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List of works by Peter Cowan

A bacterial ecto-triphosphate diphosphohydrolase similar to human CD39 is essential for intracellular multiplication of Legionella pneumophila

scientific article published on 26 March 2007

Allogeneic sensitization is more effective than xenogeneic sensitization in eliciting Gal-mediated skin graft rejection

scientific article published on 01 March 2004

Altered glycosylation in donor mice causes rejection of strain-matched skin and heart grafts

scientific article published on 06 February 2014

Altered immune system glycosylation causes colitis in alpha1,2-fucosyltransferase transgenic mice

scientific article published in September 2004

Ambient fine particulate matter induces apoptosis of endothelial progenitor cells through reactive oxygen species formation

scientific article

Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model

scientific article

Anti-Gal antibody-mediated skin graft rejection requires a threshold level of Gal expression

scientific article published in February 2008

Anti-alpha1,3-galactose-mediated hyperacute rejection of vascularized transplants in a small animal model

scientific article published on 01 November 2000

Anti-inflammatory and anticoagulant effects of transgenic expression of human thrombomodulin in mice

scientific article published on 6 January 2010

Anti-non-Gal-specific combination treatment with an anti-idiotypic Ab and an inhibitory small molecule mitigates the xenoantibody response.

scientific article

Antioxidant network expression abrogates oxidative posttranslational modifications in mice ⬇️

scientific article published on February 18, 2011

Blockade of the CD28 and CD40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice

scientific article published on 01 October 2001

Blockade of the G-CSF Receptor Is Protective in a Mouse Model of Renal Ischemia-Reperfusion Injury

scientific article published on 27 July 2020

Blockade of the passive cell death pathway does not prevent tolerance induction to islet grafts

scientific article published on March 2007

Building on the GalKO platform

scientific article published on 01 July 2007

Cardiac and skin xenograft survival in different recipient mouse strains

scientific article published on 01 November 2006

Characterization of pig intercellular adhesion molecule-2 and its interaction with human LFA-1.

scientific article published on April 2004

Clinical trial of islet xenotransplantation in Mexico

scientific article published on 01 September 2006

Clinicopathological findings in non-human primate recipients of porcine renal xenografts: quantitative and qualitative evaluation of proteinuria

scientific article published on 24 September 2013

Clonidine inhibits anti-non-Gal IgM xenoantibody elicited in multiple pig-to-primate models.

scientific article published on 21 October 2015

Co-expression of a scFv antibody fragment and a reporter protein using lentiviral shuttle plasmid containing a self-processing furin-2A sequence

scientific article published on 30 August 2013

Complement activation and coagulation in xenotransplantation.

scientific article published on 20 January 2009

Complex organisation of the 5′-end of the human glycine tRNA synthetase gene ⬇️

scientific article published on March 16, 1998

Control of IBMIR in neonatal porcine islet xenotransplantation in baboons

scientific article

Controlling coagulation dysregulation in xenotransplantation

scientific article

Crystal structure of a Legionella pneumophila ecto -triphosphate diphosphohydrolase, a structural and functional homolog of the eukaryotic NTPDases

scientific article

Deficiency or inhibition of CD73 protects in mild kidney ischemia-reperfusion injury

scientific article published on December 2010

Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation

scientific article published on 14 September 2013

Ectonucleotide Triphosphate Diphosphohydrolase-1 (CD39) Mediates Resistance to Occlusive Arterial Thrombus Formation after Vascular Injury in Mice ⬇️

scientific article published on May 18, 2012

Effect of DNA concentration on transgenesis rates in mice and pigs

scientific article published on 01 December 2001

Enhanced expression of glutathione peroxidase protects islet beta cells from hypoxia-reoxygenation

scientific article published on January 2004

Enhanced protection of the renal vascular endothelium improves early outcome in kidney transplantation: Preclinical investigations in pig and mouse.

scientific article published on 26 March 2018

Enzymatic properties of an ecto-nucleoside triphosphate diphosphohydrolase from Legionella pneumophila: substrate specificity and requirement for virulence

scientific article published on 12 March 2008

Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets.

