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List of works by Johannes M van Noort

A novel rationale for inhibition of gelatinase B in multiple sclerosis: MMP-9 destroys alpha B-crystallin and generates a promiscuous T cell epitope.

scientific article published on August 2003

Activation of an immune-regulatory macrophage response and inhibition of lung inflammation in a mouse model of COPD using heat-shock protein alpha B-crystallin-loaded PLGA microparticles.

scientific article

Alpha-B-crystallin induces an immune-regulatory and antiviral microglial response in preactive multiple sclerosis lesions

scientific article

AlphaB-crystallin-reactive T cells from knockout mice are not encephalitogenic

scientific article published on 14 July 2006

Alphab-crystallin is a target for adaptive immune responses and a trigger of innate responses in preactive multiple sclerosis lesions

scientific article published on 01 July 2010

Anti-alpha B-crystallin immunoreactivity in inflammatory nervous system diseases

scientific article published on 01 December 2000

Autoantibodies against alpha B-crystallin, a candidate autoantigen in multiple sclerosis, are part of a normal human immune repertoire

scientific article published in June 2006

Autoimmunity in multiple sclerosis need not be abnormal

scientific article published on 24 December 2013

Comment on "Chaperone activity of α B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis"

scientific article published on 01 July 2011

Cultured human adult microglia from different donors display stable cytokine, chemokine and growth factor gene profiles but respond differently to a pro-inflammatory stimulus

scientific article published in January 2005

Cytokine, chemokine and growth factor gene profiling of cultured human astrocytes after exposure to proinflammatory stimuli

scientific article published in September 2003

Demyelination during multiple sclerosis is associated with combined activation of microglia/macrophages by IFN-γ and alpha B-crystallin

scientific article published on 5 July 2014

Differential expression of stress proteins in human adult astrocytes in response to cytokines

scientific article published on 01 July 2000

Differentiation of primary adult microglia alters their response to TLR8-mediated activation but not their capacity as APC.

scientific article published in November 2007

Encephalitogenic and immunogenic potential of the stress protein alphaB-crystallin in Biozzi ABH (H-2A(g7)) mice

scientific article published on 01 April 2000

Expression of αB-crystallin in glia cells during lesional development in multiple sclerosis

article

Fractionation of central nervous system myelin proteins by reversed-phase high-performance liquid chromatography

scientific article published on 01 March 1994

Human glial cell culture models of inflammation in the central nervous system.

scientific article

Induction of EAE by T cells specific for alpha B-crystallin depends on prior viral infection in the CNS.

scientific article

Inflammation in neurodegenerative diseases--an update

scientific article published on June 2014

Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis

scientific article published on 18 December 2006

Isolation and characterization of mutants of Aspergillus niger deficient in extracellular proteases

scientific article published on 01 August 1992

Late rather than early responses of human dendritic cells highlight selective induction of cytokines, chemokines and growth factors by probiotic bacteria.

scientific article

Methylation in vivo of elongation factor EF-Tu at lysine-56 decreases the rate of tRNA-dependent GTP hydrolysis

scientific article published on 01 November 1986

Minor myelin proteins can be major targets for peripheral blood T cells from both multiple sclerosis patients and healthy subjects

scientific article published on 01 July 1993

Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A.

scientific article published in July 2005

Multiple sclerosis: an altered immune response or an altered stress response?

scientific article published on June 1996

Multiple sclerosis: modelling the future. The Multiple Sclerosis Society of Great Britain and Northern Ireland Conference: Frontiers in Science and Patient Care Disease Management

scientific article

Multiple sclerosis: variations on a theme

scientific article published in August 1997

Native myelin oligodendrocyte glycoprotein promotes severe chronic neurological disease and demyelination in Biozzi ABH mice

scientific article published on 01 April 2005

Oligodendrocyte-microglia cross-talk in the central nervous system

scientific article published on March 2014

Oral flavonoids delay recovery from experimental autoimmune encephalomyelitis in SJL mice

scientific article published in July 2005

PECAM-1 and gelatinase B coexist in vascular cuffs of multiple sclerosis lesions

scientific article published on 01 February 2006

Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease

scientific article published on 18 November 2015

Preactive multiple sclerosis lesions offer novel clues for neuroprotective therapeutic strategies.

scientific article published on February 2011

Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination

scientific article published on 13 June 2007

Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis

article

Purification of the stress protein αB-crystallin and its differentially phosphorylated forms

scientific article published on 01 December 1998

Selective association of multiple sclerosis with infectious mononucleosis

scientific article published on 21 January 2008

Stress proteins in CNS inflammation.

scientific article published on January 2008

T cells discriminate between differentially phosphorylated forms of alphaB-crystallin, a major central nervous system myelin antigen

scientific article published in July 1998

T- and B-cell nonresponsiveness to self-alphaB-crystallin in SJL mice prevents the induction of experimental allergic encephalomyelitis

scientific article published in September 2000

Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE.

scientific article

The flavones luteolin and apigenin inhibit in vitro antigen-specific proliferation and interferon-gamma production by murine and human autoimmune T cells

scientific article

The link between small heat shock proteins and the immune system

scientific article published on 05 January 2012

The microtubule regulator stathmin is an endogenous protein agonist for TLR3.

scientific article

Therapeutic Intervention in Multiple Sclerosis with Alpha B-Crystallin: A Randomized Controlled Phase IIa Trial

scientific article published on 23 November 2015

Tolerance controls encephalitogenicity of alphaB-crystallin in the Lewis rat

scientific article published on 01 March 2000

Tolerization of an established alphaB-crystallin-reactive T-cell response by intravenous antigen

scientific article published on 26 April 2007

Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators

scientific article published in May 2006

Toll-like receptors 2 and 3 agonists differentially affect oligodendrocyte survival, differentiation, and myelin membrane formation

scientific journal article

Visualization of proteases within a complex sample following their selective retention on immobilized bacitracin, a peptide antibiotic

scientific article published in November 1991

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