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List of works by Robert H Insall

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Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

scientific article
Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3.

scientific article published on March 2000
Actin dynamics at the leading edge: from simple machinery to complex networks.

scientific article published on September 2009
Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions

scientific article published on 14 January 2007
PIP3, PIP2, and cell movement--similar messages, different meanings?

scientific article
CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium

scientific article published on September 1994
Dictyostelium RasG is required for normal motility and cytokinesis, but not growth.

scientific article published on August 1997
Actin polymerization driven by WASH causes V-ATPase retrieval and vesicle neutralization before exocytosis

scientific article
Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

scientific article
The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium

scientific article published in June 1996
N-WASP coordinates the delivery and F-actin-mediated capture of MT1-MMP at invasive pseudopods

scientific article
WASP family proteins: their evolution and its physiological implications.

scientific article
Chemotaxis: A Feedback-Based Computational Model Robustly Predicts Multiple Aspects of Real Cell Behaviour

scientific article published on May 17, 2011
Ca(2+) signalling is not required for chemotaxis in Dictyostelium

scientific article published on September 2000
PIR121 regulates pseudopod dynamics and SCAR activity in Dictyostelium

scientific article
Dynamics of the Dictyostelium Arp2/3 complex in endocytosis, cytokinesis, and chemotaxis.

scientific article
The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration

scientific article
Two cAMP receptors activate common signaling pathways in Dictyostelium.

scientific article
Understanding eukaryotic chemotaxis: a pseudopod-centred view

scientific article published on 6 May 2010
A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium

scientific article
WASP and SCAR/WAVE proteins: the drivers of actin assembly

scientific article
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression

scientific article
Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins

scientific article published in February 1996
Signaling through chemoattractant receptors in Dictyostelium

scientific article published on February 1996
The induction of autophagy by mechanical stress.

scientific article
An improved chamber for direct visualisation of chemotaxis

scientific article
PIP₃-dependent macropinocytosis is incompatible with chemotaxis

scientific article
Nap1 regulates Dictyostelium cell motility and adhesion through SCAR-dependent and -independent pathways

scientific article published in April 2006
Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease

scientific article
Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion.

scientific article
Multiple cyclic AMP receptors are linked to adenylyl cyclase in Dictyostelium

scientific article published on November 1992
A plasma membrane template for macropinocytic cups

scientific article
F-BAR domains: multifunctional regulators of membrane curvature.

scientific article published on June 2008
SCAR knockouts in Dictyostelium: WASP assumes SCAR's position and upstream regulators in pseudopods

scientific article
Regulation of actin assembly by SCAR/WAVE proteins.

scientific article
Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal

scientific article (publication date: October 2014)
WASH is required for lysosomal recycling and efficient autophagic and phagocytic digestion

scientific article published on 24 July 2013
Self-Generated Chemoattractant Gradients: Attractant Depletion Extends the Range and Robustness of Chemotaxis

scientific article
Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment

scientific article published on January 2013
The Dictyostelium RasS protein is required for macropinocytosis, phagocytosis and the control of cell movement

scientific article published on 01 February 2000
WASP homology sequences in baculoviruses

scientific article published in July 2001
Phospholipase D activity is essential for actin localization and actin-based motility in Dictyostelium

scientific article
Toxoplasma gondii F-actin forms an extensive filamentous network required for material exchange and parasite maturation

scientific article published on 21 March 2017
The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function

scientific article published in February 1997
WASH drives early recycling from macropinosomes and phagosomes to maintain surface phagocytic receptors

scientific article published on 19 September 2016
The interaction between pseudopods and extracellular signalling during chemotaxis and directed migration

scientific article published on 07 June 2013
SCAR/WAVE is activated at mitosis and drives myosin-independent cytokinesis

scientific article
Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs

scientific article published on 23 March 2007
A novel Dictyostelium RasGEF is required for normal endocytosis, cell motility and multicellular development

scientific article published in November 2000
Entamoeba histolytica cell movement: a central role for self-generated chemokines and chemorepellents

scientific article

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