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List of works by Kevin K W Wang

2-amino-4H-3,1-benzoxazin-4-ones as inhibitors of C1r serine protease

scientific article published on March 1998

A Coomassie brilliant blue G-250-based colorimetric assay for measuring activity of calpain and other proteases

scientific article published in February 1993

A Multidimensional Differential Proteomic Platform Using Dual-Phase Ion-Exchange Chromatography−Polyacrylamide Gel Electrophoresis/Reversed-Phase Liquid Chromatography Tandem Mass Spectrometry

article

A Panel of Serum MiRNA Biomarkers for the Diagnosis of Severe to Mild Traumatic Brain Injury in Humans

scientific article published on 24 June 2016

A Repetitive Concussive Head Injury Model in Mice.

scientific article published on 12 October 2016

A novel marker for traumatic brain injury: CSF alphaII-spectrin breakdown product levels

scientific article published in October 2004

A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury: operation brain trauma therapy

scientific article published on July 2011

A novel, ultrasensitive assay for tau: potential for assessing traumatic brain injury in tissues and biofluids

scientific article

A purine nucleoside phosphorylase (PNP) inhibitor induces apoptosis via caspase-3-like protease activity in MOLT-4 T cells ⬇️

scientific article published on October 1, 1997

A structural model for the inhibition of calpain by calpastatin: crystal structures of the native domain VI of calpain and its complexes with calpastatin peptide and a small molecule inhibitor

scientific article (publication date: 18 April 2003)

Accumulation of calpain and caspase-3 proteolytic fragments of brain-derived alphaII-spectrin in cerebral spinal fluid after middle cerebral artery occlusion in rats

scientific article

Accumulation of non-erythroid alpha II-spectrin and calpain-cleaved alpha II-spectrin breakdown products in cerebrospinal fluid after traumatic brain injury in rats

scientific article

Activation of apoptosis-linked caspase(s) in NMDA-injured brains in neonatal rats

scientific article published on 01 February 2000

Activation of the Ca2+-ATPase of human erythrocyte membrane by an endogenous Ca2+-dependent neutral protease

scientific article published on 01 February 1988

Acute NMDA toxicity in cultured rat cerebellar granule neurons is accompanied by autophagy induction and late onset autophagic cell death phenotype

scientific article

Acute biomarkers of traumatic brain injury: relationship between plasma levels of ubiquitin C-terminal hydrolase-L1 and glial fibrillary acidic protein

scientific article published on 09 October 2013

Age-Related Differences in Diagnostic Accuracy of Plasma Glial Fibrillary Acidic Protein and Tau for Identifying Acute Intracranial Trauma on Computed Tomography: A TRACK-TBI Study

scientific article published on 29 June 2018

Age-related intraneuronal elevation of αII-spectrin breakdown product SBDP120 in rodent forebrain accelerates in 3×Tg-AD mice

scientific article (publication date: 2012)

Alpha II Spectrin breakdown products in immature Sprague Dawley rat hippocampus and cortex after traumatic brain injury

scientific article published on 12 June 2014

Alpha II-spectrin breakdown products serve as novel markers of brain injury severity in a canine model of hypothermic circulatory arrest

scientific article

Alpha-II spectrin breakdown products in aneurysmal subarachnoid hemorrhage: a novel biomarker of proteolytic injury

scientific article

Alpha-II-spectrin after controlled cortical impact in the immature rat brain

scientific article published in January 2006

Alterations of Extracellular Calcium Elicit Selective Modes of Cell Death and Protease Activation in SH-SY5Y Human Neuroblastoma Cells

scientific article published on 01 May 1999

Amino acid starvation induced autophagic cell death in PC-12 cells: evidence for activation of caspase-3 but not calpain-1.

scientific article published in September 2006

An update on diagnostic and prognostic biomarkers for traumatic brain injury.

scientific article published on 17 January 2018

Anti-LPS Test Strip for the Detection of Food Contaminated with Salmonella and E. coli

scholarly article by Alvin Wang et al published 2011 in Journal of microbial & biochemical technology

