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List of works by Brian Dean

5-HT2A and muscarinic receptors in schizophrenia: a postmortem study

scientific article

A change in the density of [(3)H]flumazenil, but not [(3)H]muscimol binding, in Brodmann's Area 9 from subjects with bipolar disorder

scientific article

A family-based association study and gene expression analyses of netrin-G1 and -G2 genes in schizophrenia

scientific article

A high prevalence of diabetes in a rural village in Papua New Guinea

scientific article

A proposed pathological model in the hippocampus of subjects with schizophrenia

scientific article

AMPA receptor expression is increased post-mortem samples of the anterior cingulate from subjects with major depressive disorder

scientific article published on 28 October 2011

Abnormal hippocampal distribution of TDP-43 in patients with-late onset psychosis.

scientific article published in August 2009

Altered M(1) muscarinic acetylcholine receptor (CHRM1)-Galpha(q/11) coupling in a schizophrenia endophenotype

scientific article published on 29 April 2009

Altered hippocampal muscarinic M4, but not M1, receptor expression from subjects with schizophrenia.

scientific article published on 17 January 2007

Altered levels of dopamine transporter in the frontal pole and dorsal striatum in schizophrenia

scientific article published on 02 December 2019

An assay to measure the simultaneous uptake of [3H]dopamine and [14C]serotonin by the human platelet reveals an imipramine-insensitive [3H]dopamine uptake mechanism

scientific article published on 01 January 1992

An investigation of the factors that regulate muscarinic receptor expression in schizophrenia

scientific article published on 16 July 2014

Anatomical abnormalities of the anterior cingulate cortex in schizophrenia: bridging the gap between neuroimaging and neuropathology

scientific article

Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer’s disease

Associations between catechol-O-methyltransferase (COMT) genotypes at rs4818 and rs4680 and gene expression in human dorsolateral prefrontal cortex

scientific article published on 20 January 2020

Autophagy has a key role in the pathophysiology of schizophrenia

scientific article

Biomarker investigations related to pathophysiological pathways in schizophrenia and psychosis.

scientific article published on 26 June 2013

Brain distribution of selected antipsychotics in schizophrenia

scientific article

CNS 14-3-3zeta: changes with sex but not psychiatric diagnoses or psychotropic drug treatment

scientific article published on 30 March 2007

Cannabis-sensitive dopaminergic markers in postmortem central nervous system: changes in schizophrenia

scientific article published in April 2003

Cell Type-Specific Methylome-wide Association Studies Implicate Neurotrophin and Innate Immune Signaling in Major Depressive Disorder

scientific article published on 01 November 2019

Cell-type-specific methylome-wide association studies implicate neurodegenerative processes and neuroimmune communication in major depressive disorder

scholarly article published 3 October 2018

Changed cortical risk gene expression in major depression and shared changes in cortical gene expression between major depression and bipolar disorders

scientific article published on 25 June 2019

Changed frontal pole gene expression suggest altered interplay between neurotransmitter, developmental, and inflammatory pathways in schizophrenia

scientific article published on 20 February 2018

Changes in BQCA Allosteric Modulation of [(3)H]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations.

scientific article published on 29 October 2015

Changes in cholinergic and glutamatergic markers in the striatum from a sub-set of subjects with schizophrenia

scientific article published on 3 November 2015

Changes in cortical protein markers of iron transport with gender, major depressive disorder and suicide

scientific article published on 30 January 2019

Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder

scientific article published in August 2005

Changes in levels of cortical metabotropic glutamate 2 receptors with gender and suicide but not psychiatric diagnoses

scientific article published on 06 October 2018

Changes in protein kinase C and adenylate cyclase in the temporal lobe from subjects with schizophrenia

scientific article published in January 1997

Changes in serotonin2A and GABA(A) receptors in schizophrenia: studies on the human dorsolateral prefrontal cortex

scientific article published in April 1999

Changes in the molecular structure of the brain in bipolar disorder: findings using human postmortem brain tissue

scientific article published in July 2002

Changes in the serotonin transporter in the hippocampus of subjects with schizophrenia identified using [3H]paroxetine

scientific article published in January 1996

Cholinergic connectivity: it's implications for psychiatric disorders.

scientific article published on 3 May 2013

Cholinergic muscarinic M4 receptor gene polymorphisms: a potential risk factor and pharmacogenomic marker for schizophrenia

scientific article published on 11 March 2013

Cholinergic muscarinic receptors: new opportunities to treat psychiatric disorders

scientific article published in September 2013

Chromatography of serum on Sep-pak C18 corrects falsely elevated vitamin D metabolite levels measured by protein binding assay

scientific article published on 01 August 1988

Clozapine and olanzapine treatment decreases rat cortical and limbic GABA(A) receptors

scientific article published in May 1998

Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells: a potential in vitro system for the study of agranulocytosis

scientific article published on 17 July 2006

Clozapine decreases [3H] CP 55940 binding to the cannabinoid 1 receptor in the rat nucleus accumbens.

