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List of works by Qing-Yu He

14-3-3ζ reduces DNA damage by interacting with and stabilizing proliferating cell nuclear antigen.

scientific article

17 Protein Alterations in Gastric Adenocarcinoma

A hidden human proteome encoded by 'non-coding' genes

scientific article published on 01 September 2019

A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism.

scientific article published on 11 December 2012

A novel strategy of integrated microarray analysis identifies CENPA, CDK1 and CDC20 as a cluster of diagnostic biomarkers in lung adenocarcinoma.

scientific article published on 30 March 2018

A proteome analysis of the arsenite response in cultured lung cells: evidence for in vitro oxidative stress-induced apoptosis

scientific article published in September 2004

A proteomic approach for the identification of bismuth-binding proteins in Helicobacter pylori

scientific article published on 15 May 2007

AUF1-like protein binds specifically to DAS cis-acting element that regulates mouse alpha-fetoprotein gene expression

scientific article published in August 2006

Additions and corrections

Adefovir dipivoxil sensitizes colon cancer cells to vemurafenib by disrupting the KCTD12-CDK1 interaction

scientific article published on 11 March 2019

Advances in targeted therapy for esophageal cancer

scientific article published on 07 October 2020

Anion exchange in human serum transferrin N-lobe: a model study with variant His249Ala

scientific article published on 16 May 2003

Application of immobilized metal affinity chromatography in proteomics

scientific article

Application of subproteomics in the characterization of Gram-positive bacteria

scientific article published on 31 December 2011

Binomial probability distribution model-based protein identification algorithm for tandem mass spectrometry utilizing peak intensity information

scientific article published on 29 November 2012

Bioinformatic Application in Proteomic Research on Biomarker Discovery and Drug Target Validation

C20orf27 Promotes Cell Growth and Proliferation of Colorectal Cancer via the TGFβR-TAK1-NFĸB Pathway

scientific article published on 02 February 2020

Calpain-truncated CRMP-3 and -4 contribute to potassium deprivation-induced apoptosis of cerebellar granule neurons.

scientific article

Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression.

scientific article published on 10 February 2017

Cellular pharmacological properties of gold(III) porphyrin 1a, a potential anticancer drug lead

scientific article published on 21 October 2006

ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization.

scientific article published on 11 March 2015

Characterization of phosphoproteins in gastric cancer secretome

scientific article published on 20 August 2010

Chemical interference with iron transport systems to suppress bacterial growth of Streptococcus pneumoniae

scientific article

Chemical proteomics to identify molecular targets of small compounds

scientific article

Chromosome-8-coded proteome of Chinese Chromosome Proteome Data set (CCPD) 2.0 with partial immunohistochemical verifications

scientific article

Comparative Proteomics Analysis Identifies Cdc42-Cdc42BPA Signaling as Prognostic Biomarker and Therapeutic Target for Colon Cancer Invasion.

scientific article published on 26 October 2017

Comparative proteomic analysis of esophageal squamous cell carcinoma

scientific article published in July 2005

Comparative proteomic analysis of indioside D-triggered cell death in HeLa cells

scientific article

Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance

scientific article published on 16 October 2015

Comprehensive analysis of the lysine acetylome and its potential regulatory roles in the virulence of Streptococcus pneumoniae.

scientific article published on 28 January 2018

Crucial residue Trp158 of lipoprotein PiaA stabilizes the ferrichrome-PiaA complex in Streptococcus pneumoniae

scientific article published on 27 August 2016

Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes

scientific article

Curcumol Overcomes TRAIL Resistance of Non-Small Cell Lung Cancer by Targeting NRH:Quinone Oxidoreductase 2 (NQO2)

scientific article published on 15 October 2020

Current Progress in Sample Preparation for Two-Dimensional Electrophoresis in Proteomics

Cytokeratin 8 silencing in human nasopharyngeal carcinoma cells leads to cisplatin sensitization

scientific article

Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation

scientific article

Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages.

scientific article published on September 2016

Cytotoxicity of silver nanoparticles against bacteria and tumor cells

scientific article published on 7 November 2016

DOSE: an R/Bioconductor package for disease ontology semantic and enrichment analysis

scientific article published on 17 October 2014

Deep Coverage Tissue and Cellular Proteomics Revealed IL-1β Can Independently Induce the Secretion of TNF-Associated Proteins from Human Synoviocytes.

