List of works - Changfu Zhu

A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health

scientific article published on 18 April 2018

A golden era—pro-vitamin A enhancement in diverse crops

article

A novel carotenoid, 4-keto-α-carotene, as an unexpected by-product during genetic engineering of carotenogenesis in rice callus.

scientific article

A question of balance: achieving appropriate nutrient levels in biofortified staple crops.

scientific article published on 18 October 2013

An in vitro system for the rapid functional characterization of genes involved in carotenoid biosynthesis and accumulation

scientific article published on 8 January 2014

Applications of multiplex genome editing in higher plants

scientific article published on 10 April 2019

Ascorbic acid synthesis and metabolism in maize are subject to complex and genotype-dependent feedback regulation during endosperm development

scientific article published on 11 July 2013

Biofortification of crops with nutrients: factors affecting utilization and storage

scientific article published on 6 January 2017

Biofortification of plants with altered antioxidant content and composition: genetic engineering strategies

scientific article published on 13 September 2012

Bottlenecks in carotenoid biosynthesis and accumulation in rice endosperm are influenced by the precursor-product balance

scientific article published on 7 April 2015

CRISPR/Cas9-induced monoallelic mutations in the cytosolic AGPase large subunit gene APL2 induce the ectopic expression of APL2 and the corresponding small subunit gene APS2b in rice leaves

scientific article published on 11 August 2018

Can the world afford to ignore biotechnology solutions that address food insecurity?

scientific article

Carotenoid-enriched transgenic corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis

scientific article published on 2 April 2015

Characteristics of Genome Editing Mutations in Cereal Crops.

scientific article published on 16 September 2016

Cloning and Functional Characterization of the Maize (Zea mays L.) Carotenoid Epsilon Hydroxylase Gene

scientific article published on June 2015

Cloning and functional analysis of the promoters that upregulate carotenogenic gene expression during flower development in Gentiana lutea.

scientific article published on 27 December 2013

Cloning and functional characterization of the maize carotenoid isomerase and β-carotene hydroxylase genes and their regulation during endosperm maturation

scientific article

Cloning of two individual cDNAS encoding 9-cis-epoxycarotenoid dioxygenase from Gentiana lutea, their tissue-specific expression and physiological effect in transgenic tobacco

scientific article

Combinatorial genetic transformation generates a library of metabolic phenotypes for the carotenoid pathway in maize

scientific article

Combinatorial genetic transformation of cereals and the creation of metabolic libraries for the carotenoid pathway

scientific article

Combined transcript, proteome, and metabolite analysis of transgenic maize seeds engineered for enhanced carotenoid synthesis reveals pleotropic effects in core metabolism

scientific article published on 20 March 2015

Critical evaluation of strategies for mineral fortification of staple food crops

scientific article published on 15 August 2009

Differential accumulation of pelargonidin glycosides in petals at three different developmental stages of the orange-flowered gentian (Gentiana lutea L. var. aurantiaca) ⬇️

scientific article published on 11 February 2019

Engineered maize as a source of astaxanthin: processing and application as fish feed.

scientific article published on 12 August 2016

Engineering complex metabolic pathways in plants.

scientific article published on 26 February 2014

Engineering metabolic pathways in plants by multigene transformation.

scientific article published on January 2013

Fast quantitative method for the analysis of carotenoids in transgenic maize

scientific article published on 24 May 2013

Freedom-to-operate analysis of a transgenic multivitamin corn variety.

scientific article published on 15 October 2015

Functional Analysis of Genes GlaDFR1 and GlaDFR2 Encoding Dihydroflavonol 4-Reductase (DFR) in Gentiana lutea L. Var. Aurantiaca (M. Laínz) M. Laínz

scientific article published on 10 January 2022

Functional characterization of the Gentiana lutea zeaxanthin epoxidase (GlZEP) promoter in transgenic tomato plants

scientific article published in October 2012

High-value products from transgenic maize

Identification of line-specific strategies for improving carotenoid production in synthetic maize through data-driven mathematical modeling.

