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List of works by William G. Kerr

A critical role for Stat3 signaling in immune tolerance

scientific article published in September 2003

A rapid and quantitative assay to estimate gene transfer into retrovirally transduced hematopoietic stem/progenitor cells using a 96-well format PCR and fluorescent detection system universal for MMLV-based proviruses

scientific article

A role for SHIP in stem cell biology and transplantation.

scientific article published on May 2008

Analysis of apoptosis in hematopoietic stem cells by flow cytometry

scientific article published in January 2008

Analysis of lipopolysaccharide-response genes in B-lineage cells demonstrates that they can have differentiation stage-restricted expression and contain SH2 domains.

scientific article

Coordinate expansion of murine hematopoietic and mesenchymal stem cell compartments by SHIPi

scientific article published in March 2015

Cutting edge: dominance by an MHC-independent inhibitory receptor compromises NK killing of complex targets

scientific article

Deregulated expression of LRBA facilitates cancer cell growth

scientific article published in May 2004

Detection and isolation of gene-corrected cells in Gaucher disease via a fluorescence-activated cell sorter assay for lysosomal glucocerebrosidase activity.

scientific article

Discovery and development of small molecule SHIP phosphatase modulators

scientific article

Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival.

scientific article

Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein

scientific article

Expansion of myeloid suppressor cells in SHIP-deficient mice represses allogeneic T cell responses

article

Expression of individual immunoglobulin genes occurs in an unusual system consisting of multiple independent loci

article

Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells.

scientific article published on 22 February 2005

Follicular dendritic cell (FDC) precursors in primary lymphoid tissues

scientific article

Gene therapy: current status and future prospects

scientific article published on August 1994

Genetic modification of the hematolymphoid compartment for therapeutic purposes ⬇️

scientific article published on June 1, 1998

Identification of a novel lipopolysaccharide-inducible gene with key features of both A kinase anchor proteins and chs1/beige proteins

scientific journal article

Impaired T-cell survival promotes mucosal inflammatory disease in SHIP1-deficient mice

scientific article published on 30 April 2014

In situ detection of transcriptionally active chromatin and genetic regulatory elements in individual viable mammalian cells.

scientific article published in January 1989

Inappropriate recruitment and activity by the Src homology region 2 domain-containing phosphatase 1 (SHP1) is responsible for receptor dominance in the SHIP-deficient NK cell

scientific article published in December 2007

Induced SHIP deficiency expands myeloid regulatory cells and abrogates graft-versus-host disease

scientific article

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

scientific article published on 20 November 2005

Inhibitor and activator: dual functions for SHIP in immunity and cancer ⬇️

scientific article published on December 13, 2010

Introduction to Inositol Phospholipid Signaling in Physiology and Disease ⬇️

scientific article published on March 1, 2013

Lineage extrinsic and intrinsic control of immunoregulatory cell numbers by SHIP.

scientific article published on July 2012

Lipid phosphatase SHIP2 functions as oncogene in colorectal cancer by regulating PKB activation

scientific article published on 28 September 2016

Ly49Q positively regulates type I IFN production by plasmacytoid dendritic cells in an immunoreceptor tyrosine-based inhibitory motif-dependent manner.

scientific article published on 11 March 2013

Major remodelling of the murine stem cell kinome following differentiation in the hematopoietic compartment

scientific article published on 28 June 2011

Mouse natural killer cell development and maturation are differentially regulated by SHIP-1.

scientific article

Myeloid cell-specific expression of Ship1 regulates IL-12 production and immunity to helminth infection

article

Overexpression of SH2-Containing Inositol Phosphatase Contributes to Chronic Lymphocytic Leukemia Survival

scientific article published on 13 December 2019

Pan-SHIP1/2 inhibitors promote microglia effector functions essential for CNS homeostasis

scientific article published on 10 January 2020

Progress towards a new wave of immune-based therapeutics

article

Quorum Sensing Contributes to Activated IgM-Secreting B Cell Homeostasis ⬇️

scientific article published on December 3, 2012

Regulation of IgM and IgD expression in human B-lineage cells

scientific article published on May 1991

Relationship between selectin-mediated rolling of hematopoietic stem and progenitor cells and progression in hematopoietic development

scientific article published in January 2000

Role of SHIP1 in Invariant NKT Cell Development and Functions

scientific article published on 31 July 2015

Role of SHIP1 in bone biology

scientific article published on March 2013

Role of SHIP1 in cancer and mucosal inflammation

scientific article published on March 2013

Role of c-mpl in early hematopoiesis.

scientific article published in July 1998

Role of inositol phospholipid signaling in natural killer cell biology.

scientific article published on 06 March 2013

Role of inositol poly-phosphatases and their targets in T cell biology

scientific article published on 23 September 2013

SH2-inositol phosphatase 1 negatively influences early megakaryocyte progenitors

scientific article

SHIP deficiency causes Crohn's disease-like ileitis

scientific article

SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation

scientific article

SHIP influences signals from CD48 and MHC class I ligands that regulate NK cell homeostasis, effector function, and repertoire formation

scientific article published on 2 April 2010

SHIP is required for a functional hematopoietic stem cell niche.

scientific article published on 12 December 2008

SHIP limits immunoregulatory capacity in the T-cell compartment.

scientific article published on 09 January 2009

SHIP represses Th2 skewing by inhibiting IL-4 production from basophils

scientific article published on 3 December 2010

SHIP-1 Couples to the Dectin-1 hemITAM and Selectively Modulates Reactive Oxygen Species Production in Dendritic Cells in Response to Candida albicans

scientific article

SHIP-1 deficiency in the myeloid compartment is insufficient to induce myeloid expansion or chronic inflammation

scientific article published on 6 March 2014

SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells.

scientific article

SHIP1 intrinsically regulates NK cell signaling and education, resulting in tolerance of an MHC class I-mismatched bone marrow graft in mice

scientific article published on 16 February 2015

SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/β-catenin/Id2 axis

scientific article

SHIP1-expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging.

scientific article published on 5 February 2015

SHIPi Enhances Autologous and Allogeneic Hematolymphoid Stem Cell Transplantation.

scientific article published on March 2015

Small molecule targeting of SHIP1 and SHIP2

scientific article published on 01 February 2020

Stage-specific transcription of germline IgH C gamma and C alpha regions during human B cell differentiation

scientific article published on November 1991

TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

scientific article

The Next Generation of Immunotherapy for Cancer: Small Molecules Could Make Big Waves

scientific article published on 01 January 2019

The mouse that lost its appetite for human

scientific article published on December 2013

The thrombopoietin receptor, c-Mpl, is a selective surface marker for human hematopoietic stem cells.

scientific article

Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer

scientific article published on 10 February 2012

Transcriptionally defective retroviruses containing lacZ for the in situ detection of endogenous genes and developmentally regulated chromatin

scientific article published in January 1989

Widespread deregulation of phosphorylation-based signaling pathways in multiple myeloma cells: opportunities for therapeutic intervention

scientific article published on 28 April 2011

miR-155 Upregulation in Dendritic Cells Is Sufficient To Break Tolerance In Vivo by Negatively Regulating SHIP1.

scientific article published on 7 October 2015

s-SHIP associates with receptor complexes essential for pluripotent stem cell growth and survival.

scientific article

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