Search filters

List of works by Menno C van Zelm

A mutation in the human tetraspanin CD81 gene is expressed as a truncated protein but does not enable CD19 maturation and cell surface expression.

scientific article

Abnormalities in CD57+ cytotoxic T cells and Vδ1+ γδT cells in subclinical celiac disease in childhood are affected by cytomegalovirus. The Generation R Study

scientific article published on 26 April 2017

Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans

scientific article published on 24 August 2018

Absence of surface IgD does not impair naive B cell homeostasis and memory B cell formation in humans

Age-Dependent Pre-Vaccination Immunity Affects the Immunogenicity of Varicella Zoster Vaccination in Middle-aged Adults

scientific article published on 23 January 2018

Age-associated distribution of normal B-cell and plasma cell subsets in peripheral blood.

scientific article published on 2 March 2018

Alterations in peripheral blood B cell subsets and dynamics of B cell responses during human schistosomiasis

scientific article

An Explorative Biomarker Study for Vaccine Responsiveness after a Primary Meningococcal Vaccination in Middle-Aged Adults

scientific article published in January 2017

An antibody-deficiency syndrome due to mutations in the CD19 gene

scientific article (publication date: 4 May 2006)

Antibody deficiency due to a missense mutation in CD19 demonstrates the importance of the conserved tryptophan 41 in immunoglobulin superfamily domain formation

scientific article published on 17 February 2011

Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity.

scientific article published on 6 April 2013

Artemis splice defects cause atypical SCID and can be restored in vitro by an antisense oligonucleotide.

scientific article published on 10 March 2011

Associations of Th2, Th17, Treg cells, and IgA+ memory B cells with atopic disease in children: The Generation R Study

scientific article published on 23 August 2019

B cells take their time: sequential IgG class switching over the course of an immune response?

scientific article published on 17 June 2014

B-Cell Dysregulation in Crohn's Disease Is Partially Restored with Infliximab Therapy

scientific article

B-cell maturation and antibody responses in individuals carrying a mutated CD19 allele.

scientific article published on 6 May 2010

B-cell prolymphocytic leukemia: a specific subgroup of mantle cell lymphoma

scientific article

B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency

scientific article published on 31 October 2011

Basal Ca(2+) signaling is particularly increased in mutated chronic lymphocytic leukemia.

scientific article published on 11 June 2014

Beyond monogenetic rare variants: tackling the low rate of genetic diagnoses in predominantly antibody deficiency

scientific article published on 17 August 2020

Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.

scientific article

CD Maps-Dynamic Profiling of CD1-CD100 Surface Expression on Human Leukocyte and Lymphocyte Subsets

scientific article published on 23 October 2019

CD Nomenclature 2015: Human Leukocyte Differentiation Antigen Workshops as a Driving Force in Immunology

scientific article published on November 2015

CD21 and CD19 deficiency: Two defects in the same complex leading to different disease modalities

scientific article published on 29 August 2015

CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency

scientific article

Cell type specific DNA methylation in cord blood: A 450K-reference data set and cell count-based validation of estimated cell type composition

scientific article

Checkpoints of B cell differentiation: visualizing Ig-centric processes.

scientific article published in December 2011

Chromatin architecture and the generation of antigen receptor diversity

scientific article published on August 2009

Chronic signs of memory B cell activation in patients with Behçet's disease are partially restored by anti-tumour necrosis factor treatment

scientific article published on 15 October 2016

Circulating Human CD27-IgA+ Memory B Cells Recognize Bacteria with Polyreactive Igs

scientific article

Clinical Spectrum of SCID: The Key is in the Thymus?

scientific article published on 19 March 2014

Clinical and genetic characteristics of XIAP deficiency in Japan

scientific article published on 8 January 2012

Comel-Netherton syndrome: A local skin barrier defect in the absence of an underlying systemic immunodeficiency

scientific article published on 24 January 2020

Common variable immunodeficiency and idiopathic primary hypogammaglobulinemia: two different conditions within the same disease spectrum

scientific article published on 10 June 2013

Common variable immunodeficiency classification by quantifying T-cell receptor and immunoglobulin κ-deleting recombination excision circles

scientific article published on 28 December 2012

Cytomegalovirus- and Epstein-Barr Virus-Induced T-Cell Expansions in Young Children Do Not Impair Naive T-cell Populations or Vaccination Responses: The Generation R Study.