Apolipoprotein E epsilon 4 (APOE-ε4) genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury

scientific article published on 9 August 2017

Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments for a Multicenter Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury: Operation Brain Trauma Therapy

scientific article published on 06 October 2015

Assessing neuro-systemic & behavioral components in the pathophysiology of blast-related brain injury

scientific article

Assessment of Follow-up Care After Emergency Department Presentation for Mild Traumatic Brain Injury and Concussion: Results From the TRACK-TBI Study

scientific article published on 18 May 2018

Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study

scientific article published on 23 August 2019

Aurintricarboxylic acid is an inhibitor of mu- and m-calpain

scientific article published on June 1, 1995

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice

scientific article published in May 2002

Baicalein enhances the effect of low dose Levodopa on the gait deficits and protects dopaminergic neurons in experimental Parkinsonism

scientific article published on 21 March 2019

Benzenesulfonamide derivatives of 2-substituted 4H-3,1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease

scientific article published on 01 March 1999

Binding and aggregation of human μ-calpain by terbium ion

scientific article published on 01 January 1996

Biochemical, structural, and biomarker evidence for calpain-mediated cytoskeletal change after diffuse brain injury uncomplicated by contusion

scientific article published on March 2009

Biokinetic analysis of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in severe traumatic brain injury patient biofluids

scientific article

Biomarker identification in psychiatric disorders: from neuroscience to clinical practice

scientific article

Biomarkers for CNS Injury and Regeneration

Biomarkers improve clinical outcome predictors of mortality following non-penetrating severe traumatic brain injury

scientific article

Biomarkers in Spinal Cord Injury

article published in 2014

Biomarkers of blast-induced neurotrauma: profiling molecular and cellular mechanisms of blast brain injury.

scientific article published on June 2009

Biomarkers of proteolytic damage following traumatic brain injury

scientific article published on April 2004

Biomarkers track damage after graded injury severity in a rat model of penetrating brain injury

scientific article published in July 2013

Blood-Based Protein Biomarkers for the Management of Traumatic Brain Injuries in Adults Presenting with Mild Head Injury to Emergency Departments: A Living Systematic Review and Meta-Analysis

scientific article published on 12 October 2017

Blood-based diagnostics of traumatic brain injuries

scientific article

Brain biomarkers and brain tissue oxygenation: changes and correlations following severe head injury.

scientific article published in March 2010

Brain injury biomarkers may improve the predictive power of the IMPACT outcome calculator

scientific article

COMT Val 158 Met polymorphism is associated with nonverbal cognition following mild traumatic brain injury

scientific article

COMT Val158Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury.

scientific article published on 18 October 2016

Calcium-activated neutral protease effects upon skeletal muscle sarcoplasmic reticulum protein structure and calcium release.

scientific article

Calcium-activated proteases in the bovine parathyroid gland: potential role in degradation of parathyroid hormone to peptide fragments

scientific article published on 01 August 1995

Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis

scientific article

Calcium/calmodulin-dependent protein kinase inhibition potentiates thapsigargin-mediated cell death in SH-SY5Y human neuroblastoma cells

scientific article published in March 2001

Calmodulin-binding proteins as calpain substrates.

scientific article published on September 1989

Calmodulin-binding proteome in the brain

scientific article published in January 2009

Calpain I activates Ca2+ transport by the reconstituted erythrocyte Ca2+ pump

scientific article published on 01 December 1989

Calpain Zymography: General Methodology and Protocol

scientific article published in January 2017

Calpain and caspase processing of caspase-12 contribute to the ER stress-induced cell death pathway in differentiated PC12 cells

scientific article published on December 2010

Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA.

scientific article

Calpain and caspase: can you tell the difference?