scientific article

Deletion of aldose reductase leads to protection against cerebral ischemic injury

scientific article published on 7 February 2007

Detergent-Insoluble Proteome Analysis Revealed Aberrantly Aggregated Proteins in Human Preeclampsia Placentas

scientific article

Differential effect of a his tag at the N- and C-termini: functional studies with recombinant human serum transferrin

scientific article

Dinuclear five-co-ordinate zinc complexes bridged by a phosphate monoester or an inorganic phosphate group

article

Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: a proteomic-based study

scientific article published on 2 November 2007

Dioscin induced activation of p38 MAPK and JNK via mitochondrial pathway in HL-60 cell line

scientific article published on 19 April 2014

Direct interaction of 14-3-3ζ with ezrin promotes cell migration by regulating the formation of membrane ruffle

scientific article

Dirhodium (II) complex interferes with iron-transport system to exert antibacterial action against Streptococcus pneumoniae

scientific article published on 04 December 2018

Dispec: a novel peptide scoring algorithm based on peptide matching discriminability

scientific article

Diverse proteomic alterations in gastric adenocarcinoma.

scientific article

Dual role of Lys206-Lys296 interaction in human transferrin N-lobe: iron-release trigger and anion-binding site

scientific article published on July 1999

Dynamic quantitative proteomics characterization of TNF-α-induced necroptosis

scientific article published on 04 October 2016

Echinatin suppresses esophageal cancer tumor growth and invasion through inducing AKT/mTOR-dependent autophagy and apoptosis

scientific article published on 13 July 2020

Editorial:[Special Issue: Post-Translational Proteomics and its Application (Guest Editor: Qing-Yu He)]

Effects of mutations of aspartic acid 63 on the metal-binding properties of the recombinant N-lobe of human serum transferrin

scientific article published in May 1997

Epidermal growth factor-induced epithelial-mesenchymal transition in human esophageal carcinoma cells--a model for the study of metastasis

scientific article published on 21 April 2010

Evolution and molecular mechanism of PitAs in iron transport of Streptococcus species.

scientific article published on 10 February 2018

Expression and characterization of a histidine-rich protein, Hpn: potential for Ni2+ storage in Helicobacter pylori.

scientific article published on January 2006

Expression, purification, and characterization of recombinant nonglycosylated human serum transferrin containing a C-terminal hexahistidine tag.

scientific article

FANSe2: a robust and cost-efficient alignment tool for quantitative next-generation sequencing applications

scientific article

Finding Missing Proteins from the Epigenetically Manipulated Human Cell with Stringent Quality Criteria

scientific article published on 23 July 2015

Functional proteomics to identify critical proteins in signal transduction pathways.

scientific article published on 17 August 2007

Functional similarity analysis of human virus-encoded miRNAs.

scientific article

Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study.

scientific article published on August 2012

Genome-Wide and Experimental Resolution of Relative Translation Elongation Speed at Individual Gene Level in Human Cells

scientific article

Genomic and proteomic approaches for predicting toxicity and adverse drug reactions

article

Genomics and Proteomics in Drug Design and Discovery

Global identification of miR-373-regulated genes in breast cancer by quantitative proteomics

scientific article published on 27 January 2011

Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis

scientific article published on 8 September 2008

Glucose-regulated protein 78 is an intracellular antiviral factor against hepatitis B virus

scientific article published on 11 August 2009

Gold(III) Porphyrin 1a Induced Apoptosis by Mitochondrial Death Pathways Related to Reactive Oxygen Species

article

Heavy metals chromium and neodymium reduced phosphorylation level of heat shock protein 27 in human keratinocytes

scientific article

Heparin chromatography to deplete high-abundance proteins for serum proteomics

scientific article

Heteroleptic tripodal complexes of copper(II): towards a synthetic model for the active site in galactose oxidase

article

How to discover new proteins—translatome profiling

scientific article published on 16 February 2014

Hunting Molecular Targets for Anticancer Reagents by Chemical Proteomics

IGF2 induces CD133 expression in esophageal cancer cells to promote cancer stemness.

scientific article published on 28 March 2018

Id-1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K/AKT signaling pathway

scientific article published on 01 December 2009

Id1-induced IGF-II and its autocrine/endocrine promotion of esophageal cancer progression and chemoresistance--implications for IGF-II and IGF-IR-targeted therapy

scientific article published on 5 March 2014

Identification and characterization of molecular targets of natural products by mass spectrometry.

scientific article

Identification of Missing Proteins Defined by Chromosome-Centric Proteome Project in the Cytoplasmic Detergent-Insoluble Proteins.

