy and Clinical Immunology

Autologous Whole Blood Injections to Patients with Chronic Urticaria and a Positive Autologous Serum Skin Test: A Placebo-Controlled Trial

article by P. Staubach et al published 2006 in Dermatology

Autoreaktive Urtikaria und Autoimmunurtikaria

Barzolvolimab Significantly Decreases Chronic Spontaneous Urticaria Disease Activity and is Well Tolerated: Top Line Results from a Phase 2 Trial

scholarly article

Benefit from reslizumab treatment in a patient with chronic spontaneous urticaria and cold urticaria

scientific article published on 19 September 2017

Benefit of mepolizumab treatment in a patient with chronic spontaneous urticaria

scientific article published on 26 March 2018

Best practices, new perspectives and the perfect emollient: optimizing the management of contact dermatitis

scientific article published on 4 September 2017

Characterization of cowhage-induced pruritus in inflamed and non-inflamed skin

scientific article published on 04 September 2019

Chronic Nodular Prurigo: A European Cross-sectional Study of Patient Perspectives on Therapeutic Goals and Satisfaction

scientific article published on 15 December 2020

Chronic pruritus associated with dermatologic disease in infancy and childhood: update from an interdisciplinary group of dermatologists and pediatricians

scientific article published on September 2013

Chronic pruritus – pathogenesis, clinical aspects and treatment ⬇️

scientific article published on September 15, 2010

Chronic spontaneous urticaria: how to assess quality of life in patients receiving treatment

scientific article published in October 2011

Chronische Urtikaria

Chymase-Cre; Mcl-1fl/fl Mice Exhibit Reduced Numbers of Mucosal Mast Cells

scientific article published on 15 October 2019

Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of FcεRI-positive cells in the skin

scientific article

Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: A systematic review

scientific article published on 13 April 2017

Comparison and Interpretability of the available Urticaria Activity Scores.

scientific article published on 16 August 2017

Comparison of pruritus and sensory qualities induced by capsaicin, histamine and cowhage

scientific article published on 08 July 2019

Control of Pseudomonas aeruginosa skin infections in mice is mast cell-dependent

scientific article published on June 2007

Critical role of IL-10 in the induction of low zone tolerance to contact allergens

Critical role of IL-10 in the induction of low zone tolerance to contact allergens

scientific article published on 15 July 2003

Definition, aims, and implementation of GA(2) LEN Urticaria Centers of Reference and Excellence

scientific article published in April 2016

Definition, aims, and implementation of GA2 LEN/HAEi Angioedema Centers of Reference and Excellence

scientific article published on 05 April 2020

Development and Validation of a Patient-Reported Outcome Measure to Assess Disease Control in Chronic Prurigo

scholarly article published in February 2024

Development and Validation of a Questionnaire for the Assessment of Pelvic Floor Disorders and Their Risk Factors During Pregnancy and Post Partum

scientific article

Development and construct validation of the angioedema quality of life questionnaire

scientific article published on 23 August 2012

Development and validation of the Urticaria Control Test: a patient-reported outcome instrument for assessing urticaria control.

scientific article published on 9 February 2014

Development of the Angioedema Control Test-A patient-reported outcome measure that assesses disease control in patients with recurrent angioedema

scientific article published on 09 December 2019

Development, validation, and initial results of the Angioedema Activity Score

scientific article

Diagnosis and therapy of chronic urticaria-what is expected from the revision and update of the international guidelines? A report of the public consensus conference "URTICARIA 2012"

scientific article

Diagnosis and treatment of chronic inducible urticaria

scientific article published on 02 June 2019

Differential effects of skin nerves on allergic skin inflammation

scientific article published on 6 February 2009

Distinct roles for nerve growth factor and brain-derived neurotrophic factor in controlling the rate of hair follicle morphogenesis

scientific article published in February 2000

Dupilumab in Treatment of Chronic Prurigo: A Case Series and Literature Review

scientific article published on 01 September 2019

EADV European Prurigo Project: Expert Consensus on the Definition, Classification and Terminology of Chronic Prurigo.