scientific article

Calpain and caspase: can you tell the difference?, by Kevin K.W. Wang

scientific article published on 01 February 2000

Calpain in the CNS: from synaptic function to neurotoxicity

scientific article

Calpain inhibition: an overview of its therapeutic potential

scientific article published on November 1994

Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

scientific article

Calpain- and caspase-mediated alphaII-spectrin and tau proteolysis in rat cerebrocortical neuronal cultures after ecstasy or methamphetamine exposure

scientific article published on 2 August 2006

Calpain-mediated collapsin response mediator protein-1, -2, and -4 proteolysis after neurotoxic and traumatic brain injury

scientific journal article

Calpains mediate calcium and chloride influx during the late phase of cell injury

article

Casein zymography: a method to study mu-calpain, m-calpain, and their inhibitory agents

scientific article published on May 1995

Caspase 7: increased expression and activation after traumatic brain injury in rats

scientific article published in July 2005

Caspase-3-Like Activity Is Necessary for IL-2 Release in Activated Jurkat T-cells

article published in 1998

Caspase-Mediated Fragmentation of Calpain Inhibitor Protein Calpastatin during Apoptosis ⬇️

scientific article published on August 15, 1998

Caspase-mediated calcineurin activation contributes to IL-2 release during T cell activation.

scientific article

Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells

scientific article published in July 2000

Cathepsin B mRNA and protein expression following contusion spinal cord injury in rats

scientific article

Cell-Specific Upregulation of Survivin after Experimental Traumatic Brain Injury in Rats

Cell-specific DNA fragmentation may be attenuated by a survivin-dependent mechanism after traumatic brain injury in rats

scientific article published on 29 October 2005

Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat

scientific journal article

Changes in autophagy proteins in a rat model of controlled cortical impact induced brain injury

scientific article published on 16 May 2008

Chapter 9 Intracellular calcium-binding proteins

article published in 1996

Characterization of the fragmented forms of calcineurin produced by calpain I

scientific article published on 01 October 1989

Circulating damage marker profiles support a neuroprotective effect of erythropoietin in ischemic stroke patients

scientific article published on 2 September 2011

Clinical significance of alphaII-spectrin breakdown products in cerebrospinal fluid after severe traumatic brain injury

scientific article published in February 2007

Clinical utility of serum levels of ubiquitin C-terminal hydrolase as a biomarker for severe traumatic brain injury.

scientific article published on March 2012

Collapsin response mediator protein-2 is a calmodulin-binding protein

scientific article published on February 2009

Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau-Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers

scientific article

Comparing calpain- and caspase-3-mediated degradation patterns in traumatic brain injury by differential proteome analysis

scientific article published in March 2006

Comparing levels of biochemical markers in CSF from cannulated and non-cannulated rats

scientific article

Concurrent Assessment of Calpain and Caspase-3 Activation after Oxygen–Glucose Deprivation in Primary Septo-Hippocampal Cultures ⬇️

scientific article published on November 1, 2001

Concurrent calpain and caspase-3 mediated proteolysis of alpha II-spectrin and tau in rat brain after methamphetamine exposure: a similar profile to traumatic brain injury

scientific article published on 25 August 2005

Copenhagen Head Injury Ciclosporin Study: A Phase IIa Safety, Pharmacokinetics, and Biomarker Study of Ciclosporin in Severe Traumatic Brain Injury Patients

scientific article published on 01 August 2019

Correction to: Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury

scientific article published on 17 January 2018

Corrigendum: Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model

scientific article published on 18 December 2015

Crystal structure of calcium bound domain VI of calpain at 1.9 Å resolution and its role in enzyme assembly, regulation, and inhibitor binding

scientific article published on July 1, 1997

Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

scientific article

Cytochrome c translocation does not lead to caspase activation in maitotoxin-treated SH-SY5Y neuroblastoma cells

scientific article

DRD2 C957T polymorphism is associated with improved 6-month verbal learning following traumatic brain injury

scientific article published on 8 November 2016

Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions

scientific article

Detection of protein biomarkers using high-throughput immunoblotting following focal ischemic or penetrating ballistic-like brain injuries in rats

