Search filters

List of works by Alberto Ocana

A Transcriptomic Immunologic Signature Predicts Favorable Outcome in Neoadjuvant Chemotherapy Treated Triple Negative Breast Tumors

scientific article published on 18 December 2019

A phase I trial of pantoprazole in combination with doxorubicin in patients with advanced solid tumors: evaluation of pharmacokinetics of both drugs and tissue penetration of doxorubicin

scientific article published on 12 September 2014

Absolute benefit from adjuvant chemotherapy in contemporary clinical trials: A systemic review and meta-analysis

article

Absolute benefits of aromatase inhibitors in adjuvant treatment of breast cancer: should we know more?

scientific article published on 10 May 2010

Achilles' heel of triple negative cancer

scientific article

Activation of the PI3K/mTOR/AKT pathway and survival in solid tumors: systematic review and meta-analysis

scientific article

Activity of BET-proteolysis targeting chimeric (PROTAC) compounds in triple negative breast cancer

scientific article published on 30 August 2019

Adaptive resistance to trastuzumab impairs response to neratinib and lapatinib through deregulation of cell death mechanisms

scientific article published on 22 November 2019

Addition of bevacizumab to chemotherapy for treatment of solid tumors: similar results but different conclusions

scientific article published on 13 December 2010

Adjuvant Radiation Therapy After Radical Nephrectomy in Patients with Localized Renal Cell Carcinoma: A Systematic Review and Meta-analysis

scientific article published on 05 November 2018

An update into the pathophysiological role of HER2 in cancer: therapeutic implications

scientific article published on 01 September 2007

Androgen receptor expression and outcomes in early breast cancer: a systematic review and meta-analysis

scientific article

Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer

scientific article

Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2

scientific article published on 30 September 2015

Assessment of Frequency and Reporting of Changes in Cancer Trial Design After Initiation of Patient Accrual

scientific article published on 01 January 2019

Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer

scientific article published on 15 June 2015

Association of aromatase inhibitors with coronary heart disease in women with early breast cancer

scientific article published on 18 February 2014

Author financial conflicts of interest, industry funding, and clinical practice guidelines for anticancer drugs

scientific article

BET inhibitors as novel therapeutic agents in breast cancer.

scientific article published on August 2017

Benefits and harms of detecting clinically occult breast cancer

scientific article

Bias in reporting of end points of efficacy and toxicity in randomized, clinical trials for women with breast cancer

scientific article published on 9 January 2013

Bias in reporting of randomised clinical trials in oncology

scientific article

Biological insights into effective and antagonistic combinations of targeted agents with chemotherapy in solid tumors

scientific article published on March 2014

Body size and breast cancer prognosis in relation to hormone receptor and menopausal status: a meta-analysis

scientific article published on 5 May 2012

Breast cancer dissemination promoted by a neuregulin-collagenase 3 signalling node.

scientific article

Cardiovascular toxicity of multi-tyrosine kinase inhibitors in advanced solid tumors: a population-based observational study

scientific article

Case 3. Upper limb lymphangiosarcoma following breast cancer therapy

scientific article published on 01 March 2006

Chemotherapy: dose-dense treatment for triple-negative breast cancer

scientific article published on 01 February 2010

Circulating DNA and Survival in Solid Tumors

scientific article

Comparison of absolute benefits of anticancer therapies determined by snapshot and area methods

scientific article published on 24 June 2012

Concomitant versus sequential chemotherapy in the treatment of early-stage and metastatic breast cancer.

scientific article

Do we have to change the way targeted drugs are developed?

scientific article published on 21 June 2010

Drug resistance in metastatic castration-resistant prostate cancer

scientific article

Dual targeting of HER2-positive breast cancer with trastuzumab emtansine and pertuzumab: understanding clinical trial results

scientific article published on 07 August 2018

Effect of multifocality and multicentricity on outcome in early stage breast cancer: a systematic review and meta-analysis

scientific article

Effect of multikinase inhibitors on caspase-independent cell death and DNA damage in HER2-overexpressing breast cancer cells

scientific article published on September 2010

Effects of Thyme Extract Oils (from Thymus vulgaris, Thymus zygis, and Thymus hyemalis) on Cytokine Production and Gene Expression of oxLDL-Stimulated THP-1-Macrophages

scientific article published on 17 April 2012

Efficacy and safety of dasatinib with trastuzumab and paclitaxel in first line HER2-positive metastatic breast cancer: results from the phase II GEICAM/2010-04 study

scientific article published on 03 January 2019

Efficacy of extended adjuvant therapy with aromatase inhibitors in early breast cancer among common clinicopathologically-defined subgroups: A systematic review and meta-analysis

scientific article published on 24 August 2017

Efficacy, safety, tolerability and price of newly approved drugs in solid tumors.

