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List of works by Gerhardt Attard

A first-in-man phase i and pharmacokinetic study on CHR-2797 (Tosedostat), an inhibitor of M1 aminopeptidases, in patients with advanced solid tumors

scientific article

A novel, spontaneously immortalized, human prostate cancer cell line, Bob, offers a unique model for pre-clinical prostate cancer studies

scientific article

A phase I study of intravenous TZT-1027 administered on day 1 and day 8 of a three-weekly cycle in combination with carboplatin given on day 1 alone in patients with advanced solid tumours

scientific article published on 25 May 2006

A step toward functionally characterized prostate cancer molecular subtypes ⬇️

scientific article published on August 1, 2013

Abiraterone acetate is well tolerated without concomitant use of corticosteroids

scientific article published on 30 August 2010

Abiraterone in "High-" and "Low-risk" Metastatic Hormone-sensitive Prostate Cancer

scientific article published on 23 August 2019

Activity of cabazitaxel in castration-resistant prostate cancer progressing after docetaxel and next-generation endocrine agents

scientific article published on 17 December 2013

Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol.

scientific article published on 26 February 2018

Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial

scientific article published on 01 December 2019

Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial

scientific article published on 21 December 2015

Advances in the management of high-risk localised and metastatic prostate cancer

scientific article published in March 2012

All circulating EpCAM+CK+CD45- objects predict overall survival in castration-resistant prostate cancer.

scientific article published on 10 February 2010

Androgen receptor expression in circulating tumour cells from castration-resistant prostate cancer patients treated with novel endocrine agents.

scientific article

Anti-androgen monotherapy for metastatic prostate cancer

scientific article published on 14 April 2014

Antitumor activity with CYP17 blockade indicates that castration-resistant prostate cancer frequently remains hormone driven.

scientific article

Antitumour activity of abiraterone acetate against metastatic castration-resistant prostate cancer progressing after docetaxel and enzalutamide (MDV3100).

scientific article published on 10 April 2013

Antitumour activity of abiraterone and diethylstilboestrol when administered sequentially to men with castration-resistant prostate cancer.

scientific article published on 8 August 2013

Antitumour activity of docetaxel following treatment with the CYP17A1 inhibitor abiraterone: clinical evidence for cross-resistance?

scientific article

Antitumour activity of enzalutamide (MDV3100) in patients with metastatic castration-resistant prostate cancer (CRPC) pre-treated with docetaxel and abiraterone

scientific article published on 25 September 2013

Baseline Circulating Tumor Cell Counts Significantly Enhance a Prognostic Score for Patients Participating in Phase I Oncology Trials

scientific article published on 29 April 2011

Beyond Hormone Therapy for Prostate Cancer with PARP inhibitors

scientific article published on 01 May 2011

CYP17 inhibition as a hormonal strategy for prostate cancer.

scientific article

Castration-Resistant Prostate Cancer Tissue Acquisition From Bone Metastases for Molecular Analyses

scientific article published on 05 May 2016

Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.

scientific article

Circulating Tumor Cells Count and Morphological Features in Breast, Colorectal and Prostate Cancer.

scientific article

Circulating cell-free AR and CYP17A1 copy number variations may associate with outcome of metastatic castration-resistant prostate cancer patients treated with abiraterone.

scientific article published on 21 April 2015

Circulating tumor cell biomarker panel as an individual-level surrogate for survival in metastatic castration-resistant prostate cancer

scientific article published on 23 March 2015

Clinical and Biochemical Consequences of CYP17A1 Inhibition with Abiraterone Given with and without Exogenous Glucocorticoids in Castrate Men with Advanced Prostate Cancer

scholarly article by Gerhardt Attard et al published February 2012 in The Journal of Clinical Endocrinology and Metabolism

Clinical variables associated with PSA response to abiraterone acetate in patients with metastatic castration-resistant prostate cancer.

scientific article published on 23 January 2014

Combining Enzalutamide with Abiraterone, Prednisone, and Androgen Deprivation Therapy in the STAMPEDE Trial

scientific article published on 27 June 2014

Complex patterns of ETS gene alteration arise during cancer development in the human prostate

scientific article published on 8 October 2007

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer ⬇️

scientific article

Diagnostic Gleason score and castration-resistant prostate cancer

scientific article

Evolution of androgen receptor targeted therapy for advanced prostate cancer

scientific article published on 20 May 2014

Expression profiling of CD133+ and CD133- epithelial cells from human prostate.

