List of works - Jesper Thorvald Troelsen

1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice

scientific article published on 01 April 1994

A novel approach for microRNA in situ hybridization using locked nucleic acid probes

scientific article published on 24 February 2021

Adult-type hypolactasia and regulation of lactase expression

scientific article (publication date: 25 May 2005)

An enhancer activates the pig lactase phlorizin hydrolase promoter in intestinal cells

scientific article published in February 2003

An upstream polymorphism associated with lactase persistence has increased enhancer activity

scientific article (publication date: December 2003)

Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression

scientific article

CDX2 downregulation is associated with poor differentiation and MMR deficiency in colon cancer

scientific article published on 6 November 2015

CDX2 expression and perioperative patient serum affects the adhesion properties of cultured colon cancer cells

scientific article published on 14 May 2020

CVD: the intestinal crypt/villus in situ hybridization database

scientific article published on 10 February 2004

Carriers of a VEGFA enhancer polymorphism selectively binding CHOP/DDIT3 are predisposed to increased circulating levels of thyroid-stimulating hormone

scientific article (publication date: 14 September 2016)

Cellular cross talk in the small intestinal mucosa: postnatal lymphocytic immigration elicits a specific epithelial transcriptional response

scientific article published on 3 April 2008

Cellular inhibitor of apoptosis protein 2 controls human colonic epithelial restitution, migration, and Rac1 activation

scientific article

Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies.

scientific article published on 25 April 2018

Clinical implications of intestinal stem cell markers in colorectal cancer.

scientific article published on 24 December 2014

Control of intestinal promoter activity of the cellular migratory regulator gene ELMO3 by CDX2 and SP1.

scientific article

Converging signals synergistically activate the LAMC2 promoter and lead to accumulation of the laminin gamma 2 chain in human colon carcinoma cells.

scientific article published on April 2003

Current and emerging approaches to define intestinal epithelium-specific transcriptional networks.

scientific article

Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome-wide gene expression data

scientific article

Differences in inflammation and acute phase response but similar genotoxicity in mice following pulmonary exposure to graphene oxide and reduced graphene oxide.

scientific article

Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells.

scientific article

Diversity of lactase persistence alleles in Ethiopia: signature of a soft selective sweep.

scientific article published on 29 August 2013

Driver Gene Mutations and Epigenetics in Colorectal Cancer

scientific article published on 07 June 2019

Escape from epigenetic silencing of lactase expression is triggered by a single-nucleotide change.

scientific article

Genome-wide analysis of CDX2 binding in intestinal epithelial cells (Caco-2)

scientific article published on 15 June 2010

HNF1 alpha activates the aminopeptidase N promoter in intestinal (Caco-2) cells

scientific article published on April 1994

HNF4α and CDX2 Regulate Intestinal YAP1 Promoter Activity

scientific article published on 18 June 2019

HOXB4 Gene Expression Is Regulated by CDX2 in Intestinal Epithelial Cells

scientific article

Identification and Functional Analysis of Gene Regulatory Sequences Interacting with Colorectal Tumor Suppressors.

scientific article published in January 2018

Identification of TNF-α-responsive promoters and enhancers in the intestinal epithelial cell model Caco-2.

scientific article

Identification of a functional hepatocyte nuclear factor 4 binding site in the neutral ceramidase promoter

scientific article published on 01 December 2010

Impact of in Vivo Ischemic Time on RNA Quality--Experiences from a Colon Cancer Biobank.

scientific article published on 17 July 2015

In Vitro Functional Analyses of Infrequent Nucleotide Variants in the Lactase Enhancer Reveal Different Molecular Routes to Increased Lactase Promoter Activity and Lactase Persistence

scientific article published on 7 October 2016

Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture

scientific article published in January 2008

Interaction between the homeodomain proteins Cdx2 and HNF1α mediates expression of the lactase-phlorizin hydrolase gene

article

Intestinal regulation of suppression of tumorigenicity 14 (ST14) and serine peptidase inhibitor, Kunitz type -1 (SPINT1) by transcription factor CDX2

scientific article published in Scientific Reports

Involvement of CDX2 in the cross talk between TNF-α and Wnt signaling pathway in the colon cancer cell line Caco-2.