scientific article published on September 2008

Development and characterization of antibodies specific to caspase-3-produced alpha II-spectrin 120 kDa breakdown product: marker for neuronal apoptosis

article

Development and therapeutic potential of calpain inhibitors

scientific article published on January 1997

Dicyclomine, an M1 muscarinic antagonist, reduces biomarker levels, but not neuronal degeneration, in fluid percussion brain injury

scientific article

Differential Neuroproteomic and Systems Biology Analysis of Spinal Cord Injury

scientific article published on 05 May 2016

Differential proteolysis of the full-length form of the L-type calcium channel alpha 1 subunit by calpain

scientific article published on 01 October 1994

Direct Rho-associated kinase inhibition [correction of inhibiton] induces cofilin dephosphorylation and neurite outgrowth in PC-12 cells

scientific article published in January 2006

Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury

scientific article

Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions

scientific article

Ecstasy toxicity: a comparison to methamphetamine and traumatic brain injury

scientific article published in January 2006

Effect of Second-Hand Tobacco Smoke on the Nitration of Brain Proteins: A Systems Biology and Bioinformatics Approach

scientific article published on January 2017

Effects of ICE-like protease and calpain inhibitors on neuronal apoptosis

scientific article published in December 1996

Effects of Injury Severity on Regional and Temporal mRNA Expression Levels of Calpains and Caspases after Traumatic Brain Injury in Rats

scientific article published on 01 July 2004

Effects of environmental tobacco smoke on adult rat brain biochemistry

scientific article

Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention

scientific article

Elevation of cytoskeletal protein breakdown in aged Wistar rat brain

Endogenous bax translocation in SH-SY5Y human neuroblastoma cells and cerebellar granule neurons undergoing apoptosis

scientific article published in May 1999

Engineered multifunctional nanotools for biological applications

scientific article published in January 2011

Enhanced amphetamine-mediated dopamine release develops in PC12 cells after repeated amphetamine treatment

scientific article published on September 2002

Erratum to: Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions

scientific article published on 27 September 2017

Erythropoietin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

scientific article published on 16 December 2015

Examining the Neural and Astroglial Protective Effects of Cellular Prion Protein Expression and Cell Death Protease Inhibition in Mouse Cerebrocortical Mixed Cultures

scientific article published on 4 September 2015

Extensive degradation of myelin basic protein isoforms by calpain following traumatic brain injury

scientific article published in August 2006

Further characterization of calpain-mediated proteolysis of the human erythrocyte plasma membrane Ca2+-ATPase

scientific article published on 01 November 1988

GFAP out-performs S100β in detecting traumatic intracranial lesions on computed tomography in trauma patients with mild traumatic brain injury and those with extracranial lesions

scientific article

Generation of aberrant forms of DFF40 concurrent with caspase-3 activation during acute and chronic liver injury in rats

scientific article published on 22 September 2006

Glial fibrillary acidic protein: a promising biomarker in pediatric brain injury

scientific article published in September 2011

Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker

scientific article published on 11 May 2015

Glial neuronal ratio: a novel index for differentiating injury type in patients with severe traumatic brain injury

scientific article published in April 2012

Hormone-induced phosphorylation of the plasma membrane calcium pump in cultured aortic endothelial cells

scientific article published on 01 August 1991

Human traumatic brain injury induces autoantibody response against glial fibrillary acidic protein and its breakdown products.

scientific article

Hypothesis: Exosomal microRNAs as potential biomarkers for schizophrenia

scientific article published on 4 April 2017

Hypothesizing that designer drugs containing cathinones ("bath salts") have profound neuro-inflammatory effects and dangerous neurotoxic response following human consumption

scientific article published on 8 July 2013

Identification and characterization of DNA aptamers specific for phosphorylation epitopes of Tau protein

scientific article published on 16 October 2018

Identification and preliminary validation of novel biomarkers of acute hepatic ischaemia/reperfusion injury using dual-platform proteomic/degradomic approaches

scientific article published on 01 July 2006

Identification of tyrosine nitration in UCH-L1 and GAPDH.

