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List of works by Ichirō Sakuma

A hydroxymethylglutaryl coenzyme A reductase inhibitor improves endothelial function within 7 days in patients with chronic hemodialysis.

scientific article published on 28 May 2009

A mutant cardiac sodium channel with multiple biophysical defects associated with overlapping clinical features of Brugada syndrome and cardiac conduction disease

scientific article published on February 2002

A role of myofilament Ca2+ sensitivity in enhanced vascular reactivity in cardiomyopathic hamsters

scientific article published on 01 July 1998

Age-related changes in cardiac expression of VEGF and its angiogenic receptor KDR in stroke-prone spontaneously hypertensive rats

scientific article published on 01 April 2005

Agonist-independent tonic inhibitory influence of Gi on adenylate cyclase activity in rabbit ventricular myocardium and its removal by pertussis toxin: a role of empty receptor-mediated Gi activation

scientific article published on February 1997

Alterations in endothelium-dependent hyperpolarization and relaxation in mesenteric arteries from streptozotocin-induced diabetic rats

scientific article published on August 1997

Altered expression of endothelin and its receptors in the brain of SHR-SP at malignant hypertensive stage

scientific article published in November 2004

An S-nitrosylated hemoglobin derivative protects the rat hippocampus from ischemia-induced long-term potentiation impairment with a time window

scientific article published on 09 October 2004

Angiotensin converting enzyme inhibitors remain the first treatment of choice

scientific article published on 26 February 2016

Antagonism of endothelin action normalizes altered levels of VEGF and its signaling in the brain of stroke-prone spontaneously hypertensive rat

scientific article published on 21 July 2007

Antiatherosclerotic and anti-insulin resistance effects of adiponectin: basic and clinical studies.

scientific article published on September 2009

Assessment of newly developed perfluorocarbon emulsion: oxygen carrying capacity as the blood substitute in vivo

scientific article published in September 2001

Attenuation of hypothermia-induced platelet activation and platelet adhesion to artificial surfaces in vitro by modification of hemoglobin to carry S-nitric oxide and polyethylene glycol

scientific article published on 01 December 2000

Behavioral and biochemical changes following acute administration of MPTP and MPP+

scientific article published on 01 March 1987

Brain expression of VEGF and its receptors in SHR-SP and effects of an endothelin blocker

scientific article published in November 2004

Calming down chaos regarding redefining blood pressure targets-the importance of statin-based therapy.

scientific article

Cardioprotective effect of perfluorochemical emulsion for cardiac preservation after six-hour cold storage

scientific article

Cardiopulmonary bypass influences the plasma levels of calcitonin gene-related peptides in dogs: effects of hemofiltration and hemodilution

scientific article published on 12 July 2006

Caveats to aggressive lowering of lipids by specific statins.

scientific article

Change in carotid intima-media thickness in a high-risk group of patients by intensive lipid-lowering therapy with rosuvastatin: subanalysis of the JART study

scientific article published on 14 March 2014

Characterization of regional cerebral blood flow and expression of angiogenic growth factors in the frontal cortex of juvenile male SHRSP and SHR.

scientific article

Characterization of vascular endothelial growth factor (VEGF) in the uterine cervix over pregnancy: effects of denervation and implications for cervical ripening.

scientific article published in December 2004

Colestimide, an anion exchange resin agent, can decrease the number of LDL particles without affecting their size in patients with hyperlipidemia

scientific article published on 4 October 2009

Combination pravastatin and valsartan treatment has additive beneficial effects to simultaneously improve both metabolic and cardiovascular phenotypes beyond that of monotherapy with either drug in patients with primary hypercholesterolemia

scientific article published on 17 July 2013

Contribution of KChIP2 to the developmental increase in transient outward current of rat cardiomyocytes

scientific journal article

Coronary capillary network remodeling and hypofibrinolysis in aged obese diabetic rats: implications for increased myocardial vulnerability to ischemia

scientific article published in June 2003

Depressed responsiveness to angiotensin II in ventricular myocytes of hypertrophic cardiomyopathic Syrian hamster

scientific article published on 01 November 1994

Differential metabolic effects of distinct statins.

scientific article

Differential metabolic effects of rosuvastatin and pravastatin in hypercholesterolemic patients.

scientific article published on 26 December 2011

Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a type II diabetic rat model: a possible cause for erectile dysfunction in diabetes.

