List of works - Paula M. Agostinho

Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology.

scientific article published in January 2009

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.

scientific article

Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes.

scientific article published in February 2012

Adenosine A2A receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells

scientific article

Adenosine modulation of d-[3H]aspartate release in cultured retina cells exposed to oxidative stress

scientific article published on 01 March 2000

Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration ⬇️

scientific article published on 09 December 2010

Age-Related Changes in the Synaptic Density of Amyloid-β Protein Precursor and Secretases in the Human Cerebral Cortex.

scientific article published on 18 April 2016

Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies.

scientific article

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades

scientific article published on 22 August 2008

Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes

scientific article

Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide

scientific article

Anthocyanins restore behavioral and biochemical changes caused by streptozotocin-induced sporadic dementia of Alzheimer's type

scientific article published on 28 November 2013

Astrocytic adenosine A2A receptors control the amyloid-β peptide-induced decrease of glutamate uptake

scientific article published in January 2012

Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway ⬇️

scientific article published on August 20, 2012

Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease

scientific article published on 31 May 2018

Caffeine Consumption Prevents Diabetes-Induced Memory Impairment and Synaptotoxicity in the Hippocampus of NONcZNO10/LTJ Mice ⬇️

scientific article published on April 13, 2012

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses

scientific article published on 9 February 2016

Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress

scientific article

Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life

scientific article published on 30 October 2009

Cdk5: multitasking between physiological and pathological conditions

scientific article

Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system

scientific article published on 26 April 2014

Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline

scientific article published on January 2010

Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegeneration

scientific article

Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia

scientific article

Depression as a Glial-Based Synaptic Dysfunction

scientific article

Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-β Levels in Patients with Alzheimer's Disease?

scientific article published in August 2015

Effect of oxidative stress on the release of [3H]GABA in cultured chick retina cells

scientific article published on 01 August 1994

Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A2A receptor over-activation in a rat model of Parkinson's disease

scientific article published on 01 August 2019

Enhanced role of adenosine A(2A) receptors in the modulation of LTP in the rat hippocampus upon ageing

scientific article published on 25 May 2011

Expression and subcellular localization of a novel nuclear acetylcholinesterase protein

scientific article published on 2 July 2007

Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum.

scientific article published on August 2013

Galantamine protects against oxidative stress induced by amyloid-beta peptide in cortical neurons

scientific article published in February 2009

Glutamate in Life and Death of Retinal Amacrine Cells*

scientific article published on 01 March 1998

Influence of oxidative stress on membrane potential and on K+ channels in neuronal cells

article published in 1995

Intracellular free Na+ concentration increases in cultured retinal cells under oxidative stress conditions

Involvement of calcineurin in the neurotoxic effects induced by amyloid-beta and prion peptides

scientific article published in March 2003

Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide

scientific article published on January 2003

Localization and Trafficking of Amyloid-β Protein Precursor and Secretases: Impact on Alzheimer's Disease

scientific article

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-β Peptides Modeling Alzheimer's Disease.

scientific article published in September 2017

Neurodegeneration in an Aβ-induced model of Alzheimer’s disease: the role of Cdk5

article

Neuroinflammation and Mitochondrial Dysfunction in Alzheimer's and Prion's Diseases

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions

scientific article published on 01 November 2018

Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats

scientific article published on 24 December 2013

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity

scientific article

Overactivation of calcineurin induced by amyloid-beta and prion proteins

scientific article

Oxidative stress affects the selective ion permeability of voltage-sensitive Ca2+ channels in cultured retinal cells

scientific article published on 01 April 1997

Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences

scientific article published on 17 May 2012

Prion protein aggregation and neurotoxicity in cortical neurons

scientific article

Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens

scientific article published on 25 December 2013

Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies.

scientific article published on 27 October 2007

Spatial memory impairments in a prediabetic rat model

scientific article

Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease

scientific article published on 11 March 2016

Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum

scientific article published on 4 March 2014

Susceptibility of hippocampal neurons to Abeta peptide toxicity is associated with perturbation of Ca2+ homeostasis

scientific article

Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

scientific article published on 05 August 2019

Synaptic and sub-synaptic localization of amyloid-β protein precursor in the rat hippocampus

scientific article published in January 2014

Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents

scientific article published on 30 August 2019

Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity.

scientific article published on 4 February 2013

The Association of Amyloid-β Protein Precursor With α- and β-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease.

scientific article published on 26 October 2015

List of works by Paula M. Agostinho

Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology.

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.

Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes.

Adenosine A2A receptors regulate the extracellular accumulation of excitatory amino acids upon metabolic dysfunction in chick cultured retinal cells

Adenosine modulation of d-[3H]aspartate release in cultured retina cells exposed to oxidative stress

Adenosine receptors and brain diseases: Neuroprotection and neurodegeneration ⬇️

Age-Related Changes in the Synaptic Density of Amyloid-β Protein Precursor and Secretases in the Human Cerebral Cortex.

Alzheimer's disease-associated neurotoxic mechanisms and neuroprotective strategies.

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades

Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes

Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide

Anthocyanins restore behavioral and biochemical changes caused by streptozotocin-induced sporadic dementia of Alzheimer's type

Astrocytic adenosine A2A receptors control the amyloid-β peptide-induced decrease of glutamate uptake

Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway ⬇️

Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease

Caffeine Consumption Prevents Diabetes-Induced Memory Impairment and Synaptotoxicity in the Hippocampus of NONcZNO10/LTJ Mice ⬇️

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses

Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress

Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life

Cdk5: multitasking between physiological and pathological conditions

Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system

Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline

Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegeneration

Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia

Depression as a Glial-Based Synaptic Dysfunction

Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-β Levels in Patients with Alzheimer's Disease?

Effect of oxidative stress on the release of [3H]GABA in cultured chick retina cells

Enhanced ATP release and CD73-mediated adenosine formation sustain adenosine A2A receptor over-activation in a rat model of Parkinson's disease

Enhanced role of adenosine A(2A) receptors in the modulation of LTP in the rat hippocampus upon ageing

Expression and subcellular localization of a novel nuclear acetylcholinesterase protein

Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum.

Galantamine protects against oxidative stress induced by amyloid-beta peptide in cortical neurons

Glutamate in Life and Death of Retinal Amacrine Cells*

Influence of oxidative stress on membrane potential and on K+ channels in neuronal cells

Intracellular free Na+ concentration increases in cultured retinal cells under oxidative stress conditions

Involvement of calcineurin in the neurotoxic effects induced by amyloid-beta and prion peptides

Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide

Localization and Trafficking of Amyloid-β Protein Precursor and Secretases: Impact on Alzheimer's Disease

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-β Peptides Modeling Alzheimer's Disease.

Neurodegeneration in an Aβ-induced model of Alzheimer’s disease: the role of Cdk5

Neuroinflammation and Mitochondrial Dysfunction in Alzheimer's and Prion's Diseases

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions

Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity

Overactivation of calcineurin induced by amyloid-beta and prion proteins

Oxidative stress affects the selective ion permeability of voltage-sensitive Ca2+ channels in cultured retinal cells

Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences

Prion protein aggregation and neurotoxicity in cortical neurons

Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens

Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-Beta and prion peptides: implications for Alzheimer's disease and prion-related encephalopathies.

Spatial memory impairments in a prediabetic rat model

Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease

Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum

Susceptibility of hippocampal neurons to Abeta peptide toxicity is associated with perturbation of Ca2+ homeostasis

Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine

Synaptic and sub-synaptic localization of amyloid-β protein precursor in the rat hippocampus

Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents

Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity.

The Association of Amyloid-β Protein Precursor With α- and β-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease.