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List of works by Bruno Silva-Santos

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

scientific article published on 01 May 2020

At the Bench: Preclinical rationale for exploiting NK cells and γδ T lymphocytes for the treatment of high-risk leukemias

scientific article published on 09 October 2013

Author Correction: Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

scientific article published on 26 November 2019

B7-CD28 costimulatory signals control the survival and proliferation of murine and human γδ T cells via IL-2 production.

scientific article

Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells

scientific article published on 20 March 2019

CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets

scientific article

CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human γδ peripheral blood lymphocytes

scientific article published on 3 December 2010

Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling.

scientific article

Chicago 2014--30 years of γδ T cells.

scientific article published on 8 November 2014

Cross-regulation between cytokine and microRNA pathways in T cells.

scientific article published on 13 May 2015

Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-γ- or IL-17-producing γδ T cells upon infection

scientific article published on 29 October 2010

Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept

scientific article published on 15 June 2016

Developmental and Functional Assays to Study Murine and Human γδ T Cells.

scientific article

Differentiation and activation of γδ T Lymphocytes: Focus on CD27 and CD28 costimulatory receptors.

scientific article published on January 2013

Differentiation of human peripheral blood Vδ1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells.

scientific article published in June 2011

Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

scientific article published on 18 January 2021

Driving IL‐17+ γδ T‐cell migration in allergic reactions: A new “inflammatory” role for the “homeostatic” chemokine CCL25 ⬇️

scientific article published on 01 May 2012

Early events in the thymus affect the balance of effector and regulatory T cells

scientific article published in Nature

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.

scientific article

Engagement of NKp30 on Vδ1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication

scientific article published on 8 March 2012

Epigenetic and transcriptional regulation of γδ T cell differentiation: Programming cells for responses in time and space.

scientific article published on 25 February 2015

Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets

scientific article published on September 2013

Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway

scientific article

Five Layers of Receptor Signaling in γδ T-Cell Differentiation and Activation

scientific article

Foxp3 induction in human and murine thymus precedes the CD4+ CD8+ stage but requires early T-cell receptor expression.

scientific article published on 9 February 2010

From thymus to periphery: Molecular basis of effector γδ-T cell differentiation

scientific article published on 15 November 2020

Functional development of γδ T cells

scientific article published on August 2013

Gammadelta T cell development--having the strength to get there

scientific article published in April 2005

High-throughput analysis of the human thymic Vδ1+ T cell receptor repertoire

scientific article published on 04 July 2019

Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells

scientific article

Human γδ thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2/IL-15 signaling.

scientific article

IL-23 drives differentiation of peripheral γδ17 T cells from adult bone marrow-derived precursors

scientific article published on 30 August 2017

Identification of Regulatory Foxp3+ Invariant NKT Cells Induced by TGF-

scientific article published on 16 July 2010

Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gammadelta T cells

scientific article published on 10 March 2010

Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver

scientific article published on 17 October 2011

Inhibition of murine gammadelta lymphocyte expansion and effector function by regulatory alphabeta T cells is cell-contact-dependent and sensitive to GITR modulation

scientific article published on 01 January 2010

Innately versatile: γδ17 T cells in inflammatory and autoimmune diseases

scientific article published in December 2017

Intra-tumour heterogeneity - going beyond genetics.

scientific article published on 4 March 2016

Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

scientific article published on 01 November 2019

Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors

scientific article published on 9 December 2004

Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory

scientific article published on 01 October 2019

MicroRNA-146a controls functional plasticity in γδ T cells by targeting NOD1

scientific article published on 01 May 2018

Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

scientific article published on 05 December 2013

Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages

scientific article

NKp46-expressing human gut-resident intraepithelial Vδ1 T cell subpopulation exhibits high antitumor activity against colorectal cancer

scientific article published on 19 December 2019

Natural cytotoxicity receptors: broader expression patterns and functions in innate and adaptive immune cells.

scientific article published on 20 March 2013

Non-classical major histocompatibility complex proteins as determinants of tumour immunosurveillance.

scientific article published on November 2007

Pre-TCR signaling regulates IL-7 receptor α expression promoting thymocyte survival at the transition from the double-negative to double-positive stage

scientific article published on 01 July 2003

PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization

scientific article published on 19 July 2011

Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.

scientific article

Promoting angiogenesis within the tumor microenvironment: the secret life of murine lymphoid IL-17-producing gammadelta T cells

scientific article published on 01 July 2010

Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic γδ T lymphocytes to tumor beds.

scientific article published on 17 May 2013

Recruitment of γδ T lymphocytes to tumors: A new role for the pleiotropic chemokine CCL2.

scientific article published on July 2013

Searching for "signal 2": costimulation requirements of γδ T cells.

scientific article published on 04 May 2011

Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells

scientific article published on 01 June 2019

Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells

scientific article published on June 2017

Subset-specific alterations in frequencies and functional signatures of γδ T cells in systemic sclerosis patients.

scientific article published on 30 August 2016

TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets

scientific article published on 4 April 2016

Targeting γδ T lymphocytes for cancer immunotherapy: from novel mechanistic insight to clinical application

scientific article published on December 2010

The MHC class Ib protein ULBP1 is a nonredundant determinant of leukemia/lymphoma susceptibility to gammadelta T-cell cytotoxicity

scientific article

The blind-spot of regulatory T cells.

scientific article

The emerging Protumor role of γδ T lymphocytes: implications for cancer immunotherapy

scientific article published on 06 February 2015

The inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells

scientific article published on 21 September 2003

The split nature of tumor-infiltrating leukocytes: Implications for cancer surveillance and immunotherapy

scientific article published on August 2012

Thymic Determinants of γδ T Cell Differentiation

scientific article

Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

scientific article published on 06 September 2019

Tumor cell recognition by γδ T lymphocytes: T-cell receptor vs. NK-cell receptors

scientific article published on January 2013

VEGFR-2-mediated reprogramming of mitochondrial metabolism regulates the sensitivity of acute myeloid leukemia to chemotherapy

scientific article published on 11 December 2017

γδ T cells get adaptive

scientific article

γδ T cells in cancer

scientific article published on 09 October 2015

γδ T cells in tissue physiology and surveillance

scientific article published on 14 October 2020

γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer

scientific article published on 01 July 2019

γδ T-cell conference 2012: close encounters for the fifth time

scientific article published in December 2012

γδ cells making IL-17 ⬇️

scientific article published on 01 July 2011

γδ-T cells promote IFN-γ-dependent Plasmodium pathogenesis upon liver-stage infection

scientific article published on 26 April 2019

γẟ T cells in malaria: a double edged sword

scientific article published on 24 July 2020

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