scientific article published in May 2005

Clozapine reverses schizophrenia-related behaviours in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor up-regulation

scientific article published on 2 July 2008

Coexpression network analysis of neural tissue reveals perturbations in developmental processes in schizophrenia.

scientific article

Confirmation of the diagnosis of schizophrenia after death using DSM-IV: a Victorian experience

scientific article published on February 1998

Consistent with dopamine supersensitivity, RGS9 expression is diminished in the amphetamine-treated animal model of schizophrenia and in postmortem schizophrenia brain

scientific article published in May 2007

Cortical biometals: Changed levels in suicide and with mood disorders

scientific article published on 12 September 2018

Cortical glutamatergic markers in schizophrenia

scientific article published in August 2005

Cortical serotonin7, 1D and 1F receptors: effects of schizophrenia, suicide and antipsychotic drug treatment

scientific article published on 17 August 2006

Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia

scientific article published on December 2010

Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA.

scientific article published on 19 February 2013

Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia.

scientific article published on 4 March 2008

Decreased density of [3H]TCP binding following antipsychotic drug withdrawal in rats

scientific article published on April 2002

Decreased frontal cortical serotonin2A receptors in schizophrenia

scientific article published in September 1996

Decreased hippocampal (CA3) NMDA receptors in schizophrenia

scientific article published in April 1999

Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder

scientific article published on August 2003

Decreased kainate receptors in the hippocampus of apolipoprotein D knockout mice

scientific article published on 4 December 2009

Decreased muscarinic receptor binding in subjects with schizophrenia: a study of the human hippocampal formation

scientific article published in September 2000

Decreased muscarinic receptor binding in the frontal cortex of bipolar disorder and major depressive disorder subjects

scientific article

Decreased phorbol ester binding in the parahippocampal gyrus from subjects with schizophrenia is not associated with changes in protein kinase C.

scientific article published in January 2002

Differences in neuroanatomical sites of apoD elevation discriminate between schizophrenia and bipolar disorder

scientific article published in February 2003

Different changes in cortical tumor necrosis factor-α-related pathways in schizophrenia and mood disorders

scientific article

Differential age- and disease-related effects on the expression of genes related to the arachidonic acid signaling pathway in schizophrenia

scientific article

Differential changes in apolipoprotein E in schizophrenia and bipolar I disorder

scientific article published in April 2005

Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders ⬇️

scientific article published on December 20, 2011

Dopamine uptake by platelets from subjects with schizophrenia: a correlation with the delusional state of the patient

scientific article published on 01 January 1992

Dopamine uptake by platelets is selective, temperature dependent and not influenced by the dopamine-D1 or dopamine-D2 receptor

scientific article published in January 1989

Dopamine uptake by the human platelet: effects of dopamine receptor agonists

scientific article published on December 1989

Effects of benzodiazepine treatment on cortical GABA(A) and muscarinic receptors: studies in schizophrenia and rats

scientific article published on 16 May 2010

Epigenetic mechanisms and the serotonin 2A receptor in schizophrenia

scientific article published on 8 February 2013

Evaluation of treatment in 35 cases of bipolar suicide.

scientific article published on June 2009

Evidence for Altered Metabolism of Sphingosine-1-Phosphate in the Corpus Callosum of Patients with Schizophrenia

scientific article published on 29 April 2020

Evidence for altered post-receptor modulation of the serotonin 2a receptor in schizophrenia

scientific article published on 8 August 2008

Evidence for disruption of sphingolipid metabolism in schizophrenia.

scientific article published on January 2009

Evidence for impaired glucose metabolism in the striatum, obtained postmortem, from some subjects with schizophrenia

scientific article

Evidence that a working memory cognitive phenotype within schizophrenia has a unique underlying biology.

scientific article published in 2022

Evidence that the frontal pole has a significant role in the pathophysiology of schizophrenia

scientific article published in 2022

Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex.

scientific article published on August 2004

Extended treatment with typical and atypical antipsychotic drugs differential effects on the densities of dopamine D2-like and GABAA receptors in rat striatum

scientific article published in August 2001

GSK-3 parameters in postmortem frontal cortex and hippocampus of schizophrenic patients

scientific article published in December 2004

Gene expression profiling in Brodmann's area 46 from subjects with schizophrenia

scientific article published in April 2007

Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation

scientific article published on 10 May 2006

High-resolution phosphor imaging: validation for use with human brain tissue sections to determine the affinity and density of radioligand binding

scientific article published in May 2002

Higher levels of different muscarinic receptors in the cortex and hippocampus from subjects with Alzheimer's disease.