scientific article

Inactivation of rice starch branching enzyme IIb triggers broad and unexpected changes in metabolism by transcriptional reprogramming

scientific article published on 05 October 2020

Increasing the vitamin E content of food by in-plant production

article

Influence of Cooking Conditions on Carotenoid Content and Stability in Porridges Prepared from High-Carotenoid Maize

scientific article published on 29 March 2017

Knowledge-driven approaches for engineering complex metabolic pathways in plants

scientific article

Light-dark regulation of carotenoid biosynthesis in pepper (Capsicum annuum) leaves.

scientific article

Maize cDNAs expressed in endosperm encode functional farnesyl diphosphate synthase with geranylgeranyl diphosphate synthase activity.

scientific article published on 31 March 2006

Metabolic engineering of ketocarotenoid biosynthesis in higher plants

scientific article published on 29 October 2008

Metabolic engineering of ketocarotenoid biosynthesis in leaves and flowers of tobacco species.

scientific article published in October 2007

Mice fed on a diet enriched with genetically engineered multivitamin corn show no sub-acute toxic effects and no sub-chronic toxicity

scientific article published on 29 August 2012

Molecular characterization of the Arginine decarboxylase gene family in rice

scientific article published on 16 January 2010

Multigene engineering of starch biosynthesis in maize endosperm increases the total starch content and the proportion of amylose

scientific article published on 6 June 2013

Nicotiana glauca engineered for the production of ketocarotenoids in flowers and leaves by expressing the cyanobacterial crtO ketolase gene.

scientific article published on 17 October 2007

Nutritionally enhanced crops and food security: scientific achievements versus political expediency

scientific article

Nutritious crops producing multiple carotenoids--a metabolic balancing act.

scientific article published on 06 September 2011

Patterns of CRISPR/Cas9 activity in plants, animals and microbes

scientific article

Promoter diversity in multigene transformation

scientific article published on 31 March 2010

Protoplast culture and plant regeneration ofPinellia ternata

scientific article published on 01 November 1996

Provitamin A carotenoids from an engineered high-carotenoid maize are bioavailable and zeaxanthin does not compromise β-carotene absorption in poultry

scientific article published on 23 June 2017

Reconstruction of the astaxanthin biosynthesis pathway in rice endosperm reveals a metabolic bottleneck at the level of endogenous β-carotene hydroxylase activity

scientific article

Red Anthocyanins and Yellow Carotenoids Form the Color of Orange-Flower Gentian (Gentiana lutea L. var. aurantiaca)

scientific article

Simultaneous expression of Arabidopsis ρ-hydroxyphenylpyruvate dioxygenase and MPBQ methyltransferase in transgenic corn kernels triples the tocopherol content

Synergistic metabolism in hybrid corn indicates bottlenecks in the carotenoid pathway and leads to the accumulation of extraordinary levels of the nutritionally important carotenoid zeaxanthin.

scientific article

Targeted transcriptomic and metabolic profiling reveals temporal bottlenecks in the maize carotenoid pathway that may be addressed by multigene engineering

scientific article published on 30 May 2013

The Arabidopsis ORANGE (AtOR) gene promotes carotenoid accumulation in transgenic corn hybrids derived from parental lines with limited carotenoid pools.

scientific article published on 17 March 2017

The Silencing of Carotenoid β-Hydroxylases by RNA Interference in Different Maize Genetic Backgrounds Increases the β-Carotene Content of the Endosperm.

scientific article published on 24 November 2017

The biotechnological potential of the al-2 gene from Neurospora [correction of Neurospra] crassa for the production of monocyclic keto hydroxy carotenoids.

scientific article

The carotenoid cleavage dioxygenase CCD2 catalysing the synthesis of crocetin in spring crocuses and saffron is a plastidial enzyme.

scientific article published on 17 September 2015

The contribution of transgenic plants to better health through improved nutrition: opportunities and constraints

scientific article (publication date: 2013)

