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List of works by Anders Nykjaer

A carboxyl-terminal fragment of lipoprotein lipase binds to the low density lipoprotein receptor-related protein and inhibits lipase-mediated uptake of lipoprotein in cells.

scientific article

A two-receptor pathway for catabolism of Clara cell secretory protein in the kidney

scientific article (publication date: 20 April 2001)

APP involvement in retinogenesis of mice

scientific article published on 27 October 2010

Alpha 2-macroglobulin receptor mediates binding and cytotoxicity of plant ribosome-inactivating proteins

scientific article

Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha 2-macroglobulin receptor containing a cluster of eight complement-type

scientific article published on 01 June 1993

Analysis of ligand binding to the alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that lipoprotein lipase and the carboxyl-terminal domain of the receptor-associated protein bind to the same site.

scientific article

Assessing low-dose gentamicin-induced kidney injury in rats by analysis of urine

scientific article published on 24 July 2009

Bioactive human recombinant tumor necrosis factor-alpha: an unstable dimer?

scientific article published on 01 October 1989

Both pro-uPA and uPA: PAI-1 complex bind to the alpha 2-macroglobulin receptor/LDL receptor-related protein. Evidence for multiple independent contacts between the ligands and receptor

scientific article published on 01 September 1994

Brain-derived neurotrophic factor reduces amyloidogenic processing through control of SORLA gene expression.

scientific article published in December 2009

Cellular targets and receptors for interleukin-6. II. Characterization of IL-6 binding and receptors in peripheral blood cells and macrophages

scientific article published on 01 August 1990

Characterization of a saporin isoform with lower ribosome-inhibiting activity

scientific article published on March 1997

Complement activation caused by beta-amyloid in Alzheimer's dementia

scientific article published in September 1993

Cubilin and megalin co-localize in the neonatal inner ear.

scientific article published on 6 February 2009

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)

scientific article

Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head.

scientific article published on 16 April 2013

DiDBiT-TMT: A novel method to quantify changes in the proteomic landscape induced by neural plasticity

scientific article published on 12 March 2024

Different motifs regulate trafficking of SorCS1 isoforms

scientific article published on 27 February 2008

Dissecting the role of sortilin receptor signaling in neurodegeneration induced by NGF deprivation.

scientific article published on 11 January 2013

Efficient eukaryotic expression system for authentic human sex hormone-binding globulin ⬇️

scientific article published on December 15, 2001

Endocytosis of sex steroids: the hypothesis of free hormones revisited

scientific article published on 14 April 2008

Evidence for an essential role of megalin in transepithelial transport of retinol

scientific article (publication date: April 1999)

Expression of the 100-kDa neurotensin receptor sortilin during mouse embryonal development

scientific article published in March 1999

Expression profiling confirms the role of endocytic receptor megalin in renal vitamin D3 metabolism.

scientific article published in November 2002

From holoprosencephaly to osteopathology: role of multifunctional endocytic receptors in absorptive epithelia.

scientific article

Functional organization of the sortilin Vps10p domain

scientific article

Gentamicin Binds to the Megalin Receptor as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats: INSIGHT FROM THE NMR STRUCTURE OF THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE AND IN COMPLEX WITH GENTAMICIN

scientific article

Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin

scientific article published on 22 June 2010

Hypocalcemia and osteopathy in mice with kidney-specific megalin gene defect

scientific article published on 3 December 2002

Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin

scientific journal article

Identification and characterization of urokinase receptors in natural killer cells and T-cell-derived lymphokine activated killer cells

scientific article published in March 1992

Identification of a linear epitope in sortilin that partakes in pro-neurotrophin binding.

scientific article

Impaired aldosterone responsiveness in corticosteroid binding globulin deficient mice

scientific article published on 12 November 2010

Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP.

scientific article published on June 2007

Lipoprotein receptors: new roles for ancient proteins.

scientific article

Loss of BDNF or its receptors in three mouse models has unpredictable consequences for anxiety and fear acquisition

scientific article published on September 2013

Mannose 6-Phosphate/Insulin-like Growth Factor–II Receptor Targets the Urokinase Receptor to Lysosomes via a Novel Binding Interaction ⬇️

scientific article published on May 4, 1998

Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosis

scientific article

Mature BDNF, but not proBDNF, reduces excitability of fast-spiking interneurons in mouse dentate gyrus

scientific article published in October 2009

Megalin antagonizes activation of the parathyroid hormone receptor.