scientific article published on 31 August 2017

Early macrophage influx to sites of cutaneous granuloma formation is dependent on MIP-1alpha /beta released from neutrophils recruited by mast cell-derived TNFalpha

scientific article published on 15 August 2002

Effect of omalizumab on angioedema in H1 -antihistamine-resistant chronic spontaneous urticaria patients: results from X-ACT, a randomized controlled trial

scientific article published on 24 March 2016

Effective control of recalcitrant pruritus by bevacizumab: a possible role for vascular endothelial growth factor in chronic itch?

scientific article

Effective treatment of a lymphocytic variant of hypereosinophilic syndrome with reslizumab

scientific article published on 01 November 2019

Effective treatment of a lymphocytic variant of hypereosinophilic syndrome with reslizumab

scientific article published on 03 September 2019

Effective treatment of therapy-resistant chronic spontaneous urticaria with omalizumab

Effective treatment with mepolizumab in a patient with refractory Wells syndrome

scientific article published on 01 July 2020

Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses

scientific article

Effects of antihistamines on innate immune responses to severe bacterial infection in mice

scientific article published on 22 February 2011

Efficacy and safety of canakinumab in Schnitzler syndrome: A multicenter randomized placebo-controlled study

scientific article published on 19 September 2016

Efficacy and safety of canakinumab in urticarial vasculitis: an open-label study

scientific article published on 24 May 2013

Efficacy of Remibrutinib in Patients With Chronic Spontaneous Urticaria With or Without Prior Exposure to Biologics in the Phase 3 REMIX-1 and REMIX-2 Studies

scholarly article

Eosinopenia, in Chronic Spontaneous Urticaria, Is Associated with High Disease Activity, Autoimmunity, and Poor Response to Treatment

scientific article published on 28 August 2019

Erfassung von Pruritus – aktuelle Standards und Implikationen für die Praxis

scientific article published on 01 July 2012

Erfolgreiche Behandlung mit Mepolizumab bei einem Patienten mit therapieresistentem Wells-Syndrom

scientific article published on 01 July 2020

Erratum to: Looking forward to new targeted treatments for chronic spontaneous urticaria

scientific article published on 3 April 2017

Erratum zu: Erfassung von Pruritus: aktuelle Standards und Implikationen für die Praxis

scholarly article published in Hautarzt

Evidence for Non-Allergic Mast Cell Activation in Pollen-Associated Inflammation

article

Evidence that the endothelin A receptor can enhance IgE-dependent anaphylaxis in mice.

scientific article published on 8 May 2011

Executive summary: Methods and evidence report for the evidence - and consensus- based (S3) Guideline for the definition, classification, diagnosis, and management of urticaria - revision and update 2017.

scientific article

Fasciola hepatica Tegumental Coat Impairs Mast Cells' Ability To Drive Th1 Immune Responses

article

Frequency and clinical implications of skin autoreactivity to serum versus plasma in patients with chronic urticaria

Galactose-α-1,3-Galactose Allergy Is Not a Hitherto Unrecognized Cause of Chronic Spontaneous Urticaria

scientific article published on 2 October 2015

German version of ItchyQoL: validation and initial clinical findings

scientific article published in September 2013

H1-antihistamine inhibition of histamine- and codeine-induced wheals does not predict response in chronic cold urticaria

scientific article published on 29 January 2019

High prevalence of mental disorders and emotional distress in patients with chronic spontaneous urticaria

scientific article published in September 2011

Histamine, TNF, C5a, IL-6, -9, -18, -31, -33, TSLP, neopterin, and VEGF are not elevated in chronic spontaneous urticaria

scientific article published on 21 March 2013

Human Mast Cell Tryptase Is a Potential Treatment for Snakebite Envenoming Across Multiple Snake Species

scientific article published on 09 July 2018

IL-15 constrains mast cell-dependent antibacterial defenses by suppressing chymase activities.

scientific article published on 22 July 2007

IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression

scientific article

IgE Antibodies and FcεRI Are Critical For Acquired Resistance Against Honeybee Venom In Mice

scholarly article by Philipp Starkl et al published February 2014 in The Journal of Allergy and Clinical Immunology

IgE mediated autoallergy against thyroid peroxidase--a novel pathomechanism of chronic spontaneous urticaria?