scientific article published in June 2011

Imaging Neural Plasticity following Brain Injury.

scientific article published on 28 February 2017

In Vitro Neurotoxicity Resulting from Exposure of Cultured Neural Cells to Several Types of Nanoparticles

scientific article

In vitro MS-based proteomic analysis and absolute quantification of neuronal-glial injury biomarkers in cell culture system

scientific article

Increased expression and processing of caspase-12 after traumatic brain injury in rats

scientific article

Increased expression of tissue-type transglutaminase following middle cerebral artery occlusion in rats

scientific article

Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury

scientific article published on 13 July 2012

Inhibition of LPS toxicity by hepatic argininosuccinate synthase (ASS): Novel roles for ASS in innate immune responses to bacterial infection ⬇️

scientific article published on April 7, 2011

Initial biological qualification of SBDP-145 as a biomarker of compound-induced neurodegeneration in the rat.

scientific article published on 11 July 2014

Insight into Pre-Clinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy

scientific article

Interactome and reciprocal activation of pathways in topical mesenchymal stem cells and the recipient cerebral cortex following traumatic brain injury

scientific article published on 10 July 2017

Ischemia-reperfusion-induced calpain activation and SERCA2a degradation are attenuated by exercise training and calpain inhibition

scientific article

Lateral Ventricle Volume Asymmetry Predicts Midline Shift in Severe Traumatic Brain Injury

scientific article

Lestaurtinib (CEP-701) modulates the effects of early life hypoxic seizures on cognitive and emotional behaviors in immature rats

scientific article published on 13 February 2019

Leveraging biomarker platforms and systems biology for rehabilomics and biologics effectiveness research

scientific article published on June 2011

Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

scientific article

Longitudinal Investigation of Neurotrauma Serum Biomarkers, Behavioral Characterization, and Brain Imaging in Soldiers Following Repeated Low-Level Blast Exposure (New Zealand Breacher Study).

scientific article published in March 2018

Maitotoxin induces calpain activation in SH-SY5Y neuroblastoma cells and cerebrocortical cultures

scientific article

Maitotoxin induces calpain but not caspase-3 activation and necrotic cell death in primary septo-hippocampal cultures

scientific article published in March 1999

Mass spectrometry based translational neuroinjury proteomics

article published in 2013

Methamphetamine- and trauma-induced brain injuries: comparative cellular and molecular neurobiological substrates

scientific article

Methods in drug abuse models: comparison of different models of methamphetamine paradigms

scientific article published in January 2012

Methods in drug abuse neuroproteomics: methamphetamine psychoproteome

scientific journal article

Methods in systems biology of experimental methamphetamine drug abuse

scientific article published on January 2010

Methods in tobacco abuse: proteomic changes following second-hand smoke exposure

scientific article published in January 2012

MicroRNAs as potential prognosticators of neurological outcome in out-of-hospital cardiac arrest patients

scientific article published on 8 December 2017

Modulation of hypoxia-induced calpain activity in rat renal proximal tubules

article

Molecular cloning and characterization of a novel caspase-3 variant that attenuates apoptosis induced by proteasome inhibition

scientific article published on May 2001

Molecular cloning and characterization of rat and human calpain-5.

scientific article

Molecular consequences of activated microglia in the brain: overactivation induces apoptosis

article published in 2008

Morphologic and biochemical characterization of brain injury in a model of controlled blast overpressure exposure

scientific article published in October 2010

Multi-Center Pre-clinical Consortia to Enhance Translation of Therapies and Biomarkers for Traumatic Brain Injury: Operation Brain Trauma Therapy and Beyond

scientific article published on 07 August 2018

Multiple alphaII-spectrin breakdown products distinguish calpain and caspase dominated necrotic and apoptotic cell death pathways

scientific article published in November 2009

NMDA receptor antagonist felbamate reduces behavioral deficits and blood-brain barrier permeability changes after experimental subarachnoid hemorrhage in the rat.