scientific article

Dipyridamole potentiates the anti-aggregating effect of endothelium-derived relaxing factor

scientific article published on 01 January 1990

Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation

scientific article published on September 2002

Effect of prolonged treatment with amlodipine on enhanced vascular contractility in cardiomyopathic hamsters

scientific article published on 01 July 1999

Effects of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on beta-adrenoceptor signaling in heart failure produced by myocardial Infarction in rabbits: reversal of altered expression of beta-adrenoceptor kinase

scientific article published on 01 January 2003

Effects of conventional or lower doses of hormone replacement therapy in postmenopausal women.

scientific article

Effects of endothelin receptor antagonist on expression of AT1 and AT2 receptors in the heart of SHR-SP

scientific article published on 01 November 2004

Effects of fenofibrate on lipoproteins, vasomotor function, and serological markers of inflammation, plaque stabilization, and hemostasis

scientific article

Effects of fenofibrate therapy on circulating adipocytokines in patients with primary hypertriglyceridemia

scientific article published on 29 October 2010

Effects of simvastatin therapy on circulating adipocytokines in patients with hypercholesterolemia

scientific article published on 20 November 2010

Efficacy of HMG-CoA reductase inhibitors in the prevention of cerebrovascular attack in 1016 patients older than 75 years among 4014 type 2 diabetic individuals.

scientific article published on 5 November 2014

Estrogen receptor alpha and beta are both involved in the cerebral VEGF/Akt/NO pathway and cerebral angiogenesis in female mice

scientific article published in December 2010

Evidence against a role of cytochrome P450-derived arachidonic acid metabolites in endothelium-dependent hyperpolarization by acetylcholine in rat isolated mesenteric artery

scientific article published on February 1997

Evidence for a potential role of estrogen in the penis: detection of estrogen receptor-alpha and -beta messenger ribonucleic acid and protein

scientific article published on December 2002

Evidence for selective inhibition by lysophosphatidylcholine of acetylcholine-induced endothelium-dependent hyperpolarization and relaxation in rat mesenteric artery

scientific article published on September 1995

Expression of endothelin receptors in the brain of SHR-SP and effects of an endothelin blocker

scientific article published in November 2004

Gonadal hormones and frontocortical expression of vascular endothelial growth factor in male stroke-prone, spontaneously hypertensive rats, a model for attention-deficit/hyperactivity disorder

scientific article

Histamine H1 and H2 receptor gene and protein levels are differentially expressed in the hearts of rodents and humans.

scientific article

How to balance cardiorenometabolic benefits and risks of statins

scientific article published on 16 June 2014

How to control residual cardiovascular risk despite statin treatment: focusing on HDL-cholesterol.

scientific article published on 12 April 2012

Hypertriglyceridemia and Cardiovascular Diseases: Revisited

scientific article

In vivo estrogen manipulations on coronary capillary network and angiogenic molecule expression in middle-aged female rats

scientific article published in October 2002

Inhibition of endothelium-dependent relaxation by hemoglobin in rabbit aortic strips: comparison between acellular hemoglobin derivatives and cellular hemoglobins

scientific article published on 01 July 1996

Interactions of sildenafil with various coronary vasodilators in isolated porcine coronary artery

scientific article published in February 2002

Intravascular ultrasound evaluation of coronary plaque regression by low density lipoprotein-apheresis in familial hypercholesterolemia: the Low Density Lipoprotein-Apheresis Coronary Morphology and Reserve Trial (LACMART).

scientific article published in July 2002

L-NG-monomethyl arginine inhibits the vasodilating effects of low dose of endothelin-3 on rat mesenteric arteries

scientific article published on 01 March 1990

Lipoprotein metabolism, insulin resistance, and adipocytokine levels in Japanese female adolescents with a normal body mass index and high body fat mass.

scientific article

Long-acting calcium channel blocker benidipine suppresses expression of angiogenic growth factors and prevents cardiac remodelling in a Type II diabetic rat model

scientific article published on 01 March 2002

Low HDL-cholesterol, hypertension and impaired glucose tolerance as predictors of acute myocardial infarction in northern area of Japan.

scientific article published in January 2006

Lysophosphatidylcholine, a component of stromal phospholipids, as a candidate vasoconstrictive factor in stroma-free hemoglobin

scientific article published on 01 March 1994

Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease.