scientific article

Immunoglobulin E-Mediated Autoimmunity

scientific article published on 9 April 2018

In chronic spontaneous urticaria, high numbers of dermal endothelial cells, but not mast cells, are linked to recurrent angio-oedema

scientific article published on 24 October 2017

Increased angiogenesis and VEGF expression correlates with disease severity in prurigo patients

scientific article published on 7 October 2015

Inflammatory murine skin responses to UV-B light are partially dependent on endothelin-1 and mast cells

scientific article published on September 2006

Innate immunity and allergy in the skin

scientific article published on 12 October 2009

Interleukin-31 does not induce immediate itch in atopic dermatitis patients and healthy controls after skin challenge.

scientific article published on 20 November 2013

Itch Management: Topical Agents

scientific article

Kälteinduzierte Quaddeln und Angioödeme

Ligelizumab for Chronic Spontaneous Urticaria

scientific article published on 01 October 2019

Ligelizumab for Chronic Spontaneous Urticaria. Reply

scientific article published on 01 February 2020

Looking forward to new targeted treatments for chronic spontaneous urticaria

scientific article published on 10 January 2017

MRGPRX2 Small Molecule Antagonists Potently Inhibit Agonist-Induced Skin Mast Cell Degranulation

scholarly article

Magistral formulations and pruritus therapy - What is established, what is confirmed, what is new?

article published in 2013

Magistral formulations and pruritus therapy - What is established, what is confirmed, what is new?

scientific article

Management of urticarial vasculitis: A worldwide physician perspective

scientific article published on 05 March 2020

Mas-related G protein-coupled receptor X2 and its activators in dermatologic allergies

scientific article published on 15 October 2020

Mast Cells Limit the Exacerbation of Chronic Allergic Contact Dermatitis in Response to Repeated Allergen Exposure

scientific article published on 2 November 2016

Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice

scientific article

Mast cell functions in the innate skin immune system

scientific article published on 31 December 2007

Mast cell-mediated reactions in vivo

Mast cells are critical for controlling the bacterial burden and the healing of infected wounds

scientific article published on 23 September 2019

Mast cells are critical for the limitation of thrombin-induced skin inflammation

scientific article published on 8 August 2017

Mast cells as protectors of health

scientific article published on 20 November 2018

Mast cells can enhance resistance to snake and honeybee venoms

scientific article

Mast cells cultured from IL-3-treated mice show impaired responses to bacterial antigen stimulation

article

Mast cells determine the magnitude of bacterial toxin-induced skin inflammation

scientific article published on 17 July 2008

Mast cells in the promotion and limitation of chronic inflammation.

scientific article published on June 2007

Mast cells orchestrate type 2 immunity to helminths through regulation of tissue-derived cytokines

scientific article published on 9 April 2012

Mast cells promote homeostasis by limiting endothelin-1-induced toxicity.

scientific article

Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4.

scientific article published on 27 November 2012

Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4.

scientific article published on 26 September 2013

Mast cells protect from skin tumor development and limit tumor growth during cutaneous de novo carcinogenesis in a Kit-dependent mouse model

scientific article published in March 2014

Mast cells rescue implantation defects caused by c-kit deficiency.

scientific article published on 17 January 2013

Mast cells, basophils and mastocytosis

Mast cells--key effector cells in immune responses

scientific article published on 2 April 2007

Mast cells: Promoters of health and modulators of disease

scientific article published on 28 February 2019

Mast cells: makers and breakers of allergic inflammation

scientific article published on October 2009

Mast cell–driven skin inflammation is impaired in the absence of sensory nerves

Membrane-bound stem cell factor is the major but not only driver of fibroblast-induced murine skin mast cell differentiation

scientific article published on 13 September 2016

Methods report on the development of the 2013 revision and update of the EAACI/GA2 LEN/EDF/WAO guideline for the definition, classification, diagnosis, and management of urticaria

scientific article

Miltefosine: a novel treatment option for mast cell-mediated diseases

scientific article published on 05 August 2012

Murine mast cells secrete a unique profile of cytokines and prostaglandins in response to distinct TLR2 ligands

scientific article published in May 2009

Neue Therapeutika beim Hereditären Angioödem unbeantwortete Fragen beim Hereditären Angioödem

Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis

scientific article

Neurotrophin-3 regulates mast cell functions in neonatal mouse skin

scientific article published on May 2004

Non-pathogenic commensal Escherichia coli bacteria can inhibit degranulation of mast cells

scientific article

Nutzen von Mepolizumab bei einer Patientin mit chronischer spontaner Urtikaria

scientific article published in April 2018

Omalizumab Improves Angioedema-Related Quality of Life Impariment in Patients with Chronic Idiopathic/Chronic Spontaneous Urticaria: Results from the X-Act Study

scholarly article published on 23 February 2018

Omalizumab Updosing in Chronic Spontaneous Urticaria: an Overview of Real-World Evidence

scientific article published on 16 May 2020

Omalizumab in chronic urticaria ⬇️

scientific article published on August 1, 2012

Omalizumab is an effective and rapidly acting therapy in difficult-to-treat chronic urticaria: a retrospective clinical analysis

scientific article

Omalizumab is effective in cold urticaria-results of a randomized placebo-controlled trial

scientific article published on 4 April 2017

Omalizumab is effective in symptomatic dermographism-results of a randomized placebo-controlled trial

scientific article published on 4 April 2017

Omalizumab may not inhibit mast cell and basophil activation in vitro

scientific article published on 26 September 2014

Omalizumab normalizes the gene expression signature of lesional skin in patients with chronic spontaneous urticaria: a randomized, double-blind, placebo-controlled study

article

Omalizumab rapidly improves angioedema-related quality of life in adult patients with chronic spontaneous urticaria: X-ACT study data

scientific article published on 23 October 2017

Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence

scientific article

Pathomechanismus von Angioödemen

Pathophysiology of itch and new treatments

scientific article published on October 2011

Patients with chronic urticaria exhibit increased rates of sensitisation toCandida albicans, but not to common moulds

scientific article published in 2009

Peltier effect-based temperature challenge: an improved method for diagnosing cold urticaria

scientific article published in November 2004

Polidocanol inhibits cowhage - but not histamine-induced itch in humans

scientific article

Potential blood biomarkers in chronic spontaneous urticaria

scientific article published on 7 December 2016

Practical algorithm for diagnosing patients with recurrent wheals or angioedema

scientific article published on 6 May 2013

Prevalence and relevance of skin autoreactivity in chronic urticaria

Prevention of signs and symptoms of dermographic urticaria by single-dose ebastine 20 mg.

scientific article

Protocols for the Induction and Evaluation of Systemic Anaphylaxis in Mice ⬇️

scientific article published on January 1, 2013

Pruritus and sleep disturbances in patients with psoriasis

scientific article published on 15 October 2019

Pruritus: an overview of current concepts

scientific article published on 20 January 2011

Quality of life in patients with chronic urticaria is differentially impaired and determined by psychiatric comorbidity

scientific article published in February 2006

Real life treatment of Cholinergic Urticaria with Omalizumab

scientific article published on 09 October 2018

Reply

scholarly article by Pavel Kolkhir et al published March 2018 in The Journal of Allergy and Clinical Immunology

Reply

Responsiveness and minimal important difference of the urticaria control test

scientific article published on 15 June 2017

Retardation of Hair Follicle Development by the Deletion of TrkC, High-Affinity Neurotrophin-3 Receptor

article

Retreatment with omalizumab results in rapid remission in chronic spontaneous and inducible urticaria

scientific article published in March 2014

Revisions to the international guidelines on the diagnosis and therapy of chronic urticaria

scientific article published on 19 August 2013

Revisions to the international guidelines on the diagnosis and therapy of chronic urticaria

Role and relevance of mast cells in fungal infections

scientific article published on 13 June 2012

Role of Substance P and Its Receptor Neurokinin 1 in Chronic Prurigo: A Randomized, Proof-of-Concept, Controlled Trial with Topical Aprepitant

scientific article published on 30 August 2017

Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria.

scientific article published in January 2010

Rupatadine for the treatment of allergic rhinitis and urticaria

scientific article published on January 2011

Rupatadine improves quality of life in mastocytosis: a randomized, double-blind, placebo-controlled trial

scientific article

Rupatadine in Established Treatment Schemes Improves Chronic Spontaneous Urticaria Symptoms and Patients' Quality of Life: a Prospective, Non-interventional Trial

scientific article

S2k Guidelines for the diagnosis and treatment of chronic pruritus - update - short version

scientific article

Serlopitant reduced pruritus in patients with prurigo nodularis in a phase 2, randomized, placebo-controlled trial

scientific article published on 17 March 2019

Serum autoreactivity predicts time to response to omalizumab therapy in chronic spontaneous urticaria

scientific article published on 9 November 2016

Severe contact dermatitis caused by urushiol in Japanese lacquer

scientific article published on 03 September 2018

Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions

scientific article published on 01 December 2019

Skin mast cells control T cell-dependent host defense in Leishmania major infections