scientific article published on 25 June 2015

Identification of Tumor Antigens as Targets for Novel Antitumor Therapies

Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance

scientific article published on 28 February 2019

Identification of miR-515-3p and its targets, vimentin and MMP3, as a key regulatory mechanism in esophageal cancer metastasis: functional and clinical significance

scientific article published on 27 November 2020

Identification of novel signaling components in genistein-regulated signaling pathways by quantitative phosphoproteomics

scientific article published on 17 September 2011

Identification of platination sites on human serum transferrin using 13C and 15N NMR spectroscopy

article

Identification of potential biomarkers for predicting acute dermal irritation by proteomic analysis.

scientific article

Identification of tumor-associated proteins in oral tongue squamous cell carcinoma by proteomics.

scientific article published in January 2004

Identification of ubiquitinated proteins from human multiple myeloma U266 cells by proteomics.

scientific article

Improved SILAC method for double labeling of bacterial proteome

scientific article published on 13 December 2018

Inequivalence of the Two Tyrosine Ligands in the N-Lobe of Human Serum Transferrin†

article

Inhibition of Nrf2 enhances the anticancer effect of 6-O-angeloylenolin in lung adenocarcinoma

scientific article published on 16 January 2017

Investigation of the mechanism of iron release from the C-lobe of human serum transferrin: mutational analysis of the role of a pH sensitive triad

scientific article published in April 2003

Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2.

scientific article

Iron-containing lipoprotein SiaA in SiaABC, the primary heme transporter of Streptococcus pyogenes

scientific article published on 6 July 2010

Isodeoxyelephantopin induces protective autophagy in lung cancer cells via Nrf2-p62-keap1 feedback loop

scientific article published on 15 June 2017

Iterative genome correction largely improves proteomic analysis of nonmodel organisms

scientific article

Jolkinolide B induces apoptosis of colorectal carcinoma through ROS-ER stress-Ca2+-mitochondria dependent pathway

scientific article

KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.

scientific article

LXtoo: an integrated live Linux distribution for the bioinformatics community

scientific article

Liensinine perchlorate inhibits colorectal cancer tumorigenesis by inducing mitochondrial dysfunction and apoptosis

scientific article published on 01 November 2018

Linear trinuclear copper(II) complexes derived from acyclic hexadentate schiff base ligands

Lipoprotein FtsB in Streptococcus pyogenes binds ferrichrome in two steps with residues Tyr137 and Trp204 as critical ligands

scientific article (publication date: 2013)

Lipoprotein MtsA of MtsABC in Streptococcus pyogenes primarily binds ferrous ion with bicarbonate as a synergistic anion

scientific article

Lung cancer deficient in the tumor suppressor GATA4 is sensitive to TGFBR1 inhibition

scientific article published on 10 April 2019

Mammary serine protease inhibitor inhibits epithelial growth factor-induced epithelial-mesenchymal transition of esophageal carcinoma cells

scientific article

MicroRNA-377 suppresses initiation and progression of esophageal cancer by inhibiting CD133 and VEGF

scientific article

Modulation of gold(III) porphyrin 1a-induced apoptosis by mitogen-activated protein kinase signaling pathways

scientific article published on February 2008

Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes

scientific article published on 07 June 2017

Multifaceted Stoichiometry Control of Bacterial Operons Revealed by Deep Proteome Quantification.

scientific article published on 24 May 2019

Multiple pathways were involved in tubeimoside-1-induced cytotoxicity of HeLa cells

scientific article published on 28 August 2011

Mutation of the iron ligand His 249 to Glu in the N-lobe of human transferrin abolishes the dilysine "trigger" but does not significantly affect iron release

scientific article

Mutations at nonliganding residues Tyr-85 and Glu-83 in the N-lobe of human serum transferrin. Functional second shell effects

scientific article

Mutations at the histidine 249 ligand profoundly alter the spectral and iron-binding properties of human serum transferrin N-lobe

scientific article

NMR structures and orientation of the fourth transmembrane domain of the rat divalent metal transporter (DMT1) with G185D mutation in SDS micelles.

scientific article

Nm23-H1 regulates the proliferation and differentiation of the human chronic myeloid leukemia K562 cell line: a functional proteomics study.

scientific article published on 2 February 2009

Novel Mechanistic Insights into Bacterial Fluoroquinolone Resistance

scientific article published on 23 October 2019

Omics evidence: single nucleotide variants transmissions on chromosome 20 in liver cancer cell lines.

scientific article published on 5 December 2013

Oncoproteomics of hepatocellular carcinoma: from cancer markers' discovery to functional pathways.