scientific article published on 5 February 2014

Involvement of activator protein 1 complexes in the epithelium-specific activation of the laminin γ2-chain gene promoter by hepatocyte growth factor (scatter factor)

scientific article (publication date: 15 April 2000)

Lactose intolerance. Genotyping simplifies and improves diagnosis

scientific article

Low expression of insulin in the thymus of non-obese diabetic mice

scientific article published on 01 December 2002

Mapping of HNF4alpha target genes in intestinal epithelial cells

scientific article published on 17 September 2009

Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development

scientific article published on 31 August 2017

Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation

scientific article published on 25 July 2006

Mitogen activated protein kinases: a role in inflammatory bowel disease?

scientific article published on 30 September 2009

Preaxial polydactyly/triphalangeal thumb is associated with changed transcription factor-binding affinity in a family with a novel point mutation in the long-range cis-regulatory element ZRS

scientific article

Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression.

scientific article published on 4 May 2017

Rectal Insulin Instillation Inhibits Inflammation and Tumor Development in Chemically Induced Colitis

scientific article published on 01 November 2018

Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells

scientific article published on 7 February 2013

Regulation of Laminin γ2 Expression by CDX2 in Colonic Epithelial Cells Is Impaired During Active Inflammation

scientific article published on 23 June 2016

SOX9 expression predicts relapse of stage II colon cancer patients.

scientific article published in February 2016

T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro

scientific article

TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis

scientific article published on 3 February 2012

The -14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1α binding site and increases lactase promoter activity

scientific article

The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2

scientific article published on 05 July 2018

The clinical perspectives of CDX2 expression in colorectal cancer: a qualitative systematic review.

scientific article

The prognostic value of polycomb group protein B-cell-specific moloney murine leukemia virus insertion site 1 in stage II colon cancer patients.

scientific article

The role of CDX2 in intestinal homeostasis and inflammation

scientific article

The value of circulating microRNAs for early diagnosis of B-cell lymphoma: A case-control study on historical samples

scientific article published on 15 June 2020

Transcriptional control of steroid biosynthesis genes in the Drosophila prothoracic gland by ventral veins lacking and knirps

scientific article (publication date: June 2014)

Two intestinal specific nuclear factors binding to the lactase-phlorizin hydrolase and sucrase-isomaltase promoters are functionally related oligomeric molecules.

scientific article published on April 1994

pcaGoPromoter--an R package for biological and regulatory interpretation of principal components in genome-wide gene expression data

scientific article

List of works by Jesper Thorvald Troelsen

1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice

A novel approach for microRNA in situ hybridization using locked nucleic acid probes

Adult-type hypolactasia and regulation of lactase expression

An enhancer activates the pig lactase phlorizin hydrolase promoter in intestinal cells

An upstream polymorphism associated with lactase persistence has increased enhancer activity

Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression

CDX2 downregulation is associated with poor differentiation and MMR deficiency in colon cancer

CDX2 expression and perioperative patient serum affects the adhesion properties of cultured colon cancer cells

CVD: the intestinal crypt/villus in situ hybridization database

Carriers of a VEGFA enhancer polymorphism selectively binding CHOP/DDIT3 are predisposed to increased circulating levels of thyroid-stimulating hormone

Cellular cross talk in the small intestinal mucosa: postnatal lymphocytic immigration elicits a specific epithelial transcriptional response

Cellular inhibitor of apoptosis protein 2 controls human colonic epithelial restitution, migration, and Rac1 activation

Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies.

Clinical implications of intestinal stem cell markers in colorectal cancer.

Control of intestinal promoter activity of the cellular migratory regulator gene ELMO3 by CDX2 and SP1.

Converging signals synergistically activate the LAMC2 promoter and lead to accumulation of the laminin gamma 2 chain in human colon carcinoma cells.