scientific article

External Validation of a Prognostic Model Predicting Overall Survival in Metastatic Castrate-resistant Prostate Cancer Patients Treated with Abiraterone

article

Failure-Free Survival and Radiotherapy in Patients With Newly Diagnosed Nonmetastatic Prostate Cancer: Data From Patients in the Control Arm of the STAMPEDE Trial

scientific article

Familial factors in diabetic nephropathy: an offspring study

scientific article published in March 2006

First-in-human Phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide to exon 4 of the androgen receptor mRNA in patients with castration-resistant prostate cancer.

scientific article published on 29 October 2013

Hormone-sensitive prostate cancer: a case of ETS gene fusion heterogeneity

article

Hsp-27 expression at diagnosis predicts poor clinical outcome in prostate cancer independent of ETS-gene rearrangement

scientific article published on 25 August 2009

Identifying prognostic signatures in the blood of ovarian cancer patients

scientific article published on 01 January 2013

Improved survival in a cohort of trial participants with metastatic castration-resistant prostate cancer demonstrates the need for updated prognostic nomograms

scientific article

Improved therapeutic targeting of the androgen receptor: rational drug design improves survival in castration-resistant prostate cancer.

scientific article

Improvements in Radiographic Progression-Free Survival Stratified by ERG Gene Status in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Abiraterone Acetate

scientific article published on 15 January 2015

Improving the outcome of patients with castration-resistant prostate cancer through rational drug development.

scientific article published on 19 September 2006

Integration of ERG gene mapping and gene-expression profiling identifies distinct categories of human prostate cancer

scientific article published on 25 November 2008

Integrative clinical genomics of advanced prostate cancer

scientific article

Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100.

scientific article

Making sense of antisense

scientific article published on 09 November 2005

Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019

scientific article published on 27 January 2020

Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017.

scientific article

Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015

scientific article published on 02 May 2016

Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015.

scientific article published on 3 June 2015

Molecular Pathways: Inhibiting Steroid Biosynthesis in Prostate Cancer ⬇️

scientific article published on 07 March 2013

Multi-purpose utility of circulating plasma DNA testing in patients with advanced cancers

scientific article

New prostate cancer drug: Prostate cancer's day in the sun.

scientific article published on 11 August 2008

New strategies in metastatic prostate cancer: targeting the androgen receptor signaling pathway

scientific article

Novel strategies to test biological hypotheses in early drug development for advanced prostate cancer

scientific article

Novel, gross chromosomal alterations involving PTEN cooperate with allelic loss in prostate cancer

scientific article published on 30 March 2012

Open-label phase II study evaluating the efficacy and safety of two doses of pertuzumab in castrate chemotherapy-naive patients with hormone-refractory prostate cancer.

scientific article

PSA as an intermediate end point in clinical trials

scientific article published on 01 September 2009

PTEN loss in circulating tumour cells correlates with PTEN loss in fresh tumour tissue from castration-resistant prostate cancer patients

scientific article

PTEN protein loss and clinical outcome from castration-resistant prostate cancer treated with abiraterone acetate.

scientific article published on 4 November 2014

Pharmacokinetics, Safety, and Antitumor Effect of Apalutamide with Abiraterone Acetate plus Prednisone in Metastatic Castration-Resistant Prostate Cancer: Phase 1b Study

scientific article published on 04 May 2020

Phase 1 and Pharmacokinetic Study of Lexatumumab in Patients with Advanced Cancers

scientific article published on 01 October 2007

Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven.

scientific article

Phase I study of nintedanib incorporating dynamic contrast-enhanced magnetic resonance imaging in patients with advanced solid tumors.

scientific article published on 20 March 2015

Phase II, two-stage, single-arm trial of the histone deacetylase inhibitor (HDACi) romidepsin in metastatic castration-resistant prostate cancer (CRPC).

scientific article published on 16 July 2009

Plasma AR and abiraterone-resistant prostate cancer.

scientific article

Plasma AR status and cabazitaxel in heavily treated metastatic castration-resistant prostate cancer

scientific article published on 11 June 2019

Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer

scientific article published on 26 October 2018

Poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of advanced germline BRCA2 mutant prostate cancer

scientific article published on 22 March 2013

Potential Applications for Circulating Tumor Cells Expressing the Insulin-Like Growth Factor-I Receptor

article

Preclinical evaluation of imaging biomarkers for prostate cancer bone metastasis and response to cabozantinib.