The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage

scientific article published on 14 October 2016

The potential impact of plant biotechnology on the Millennium Development Goals

scientific article published on 20 January 2011

The regulation of carotenoid pigmentation in flowers

scientific article published on 03 August 2010

Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways

scholarly article

Transgenic rice grains expressing a heterologous ρ-hydroxyphenylpyruvate dioxygenase shift tocopherol synthesis from the γ to the α isoform without increasing absolute tocopherol levels

scientific article published on 24 February 2012

Transgenic strategies for the nutritional enhancement of plants

scientific article

Transgenic wheat plants expressing an oat arginine decarboxylase cDNA exhibit increases in polyamine content in vegetative tissue and seeds

article

Travel advice on the road to carotenoids in plants

article

When more is better: multigene engineering in plants

scientific article published on 21 October 2009

ZmPBF and ZmGAMYB transcription factors independently transactivate the promoter of the maize (Zea mays) β-carotene hydroxylase 2 gene

scientific article published on 04 January 2019

cDNA cloning and expression of carotenogenic genes during flower development in Gentiana lutea

scientific article

cDNAs for the synthesis of cyclic carotenoids in petals of Gentiana lutea and their regulation during flower development.

scientific article

List of works by Changfu Zhu

A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health

A golden era—pro-vitamin A enhancement in diverse crops

A novel carotenoid, 4-keto-α-carotene, as an unexpected by-product during genetic engineering of carotenogenesis in rice callus.

A question of balance: achieving appropriate nutrient levels in biofortified staple crops.

An in vitro system for the rapid functional characterization of genes involved in carotenoid biosynthesis and accumulation

Applications of multiplex genome editing in higher plants

Ascorbic acid synthesis and metabolism in maize are subject to complex and genotype-dependent feedback regulation during endosperm development

Biofortification of crops with nutrients: factors affecting utilization and storage

Biofortification of plants with altered antioxidant content and composition: genetic engineering strategies

Bottlenecks in carotenoid biosynthesis and accumulation in rice endosperm are influenced by the precursor-product balance

CRISPR/Cas9-induced monoallelic mutations in the cytosolic AGPase large subunit gene APL2 induce the ectopic expression of APL2 and the corresponding small subunit gene APS2b in rice leaves

Can the world afford to ignore biotechnology solutions that address food insecurity?

Carotenoid-enriched transgenic corn delivers bioavailable carotenoids to poultry and protects them against coccidiosis

Characteristics of Genome Editing Mutations in Cereal Crops.

Cloning and Functional Characterization of the Maize (Zea mays L.) Carotenoid Epsilon Hydroxylase Gene

Cloning and functional analysis of the promoters that upregulate carotenogenic gene expression during flower development in Gentiana lutea.

Cloning and functional characterization of the maize carotenoid isomerase and β-carotene hydroxylase genes and their regulation during endosperm maturation

Cloning of two individual cDNAS encoding 9-cis-epoxycarotenoid dioxygenase from Gentiana lutea, their tissue-specific expression and physiological effect in transgenic tobacco

Combinatorial genetic transformation generates a library of metabolic phenotypes for the carotenoid pathway in maize

Combinatorial genetic transformation of cereals and the creation of metabolic libraries for the carotenoid pathway

Combined transcript, proteome, and metabolite analysis of transgenic maize seeds engineered for enhanced carotenoid synthesis reveals pleotropic effects in core metabolism

Critical evaluation of strategies for mineral fortification of staple food crops

Differential accumulation of pelargonidin glycosides in petals at three different developmental stages of the orange-flowered gentian (Gentiana lutea L. var. aurantiaca) ⬇️

Engineered maize as a source of astaxanthin: processing and application as fish feed.

Engineering complex metabolic pathways in plants.

Engineering metabolic pathways in plants by multigene transformation.

Fast quantitative method for the analysis of carotenoids in transgenic maize

Freedom-to-operate analysis of a transgenic multivitamin corn variety.

Functional Analysis of Genes <i>GlaDFR1</i> and <i>GlaDFR2</i> Encoding Dihydroflavonol 4-Reductase (DFR) in <i>Gentiana lutea</i> L. Var. <i>Aurantiaca</i> (M. Laínz) M. Laínz

Functional characterization of the Gentiana lutea zeaxanthin epoxidase (GlZEP) promoter in transgenic tomato plants

High-value products from transgenic maize

Identification of line-specific strategies for improving carotenoid production in synthetic maize through data-driven mathematical modeling.

