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List of works by Christoph Garbers

A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3 (Tim-3)

scientific article published on 11 October 2013

A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor

scientific article (publication date: 6 June 2014)

A soluble form of the interleukin-6 family signal transducer gp130 is dimerized via a C-terminal disulfide bridge resulting from alternative mRNA splicing

scientific article published on 22 January 2016

ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.

scientific article published on 22 February 2018

ADAM17: a molecular switch to control inflammation and tissue regeneration

scientific article published on 13 July 2011

Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling

scientific article published on 13 May 2019

Alternative intronic polyadenylation generates the interleukin-6 trans-signaling inhibitor sgp130-E10

scientific article

An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer

scientific article published on 3 December 2012

Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).

scientific article published on 18 September 2013

Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation

scientific article

Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.

scientific article

Constitutively active mutant gp130 receptor protein from inflammatory hepatocellular adenoma is inhibited by an anti-gp130 antibody that specifically neutralizes interleukin 11 signaling

scientific article published on April 2012

Different Soluble Forms of the Interleukin-6 Family Signal Transducer gp130 Fine-tune the Blockade of Interleukin-6 Trans-signaling

scientific article

Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling

Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation

scientific article

IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function

scientific article published on 4 September 2014

Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor

scientific article published on 11 October 2011

Interleukin-6 and interleukin-11: same same but different

scientific article published on September 2013

Interleukin-6 and its receptors: a highly regulated and dynamic system

scientific article published on 28 June 2014

Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis

scientific article published on 27 June 2014

Interleukin-6-dependent phenotypic modulation of cardiac fibroblasts after acute myocardial infarction

scientific article published on 19 September 2014

Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities

scientific article published on 08 December 2013

Minimal interleukin 6 (IL-6) receptor stalk composition for IL-6 receptor shedding and IL-6 classic signaling

scientific article published on 5 April 2013

Modular organization of Interleukin-6 and Interleukin-11 α-receptors

scientific article published on 6 November 2015

Pharmaceutical relevant cytokine receptors: lessons from the first drafts of the human proteome

scientific article published on 8 December 2014

Plasticity and cross-talk of interleukin 6-type cytokines

scientific article published on 15 May 2012

Proteolytic control of Interleukin-11 and Interleukin-6 biology

scientific article

Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35

scientific article

Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding.

scientific article published on 30 July 2014

Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine

scientific article published on 25 November 2013

Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding

scientific article published on 15 March 2011

The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR).

scientific article published on 6 May 2014

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.

scientific article

The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II

scientific article published on 21 March 2012

The soluble Interleukin 6 receptor: generation and role in inflammation and cancer

scientific article published on 08 December 2010

Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation by proteolytic cleavage

scientific article published on 14 December 2018

Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells

scientific article published on 04 May 2020

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

scientific article

Trans-signaling of interleukin-6 (IL-6) is mediated by the soluble IL-6 receptor, but not by soluble CD5.

scientific article published on 31 January 2017

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