scientific article published on March 2007

Expression and functional analysis of glycosyl-phosphatidyl inositol-linked CD46 in transgenic mice

scientific article published on 01 December 1998

Fate of alphaGal +/+ pancreatic islet grafts after transplantation into alphaGal knockout mice

scientific article

First quantification of alpha-Gal epitope in current glutaraldehyde-fixed heart valve bioprostheses.

scientific article

FokI-dCas9 mediates high-fidelity genome editing in pigs

scientific article published on 12 August 2019

Gene-modified pigs

scientific article published in March 2008

Genetic modification for xenotransplantation: transgenics and clones

scientific article published on 01 November 2001

Genetic modification of pigs for solid organ xenotransplantation.

scientific article published on January 2011

Genetically variable triplet repeats in a RING-finger ORF of Helicoverpa species baculoviruses.

scientific article published on May 1997

Glycosylation changes in hFUT1 transgenic mice increase TCR signaling and apoptosis resulting in thymocyte maturation arrest

scientific article

High-level endothelial expression of human CD59 prolongs heart function in an ex vivo model of xenograft rejection

scientific article published on 01 March 1998

Human factor H-related protein 5 (FHR-5). A new complement-associated protein

scientific article

Human-specific bacterial pore-forming toxins induce programmed necrosis in erythrocytes

scientific article

Hyperacute rejection of vascularized heart transplants in BALB/c Gal knockout mice

scientific article published on 01 November 2000

Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer ⬇️

scientific article published on April 2, 2011

In situ protection against islet allograft rejection by CTLA4Ig transduction

scientific article published on November 2010

Intravascular thrombosis in discordant xenotransplantation.

scientific article published on November 2006

Kidney xenotransplantation

scientific article

Knock out of alpha1,3-galactosyltransferase or expression of alpha1,2-fucosyltransferase further protects CD55- and CD59-expressing mouse hearts in an ex vivo model of xenograft rejection

scientific article

Liver grafts from CD39-overexpressing rodents are protected from ischemia reperfusion injury due to reduced numbers of resident CD4+ T cells

scientific article published on 14 March 2013

Miscellaneous

scientific article published on 28 November 2017

Modification of kidney barrier function by the urokinase receptor.

scientific article published on 16 December 2007

Molecular regulation of xenoreactivity

scientific article published on February 2007

Monoclonal antibodies generated by DNA immunization recognize CD2 from a broad range of primates

scientific article published on 10 February 2009

Naturally acquired anti-alpha Gal antibodies in a murine allograft model similar to delayed xenograft rejection

scientific article published on 01 February 2000

On the need for porcine embryonic stem cells to produce Gal KO pigs expressing multiple transgenes to advance xenotransplantation research

scientific article published on 01 November 2010

Optimizing transduction of pig islet cell clusters for xenotransplantation.

scientific article published in January 2009

Overexpression of Human CD55 and CD59 or Treatment with Human CD55 Protects against Renal Ischemia-Reperfusion Injury in Mice

scientific article

Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function

scientific article published in July 2005

Pig endothelial protein C receptor is functionally compatible with the human protein C pathway

scientific article published on 25 September 2019

Pig thrombomodulin binds human thrombin but is a poor cofactor for activation of human protein C and TAFI

scientific article published on 29 April 2008

Preservation of cochlear function in Cd39 deficient mice

scientific article

Prevention of Hyperacute Rejection in a Model of Orthotopic Liver Xenotransplantation From Pig to Baboon Using Polytransgenic Pig Livers (CD55, CD59, and H-Transferase)

article

Production of homozygous alpha-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer

scientific article published in July 2007

Progress towards overcoming coagulopathy and hemostatic dysfunction associated with xenotransplantation

scientific article

Protective effects of transgenic human endothelial protein C receptor expression in murine models of transplantation.