scientific article

Epidermal growth factor receptor overexpression and outcomes in early breast cancer: A systematic review and a meta-analysis

scientific article published on 31 October 2017

Epigenetic modulation of FOXM1-gene interacting network by BET inhibitors in breast cancer

scientific article published on 11 September 2018

Erratum: Achilles' heel of triple negative cancer

scientific article published on 13 December 2014

Evaluation of transcriptionally regulated genes identifies NCOR1 in hormone receptor negative breast tumors and lung adenocarcinomas as a potential tumor suppressor gene

scientific article published in PLoS ONE

Evolution in the eligibility criteria of randomized controlled trials for systemic cancer therapies

scientific article published on 31 December 2015

Expert Opinion and Recommendations for the Management of Attention-Deficit/Hyperactivity Disorder in Correctional Facilities.

scientific article published on January 2016

Expression of MHC class I, HLA-A and HLA-B identifies immune-activated breast tumors with favorable outcome

scientific article published on 03 July 2019

Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer.

scientific article published on April 2007

Extended adjuvant tamoxifen for early breast cancer: a meta-analysis.

scientific article

Failures in Phase III: Causes and Consequences

scientific article published on 01 October 2015

Fulvestrant for advanced breast cancer: a meta-analysis

scientific article published on 10 June 2013

Functional transcriptomic annotation and protein-protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer.

scientific article published on 25 March 2018

Functional transcriptomic annotation and protein-protein interaction network analysis identify NEK2, BIRC5, and TOP2A as potential targets in obese patients with luminal A breast cancer.

scientific article published on 12 January 2018

Functioning of autobiographical memory specificity and self-defining memories in people with cancer diagnosis

scientific article published on 19 December 2019

Genetic Susceptibility in Head and Neck Squamous Cell Carcinoma in a Spanish Population.

scientific article published on 7 April 2019

Genetic mutational status of genes regulating epigenetics: Role of the histone methyltransferase KMT2D in triple negative breast tumors

article

HER2 heterogeneity and resistance to anti-HER2 antibody-drug conjugates

scientific article published on 31 January 2020

HER3 overexpression and survival in solid tumors: a meta-analysis

scientific article published on 8 December 2012

Hepatic pneumatosis as a complication of an abdominal desmoid tumor

scientific article published on 01 March 2007

Honorary and ghost authorship in reports of randomised clinical trials in oncology

scientific article published on 5 August 2016

How valid are claims for synergy in published clinical studies?

scientific article published on 07 February 2012

Human recombinant erythropoietic agents do not induce changes in circulating levels of endoglin and vascular endothelial growth factor in anemic cancer patients

scientific article published on 04 May 2007

Hyperglycaemia and Survival in Solid Tumours: A Systematic Review and Meta-analysis.

scientific article published on 29 January 2018

Identification and Validation of a Novel Biologics Target in Triple Negative Breast Cancer

scientific article published on 17 October 2019

Identification of a stemness-related gene panel associated with BET inhibition in triple negative breast cancer

scientific article published on 12 March 2020

Identification of therapeutic targets in ovarian cancer through active tyrosine kinase profiling

scientific article published on 13 August 2015

Identifying breast cancer druggable oncogenic alterations: lessons learned and future targeted options.

scientific article published on February 2008

Impact of Availability of Companion Diagnostics on the Clinical Development of Anticancer Drugs

scientific article published on 28 February 2017

Impact of Geographic Region on Benefit of Approved Anticancer Drugs Evaluated in International Phase III Clinical Trials

scientific article published on 2 November 2015

Impact of comorbidity on the outcome in men with advanced prostate cancer treated with docetaxel.

scientific article

In Silico Analysis Guides Selection of BET Inhibitors for Triple-Negative Breast Cancer Treatment.

scientific article

In silico analyses identify gene-sets, associated with clinical outcome in ovarian cancer: role of mitotic kinases.

scientific article published on 16 March 2016

Influence of censoring on conclusions of trials for women with metastatic breast cancer

scientific article

Influence of companion diagnostics on efficacy and safety of targeted anti-cancer drugs: systematic review and meta-analyses

scientific article

Influence of control group therapy on the benefit from dose-dense chemotherapy in early breast cancer: a systemic review and meta-analysis.

scientific article published on 8 February 2018

Influence of non-measurable disease on progression-free survival in patients with metastatic breast cancer.

scientific article

Inhibition of SRC family kinases and receptor tyrosine kinases by dasatinib: possible combinations in solid tumors.

scientific article published on 13 June 2011

Integrating trastuzumab in the treatment of breast cancer. Current status and future trends

scientific article published on 01 April 2005

Integrin ανβ6 Protein Expression and Prognosis in Solid Tumors: A Meta-Analysis

scientific article published on 01 April 2020

Interaction between Hormonal Receptor Status, Age and Survival in Patients with BRCA1/2 Germline Mutations: A Systematic Review and Meta-Regression

scientific article

Irreversible pan-ErbB tyrosine kinase inhibitors and breast cancer: current status and future directions.