scientific article

Menopause and cardiovascular diseases in women

scientific article published in February 2004

Notes on the acetylcholine-induced relaxation of porcine coronary arteries

scientific article published in January 1994

Omega-3 fatty acid therapy dose-dependently and significantly decreased triglycerides and improved flow-mediated dilation, however, did not significantly improve insulin sensitivity in patients with hypertriglyceridemia

scientific article published on 07 August 2014

Ovariectomy attenuates hyperpolarization and relaxation mediated by endothelium-derived hyperpolarizing factor in female rat mesenteric artery: a concomitant decrease in connexin-43 expression

scientific article

Peptidoleukotrienes induce an endothelium-dependent relaxation of guinea pig main pulmonary artery and thoracic aorta

scientific article published in November 1987

Potentially important considerations in choosing specific statin treatments to reduce overall morbidity and mortality.

scientific article

Regulatory molecules for coronary expressions of VEGF and its angiogenic receptor KDR in hypoestrogenic middle-aged female rats

scientific article

Relaxation in different-sized rat blood vessels mediated by endothelium-derived hyperpolarizing factor: importance of processes mediating precontractions

scientific article published on 01 July 1999

Renin-angiotensin system inhibitor and statins combination therapeutics - what have we learnt?

scientific article published on 08 March 2015

Reply to comment on: Effects of ezetimibe/simvastatin combination on metabolic parameters by Prof. Moses S Elisaf

scientific article published on 25 August 2015

Role of angiotensin II in altered expression of molecules responsible for coronary matrix remodeling in insulin-resistant diabetic rats

scientific article published on 4 September 2003

Role of renin-angiotensin system blockades in reciprocal relationship between insulin resistance and endothelial dysfunction

scientific article published on 08 November 2010

Rosuvastatin dose-dependently improves flow-mediated dilation, but reduces adiponectin levels and insulin sensitivity in hypercholesterolemic patients

scientific article

S-nitrosylated and pegylated hemoglobin, a newly developed artificial oxygen carrier, exerts cardioprotection against ischemic hearts.

scientific article published on 17 January 2007

Should progestins be blamed for the failure of hormone replacement therapy to reduce cardiovascular events in randomized controlled trials?

scientific article published on 6 May 2004

Significant differential effects of omega-3 fatty acids and fenofibrate in patients with hypertriglyceridemia.

scientific article published on 19 November 2011

Sources of Ca2+ in relation to generation of acetylcholine-induced endothelium-dependent hyperpolarization in rat mesenteric artery

scientific article published on April 1997

Statins and renin-angiotensin system inhibitor combination treatment to prevent cardiovascular disease

scientific article

Structural differences in the ability of lysophospholipids to inhibit endothelium-dependent hyperpolarization by acetylcholine in rat mesenteric arteries

scientific article published on 01 October 1996

Subdepressor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by normalization of upregulated endothelin system in rats

scientific article published on 30 December 2005

Temporal changes in pulmonary expression of key procoagulant molecules in rabbits with endotoxin-induced acute lung injury: elevated expression levels of protease-activated receptors

scientific article published on 01 November 2004

Temporal effects of edaravone, a free radical scavenger, on transient ischemia-induced neuronal dysfunction in the rat hippocampus

scientific article

Thapsigargin- and cyclopiazonic acid-induced endothelium-dependent hyperpolarization in rat mesenteric artery

scientific article published on July 1995

The calcium channel antagonist benidipine reduces plasma and cardiac endothelin-1 levels in type II diabetic rat model.

scientific article

The slow cyclic GMP increase caused by serotonin in NG108-15 cells is not inhibited by antagonists of known serotonin receptors: possible existence of a new receptor subtype coupled with membrane-bound guanylate cyclase

scientific article published on August 1991

Therapeutic potentials of an artificial oxygen-carrier, liposome-encapsulated hemoglobin, for ischemia/reperfusion-induced cerebral dysfunction in rats

scientific article published on 11 September 2010

VEGF signaling is disrupted in the hearts of mice lacking estrogen receptor alpha.

scientific article published on 4 June 2010

Vascular and metabolic effects of ezetimibe combined with simvastatin in patients with hypercholesterolemia.

scientific article

Vascular and metabolic effects of omega-3 fatty acids combined with fenofibrate in patients with hypertriglyceridemia

scientific article published on 5 July 2016

What Type of Statin and What Level of Low-Density Lipoprotein Cholesterol Should Be Appropriate for Secondary Prevention for Japanese Patients With Coronary Artery Disease? ⬇️

scientific article published on April 28, 2012

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