List of works - Andrew J Murphy

"Transactivation" control signals in the promoter of the herpesvirus thymidine kinase gene.

scientific article published on February 1985

A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies

scientific article published on 01 January 2020

A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells

scientific article published on 19 August 2019

A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production

scientific article published on 11 January 2017

A rapid procedure for isolation of RNA-free genomic DNA from mammalian cells.

scientific article published on February 1993

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

scientific article

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys.

scientific article published on 11 May 2015

ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2.

scientific article

ANGPTL8/betatrophin does not control pancreatic beta cell expansion

scientific article

Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.

scientific article

Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses

scientific article published on 08 July 2020

Agouti-related protein-deficient mice display an age-related lean phenotype

scientific article published in December 2005

Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice.

scientific article

Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.

scientific article published on 06 April 2009

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

scientific article published on 06 November 2019

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.

scientific article

Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.

scientific article

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

scientific article published on 15 June 2020

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

scientific article published on 7 January 2015

C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice.

scientific article published on 16 March 2016

CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors

scientific article

CS-21EphA2 PROMOTES INFILTRATIVE INVASION OF GLIOMA STEM CELLS IN VIVO THROUGH CROSSTALK WITH Akt AND REGULATES STEM PROPERTIES

Cell-specified expression of a selectable hybrid gene ⬇️

scientific article published on August 1, 1984

Chronic allergen exposure drives accumulation of long-lived IgE plasma cells in the bone marrow, giving rise to serological memory

scientific article published on 01 January 2020

Cloning vectors for expression of cDNA libraries in mammalian cells

scientific article

Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype

scientific article published on 01 November 2018

Conditionals by inversion provide a universal method for the generation of conditional alleles

scientific journal article

Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis

scientific article

Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis

scientific article published on 01 September 2006

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

scientific article published on 25 July 2011

Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination

scientific article

EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.

scientific article

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury

article

From DNA to drugs: the orphan G-protein coupled receptors.

scientific article published in September 1998

Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo

scientific journal article

GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.

scientific article

Generation of functional multipotent adult stem cells from GPR125+ germline progenitors

scientific article

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

scientific article published on 24 May 2017

Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis

scientific article published on 15 February 2007

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

scientific article published on 13 June 2018

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

scientific article

Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys

scientific article published on 28 May 2015

Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation

scientific article

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

scholarly article

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

scientific article (publication date: June 2003)

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

scientific article

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

scientific article

Humanized mouse model supports development, function, and tissue residency of human natural killer cells

scientific article

Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis.

scientific article

IL-22 promotes fibroblast-mediated wound repair in the skin

scientific article

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

scientific journal article

Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast.

scientific article

In Vivo Quantitative Microcomputed Tomographic Analysis of Vasculature and Organs in a Normal and Diseased Mouse Model

scientific article (publication date: 2016)

In-silico discovery of cancer-specific peptide-HLA complexes for targeted therapy

scientific article

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

scientific article published on 02 March 2016

Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease

scientific article

Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection

scientific article published on 09 December 2010

Interleukin-19 protects mice from innate-mediated colonic inflammation

scientific article published on 01 June 2010

Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation

scientific article

Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation

scientific article published on November 2005

Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus

scientific article

Long form of latent TGF- binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling

scientific article published on 05 September 2007

Loss of SFRP4 Alters Body Size, Food Intake, and Energy Expenditure in Diet-Induced Obese Male Mice

scientific article

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

scientific journal article

Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice

scientific article published on 24 August 2016

Mice completely lacking immunoproteasomes show major changes in antigen presentation

scientific article published on 25 December 2011

Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses

scientific article

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

scientific article published on 25 March 2014

Mutants deleted in the agnogene of simian virus 40 define a new complementation group ⬇️

scientific article published on January 1, 1983

Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice

scientific article published on 9 October 2015

Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus

scientific article published on 4 July 2011

Peptide YY regulates bone turnover in rodents

scientific article published on 15 August 2007

Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.

scientific article published on January 2006

Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis

scientific article published on 01 April 2018

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes.

scientific article published on 25 March 2014

Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4.

scientific article

Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke

scientific article published on 14 May 2013

Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence ⬇️

scientific article published on 26 November 2019

Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections.

scientific article

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

scientific article published on 09 October 2020

RORgamma-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F.

scientific article

Regulation of the germinal center response by microRNA-155

scientific article (publication date: 27 April 2007)

Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5

scientific article

Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility

scientific article published on July 2006

Ric-8 proteins are molecular chaperones that direct nascent G protein α subunit membrane association

scientific article

Role of the leucine-rich repeat domain of cryopyrin/NALP3 in monosodium urate crystal-induced inflammation in mice.

