Search filters

List of works by Jerson Lima

A biophysical characterization of the interaction of a hepatitis C virus membranotropic peptide with micelles

scientific article

A contribution of the mitochondrial adenosinetriphosphatase inhibitor protein to the thermal stability of the F0F1-ATPase complex

scientific article published on 01 July 1997

A hypothesis to reconcile the physical and chemical unfolding of proteins

scientific article

Agathisflavone, a Biflavonoid from Anacardium occidentale L., Inhibits Influenza Virus Neuraminidase

scientific article published on 01 January 2020

Aggregation and Prion-Like Properties of Misfolded Tumor Suppressors: Is Cancer a Prion Disease?

scientific article

Aggregation tendencies in the p53 family are modulated by backbone hydrogen bonds

scientific article published on 07 September 2016

Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer

scientific article published in Journal of Biological Chemistry

Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+ Ion.

scientific article

Alpha-synuclein stepwise aggregation reveals features of an early onset mutation in Parkinson's disease

scientific article published on 11 October 2019

Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C

scientific article

Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues

scientific article published on 18 February 2020

Arc repressor will not denature under pressure in the absence of water

scientific article published in July 1994

Backbone resonance assignments of the human p73 DNA binding domain

scientific article

Biophysical and morphological studies on the dual interaction of non-octarepeat prion protein peptides with copper and nucleic acids

scientific article published on 21 February 2014

Biophysical characterization of p53 core domain aggregates

scientific article published on 01 January 2020

Ca(2+) and Mg(2+) binding to weak sites of TnC C-domain induces exposure of a large hydrophobic surface that leads to loss of TnC from the thin filament

scientific article published on 9 September 2005

Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target.

scientific article

Cavity defects in the procapsid of bacteriophage P22 and the mechanism of capsid maturation

scientific article published on 01 April 1999

Characterization of a Partially Folded Monomer of the DNA-binding Domain of Human Papillomavirus E2 Protein Obtained at High Pressure

scientific article published in Journal of Biological Chemistry

Charge neutralization as the major factor for the assembly of nucleocapsid-like particles from C-terminal truncated hepatitis C virus core protein

scientific article published on 9 November 2016

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors

scientific article published on 05 November 2010

Cognate DNA stabilizes the tumor suppressor p53 and prevents misfolding and aggregation.

scientific article

Concentration dependence of the subunit association of oligomers and viruses and the modification of the latter by urea binding.

scientific article published on January 1996

Conformational changes in bovine lactoferrin induced by slow or fast temperature increases

scientific article

Conformational selection, dynamic restriction and the hydrophobic effect coupled to stabilization of the BIR3 domain of the human X-linked inhibitor of apoptosis protein by the tetrapeptide AVPI ⬇️

scientific article published on August 17, 2010

Controlling {beta}-amyloid oligomerization by the use of naphthalene sulfonates: trapping low molecular weight oligomeric species

scientific article

Conversion of wild-type p53 core domain into a conformation that mimics a hot-spot mutant

scientific article published on October 2003

Cytosolic-free calcium elevation in Trypanosoma cruzi is required for cell invasion ⬇️

scientific article

DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregation

scientific article published on 16 October 2001

Differences in pressure stability of the three components of cowpea mosaic virus: implications for virus assembly and disassembly

scientific article published in July 1994

Different urea stoichiometries between the dissociation and denaturation of tobacco mosaic virus as probed by hydrostatic pressure

scientific article published on 25 February 2008

Dissecting the role of protein-protein and protein-nucleic acid interactions in MS2 bacteriophage stability.

scientific article

Dissociation of a native dimer to a molten globule monomer. Effects of pressure and dilution on the association equilibrium of arc repressor

scientific article

Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities

scientific article published on 4 August 2003

Distinct modulatory role of RNA in the aggregation of the tumor suppressor protein p53 core domain.

scientific article published on 18 April 2017

Effect of hydrostatic pressure on the mitochondrial ATP synthase

scientific article published on 01 September 1988

Effects of high pressure and temperature on the wild-type and F29W mutant forms of the N-domain of avian troponin C.

scientific article

Energy coupling between DNA binding and subunit association is responsible for the specificity of DNA-Arc interaction

scientific article published on June 1993

Enhanced prion protein stability coupled to DNA recognition and milieu acidification

scientific article published on 5 January 2009

Envelope lipid-packing as a critical factor for the biological activity and stability of alphavirus particles isolated from mammalian and mosquito cells.