Skin provocation tests may help to diagnose atopic dermatitis

scientific article published on 18 August 2016

Substance P is upregulated in the serum of patients with chronic spontaneous urticaria.

scientific article published on 20 May 2014

Successful treatment of cholinergic urticaria with anti-immunoglobulin E therapy

scientific article

Successful treatment of hereditary angioedema with bradykinin B2-receptor antagonist icatibant

Successful treatment of hereditary angioedema with bradykinin B2-receptor antagonist icatibant

scientific article published on 16 September 2009

Successful treatment of solar urticaria with anti-immunoglobulin E therapy

scientific article

T cell killing by tolerogenic dendritic cells protects mice from allergy

scientific article published on September 2011

TLR3-induced activation of mast cells modulates CD8+ T-cell recruitment

scientific article published on 19 April 2005

Targeting histamine receptor 4 in cholinergic urticaria with izuforant (LEO 152020): results from a phase IIa randomized double-blind placebo-controlled multicentre crossover trial

scholarly article

The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update

The EAACI/GA²LEN/EDF/WAO Guideline for the Definition, Classification, Diagnosis and Management of Urticaria. The 2017 Revision and Update

scientific article

The Urticaria Activity Score-Validity, Reliability, and Responsiveness.

scientific article published on 8 November 2017

The definition and diagnostic testing of physical and cholinergic urticarias--EAACI/GA2LEN/EDF/UNEV consensus panel recommendations

scientific article published on 30 September 2009

The definition, diagnostic testing, and management of chronic inducible urticarias - The EAACI/GA(2) LEN/EDF/UNEV consensus recommendations 2016 update and revision

scientific article published on 18 March 2016

The effects of Fasciola hepatica tegumental antigens on mast cell function

scientific article published on 25 March 2013

The potential pharmacologic mechanisms of omalizumab in patients with chronic spontaneous urticaria

scientific article

The response to treatment in chronic spontaneous urticaria depends on how it is measured

scientific article published on 04 February 2019

The role and relevance of mast cells in urticaria

scientific article published in March 2018

The role of eosinophils in chronic spontaneous urticaria

scientific article published on 26 March 2020

The role of interleukin-1 in allergy-related disorders

scientific article published on October 2012

The status quo and quo vadis of mast cells

scientific article

Therapeutic alternatives for antihistamine-refractory urticaria

scientific article published on September 2010

Total IgE levels are linked to the response of chronic spontaneous urticaria patients to omalizumab

scholarly article by Karsten Weller et al published 4 August 2018 in Allergy

Treatment of notalgia paraesthetica with an 8% capsaicin patch

article published in 2011

Treatments for chronic pruritus outside of the box

scientific article published on 16 July 2019

Une réponse allergique pour lutter contre les venins

Updosing of bilastine is effective in moderate to severe chronic spontaneous urticaria: A real-life study

scholarly article by K. Weller et al published 5 June 2018 in Allergy

Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020

scientific article published on 30 March 2020

Validation of the Angioedema Control Test (AECT)-A Patient-Reported Outcome Instrument for Assessing Angioedema Control

scientific article published on 12 March 2020

Viewpoint 5

What is the physiological function of mast cells?

scientific article published on 01 December 2003

Who is really in control of skin immunity under physiological circumstances - lymphocytes, dendritic cells or keratinocytes?

scientific article published on November 2006

Wytyczne EAACI/GA2LEN/EDF/WAO dotyczące definicji, klasyfikacji, rozpoznawania i leczenia pokrzywki: weryfikacja z 2013 roku z poprawkami

[Antipruritic efficacy of a high-dosage antihistamine therapy. Results of a retrospectively analysed case series].

scientific article published in July 2009

[Therapy for chronic pruritus-light at the end of a long tunnel?]

scientific article published on 16 July 2020

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