scientific article published in April 2007

Neuro-glial and systemic mechanisms of pathological responses in rat models of primary blast overpressure compared to "composite" blast

scientific article published on 9 February 2012

Neurochemical biomarkers in spinal cord injury

scientific article published on 04 July 2019

Neurological Exam in Rats Following Stroke and Traumatic Brain Injury

scientific article published on 01 January 2019

Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study

scientific article published on 24 June 2011

Neuronal nitric oxide synthase and calmodulin-dependent protein kinase IIalpha undergo neurotoxin-induced proteolysis.

scientific article published in September 1997

Neuroprotection targets after traumatic brain injury

scientific article

Neuroproteomics 101

Neuroproteomics and Systems Biology Approach to Identify Temporal Biomarker Changes Post Experimental Traumatic Brain Injury in Rats.

scientific article

Neuroproteomics and systems biology-based discovery of protein biomarkers for traumatic brain injury and clinical validation

scientific article published on 26 August 2008

Neuroproteomics approach and neurosystems biology analysis: ROCK inhibitors as promising therapeutic targets in neurodegeneration and neurotrauma

scientific article

Neuroproteomics in neurotrauma

scientific article

Neuroproteomics: a biochemical means to discriminate the extent and modality of brain injury

scientific article

Nicotinamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

scientific article

Novel Peptidomic Approach for Identification of Low and High Molecular Weight Tauopathy Peptides Following Calpain Digestion, and Primary Culture Neurotoxic Challenges

scientific article published on 21 October 2019

Novel differential neuroproteomics analysis of traumatic brain injury in rats

scientific article published on 26 June 2006

Novel neuroproteomic approaches to studying traumatic brain injury

scientific article published on January 2007

Operation Brain Trauma Therapy: 2016 Update

scientific article published in March 2018

Overexpression of CRF in the BNST diminishes dysphoria but not anxiety-like behavior in nicotine withdrawing rats.

scientific article published on 22 July 2016

Overpressure blast injury-induced oxidative stress and neuroinflammation response in rat frontal cortex and cerebellum.

scientific article published on 15 April 2017

Overpressure blast-wave induced brain injury elevates oxidative stress in the hypothalamus and catecholamine biosynthesis in the rat adrenal medulla

scientific article published on 6 April 2013

P43/pro-EMAPII: a potential biomarker for discriminating traumatic versus ischemic brain injury

scientific article

Performance Evaluation of a Multiplex Assay for Simultaneous Detection of Four Clinically Relevant TBI Biomarkers.

scientific article published on 25 April 2018

Persistent Ca2+-induced activation of erythrocyte membrane Ca2+-ATPase unrelated to calpain proteolysis

scientific article published on 01 May 1990

Phosphorylated and non-phosphorylated connexin-32 molecules in gap junction plaques are protected against calpain proteolysis after phosphorylation by protein kinase C

scientific article published on 01 August 1994

Phosphorylation of connexin-32 by protein kinase C prevents its proteolysis by mu-calpain and m-calpain

scientific article published in Journal of Biological Chemistry

Physiological and pathological actions of calpains in glutamatergic neurons

scientific article published on 10 June 2008

Plasma Anti-Glial Fibrillary Acidic Protein Autoantibody Levels during the Acute and Chronic Phases of Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot Study

scientific article

Post-genomics nanotechnology is gaining momentum: nanoproteomics and applications in life sciences

scientific article published on 10 January 2014

Potential contribution of proteases to neuronal damage

scientific article published on 01 May 1998

PrPC expression and calpain activity independently mediate the effects of closed head injury in mice

scientific article

Procaspase-3 and poly(ADP)ribose polymerase (PARP) are calpain substrates

scientific article published on September 1999

Processing of cdk5 Activator p35 to Its Truncated Form (p25) by Calpain in Acutely Injured Neuronal Cells

article

Prognostic utility of neuroinjury biomarkers in post out-of-hospital cardiac arrest (OHCA) patient management.

scientific article published on 24 June 2017

Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury.