scientific article

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

scientific article

SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease

scientific article

Single-Cell RNAseq Reveals That Pancreatic β-Cells From Very Old Male Mice Have a Young Gene Signature

scientific article published on 28 July 2016

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice

scientific journal article

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

scientific article

TLR8 deficiency leads to autoimmunity in mice

scientific article

The loss-of-allele assay for ES cell screening and mouse genotyping

scientific article published in January 2010

The transcription factor NFATc2 controls IL-6-dependent T cell activation in experimental colitis

scientific article

Treating cat allergy with monoclonal IgG antibodies that bind allergen and prevent IgE engagement.

scientific article published on 12 April 2018

Tumor-targeted CD28 bispecific antibodies enhance the antitumor efficacy of PD-1 immunotherapy

scientific article published on 01 June 2020

Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain

scientific article published on 09 December 2007

Use of the Fluidigm C1 platform for RNA sequencing of single mouse pancreatic islet cells.

scientific article published on 7 March 2016

VEGF-mediated inflammation precedes angiogenesis in adult brain

scientific article published in June 2004

Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis

scientific journal article

p lambda Zd39: a new type of cDNA expression vector for low background, high efficiency directional cloning

scientific article

List of works by Andrew J Murphy

"Transactivation" control signals in the promoter of the herpesvirus thymidine kinase gene.

A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies

A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells

A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production

A rapid procedure for isolation of RNA-free genomic DNA from mammalian cells.

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys.

ANGPTL4-αvβ3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2.

ANGPTL8/betatrophin does not control pancreatic beta cell expansion

Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.

Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses

Agouti-related protein-deficient mice display an age-related lean phenotype

Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice.

Alternatively activated macrophage-derived RELM-{alpha} is a negative regulator of type 2 inflammation in the lung.

An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.

Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations

C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice.

CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors

CS-21EphA2 PROMOTES INFILTRATIVE INVASION OF GLIOMA STEM CELLS IN VIVO THROUGH CROSSTALK WITH Akt AND REGULATES STEM PROPERTIES

Cell-specified expression of a selectable hybrid gene ⬇️

Chronic allergen exposure drives accumulation of long-lived IgE plasma cells in the bone marrow, giving rise to serological memory

Cloning vectors for expression of cDNA libraries in mammalian cells

Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype

Conditionals by inversion provide a universal method for the generation of conditional alleles

Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis

Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis

Efficient differentiation and function of human macrophages in humanized CSF-1 mice

Elements between the IgH variable (V) and diversity (D) clusters influence antisense transcription and lineage-specific V(D)J recombination

EphA2 promotes infiltrative invasion of glioma stem cells in vivo through cross-talk with Akt and regulates stem cell properties.

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury

From DNA to drugs: the orphan G-protein coupled receptors.

Functional characterization of mouse RDH11 as a retinol dehydrogenase involved in dark adaptation in vivo

GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.

Generation of functional multipotent adult stem cells from GPR125+ germline progenitors

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice.

Glucagon Receptor Blockade With a Human Antibody Normalizes Blood Glucose in Diabetic Mice and Monkeys

Goblet cell-derived resistin-like molecule beta augments CD4+ T cell production of IFN-gamma and infection-induced intestinal inflammation

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

Human IL-3/GM-CSF knock-in mice support human alveolar macrophage development and human immune responses in the lung

Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo

Humanized mouse model supports development, function, and tissue residency of human natural killer cells

Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis.

IL-22 promotes fibroblast-mediated wound repair in the skin

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast.

In Vivo Quantitative Microcomputed Tomographic Analysis of Vasculature and Organs in a Normal and Diseased Mouse Model

In-silico discovery of cancer-specific peptide-HLA complexes for targeted therapy

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease

Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease

Interleukin-19 is a negative regulator of innate immunity and critical for colonic protection

Interleukin-19 protects mice from innate-mediated colonic inflammation

Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation

Leucine aminopeptidase is not essential for trimming peptides in the cytosol or generating epitopes for MHC class I antigen presentation

Lhx6 delineates a pathway mediating innate reproductive behaviors from the amygdala to the hypothalamus

Long form of latent TGF- binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling

Loss of SFRP4 Alters Body Size, Food Intake, and Energy Expenditure in Diet-Induced Obese Male Mice

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice

Mice completely lacking immunoproteasomes show major changes in antigen presentation

Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

Mutants deleted in the agnogene of simian virus 40 define a new complementation group ⬇️

Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice

Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus

Peptide YY regulates bone turnover in rodents

Peripheral myelin protein 22 is in complex with alpha6beta4 integrin, and its absence alters the Schwann cell basal lamina.

Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis

Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes.

Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4.

Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke

Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence ⬇️

Puromycin-sensitive aminopeptidase limits MHC class I presentation in dendritic cells but does not affect CD8 T cell responses during viral infections.