scientific article

Opposed arsenite-induced signaling pathways promote cell proliferation or apoptosis in cultured lung cells

scientific article published on 26 September 2003

Overview of the metallometabolomic methodology for metal-based drug metabolism

scientific article published on March 2011

Phosphoproteome Characterization of Human Colorectal Cancer SW620 Cell-Derived Exosomes and New Phosphosite Discovery for C-HPP.

scientific article published on 29 July 2016

Phosphoproteome analysis of the pathogenic bacterium Helicobacter pylori reveals over-representation of tyrosine phosphorylation and multiply phosphorylated proteins

article

Phosphoproteomic analysis of primary human multiple myeloma cells.

scientific article published on 15 March 2010

Phosphoproteomic analysis reveals the multiple roles of phosphorylation in pathogenic bacterium Streptococcus pneumoniae

scientific article published in January 2010

Photocatalytic Protein Damage by Silver Nanoparticles Circumvents Bacterial Stress Response and Multidrug Resistance

scientific article published on 01 May 2019

Protective effects of andrographolide analogue AL-1 on ROS-induced RIN-mβ cell death by inducing ROS generation.

scientific article

Proteomic Analysis Reveals that Odoroside A Triggers G2/M Arrest and Apoptosis in Colorectal Carcinoma Through ROS-p53 Pathway

scientific article published on 18 July 2019

Proteomic Analysis of Anticancer TCMs Targeted at Mitochondria

scientific article

Proteomic analysis of a preneoplastic phenotype in ovarian surface epithelial cells derived from prophylactic oophorectomies

scientific article

Proteomic analysis of chromium cytotoxicity in cultured rat lung epithelial cells

scientific article published in June 2008

Proteomic analysis of excretory secretory products from Clonorchis sinensis adult worms: molecular characterization and serological reactivity of a excretory-secretory antigen-fructose-1,6-bisphosphatase

scientific article published on 22 March 2011

Proteomic analysis of mitochondria: biological and clinical progresses in cancer

scientific article published in September 2017

Proteomic analysis of neonatal mouse brain: evidence for hypoxia- and ischemia-induced dephosphorylation of collapsin response mediator proteins

scientific article

Proteomic analysis of putative heme-binding proteins in Streptococcus pyogenes.

scientific article published in August 2014

Proteomic analysis of the mode of antibacterial action of silver nanoparticles.

scientific article published in April 2006

Proteomic analysis on the antibacterial activity of a Ru(II) complex against Streptococcus pneumoniae.

scientific article

Proteomic analysis reveals novel binding partners of MIP-T3 in human cells

scientific article

Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells

scientific article

Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways

scientific article

Proteomic approach to study the cytotoxicity of dioscin (saponin).

scientific article published in April 2006

Proteomic characterization of the cytotoxic mechanism of gold (III) porphyrin 1a, a potential anticancer drug

scientific article published on January 2006

Proteomic identification of malignant transformation-related proteins in esophageal squamous cell carcinoma

scientific article

Proteomic investigation into the action mechanism of berberine against Streptococcus pyogenes

scientific article published on 23 January 2020

Proteomics approach to illustrate drug action mechanisms.

scientific article published on September 2006

Proteomics characterization of gastrokine 1-induced growth inhibition of gastric cancer cells

scientific article published on 2 August 2011

Proteomics in biomarker discovery and drug development.

scientific article

Proteomics of buccal squamous cell carcinoma: the involvement of multiple pathways in tumorigenesis.

scientific article

Putative cobalt- and nickel-binding proteins and motifs in Streptococcus pneumoniae

scientific article published on June 2013

Quantitative Mitochondrial Proteomics Reveals ANXA7 as a Crucial Factor in Mitophagy

scientific article published on 04 February 2020

Quantitative phosphoproteomics of proteasome inhibition in multiple myeloma cells

scientific article

Quantitative proteomics characterization on the antitumor effects of isodeoxyelephantopin against nasopharyngeal carcinoma

scientific article published on 03 October 2013

Quest for Missing Proteins: Update 2015 on Chromosome-Centric Human Proteome Project

scientific article published on 15 June 2015

RNF128 Promotes Invasion and Metastasis Via the EGFR/MAPK/MMP-2 Pathway in Esophageal Squamous Cell Carcinoma

scientific article published on 18 June 2019

ReactomePA: an R/Bioconductor package for reactome pathway analysis and visualization

scientific article published on 10 December 2015

Resolving chromosome-centric human proteome with translating mRNA analysis: a strategic demonstration

scientific article published on 15 November 2013

Role of Mitochondria in Regulating Lutein and Chlorophyll Biosynthesis in under Heterotrophic Conditions

scientific article published on 28 September 2018

Ruthenium methylimidazole complexes induced apoptosis in lung cancer A549 cells through intrinsic mitochondrial pathway

scientific article

Sequential targeting of YAP1 and p21 enhances the elimination of senescent cells induced by the BET inhibitor JQ1

scientific article published on 25 January 2021

Serological protein profiling of neuroblastoma by ProteinChip SELDI-TOF technology.