scientific article

Hippocampal 5-hydroxytryptamine receptors: abnormalities in postmortem brain from schizophrenic subjects

scientific article published in December 2004

Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia

scientific article published on 09 March 2016

Increased levels of SNAP-25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I disorder

scientific article published in April 2006

Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia.

scientific article published in September 2003

Increased levels of serotonin 2A receptors and serotonin transporter in the CNS of neuregulin 1 hypomorphic/mutant mice

scientific article published on 28 November 2007

Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA

scientific article (publication date: April 2008)

Interpreting the significance of decreased cortical serotonin 2A receptors in schizophrenia

scientific article published on 19 August 2009

Ionotropic glutamate receptors and expression of N-methyl-D-aspartate receptor subunits in subregions of human hippocampus: effects of schizophrenia

scientific article published on 01 July 2000

Is schizophrenia the price of human central nervous system complexity?

scientific article published on January 2009

Levels of [(3)H]pirenzepine binding in Brodmann's area 6 from subjects with schizophrenia is not associated with changes in the transcription factor SP1 or BACE1.

scientific article published on 13 September 2008

Levels of neuregulin 1 and 3 proteins in Brodmann's area 46 from subjects with schizophrenia and bipolar disorder

scientific article published on 17 September 2009

Low Density Lipoprotein Receptor-Related Protein and Apolipoprotein E Expression is Altered in Schizophrenia

scientific article published on 8 July 2010

Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: a study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment

scientific article

Lower cortical serotonin 2A receptors in major depressive disorder, suicide and in rats after administration of imipramine

scientific article published on 4 February 2014

M1 receptor agonism, a possible treatment for cognitive deficits in schizophrenia

scientific article

Mapping the pathophysiology of schizophrenia: interactions between multiple cellular pathways

scientific article

Measurement of dopamine D2-like receptors in postmortem CNS and pituitary: differential regional changes in schizophrenia

scientific article published in May 2004

Molecular profiles of schizophrenia in the CNS at different stages of illness.

scientific article published on 16 August 2008

Mu opioid receptor availability in people with psychiatric disorders who died by suicide: a case control study

scientific article

Muscarinic M1 receptor sequence: preliminary studies on its effects on cognition and expression

scientific article published on 4 March 2012

Muscarinic receptors in schizophrenia.

scientific article

N-Ethylmaleimide sensitive factor in the cortex of subjects with schizophrenia and bipolar I disorder

scientific article published on 13 September 2005

Neither protein kinase C nor adenylate cyclase are altered in the striatum from subjects with schizophrenia

scientific article published in November 1996

Nicotinamide-N-methyltransferase (NNMT) in schizophrenia: genetic association and decreased frontal cortex mRNA levels

scientific article published on 27 July 2011

No change in cortical muscarinic M2, M3 receptors or [35S]GTPgammaS binding in schizophrenia

scientific article

No change in the density of the serotonin1A receptor, the serotonin4 receptor or the serotonin transporter in the dorsolateral prefrontal cortex from subjects with schizophrenia.

scientific article published in February 1999

Normal human aging and early-stage schizophrenia share common molecular profiles.

scientific article published on 26 February 2009

Pathways underlying neuroprogression in bipolar disorder: focus on inflammation, oxidative stress and neurotrophic factors

scientific article published on 08 October 2010

Phorbol esters increase [(3)h]-dopamine uptake by human platelets

scientific article published in January 1990

Phospholipase C beta 1 expression in the dorsolateral prefrontal cortex from patients with schizophrenia at different stages of illness.

scientific article published on 23 November 2010

Phospholipase C-beta1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration

scientific article published on 31 July 2007

Plasma apolipoprotein E is decreased in schizophrenia spectrum and bipolar disorder

scientific article

Platelet [3H]dopamine uptake is differentially affected by neuroleptic drug treatment in schizophrenia and schizophreniform disorder.

scientific article published in January 1996

Possible involvement of post-dopamine D2 receptor signalling components in the pathophysiology of schizophrenia.

scientific article published on 6 August 2007

Postmortem brain calcineurin protein levels in schizophrenia patients are not different from controls

scientific article published on 7 February 2006

Potential clozapine target sites on peripheral hematopoietic cells and stromal cells of the bone marrow

scientific article published in January 2003

Problems and solutions to filling the drying drug pipeline for psychiatric disorders: a report from the inaugural 2012 CINP Think Tank

scientific article published on 24 September 2013

Recent advances in postmortem pathology and neurochemistry in schizophrenia

scientific article

Region and diagnosis-specific changes in synaptic proteins in schizophrenia and bipolar I disorder

scientific article

Regional and duration of illness differences in the alteration of NCAM-180 mRNA expression within the cortex of subjects with schizophrenia.

