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List of works by Robert H Insall

A G-protein-coupled chemoattractant receptor recognizes lipopolysaccharide for bacterial phagocytosis.

scientific article published on 25 May 2018

A G-rich sequence element common to Dictyostelium genes which differ radically in their patterns of expression

scientific article

A cell for all reasons

scientific article published on 01 September 1999

A computational method for the coupled solution of reaction-diffusion equations on evolving domains and manifolds: Application to a model of cell migration and chemotaxis

scientific article published on March 2016

A novel Dictyostelium RasGEF is required for normal endocytosis, cell motility and multicellular development

scientific article published in November 2000

A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium

scientific article

A plasma membrane template for macropinocytic cups

scientific article

A specific DIF binding protein in Dictyostelium

scientific article published on October 1990

Abi Mutants in Dictyostelium Reveal Specific Roles for the SCAR/WAVE Complex in Cytokinesis

scientific article published in February 2008

Abi is required for modulation and stability but not localization or activation of the SCAR/WAVE complex

scientific article

Actin dynamics at the leading edge: from simple machinery to complex networks.

scientific article published on September 2009

Actin on disease--studying the pathobiology of cell motility using Dictyostelium discoideum

scientific article published on 09 December 2010

Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis ⬇️

scientific article

Actin-based motility: WAVE regulatory complex structure reopens old SCARs

scientific article published on 01 January 2011

Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes

scientific article

An improved chamber for direct visualisation of chemotaxis

scientific article

Analogies in 3D molecular visualisations: development of a cell biology animation 'How cells move - a new interpretation of old data'

scientific article published on 23 October 2019

And now it's time for tea

scientific article published on 01 February 1996

Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease.

scientific article

CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium

scientific article published on September 1994

CYRI (FAM49) proteins are local inhibitors of Scar/WAVE induced lamellipodia that bind directly to active Rac1

Ca(2+) signalling is not required for chemotaxis in Dictyostelium

scientific article published on September 2000

Career postdocs increase scrap heap

scientific article published in March 2011

Cell motility and SCAR localisation in axenically growing Dictyostelium cells

scientific article published in September 2006

Cell-substrate adhesion drives Scar/WAVE activation and phosphorylation by a Ste20-family kinase, which controls pseudopod lifetime

scientific article published on 03 August 2020

Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions

scientific article published on 14 January 2007

Chemotaxis: A Feedback-Based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour ⬇️

scientific article published on May 17, 2011

Chemotaxis: TorC before you Akt...

scientific article

Comparative genome and transcriptome analyses of the social amoeba Acytostelium subglobosum that accomplishes multicellular development without germ-soma differentiation

scientific article

Control of SCAR activity in Dictyostelium discoideum

scientific article

Coordination by Cdc42 of Actin, Contractility, and Adhesion for Melanoblast Movement in Mouse Skin

scientific article published on 18 February 2017

Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs

scientific article published on 23 March 2007

Cyclic GMP and the big squeeze. Osmoregulation

scientific article published on May 1996

Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment

scientific article published on January 2013

Cynicism and credulity. My word

scientific article published on 01 April 1999

DIF-1 induces its own breakdown in Dictyostelium.

scientific article published on August 1992

Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles.

scientific article published on 11 March 2008

Dictyostelium RasD is required for normal phototaxis, but not differentiation

scientific article

Dictyostelium RasG is required for normal motility and cytokinesis, but not growth.

scientific article published on August 1997

Dictyostelium: an ideal organism for genetic dissection of Ras signalling networks.

scientific article

Differentiation-inducing-factor dechlorinase, a novel cytosolic dechlorinating enzyme from Dictyostelium discoideum

scientific article published on 01 September 1992

Diffusible signal molecules controlling cell differentiation and patterning in Dictyostelium

scientific article published on 01 January 1991

Distinct Interaction Sites of Rac GTPase with WAVE Regulatory Complex Have Non-redundant Functions in Vivo

scientific article published on 01 November 2018

Dogma bites back – the evidence for branched actin ⬇️

scientific article published on 07 December 2010

Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis.

scientific article

Entamoeba histolytica cell movement: a central role for self-generated chemokines and chemorepellents

scientific article

Expression of N471D strumpellin leads to defects in the endolysosomal system

scientific article published on 13 September 2018

Extracellular Signalling Modulates Scar/WAVE Complex Activity through Abi Phosphorylation

scientific article published on 10 December 2021

Extracellular cAMP can restore development in Dictyostelium cells lacking one, but not two subtypes of early cAMP receptors (cARs). Evidence for involvement of cAR1 in aggregative gene expression.