scientific article published on 14 March 2014

Prioritizing precision medicine for prostate cancer

scientific article published on 10 April 2015

Prognostic value of blood mRNA expression signatures in castration-resistant prostate cancer: a prospective, two-stage study

scientific article published on 09 October 2012

Progressive computed tomography (CT) appearances preceding malignant spinal cord compression (MSCC) in men with castration-resistant prostate cancer

scholarly article by C Pezaro et al published April 2015 in Clinical Radiology

Prostate cancer

scientific article published in The Lancet

Prostate cancer in 2011: redefining the therapeutic landscape for CRPC.

scientific article published on 17 January 2012

Prostate cancer: Cabazitaxel-a key therapeutic option in prostate cancer

scientific article published on 26 May 2015

Prostate cancers that ‘Wnt’ respond to abiraterone

Prostate epithelial stem cells.

scientific article

Prostate-specific Antigen Decline After 4 Weeks of Treatment with Abiraterone Acetate and Overall Survival in Patients with Metastatic Castration-resistant Prostate Cancer.

scientific article published on 7 March 2016

Putting the brakes on continued androgen receptor signaling in castration-resistant prostate cancer

scientific article published on October 2011

Reply to: Enzalutamide after failure of docetaxel and abiraterone in metastatic castrate resistant prostate cancer

scientific article published on 13 January 2014

Reply: 'Comment on Anti-tumour activity of abiraterone and diethylstilboestrol when administered sequentially to men with castration-resistant prostate cancer'.

scientific article published on 3 December 2013

Reporting the Capture Efficiency of a Filter-Based Microdevice: A CTC Is Not a CTC Unless It Is CD45 Negative--Letter

scientific article published on 01 May 2011

Sarcomatoid carcinoma of the prostate: ERG fluorescence in-situ hybridization confirms epithelial origin

scientific article published on 10 November 2014

Sarcopenia and change in body composition following maximal androgen suppression with abiraterone in men with castration-resistant prostate cancer

scientific article

Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells.

scientific article published on May 2016

Sequencing of agents in castration-resistant prostate cancer

scientific article published on 27 May 2015

Serial Next-Generation Sequencing of Circulating Cell-Free DNA Evaluating Tumor Clone Response To Molecularly Targeted Drug Administration

scientific article

Simple prognostic score for metastatic castration-resistant prostate cancer with incorporation of neutrophil-to-lymphocyte ratio.

scientific article published on 3 July 2014

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse

scientific article published on 06 September 2021

Steroid hormone receptors in prostate cancer: a hard habit to break?

scientific article

Strategies for managing ACTH dependent mineralocorticoid excess induced by abiraterone

scientific article published on 10 April 2013

Studies of TMPRSS2-ERG gene fusions in diagnostic trans-rectal prostate biopsies

scientific article published on 9 February 2010

Targeting extra-gonadal androgens in castration-resistant prostate cancer

scientific article published on 22 September 2014

Targeting the androgen receptor pathway in castration-resistant prostate cancer: progresses and prospects

scientific article published on 19 May 2014

The CT flare response of metastatic bone disease in prostate cancer

article

The association of PI3 kinase signaling and chemoresistance in advanced ovarian cancer.

scientific article

The development of abiraterone acetate for castration-resistant prostate cancer

scientific article published on June 2015

The role of abiraterone acetate in the management of prostate cancer: a critical analysis of the literature.

scientific article

Translating scientific advancement into clinical benefit for castration-resistant prostate cancer patients

scientific article published on June 2011

Tumor clone dynamics in lethal prostate cancer

scientific article published on September 2014

Tumour responses following a steroid switch from prednisone to dexamethasone in castration-resistant prostate cancer patients progressing on abiraterone

scientific article published on 14 October 2014

Unbiased and automated identification of a circulating tumour cell definition that associates with overall survival

scientific article (publication date: 2011)

Update on tubulin-binding agents.

scientific article

Utilizing circulating tumor cells: challenges and pitfalls

scientific article

Validation and utilisation of high-coverage next-generation sequencing to deliver the pharmacological audit trail

scientific article

Visceral disease in castration-resistant prostate cancer.

scientific article published on 22 November 2013

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