scientific article

Megalin knockout mice as an animal model of low molecular weight proteinuria.

scientific article published on October 1999

Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein

scientific article

Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography

scientific article

Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation.

scientific article published on 05 July 2011

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

scientific article

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study.

scientific article

Preservation of cortical sortilin protein levels in MCI and Alzheimer's disease.

scientific article

Prions amplify through degradation of the VPS10P sorting receptor sortilin

scientific article published on 30 June 2017

Pro-neurotrophins, sortilin, and nociception

scientific article published on February 2014

ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin.

scientific article published on June 2005

ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation ⬇️

scientific article published on October 22, 2012

Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons

scientific article published on 24 January 2011

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR).

scientific article published on 30 June 2011

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes

scientific article published on 01 July 1992

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

scientific article

Receptor-mediated endocytosis of plasminogen activators and activator/inhibitor complexes

scientific article published on February 1994

Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against

scientific article published on October 1994

Risk Locus Identification Ties Alcohol Withdrawal Symptoms to SORCS2

scientific article published on 25 October 2018

Role of endocytosis in cellular uptake of sex steroids.

scientific article

Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury

scientific article published on 14 October 2007

SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes

scientific article

SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.

scientific article

Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals

scientific article published on 6 September 2016

SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology

scientific article published on 01 March 2019

SorCS2 is required for BDNF-dependent plasticity in the hippocampus

scientific article published on 26 July 2016

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia

scientific journal article

SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET.

scientific article published on 17 January 2013

SorLA regulates the activity of lipoprotein lipase by intracellular trafficking

scientific article published on 8 March 2011

Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export

scientific article

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

scientific article

Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.

scientific article

Sortilin is essential for proNGF-induced neuronal cell death

scientific article

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles

scientific article

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

scientific article

Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction

scientific journal article

Sortilin: a receptor to regulate neuronal viability and function

scientific article

Sortilins in neurotrophic factor signaling

scientific article published on January 2014

Sortilins: new players in lipoprotein metabolism

scientific article published on April 2011

Sorting receptor sortilin-a culprit in cardiovascular and neurological diseases.

scientific article published on 18 May 2014

Structure of heparin fragments with high affinity for lipoprotein lipase and inhibition of lipoprotein lipase binding to alpha 2-macroglobulin-receptor/low-density-lipoprotein-receptor-related protein by heparin fragments

scientific article published on April 1995

Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis.

scientific article

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and beta-migrating very low density lipoprotein associated with the lipase

scientific article published on 01 July 1993

The hypercholesterolemia-risk gene SORT1 facilitates PCSK9 secretion

scientific article

The mosaic receptor sorLA/LR11 binds components of the plasminogen-activating system and platelet-derived growth factor-BB similarly to LRP1 (low-density lipoprotein receptor-related protein), but mediates slow internalization of bound ligand.

scientific article published on July 2004

The multiligand alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein (alpha 2MR/LRP). Binding and endocytosis of fluid phase and membrane-associated ligands

scientific article published in September 1994

The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain

scientific article

The proneurotrophin receptor sortilin is required for Mycobacterium tuberculosis control by macrophages.

scientific article

The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II.

scientific article

The role of SorLA in neurotrophic activity and complex behavior.

scientific article

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

scientific article

The sorting receptor SorCS3 is a stronger regulator of glutamate receptor functions compared to GABAergic mechanisms in the hippocampus.

scientific article published on 9 December 2016

The spared nerve injury (SNI) model of induced mechanical allodynia in mice

scientific article published on 18 August 2011

Transient denervation of viable myocardium after myocardial infarction does not alter arrhythmia susceptibility

scientific article

Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members

scientific article published on April 2006

Unique expression pattern of a novel mosaic receptor in the developing cerebral cortex

scientific article published in January 1998

Up-regulation of sortilin mediated by amyloid-β and p75(NTR): safety lies in the middle course

scientific article

Urokinase binds to a plasminogen activator inhibitor type-2-like molecule in placental microvillous membranes

scientific article published on 01 November 1989

Urokinase receptors in human monocytes

scientific article published on 01 May 1990

VPS10P-domain receptors - regulators of neuronal viability and function.

scientific article

[Transport receptors can signal, too]

scientific article published on 01 September 2000

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