scientific article

Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor

scientific article published on 25 July 2013

Experimental approaches to the interaction of the prion protein with nucleic acids and glycosaminoglycans: Modulators of the pathogenic conversion

scientific article published on 08 December 2010

Exploring the polymorphism, conformational dynamics and function of amyloidogenic peptides and proteins by temperature and pressure modulation

scientific article published on 14 November 2020

Fibrillar aggregates of the tumor suppressor p53 core domain

scientific article published in August 2003

Fine modulation of the respiratory syncytial virus M2-1 protein quaternary structure by reversible zinc removal from its Cys(3)-His(1) motif

scientific article published on 19 September 2013

Formation of a denatured dimer limits the thermal stability of Arc repressor 1 1Edited by P. E. Wright

article

Fourier transform infrared spectroscopy provides a fingerprint for the tetramer and for the aggregates of transthyretin

scientific article

Free-energy linkage between folding and calcium binding in EF-hand proteins

scientific article

Full inactivation of human influenza virus by high hydrostatic pressure preserves virus structure and membrane fusion while conferring protection to mice against infection

scientific article

Heparin Binding by Murine Recombinant Prion Protein Leads to Transient Aggregation and Formation of RNA-Resistant Species

article

Heparin binding confers prion stability and impairs its aggregation

scientific article

High-Pressure NMR Study of the Dissociation of Arc Repressor

scientific article published on 01 July 1994

High-pressure applications in medicine and pharmacology

scholarly article by Jerson L Silva et al published 26 March 2004 in Journal of Physics: Condensed Matter

High-pressure chemical biology and biotechnology

scientific article published on 02 June 2014

Highlights of the 3rd International Conference on High Pressure Bioscience and Biotechnology.

scientific article published on 30 July 2005

Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease

scientific article published in May 2003

Hydration and packing effects on prion folding and beta-sheet conversion. High pressure spectroscopy and pressure perturbation calorimetry studies

scientific article published in June 2004

Hydration, cavities and volume in protein folding, aggregation and amyloid assembly.

scientific article published on 10 February 2009

Hydrostatic pressure induces the fusion-active state of enveloped viruses

scientific article

Hydrostatic pressure rescues native protein from aggregates

scientific article published on 01 June 1999

In Vitro Prion Amplification Methodology for Inhibitor Screening

scientific article published on 01 January 2019

Inactivation of classical swine fever virus: association of hydrostatic pressure and ultraviolet irradiation

scientific article published on March 2003

Inactivation of simian immunodeficiency virus by hydrostatic pressure

scientific article

Increase in fatty acids and flotillins upon resveratrol treatment of human breast cancer cells

scientific article published on 27 September 2019

Inhibition of Mayaro virus infection by bovine lactoferrin.

scientific article

Insights into the intramolecular coupling between the N- and C-domains of troponin C derived from high-pressure, fluorescence, nuclear magnetic resonance, and small-angle X-ray scattering studies

scientific article published on 19 December 2012

Intermediate states of assembly in the dissociation of gastropod hemocyanin by hydrostatic pressure.

scientific article

International symposium on protein condensation, in honor of gregorio weber, may 21-25, 1997, rio de janeiro, brazil

scientific article published on July 1998

Intramolecular dynamics within the N-Cap-SH3-SH2 regulatory unit of the c-Abl tyrosine kinase reveal targeting to the cellular membrane

scientific article published on 8 August 2013

Intranasal Immunization with Pressure Inactivated Avian Influenza Elicits Cellular and Humoral Responses in Mice

scientific article (publication date: 2015)

Intriguing nucleic-acid-binding features of mammalian prion protein

scientific article published on 19 February 2008

LexA Repressor Forms Stable Dimers in Solution

scientific article published in Journal of Biological Chemistry

Ligand binding and hydration in protein misfolding: insights from studies of prion and p53 tumor suppressor proteins

scientific article

Liquid-liquid phase separation and fibrillation of the prion protein modulated by a high-affinity DNA aptamer

scientific article published on 22 November 2019

Liquid-liquid phase transitions and amyloid aggregation in proteins related to cancer and neurodegenerative diseases

scientific article published on 21 September 2019

Local heterogeneity in the pressure denaturation of the coiled-coil tropomyosin because of subdomain folding units.

scientific article

Loss of the p53 transactivation domain results in high amyloid aggregation of the Δ40p53 isoform in endometrial carcinoma cells

scientific article published on 26 April 2019

Low temperature and pressure stability of picornaviruses: implications for virus uncoating

scientific article published on March 1999

Measuring the strength of interaction between the Ebola fusion peptide and lipid rafts: implications for membrane fusion and virus infection

scientific article

Migration of vesicular stomatitis virus glycoprotein to the nucleus of infected cells.