scientific article published in May 2005

Serological proteomics of gastritis: degradation of apolipoprotein A-I and alpha1-antitrypsin is a common response to inflammation irrespective of Helicobacter pylori infection

scientific article

Serum biomarkers of hepatitis B virus infected liver inflammation: A proteomic study ⬇️

scientific article published on May 1, 2003

Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy

scientific article

Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment.

scientific article published on 21 May 2018

Silver nanoparticles: partial oxidation and antibacterial activities.

scientific article published on 16 February 2007

Spectral and metal-binding properties of three single-point tryptophan mutants of the human transferrin N-lobe

scientific article

Structural and functional consequences of binding site mutations in transferrin: crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin

scientific article

Structure, assembly, and topology of the G185R mutant of the fourth transmembrane domain of divalent metal transporter

scientific article

Subcellular proteomics revealed the epithelial–mesenchymal transition phenotype in lung cancer ⬇️

scientific article published on January 3, 2011

Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling

scientific article published on 27 August 2018

Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization

scientific article published on 25 October 2006

Systematic analyses of the transcriptome, translatome, and proteome provide a global view and potential strategy for the C-HPP.

scientific article published on 16 December 2013

The BET Bromodomain Inhibitor JQ1 Suppresses Chondrosarcoma Cell Growth via Regulation of YAP/p21/c-Myc Signaling.

scientific article

The E3 ubiquitin ligase CHIP mediates ubiquitination and proteasomal degradation of PRMT5.

scientific article published on 2 December 2015

The chloride effect is related to anion binding in determining the rate of iron release from the human transferrin N-lobe

scientific article published on September 2000

The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction.

scientific article

The flightless I protein interacts with RNA-binding proteins and is involved in the genome-wide mRNA post-transcriptional regulation in lung carcinoma cells

scientific article

The low pKa value of iron-binding ligand Tyr188 and its implication in iron release and anion binding of human transferrin

scientific article published on August 2004

The mechanism of iron-compensation for manganese deficiency of Streptococcus pneumoniae

scientific article published on 18 June 2018

The position of arginine 124 controls the rate of iron release from the N-lobe of human serum transferrin. A structural study

scientific article

The preventive effect of oral EGCG in a fetal alcohol spectrum disorder mouse model

scientific article published on November 2010

The stepwise process of chromium-induced DNA breakage: characterization by electrochemistry, atomic force microscopy, and DNA electrophoresis.

scientific article published in October 2005

The use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndrome.

scientific article published in November 2004

Thermodynamic and kinetic aspects of metal binding to the histidine-rich protein, Hpn.

scientific article

Toward the proteomic identification of biomarkers for the prediction of HBV related hepatocellular carcinoma

scientific article

Transcriptomic and proteomic approach to studying SNX-2112-induced K562 cells apoptosis and anti-leukemia activity in K562-NOD/SCID mice

scientific article

Transfer RNAs Mediate the Rapid Adaptation of Escherichia coli to Oxidative Stress.

scientific article published on 19 June 2015

Transferrin-mediated gold nanoparticle cellular uptake

scientific article

Translating mRNAs strongly correlate to proteins in a multivariate manner and their translation ratios are phenotype specific.

scientific article published on 21 March 2013

Tubeimoside-1 exerts cytotoxicity in HeLa cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways

scientific article

Unraveling the molecular targets of natural products: Insights from genomic and proteomic analyses

scientific article published on 13 February 2008

Varied metal-binding properties of lipoprotein PsaA in Streptococcus pneumoniae

scientific article published on 20 February 2014

[13C]Methionine NMR and metal-binding studies of recombinant human transferrin N-lobe and five methionine mutants: conformational changes and increased sensitivity to chloride

scientific article published in December 1999

clusterProfiler: an R package for comparing biological themes among gene clusters.

scientific article published on 28 March 2012

iTRAQ-Based Proteomics Revealed the Bactericidal Mechanism of Sodium New Houttuyfonate against Streptococcus pneumoniae

scientific article published on 26 July 2016

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