scientific article published in July 1994

F-BAR domains: multifunctional regulators of membrane curvature.

scientific article published on June 2008

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

scientific article published on 24 September 2018

Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis

scientific article

Functional overlap of the dictyostelium RasG, RasD and RasB proteins.

scientific article published in April 2000

Gdt2 regulates the transition of Dictyostelium cells from growth to differentiation

scientific article

Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria

scientific article published on 25 January 2019

Glycogen synthase kinase and Dictyostelium development: old pathways pointing in new directions?

scientific article

How a paper on RAC set the standard ⬇️

scientific article published on January 23, 2012

Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast

scientific article

Impact factors: target the funding bodies

scientific article published in Nature

Impaired neutrophil directional chemotactic accuracy in chronic periodontitis patients

scientific article published on 8 January 2015

Inference of the drivers of collective movement in two cell types: Dictyostelium and melanoma

scientific article (publication date: October 2016)

LPP3 mediates self-generation of chemotactic LPA gradients by melanoma cells

scientific article

LPP3, LPA and self-generated chemotactic gradients in biomedical science.

scientific article

Laparoscopic total extra-peritoneal inguinal hernia repairs by a surgeon experienced at laparoscopic cholecystectomy

scientific article published on December 2012

Linked regulation of motility and integrin function in activated migrating neutrophils revealed by interference in remodelling of the cytoskeleton

scientific article published in February 2003

Local modulation of chemoattractant concentrations by single cells: dissection using a bulk-surface computational model

scientific article published on October 2016

Loss of Dictyostelium HSPC300 causes a scar-like phenotype and loss of SCAR protein

scientific article

Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion.

scientific article

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour

scientific article published on 7 July 2016

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal

scientific article (publication date: October 2014)

Melanomas' fatal attraction to lysophosphatidic acid trails: a new prognostic and therapeutic approach?

scientific article published on 18 May 2015

Methanol and acriflavine resistance in Dictyostelium are caused by loss of catalase.

scientific article published in January 2002

Moving matters: signals and mechanisms in directed cell migration

scientific article published on 01 August 2006

Mroh1, a lysosomal regulator localized by WASH-generated actin

scientific article published on 19 April 2017

Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium

scientific article published on November 1992

N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis

scientific article published on 24 October 2019

N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods

scientific article

Nap1 regulates Dictyostelium cell motility and adhesion through SCAR-dependent and -independent pathways

scientific article published in April 2006

Novel carotid surgery in an asymptomatic totally occluded common carotid artery

scientific article published on 01 February 2011

Overflow in science and its implications for trust.

scientific article

PH domains in WASP - a bug in the system? Wiskott-Aldrich syndrome protein

scientific article published on 01 June 1999

PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

article

PIP3, PIP2, and cell movement--similar messages, different meanings?

scientific article

PIP₃-dependent macropinocytosis is incompatible with chemotaxis

scientific article

PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium

scientific article

Parasexual genetics of Dictyostelium gene disruptions: identification of a ras pathway using diploids

scientific article

Parasexual genetics using axenic cells

scientific article published in January 2006

Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3.

scientific article published on March 2000

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

scientific article

Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium

scientific article

Phosphorylation of actin-related protein 2 (Arp2) is required for normal development and cAMP chemotaxis in Dictyostelium.

scientific article published on 5 December 2012

Predicting cell shapes in melanomas.

scientific article published on 23 October 2013

Presidential candidates failed peer-review test

scientific article published on 01 November 2004

Protein conformation: through a lens, darkly

scientific article

Pseudopod growth and evolution during cell movement is controlled through SCAR/WAVE dephosphorylation

scientific article

Pseudopodium dynamics and rapid cell movement in Dictyostelium Ras pathway mutants

scientific article published on 01 October 2002

Purification and cloning of phosphatidylinositol transfer proteins from Dictyostelium discoideum: homologues of both mammalian PITPs and Saccharomyces cerevisiae sec14p are found in the same cell

scientific article

Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression

scientific article

RacG regulates morphology, phagocytosis, and chemotaxis

scientific article published on September 2006

Rapid and efficient genetic engineering of both wild type and axenic strains of Dictyostelium discoideum.