scientific article published on 04 September 2009

Lapatinib and HER2 status: results of a meta-analysis of randomized phase III trials in metastatic breast cancer.

scientific article published on 25 January 2010

Magnitude of Clinical Benefit of Cancer Drugs Approved by the US Food and Drug Administration.

scientific article published on 13 December 2017

Management of small HER2 overexpressing tumours

scientific article published on 06 September 2012

Mapping Bromodomains in breast cancer and association with clinical outcome

scientific article published on 05 April 2019

Mechanism of drug resistance in relation to site of metastasis: Meta-analyses of randomized controlled trials in advanced breast cancer according to anticancer strategy

scientific article

Medical Oncology Workload in Europe: One Continent, Several Worlds

scientific article published on 16 July 2019

Medical oncology: Zoledronic acid for breast cancer therapy-induced bone loss

scientific article published in April 2010

Mitotic read-out genes confer poor outcome in luminal A breast cancer tumors.

scientific article published on March 2017

Multidimensional challenges in clinical drug development, regulatory approval, and marketing.

scientific article published on 11 February 2013

Neuregulin expression in solid tumors: prognostic value and predictive role to anti-HER3 therapies

scientific article published on 08 April 2016

Neuregulin expression modulates clinical response to trastuzumab in patients with metastatic breast cancer

scientific article published on 01 July 2007

Neuregulins and cancer.

scientific article published on June 2008

Neutrophils in cancer: prognostic role and therapeutic strategies.

scientific article published on 15 August 2017

New options in the treatment of locally advanced head and neck cancer: role for induction chemotherapy.

scientific article published on 14 January 2008

Novel Synthetic Lethality Approaches for Drug Combinations and Early Drug Development

scientific article

Novel tyrosine kinase inhibitors in the treatment of cancer.

scientific article

Oncogenic targets, magnitude of benefit, and market pricing of antineoplastic drugs

scientific article published on 23 May 2011

Oncologic Drugs Advisory Committee Recommendations and Approval of Cancer Drugs by the US Food and Drug Administration.

scientific article

One step forward, two steps back: The story of everolimus in advanced breast cancer.

scientific article

Outcomes of Estrogen Receptor Negative and Progesterone Receptor Positive Breast Cancer.

scientific article published on 10 July 2015

Outcomes of single versus double hormone receptor-positive breast cancer. A GEICAM/9906 sub-study

scientific article published on 21 March 2018

P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer.

scientific article

Pathological complete response in breast cancer

scientific article

Personalized therapies in the cancer "omics" era

scientific article published on 29 July 2010

Pharmacological screening and transcriptomic functional analyses identify a synergistic interaction between dasatinib and olaparib in triple-negative breast cancer

scientific article published on 07 February 2020

Phase III trials of targeted anticancer therapies: redesigning the concept

scientific article published on 23 July 2013

Phospho-kinase profile of colorectal tumors guides in the selection of multi-kinase inhibitors.

scientific article published on 22 September 2015

Phospho-kinase profile of triple negative breast cancer and androgen receptor signaling.

scientific article

Poly(Cyclohexene Phthalate) Nanoparticles for Controlled Dasatinib Delivery in Breast Cancer Therapy

scientific article published on 27 August 2019

Poor correlation between progression-free and overall survival in modern clinical trials: are composite endpoints the answer?

scientific article published on 22 November 2011

Postmarketing Modifications of Drug Labels for Cancer Drugs Approved by the US Food and Drug Administration Between 2006 and 2016 With and Without Supporting Randomized Controlled Trials

scientific article published on 11 April 2018

Postmarketing Safety-Related Modifications of Drugs Approved by the US Food and Drug Administration Between 1999 and 2014 Without Randomized Controlled Trials

scientific article published on 01 January 2019

Preclinical development of molecular-targeted agents for cancer

scientific article published on 07 December 2010

Predominance of mTORC1 over mTORC2 in the regulation of proliferation of ovarian cancer cells: therapeutic implications.

scientific article

Prognostic Value of Lymphocyte-Activation Gene 3 (LAG3) in Cancer: A Meta-Analysis

scientific article published on 15 October 2019

Prognostic relevance of receptor tyrosine kinase expression in breast cancer: a meta-analysis.