scientific article published on 29 November 2017

Protein Characterization of Extracellular Microvesicles/Exosomes Released from Cytotoxin-Challenged Rat Cerebrocortical Mixed Culture and Mouse N2a Cells

scientific article published on 10 March 2017

Protein biomarkers for traumatic and ischemic brain injury: from bench to bedside

scientific article published on 7 December 2011

Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes ⬇️

scientific article published on May 15, 1991

Proteolysis of multiple myelin basic protein isoforms after neurotrauma: characterization by mass spectrometry

scientific article published on 22 November 2007

Proteomic analysis and brain-specific systems biology in a rodent model of penetrating ballistic-like brain injury

scientific article published in December 2012

Proteomic identification of biomarkers of traumatic brain injury.

scientific article

Proteomics studies of traumatic brain injury

scientific article published in January 2004

Psychiatric research: psychoproteomics, degradomics and systems biology

scientific article published on April 2008

Qualitative versus quantitative methods in psychiatric research

scientific article published in January 2012

Quantitative pupillometry and neuron-specific enolase independently predict return of spontaneous circulation following cardiogenic out-of-hospital cardiac arrest: a prospective pilot study

scientific article published in Scientific Reports

Raising the Bar for Traumatic Brain Injury Biomarker Research: Methods Make a Difference.

scientific article published on 21 March 2017

Rapid discovery of putative protein biomarkers of traumatic brain injury by SDS-PAGE-capillary liquid chromatography-tandem mass spectrometry

scientific article published in June 2005

Recent updates on drug abuse analyzed by neuroproteomics studies: Cocaine, Methamphetamine and MDMA

article published in 2014

Recovery After Mild Traumatic Brain Injury in Patients Presenting to US Level I Trauma Centers: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study

scientific article published on 03 June 2019

Regional calpain and caspase-3 proteolysis of α-spectrin after traumatic brain injury ⬇️

scientific article published on August 3, 1998

Release of Full-Length PrP(C) from Cultured Neurons Following Neurotoxic Challenges

scientific article published on 22 October 2012

Repeated, intermittent treatment with amphetamine induces neurite outgrowth in rat pheochromocytoma cells (PC12 cells).

scientific article published in September 2002

Risk of Posttraumatic Stress Disorder and Major Depression in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study

scientific article published on 01 March 2019

Selective release of calpain produced alphalI-spectrin (alpha-fodrin) breakdown products by acute neuronal cell death

scientific article published in May 2002

Sequential degradation of alphaII and betaII spectrin by calpain in glutamate or maitotoxin-stimulated cells

scientific article

Serum biomarkers of MRI brain injury in neonatal hypoxic ischemic encephalopathy treated with whole-body hypothermia: a pilot study

scientific article published on March 2013

Serum brain biomarker level, neurocognitive performance, and self-reported symptom changes in soldiers repeatedly exposed to low-level blast: a breacher pilot study

scientific article

Serum concentrations of ubiquitin C-terminal hydrolase-L1 and αII-spectrin breakdown product 145 kDa correlate with outcome after pediatric TBI

scientific article published on January 2012

Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest

scientific article

Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention

scientific article

Serum-Based Phospho-Neurofilament-Heavy Protein as Theranostic Biomarker in Three Models of Traumatic Brain Injury: An Operation Brain Trauma Therapy Study

scientific article published on 30 August 2018

Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells

scientific article published in Journal of Biological Chemistry

Simultaneous reduction on the sarcolemmal and SR calcium ATPase activities and gene expression in cardiomyopathic hamster

article

Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

scientific article

Spillway-induced salmon head injury triggers the generation of brain alphaII-spectrin breakdown product biomarkers similar to mammalian traumatic brain injury

scientific article

Stem cells in neuroinjury and neurodegenerative disorders: challenges and future neurotherapeutic prospects.