scientific article published on August 1996

Misfolding, Aggregation, and Disordered Segments in c-Abl and p53 in Human Cancer.

scientific article

Modulation of p53 and prion protein aggregation by RNA

scientific article published on 28 February 2019

Modulation of prion protein oligomerization, aggregation, and beta-sheet conversion by 4,4'-dianilino-1,1'-binaphthyl-5,5'-sulfonate (bis-ANS).

scientific article

Molten-globule conformation of Arc repressor monomers determined by high-pressure 1H NMR spectroscopy.

scientific article

Moniliophthora perniciosa necrosis- and ethylene-inducing protein 2 (MpNep2) as a metastable dimer in solution: structural and functional implications

scientific article

Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer.

scientific article

New insights into the mechanisms of protein misfolding and aggregation in amyloidogenic diseases derived from pressure studies

scientific article published in September 2004

Nonspecific prion protein-nucleic acid interactions lead to different aggregates and cytotoxic species

scientific article

On the entry of an emerging arbovirus into host cells: Mayaro virus takes the highway to the cytoplasm through fusion with early endosomes and caveolae-derived vesicles.

scientific article

Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers

scientific article published on 08 January 2020

Osmolytes protect mitochondrial F(0)F(1)-ATPase complex against pressure inactivation

scientific article published in March 2001

Partially folded states of the capsid protein of cowpea severe mosaic virus in the disassembly pathway.

scientific article

Pathological implications of nucleic acid interactions with proteins associated with neurodegenerative diseases

scientific article

Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands

scientific article published on 26 April 2021

Positive contribution of hydration on DNA binding by E2c protein from papillomavirus

scientific article

Positive response to imatinib mesylate therapy for childhood chronic myeloid leukemia

scientific article published on 9 April 2010

PrP interactions with nucleic acids and glycosaminoglycans in function and disease

scientific article published on January 2010

Pressure Stability of Proteins

Pressure and low temperature effects on the fluorescence emission spectra and lifetimes of the photosynthetic components of cyanobacteria.

scientific article

Pressure denaturation of the bacteriophage P22 coat protein and its entropic stabilization in icosahedral shells

scientific article

Pressure effects on the interaction between natural inhibitor protein and mitochondrial F1-ATPase.

scientific article

Pressure induces folding intermediates that are crucial for protein-DNA recognition and virus assembly.

scientific article

Pressure provides new insights into protein folding, dynamics and structure

scientific article

Pressure-Inactivated Virus: A Promising Alternative for Vaccine Production

scientific article published on January 2015

Pressure-inactivated FMDV: a potential vaccine

scientific article

Pressure-inactivated yellow fever 17DD virus: implications for vaccine development

scientific article

Pressure-induced dissociation of brome mosaic virus

scientific article

Pressure-induced formation of inactive triple-shelled rotavirus particles is associated with changes in the spike protein Vp4.

scientific article published in April 2001

Pressure-induced fusogenic conformation of vesicular stomatitis virus glycoprotein

scientific article published on May 2003

Prion protein complexed to N2a cellular RNAs through its N-terminal domain forms aggregates and is toxic to murine neuroblastoma cells

scientific article published on May 2008

Prion-like aggregation of mutant p53 in cancer

scientific article published on 26 April 2014

Protein Folding in the Absence of Chemical Denaturants

scientific article published in Journal of Biological Chemistry

Protein folding and aggregation: two sides of the same coin in the condensation of proteins revealed by pressure studies

scientific article

Protein-RNA interactions and virus stability as probed by the dynamics of tryptophan side chains

scientific article published on 30 September 2002

RNA modulates aggregation of the recombinant mammalian prion protein by direct interaction

scientific article published on 27 August 2019

Recent Synthetic Approaches towards Small Molecule Reactivators of p53

scientific article published on 20 April 2020

Reciprocal remodeling upon binding of the prion protein to its signaling partner hop/STI1.

scientific article published on 24 August 2009

Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex

scientific article published on 25 August 2016

Resveratrol Induces Reactive Oxygen Species Production and Apoptosis in Breast Cancer Cells

Resveratrol Modifies Lipid Composition of Two Cancer Cell Lines

scientific article published on 19 February 2020

Resveratrol prevents p53 aggregation and in breast cancer cells

Resveratrol, Curcumin and Piperine Alter Human Glyoxalase 1 in MCF-7 Breast Cancer Cells

scientific article published on 24 July 2020

Reversible aggregation plays a crucial role on the folding landscape of p53 core domain

scientific article

Reversible pressure dissociation of R17 bacteriophage. The physical individuality of virus particles.