Current and emerging approaches to define intestinal epithelium-specific transcriptional networks.

Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome-wide gene expression data

Differences in inflammation and acute phase response but similar genotoxicity in mice following pulmonary exposure to graphene oxide and reduced graphene oxide.

Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells.

Diversity of lactase persistence alleles in Ethiopia: signature of a soft selective sweep.

Driver Gene Mutations and Epigenetics in Colorectal Cancer

Escape from epigenetic silencing of lactase expression is triggered by a single-nucleotide change.

Genome-wide analysis of CDX2 binding in intestinal epithelial cells (Caco-2)

HNF1 alpha activates the aminopeptidase N promoter in intestinal (Caco-2) cells

HNF4α and CDX2 Regulate Intestinal YAP1 Promoter Activity

HOXB4 Gene Expression Is Regulated by CDX2 in Intestinal Epithelial Cells

Identification and Functional Analysis of Gene Regulatory Sequences Interacting with Colorectal Tumor Suppressors.

Identification of TNF-α-responsive promoters and enhancers in the intestinal epithelial cell model Caco-2.

Identification of a functional hepatocyte nuclear factor 4 binding site in the neutral ceramidase promoter

Impact of in Vivo Ischemic Time on RNA Quality--Experiences from a Colon Cancer Biobank.

In Vitro Functional Analyses of Infrequent Nucleotide Variants in the Lactase Enhancer Reveal Different Molecular Routes to Increased Lactase Promoter Activity and Lactase Persistence

Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture

Interaction between the homeodomain proteins Cdx2 and HNF1α mediates expression of the lactase-phlorizin hydrolase gene

Intestinal regulation of suppression of tumorigenicity 14 (ST14) and serine peptidase inhibitor, Kunitz type -1 (SPINT1) by transcription factor CDX2

Involvement of CDX2 in the cross talk between TNF-α and Wnt signaling pathway in the colon cancer cell line Caco-2.

Involvement of activator protein 1 complexes in the epithelium-specific activation of the laminin γ2-chain gene promoter by hepatocyte growth factor (scatter factor)

Lactose intolerance. Genotyping simplifies and improves diagnosis

Low expression of insulin in the thymus of non-obese diabetic mice

Mapping of HNF4alpha target genes in intestinal epithelial cells

Mathematical modelling as a proof of concept for MPNs as a human inflammation model for cancer development

Metabolome, transcriptome, and bioinformatic cis-element analyses point to HNF-4 as a central regulator of gene expression during enterocyte differentiation

Mitogen activated protein kinases: a role in inflammatory bowel disease?

Preaxial polydactyly/triphalangeal thumb is associated with changed transcription factor-binding affinity in a family with a novel point mutation in the long-range cis-regulatory element ZRS

Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression.

Rectal Insulin Instillation Inhibits Inflammation and Tumor Development in Chemically Induced Colitis

Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells

Regulation of Laminin γ2 Expression by CDX2 in Colonic Epithelial Cells Is Impaired During Active Inflammation

SOX9 expression predicts relapse of stage II colon cancer patients.

T-13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro

TNF-α-induced down-regulation of CDX2 suppresses MEP1A expression in colitis

The -14010*C variant associated with lactase persistence is located between an Oct-1 and HNF1α binding site and increases lactase promoter activity

The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2

The clinical perspectives of CDX2 expression in colorectal cancer: a qualitative systematic review.

The prognostic value of polycomb group protein B-cell-specific moloney murine leukemia virus insertion site 1 in stage II colon cancer patients.

The role of CDX2 in intestinal homeostasis and inflammation

The value of circulating microRNAs for early diagnosis of B-cell lymphoma: A case-control study on historical samples

Transcriptional control of steroid biosynthesis genes in the Drosophila prothoracic gland by ventral veins lacking and knirps

Two intestinal specific nuclear factors binding to the lactase-phlorizin hydrolase and sucrase-isomaltase promoters are functionally related oligomeric molecules.

pcaGoPromoter--an R package for biological and regulatory interpretation of principal components in genome-wide gene expression data