scientific article published on 8 June 2012

Recombinant pig TFPI efficiently regulates human tissue factor pathways

scientific article published on May 2008

Regulatory T cells participate in CD39-mediated protection from renal injury

scientific article published on 01 September 2012

Reply to 'Critics slam Russian trial to test pig pancreas for diabetes'

scientific article published on 01 June 2007

Response to Valdes-Gonzalez ''Clinical trial of islet xenotransplantation in Mexico''

article

Rhesus monkeys and baboons develop clotting factor VIII inhibitors in response to porcine endothelial cells or islets

scientific article

Subcutaneous pig islet xenografts: getting under your skin to cure diabetes?

scientific article published on 01 November 2010

Surface modification of pig endothelial cells with a branched heparin conjugate improves their compatibility with human blood

scientific article published on 30 June 2017

Sustained function of genetically modified porcine lungs in an ex vivo model of pulmonary xenotransplantation

scientific article published on 7 August 2013

Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9.

scientific article published on 16 August 2017

Targeting gene expression to endothelial cells in transgenic mice using the human intercellular adhesion molecule 2 promoter

scientific article

Targeting gene expression to endothelium in transgenic animals: a comparison of the human ICAM-2, PECAM-1 and endoglin promoters

scientific article published on 01 May 2003

The 2017 IXA Presidential Lecture: Recent developments in xenotransplantation

scientific article published on 01 May 2018

The CD39-Adenosinergic Axis in the Pathogenesis of Immune and Nonimmune Diabetes ⬇️

scientific article published on October 14, 2012

The CD39-adenosinergic axis in the pathogenesis of renal ischemia-reperfusion injury

scientific article

The Resurgence of Xenotransplantation

scientific article published on 11 April 2017

The coagulation barrier in xenotransplantation: incompatibilities and strategies to overcome them.

scientific article published on April 2008

The human ICAM-2 promoter is endothelial cell-specific in vitro and in vivo and contains critical Sp1 and GATA binding sites

scientific article published on 01 May 1998

The impact of purinergic signaling on renal ischemia-reperfusion injury

scientific article

The protective effects of CD39 overexpression in multiple low-dose streptozotocin-induced diabetes in mice

scientific article published on 30 January 2013

The role of adenosine receptors A2A and A2B signaling in renal fibrosis

scientific article

The transgenic expression of human CD39 on murine islets inhibits clotting of human blood.

scientific article

Thromboelastographic evaluation of coagulative profiles in pig-to-monkey kidney xenotransplantation.

scientific article published on 14 February 2013

Towards endothelial cell-specific transgene expression in pigs: characterization of the pig ICAM-2 promoter.

scientific article published on November 2006

Transgenic expression of human complement regulators reduces skeletal muscle ischaemia/reperfusion injury in mice

scientific article published in January 2005

Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury.

scientific article published on 12 September 2011

Transgenic overexpression of CD39 protects against renal ischemia-reperfusion and transplant vascular injury

scientific article published on 14 September 2010

Transgenic perspectives in xenotransplantation, 2001.

scientific article

Transgenic swine: Expression of human CD39 protects against myocardial injury ⬇️

scientific article published on January 12, 2012

Transplantation of xenogeneic islets: are we there yet?

scientific article published on October 2013

Variable impact of CD39 in experimental murine colitis.

scientific article published on 9 October 2010

Vascular gene transfer driven by endoglin and ICAM-2 endothelial-specific promoters.

scientific article

Versatile co‐expression of graft‐protective proteins using 2A‐linked cassettes ⬇️

scientific article published on March 1, 2011

Which anti-platelet therapies might be beneficial in xenotransplantation?

scientific article published on March 2011

Xenoantibody response to porcine islet cell transplantation using GTKO, CD55, CD59, and fucosyltransferase multiple transgenic donors

scientific article

Xenotransplantation in Australia: Development of the regulatory process

scientific article published on 07 June 2020

Xenotransplantation of Galactosyl-Transferase Knockout, CD55, CD59, CD39, and Fucosyl-Transferase Transgenic Pig Kidneys Into Baboons

scientific article published on 01 November 2011

Xenotransplantation: past achievements and future promise.

scientific article

hCTLA4-Ig transgene expression in keratocytes modulates rejection of corneal xenografts in a pig to non-human primate anterior lamellar keratoplasty model

scientific article published on 08 July 2014

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