scientific article

Role of Entropic Interactions in Viral Capsids: Single Amino Acid Substitutions in P22 Bacteriophage Coat Protein Resulting in Loss of Capsid Stability

scientific article published on 01 January 1995

Role of hydration in the closed-to-open transition involved in Ca2+ binding by troponin C.

scientific article published in May 2003

Science and technology to combat dengue virus

scientific article published in December 2009

Self-association and modification of calcium binding in solubilized sarcoplasmic reticulum adenosine triphosphatase

scientific article published on 01 February 1983

Slab gel electrophoresis of oligomeric proteins under high hydrostatic pressure. I. Description of the system and demonstration of the pressure dissociation of a dimer

scientific article

Stability of different influenza subtypes: How can high hydrostatic pressure be a useful tool for vaccine development?

scientific article

Structural Behavior of Cardiac Troponin C Variants Present in Cardiomyopathic Patients

Structural basis for the dissociation of α-synuclein fibrils triggered by pressure perturbation of the hydrophobic core

scientific article

Structural insights into the interaction between prion protein and nucleic acid

scientific article published on August 2006

Structural insights into the stabilization of the human immunodeficiency virus type 1 capsid protein by the cyclophilin-binding domain and implications on the virus cycle

scientific article published on 16 December 2014

Structure of a membrane-binding domain from a non-enveloped animal virus: insights into the mechanism of membrane permeability and cellular entry.

scientific article

Structure of the Ebola fusion peptide in a membrane-mimetic environment and the interaction with lipid rafts

scientific article

Synthesis and anti-prion activity evaluation of aminoquinoline analogues

scientific article published on 6 August 2010

Targeting the Prion-like Aggregation of Mutant p53 to Combat Cancer

scientific article published on 20 December 2017

Tetramerization of the LexA repressor in solution: implications for gene regulation of the E.coli SOS system at acidic pH.

scientific article

The "Jekyll and Hyde" Actions of Nucleic Acids on the Prion-like Aggregation of Proteins

scientific article

The Anti-Parkinsonian Drug Selegiline Delays the Nucleation Phase of α-Synuclein Aggregation Leading to the Formation of Nontoxic Species

article

The Status of p53 Oligomeric and Aggregation States in Cancer

scientific article published on 04 April 2020

The aggregation of mutant p53 produces prion-like properties in cancer

scientific article published on January 2014

The amino-terminal PrP domain is crucial to modulate prion misfolding and aggregation

scientific article

The fusogenic state of Mayaro virus induced by low pH and by hydrostatic pressure

scientific article published on January 2006

The hypothesis of the catalytic action of nucleic acid on the conversion of prion protein

scientific article

The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation

scientific article published on 20 November 2019

The metastable state of nucleocapsids of enveloped viruses as probed by high hydrostatic pressure.

scientific article published on 22 November 2000

The p53 core domain is a molten globule at low pH: functional implications of a partially unfolded structure.

scientific article

The peculiar interaction between mammalian prion protein and RNA

scientific article published on 11 April 2008

The preaggregated state of an amyloidogenic protein: hydrostatic pressure converts native transthyretin into the amyloidogenic state

scientific journal article

The proapoptotic protein Smac/DIABLO dimer has the highest stability as measured by pressure and urea denaturation

scientific article

The push-and-pull hypothesis in protein unfolding, misfolding and aggregation

scientific article

The role of RNA in mammalian prion protein conversion

scientific article

The structural dynamics of the flavivirus fusion peptide-membrane interaction

scientific article

The use of hydrostatic pressure as a tool to study viruses and other macromolecular assemblages

scientific article

Transient transfection of a wild-type p53 gene triggers resveratrol-induced apoptosis in cancer cells

scientific article

VP4 protein from human rhinovirus 14 is released by pressure and locked in the capsid by the antiviral compound WIN.

scientific article published on 11 November 2006

Virus maturation targets the protein capsid to concerted disassembly and unfolding

scientific article published in May 2000

Volume and free energy of folding for troponin C C-domain: linkage to ion binding and N-domain interaction

scientific article

Yellow fever vaccine protects mice against Zika virus infection

scientific article published on 04 November 2021

p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) inhibits amyloid aggregation of mutant p53 in cancer cells

scientific article published on 02 January 2019

Paulina is supported by:

About Paulina

Help