scientific article

Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor

scientific article published in February 2003

Structure–function relationship of the human erythrocyte plasma membrane Ca2+-ATPase revealed by V8 protease treatment ⬇️

scientific article published on October 15, 1991

Subcellular localization and duration of mu-calpain and m-calpain activity after traumatic brain injury in the rat: a casein zymography study

scientific article published in February 1998

Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy

scientific article published on 16 December 2015

TNF-alpha stimulates caspase-3 activation and apoptotic cell death in primary septo-hippocampal cultures.

scientific article published in April 2001

Tau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion protein

scientific article

Temporal MRI characterization, neurobiochemical and neurobehavioral changes in a mouse repetitive concussive head injury model

scientific article published on 10 June 2015

Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers

scientific article published on 13 March 2017

Temporal Profile of Microtubule-Associated Protein 2: A Novel Indicator of Diffuse Brain Injury Severity and Early Mortality after Brain Trauma

scientific article published on 12 September 2017

Temporal and spatial profile of caspase 8 expression and proteolysis after experimental traumatic brain injury

article

Temporal relationships between de novo protein synthesis, calpain and caspase 3-like protease activation, and DNA fragmentation during apoptosis in septo-hippocampal cultures

scientific article published in June 1998

The Application of Proteomics to Traumatic Brain and Spinal Cord Injuries

scientific article published on March 2017

The Effect of Chronic Methamphetamine Exposure on the Hippocampal and Olfactory Bulb Neuroproteomes of Rats

scientific article

The Traumatic Brain Injury Endpoints Development (TED) Initiative: Progress on a Public-Private Regulatory Collaboration to Accelerate Diagnosis and Treatment of Traumatic Brain Injury

scientific article published on 31 March 2017

The calpain family and human disease

scientific article (publication date: August 2001)

The calpain small subunit gene is essential: its inactivation results in embryonic lethality

scientific article published in July 2000

The diagnostic values of UCH-L1 in traumatic brain injury: A meta-analysis

scientific article published on 31 October 2017

The effect of calmodulin on the interaction of carbodiimides with the purified human erythrocyte (Ca2+ + Mg2+)-ATPase

scientific article published on November 1988

The functional and structural changes in the basilar artery due to overpressure blast injury.

scientific article published on 24 June 2015

The novel calpain inhibitor SJA6017 improves functional outcome after delayed administration in a mouse model of diffuse brain injury

scientific article (publication date: November 2001)

The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types

scientific article published on January 2000

Therapeutic Approaches with Protease Inhibitors in Neurodegenerative and Neurological Diseases

Therapeutic effects of progesterone and its metabolites in traumatic brain injury may involve non-classical signaling mechanisms.

scientific article published on 13 June 2013

Topical Therapy with Mesenchymal Stem Cells Following an Acute Experimental Head Injury Has Benefits in Motor-Behavioral Tests for Rodents

scientific article published in January 2016

Translation of neurological biomarkers to clinically relevant platforms

scientific article published in January 2009

Traumatic Brain Injury in the Elderly: Is it as Bad as we Think?

scientific article published on 6 July 2012

Traumatic brain injury and methamphetamine: A double-hit neurological insult

scientific article published on 30 January 2020

Traumatic brain injury biomarkers: from pipeline to diagnostic assay development

scientific article published in January 2009

Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research

scientific article published on 6 November 2017

Ubiquitin C-terminal hydrolase is a novel biomarker in humans for severe traumatic brain injury

scientific article

Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries

scientific article

Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats

scientific article

Unfolded protein response after neurotrauma

scientific article published on June 2006

Up-regulation of tissue-type transglutaminase after traumatic brain injury

scientific article published on 01 February 2002

Use of biomarkers for diagnosis and management of traumatic brain injury patients

scientific article published on August 2008

alphaII-Spectrin breakdown product cerebrospinal fluid exposure metrics suggest differences in cellular injury mechanisms after severe traumatic brain injury

scientific article

pH dependency of mu-calpain and m-calpain activity assayed by casein zymography following traumatic brain injury in the rat.

scientific article published in May 1998

αII-spectrin breakdown products (SBDPs): diagnosis and outcome in severe traumatic brain injury patients

scientific article

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