scientific article

Regulation of WASP: PIP2 Pipped by Toca-1?

scientific article published in July 2004

Regulation of actin assembly by SCAR/WAVE proteins.

scientific article

Replacement of the essential Dictyostelium Arp2 gene by its Entamoeba homologue using parasexual genetics

scientific article

Robert Insall

scientific article published in March 2003

SCAR knockouts in Dictyostelium: WASP assumes SCAR's position and upstream regulators in pseudopods

scientific article

SCAR/WAVE is activated at mitosis and drives myosin-independent cytokinesis

scientific article

SCAR/WAVE: A complex issue

scientific article published on 13 November 2013

Scar/WAVE3 contributes to motility and plasticity of lamellipodial dynamics but not invasion in three dimensions.

scientific article

Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

scientific article

Screening by changes in stereotypical behavior during cell motility.

scientific article published on 19 June 2019

Seeing around corners: Cells solve mazes and respond at a distance using attractant breakdown

scientific article

Self-Generated Chemoattractant Gradients: Attractant Depletion Extends the Range and Robustness of Chemotaxis

scientific article

Self-generated chemotactic gradients-cells steering themselves.

scientific article published on 19 April 2016

Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins

scientific article published in February 1996

Signaling through chemoattractant receptors in Dictyostelium

scientific article published on February 1996

Single-sample image-fusion upsampling of fluorescence lifetime images

scientific article published on 24 May 2024

Solving the WAVE function

scientific article

The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration

scientific article

The Chemoattractant Glorin Is Inactivated by Ester Cleavage during Early Multicellular Development of Polysphondylium pallidum

scientific article published on 24 May 2018

The Dictyostelium RasS protein is required for macropinocytosis, phagocytosis and the control of cell movement

scientific article published on 01 February 2000

The Dictyostelium genome: the private life of a social model revealed?

scientific article

The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function.

scientific article published in February 1997

The Inositol-3-Phosphate Synthase Biosynthetic Enzyme Has Distinct Catalytic and Metabolic Roles.

scientific article published on 7 March 2016

The PKB that doesn't need to jump

scientific article published on 01 October 2000

The Rac GEF ZizB regulates development, cell motility and cytokinesis in Dictyostelium

scientific article published on 24 February 2012

The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium

scientific article published in June 1996

The enemy within. My word

scientific article published on 01 February 1997

The helC gene encodes a putative DEAD-box RNA helicase required for development in Dictyostelium discoideum

scientific article published in May 1998

The identification of Dictyostelium phosphoproteins altered in response to the activation of RasG.

scientific article published in September 2004

The induction of autophagy by mechanical stress.

scientific article

The interaction between pseudopods and extracellular signalling during chemotaxis and directed migration ⬇️

scientific article published on 07 June 2013

The right stuff

scientific article published on 01 November 1997

The trimeric coiled-coil HSBP1 protein promotes WASH complex assembly at centrosomes

scientific article published on 29 May 2018

The use of streptavidin conjugates as immunoblot loading controls and mitochondrial markers for use with Dictyostelium discoideum.

scientific article published in July 2013

Too much of a good thing?

scientific article published on 01 April 2000

Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation

scientific article published on 21 March 2017

Two cAMP receptors activate common signaling pathways in Dictyostelium.

scientific article

Understanding eukaryotic chemotaxis: a pseudopod-centred view

scientific article published on 6 May 2010

Use of the parameterised finite element method to robustly and efficiently evolve the edge of a moving cell

scientific article published on 20 October 2010

Visualizing Cancer Cell Chemotaxis and Invasion in 2D and 3D.

scientific article published in January 2016

WASH complex conservation: don't WASH away the family!

scientific article published on 28 August 2013

WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors

scientific article published on 19 September 2016

WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion

scientific article published on 24 July 2013

WASP Restricts Active Rac to Maintain Cells' Front-Rear Polarization

scientific article published on 27 November 2019

WASP and SCAR/WAVE proteins: the drivers of actin assembly

scientific article

WASP family proteins and formins compete in pseudopod- and bleb-based migration.

scientific article published on 30 November 2017

WASP family proteins: their evolution and its physiological implications.

scientific article

WASP homology sequences in baculoviruses

scientific article published in July 2001

p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils

scientific article

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