scientific article published on 3 September 2014

Prognostic role for the derived neutrophil-to-lymphocyte ratio in early breast cancer: a GEICAM/9906 substudy

scientific article published on 15 May 2018

Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis

scientific article

Prognostic role of platelet to lymphocyte ratio in solid tumors: a systematic review and meta-analysis

scientific article

Prognostic role of telomere length in malignancies: A meta-analysis and meta-regression

scientific article published on 12 May 2017

Prognostic value of receptor tyrosine kinase-like orphan receptor (ROR) family in cancer: A meta-analysis

scientific article published on 29 May 2019

Proteolysis targeting chimeras (PROTACs) in cancer therapy

scientific article published on 15 September 2020

Raising concern about the American Society of Clinical Oncology conflict of interest policy amendment

scientific article published on 4 August 2014

Refining Early Antitumoral Drug Development

article

Regulation of the prometastatic neuregulin-MMP13 axis by SRC family kinases: therapeutic implications.

scientific article published on 15 October 2017

Relevance of randomised controlled trials in oncology.

scientific article

Reporting of Randomized Trials in Common Cancers in the Lay Media

scientific article published on 18 November 2017

Resistance to Antibody-Drug Conjugates.

scientific article

Resistance to the Antibody-Drug Conjugate T-DM1 Is Based in a Reduction in Lysosomal Proteolytic Activity

scientific article published on 7 July 2017

Response

Reversal of ATP-binding cassette drug transporter activity to modulate chemoresistance: why has it failed to provide clinical benefit?

scientific article published on June 2013

Risk of incremental toxicities and associated costs of new anticancer drugs: a meta-analysis

scientific article published on 29 September 2014

Role of cooperative groups and funding source in clinical trials supporting guidelines for systemic therapy of breast cancer.

scientific article

Screening and Preliminary Biochemical and Biological Studies of [RuCl(p-cymene)(N,N-bis(diphenylphosphino)-isopropylamine)][BF4] in Breast Cancer Models

scientific article published on 01 August 2019

Synergic antitumoral effect of an IGF-IR inhibitor and trastuzumab on HER2-overexpressing breast cancer cells.

scientific article published on 17 July 2008

Synthetic lethality interaction between Aurora kinases and CHEK1 inhibitors in ovarian cancer.

scientific article published on 28 August 2017

Systemic therapy for non-clear cell renal cell carcinomas: a systematic review and meta-analysis

scientific article published on 02 June 2014

TRAIL receptor activation overcomes resistance to trastuzumab in HER2 positive breast cancer cells

scientific article published on 27 March 2019

Targeting HER receptors in cancer

scientific article published on January 2013

Targeting basal-like breast tumors with bromodomain and extraterminal domain (BET) and polo-like kinase inhibitors

scientific article published on 3 January 2017

Targeting oncogenic vulnerabilities in triple negative breast cancer: biological bases and ongoing clinical studies

scientific article

Targeting the EGF/HER Ligand-Receptor System in Cancer.

scientific article

The Price We Pay for Progress: A Meta-Analysis of Harms of Newly Approved Anticancer Drugs

scientific article published on 16 July 2012

The evolving landscape of protein kinases in breast cancer: clinical implications.

scientific article published on 15 June 2012

Therapeutic potential of ERK5 targeting in triple negative breast cancer

scientific article

Third Nerve Palsy as the Initial Presenting Sign of Metastatic Prostate Cancer

scientific article published on 01 August 2008

Tonic-clonic seizure as the presentation symptom of severe hypocalcemia secondary to zoledronic acid administration

scientific article

Toward Value-Based Pricing to Boost Cancer Research and Innovation

scientific article

Toxicity of Extended Adjuvant Therapy With Aromatase Inhibitors in Early Breast Cancer: A Systematic Review and Meta-analysis

scientific article published in January 2018

Toxicity of adjuvant endocrine therapy in postmenopausal breast cancer patients: a systematic review and meta-analysis

scientific article published on 09 July 2011

Transcriptome evolution from breast epithelial cells to basal-like tumors.

scientific article published on 8 December 2017

Transcriptomic analyses identify association between mitotic kinases, PDZ-binding kinase and BUB1, and clinical outcome in breast cancer

scientific article published on 20 February 2016

Transcriptomic immunologic signature associated with favorable clinical outcome in basal-like breast tumors

scientific article

Trastuzumab and antiestrogen therapy: focus on mechanisms of action and resistance.

scientific article published in February 2006

Trastuzumab-Targeted Biodegradable Nanoparticles for Enhanced Delivery of Dasatinib in HER2+ Metastasic Breast Cancer

scientific article published on 16 December 2019

Tumor-infiltrating lymphocytes in breast cancer: ready for prime time?

scientific article published on 9 March 2015

Tuning the Cytotoxicity of Bis-Phosphino-Amines Ruthenium(II) Para-Cymene Complexes for Clinical Development in Breast Cancer

scientific article published on 28 September 2021

Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers.

scientific article published on 13 December 2017

Under-reporting of harm in clinical trials

scientific article published on 27 April 2016

When are "positive" clinical trials in oncology truly positive?

scientific article

Paulina is supported by:

About Paulina

Help