scientific article published on 02 May 2009

Regionally specific changes in levels of cortical S100beta in bipolar 1 disorder but not schizophrenia

scientific article published in March 2006

Regionally-specific changes in levels of tumour necrosis factor in the dorsolateral prefrontal cortex obtained postmortem from subjects with major depressive disorder

scientific article published in January 2010

Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia

scientific article

Repeated antidepressant drug treatment, time of death and frequency of handling do not affect [3H]paroxetine binding in rat cortex

scientific article published in December 1997

Role of muscarinic receptors in the activity of N-desmethylclozapine: reversal of hyperactivity in the phospholipase C knockout mouse.

scientific article published in September 2008

Role of the cholinergic system in the pathology and treatment of schizophrenia.

scientific article published on January 2009

SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects

scientific article

SMAD4 protein is decreased in the dorsolateral prefrontal and anterior cingulate cortices in schizophrenia

scientific article published on 02 March 2020

Selective Activation of Muscarinic Acetylcholine Receptors for the Treatment of Schizophrenia ⬇️

scientific article published on June 1, 2012

Sensitivity to MK-801 in phospholipase C-β1 knockout mice reveals a specific NMDA receptor deficit

scientific article published on 23 February 2009

Separation of free and antibody-bound insulin in plasma using a bench ultracentrifuge (Beckman 'Airfuge')

scientific article published on 01 June 1984

Serotonin 1a receptor and associated G-protein activation in schizophrenia and bipolar disorder

scientific article published on 10 July 2006

Serotonin(2A) receptors are reduced in the planum temporale from subjects with schizophrenia

scientific article published on 01 July 2000

Serotonin2 receptors and the serotonin transporter in the schizophrenic brain

scientific article published in January 1996

Signal transmission, rather than reception, is the underlying neurochemical abnormality in schizophrenia.

scientific article

Significant correlation between 14C-5-HT uptake by and 3H-paroxetine binding to platelets from healthy volunteers

scientific article published on 01 September 1993

Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use.

scientific article published in January 2001

Studies on dopaminergic and GABAergic markers in striatum reveals a decrease in the dopamine transporter in schizophrenia

scientific article

Studies on serotonergic markers in the human hippocampus: changes in subjects with bipolar disorder

scientific article

The binding of [3H]AF-DX 384 is reduced in the caudate-putamen of subjects with schizophrenia

scientific article

The development of a method to measure [3H] dopamine uptake by washed platelets provides no evidence for circulating inhibitors of platelet dopamine uptake in schizophrenia

scientific article published on 01 November 1994

The distribution of muscarinic M1 receptors in the human hippocampus

scientific article published on 16 July 2016

The neurobiology of APOE in schizophrenia and mood disorders

scientific article published on January 2011

The neurobiology of bipolar disorder: findings using human postmortem central nervous system tissue.

scientific article published on March 2004

The use of a modified [3H]4-DAMP radioligand binding assay with increased selectivity for muscarinic M3 receptor shows that cortical CHRM3 levels are not altered in mood disorders

scientific article published on 17 August 2013

Towards a muscarinic hypothesis of schizophrenia.

scientific article published on 5 December 2006

Treatment with haloperidol and diazepam alters GABA(A) receptor density in the rat brain

scientific article published on 5 November 2007

Treatment with haloperidol or clozapine causes changes in dopamine receptors but not adenylate cyclase or protein kinase C in the rat forebrain

scientific article published in January 1996

Typical and atypical neuroleptic drugs decrease platelet 3H-dopamine uptake in the rat.

scientific article published in June 1996

Understanding the pathophysiology of schizophrenia: Contributions from the Melbourne Psychiatric Brain Bank

scientific article

Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: evidence from human peripheral studies and CNS studies ⬇️

scientific article published on December 15, 2010

Using differential solubilization and 2-D gel electrophoresis to visualize increased numbers of proteins in the human cortex and caudate nucleus and putamen

scientific article published on 30 July 2008

Validation of a method to measure the uptake of [3H]dopamine by human platelets

scientific article published on 01 January 1990

Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E.

scientific article published in January 2002

Widespread Changes in Positive Allosteric Modulation of the Muscarinic M1 Receptor in Some Participants With Schizophrenia

scientific article published on 01 October 2019

Widespread decreases in cortical muscarinic receptors in a subset of people with schizophrenia

scientific article published on 17 February 2012

[(3)H]Flumazenil binding in the human hippocampal formation, frontal cortex and cerebellum detected by high-resolution phosphorimaging

scientific article published in February 2002

[3H]RX 821002 in human dorsolateral prefrontal cortex: no changes in postmortem tissue from subjects with schizophrenia

scientific article

[3H]raclopride binding to brain tissue from subjects with schizophrenia: methodological aspects

scientific article published in June 1997

Β-actin does not show the characteristics of a reference protein in human cortex

scientific article published on 06 November 2018

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