Inactivation of rice starch branching enzyme IIb triggers broad and unexpected changes in metabolism by transcriptional reprogramming

Increasing the vitamin E content of food by in-plant production

Influence of Cooking Conditions on Carotenoid Content and Stability in Porridges Prepared from High-Carotenoid Maize

Knowledge-driven approaches for engineering complex metabolic pathways in plants

Light-dark regulation of carotenoid biosynthesis in pepper (Capsicum annuum) leaves.

Maize cDNAs expressed in endosperm encode functional farnesyl diphosphate synthase with geranylgeranyl diphosphate synthase activity.

Metabolic engineering of ketocarotenoid biosynthesis in higher plants

Metabolic engineering of ketocarotenoid biosynthesis in leaves and flowers of tobacco species.

Mice fed on a diet enriched with genetically engineered multivitamin corn show no sub-acute toxic effects and no sub-chronic toxicity

Molecular characterization of the Arginine decarboxylase gene family in rice

Multigene engineering of starch biosynthesis in maize endosperm increases the total starch content and the proportion of amylose

Nicotiana glauca engineered for the production of ketocarotenoids in flowers and leaves by expressing the cyanobacterial crtO ketolase gene.

Nutritionally enhanced crops and food security: scientific achievements versus political expediency

Nutritious crops producing multiple carotenoids--a metabolic balancing act.

Patterns of CRISPR/Cas9 activity in plants, animals and microbes

Promoter diversity in multigene transformation

Protoplast culture and plant regeneration ofPinellia ternata

Provitamin A carotenoids from an engineered high-carotenoid maize are bioavailable and zeaxanthin does not compromise β-carotene absorption in poultry

Reconstruction of the astaxanthin biosynthesis pathway in rice endosperm reveals a metabolic bottleneck at the level of endogenous β-carotene hydroxylase activity

Red Anthocyanins and Yellow Carotenoids Form the Color of Orange-Flower Gentian (Gentiana lutea L. var. aurantiaca)

Simultaneous expression of Arabidopsis ρ-hydroxyphenylpyruvate dioxygenase and MPBQ methyltransferase in transgenic corn kernels triples the tocopherol content

Synergistic metabolism in hybrid corn indicates bottlenecks in the carotenoid pathway and leads to the accumulation of extraordinary levels of the nutritionally important carotenoid zeaxanthin.

Targeted transcriptomic and metabolic profiling reveals temporal bottlenecks in the maize carotenoid pathway that may be addressed by multigene engineering

The Arabidopsis ORANGE (AtOR) gene promotes carotenoid accumulation in transgenic corn hybrids derived from parental lines with limited carotenoid pools.

The Silencing of Carotenoid β-Hydroxylases by RNA Interference in Different Maize Genetic Backgrounds Increases the β-Carotene Content of the Endosperm.

The biotechnological potential of the al-2 gene from Neurospora [correction of Neurospra] crassa for the production of monocyclic keto hydroxy carotenoids.

The carotenoid cleavage dioxygenase CCD2 catalysing the synthesis of crocetin in spring crocuses and saffron is a plastidial enzyme.

The contribution of transgenic plants to better health through improved nutrition: opportunities and constraints

The distribution of carotenoids in hens fed on biofortified maize is influenced by feed composition, absorption, resource allocation and storage

The potential impact of plant biotechnology on the Millennium Development Goals

The regulation of carotenoid pigmentation in flowers

Transgenic multivitamin corn through biofortification of endosperm with three vitamins representing three distinct metabolic pathways

Transgenic rice grains expressing a heterologous ρ-hydroxyphenylpyruvate dioxygenase shift tocopherol synthesis from the γ to the α isoform without increasing absolute tocopherol levels

Transgenic strategies for the nutritional enhancement of plants

Transgenic wheat plants expressing an oat arginine decarboxylase cDNA exhibit increases in polyamine content in vegetative tissue and seeds

Travel advice on the road to carotenoids in plants

When more is better: multigene engineering in plants

ZmPBF and ZmGAMYB transcription factors independently transactivate the promoter of the maize (Zea mays) β-carotene hydroxylase 2 gene

cDNA cloning and expression of carotenogenic genes during flower development in Gentiana lutea

cDNAs for the synthesis of cyclic carotenoids in petals of Gentiana lutea and their regulation during flower development.