scientific article published on 3 July 2015

Decreased IL7Rα and TdT expression underlie the skewed immunoglobulin repertoire of human B-cell precursors from fetal origin

scientific article published on 23 September 2016

Decreased memory B cells and increased CD8 memory T cells in blood of breastfed children: the generation R study

scientific article published on 18 May 2015

Defective B-cell memory in patients with Down syndrome

scientific article published on 23 August 2014

Defective formation of IgA memory B cells, Th1 and Th17 cells in symptomatic patients with selective IgA deficiency

scientific article published on 29 April 2020

Deficiencies in the CD19 complex

scientific article published on 31 July 2018

Delayed Diagnosis and Complications of Predominantly Antibody Deficiencies in a Cohort of Australian Adults.

scientific article published on 14 May 2018

Determinants of Ethnic Differences in Cytomegalovirus, Epstein-Barr Virus, and Herpes Simplex Virus Type 1 Seroprevalence in Childhood.

scientific article published on 17 December 2015

Dietary Patterns After the Weaning and Lactation Period Are Associated With Celiac Disease Autoimmunity in Children

scientific article published on 02 March 2018

Differences in Systemic IgA Reactivity and Circulating Th Subsets in Healthy Volunteers With Specific Microbiota Enterotypes

scientific article published on 07 March 2019

Differential effects of Cytomegalovirus carriage on the immune phenotype of middle-aged males and females

scientific article published on 31 May 2016

Differentiation stage of myeloma plasma cells: biological and clinical significance.

scientific article

Dissection of B-cell development to unravel defects in patients with a primary antibody deficiency

scientific article published on January 2011

Early increase in serum specific IgG2 upon allergen immunotherapy with a 300 IR sublingual house dust mite tablet

scientific article published in 2023

Effects of nongenetic factors on immune cell dynamics in early childhood: The Generation R Study

scientific article

Epidemic Thunderstorm Asthma Protection with Five-Grass Pollen Tablet Sublingual Immunotherapy: A Clinical Trial

scientific article published on 01 July 2018

Estimating human age from T-cell DNA rearrangements

article

Ethnic differences in coeliac disease autoimmunity in childhood: the Generation R Study

scientific article published on 4 January 2017

EuroFlow-Based Flowcytometric Diagnostic Screening and Classification of Primary Immunodeficiencies of the Lymphoid System

scientific article published on 13 June 2019

Expansion of blood IgG4+ B, TH2, and regulatory T cells in patients with IgG4-related disease

scientific article published on 19 August 2017

Functional Antibody Responses Following Allogeneic Stem Cell Transplantation for Mutant pre-B-ALL in a Patient With X-Linked Agammaglobulinemia

article

Generation R birth cohort study shows that specific enamel defects were not associated with elevated serum transglutaminase type 2 antibodies

scientific article published on 21 July 2016

Genetic analysis of contiguous X-chromosome deletion syndrome encompassing the BTK and TIMM8A genes.

scientific article

Gross deletions involving IGHM, BTK, or Artemis: a model for genomic lesions mediated by transposable elements.

scientific article published on February 2008

Herpesvirus Infections and Transglutaminase Type 2 Antibody Positivity in Childhood: The Generation R Study

scientific article

Human CD19 and CD40L deficiencies impair antibody selection and differentially affect somatic hypermutation.

scientific article published on 11 January 2014

Human CD27+IgM+IgD+ B cells: T-cell or TLR-dependent?

scientific article

Human IgE(+) B cells are derived from T cell-dependent and T cell-independent pathways.

scientific article published on 13 May 2014

Human IgG2- and IgG4-expressing memory B cells display enhanced molecular and phenotypic signs of maturity and accumulate with age.

scientific article published on 26 May 2017

Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals.

scientific article

Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways

scientific article published on 20 June 2011

Human peripheral blood B-cell compartments: a crossroad in B-cell traffic.

scientific article published on January 2010

IL-7R expression and IL-7 signaling confer a distinct phenotype on developing human B-lineage cells.

scientific article

IgE-expressing memory B cells and plasmablasts are increased in blood of children with asthma, food allergy and atopic dermatitis.

scientific article published on 30 January 2018

Immune system development varies according to age, location, and anemia in African children

scientific article published on 01 February 2020

Impaired STAT3-Dependent Upregulation of IL2Rα in B Cells of a Patient With a STAT1 Gain-of-Function Mutation

scientific article published on 24 April 2019

Impaired memory B-cell development and antibody maturation with a skewing toward IgE in patients with STAT3 hyper-IgE syndrome

scientific article published on 16 August 2019

In Vitro Measles Virus Infection of Human Lymphocyte Subsets Demonstrates High Susceptibility and Permissiveness of both Naive and Memory B Cells

scientific article published on 7 February 2018

Increased ID2 levels in adult precursor B cells as compared with children is associated with impaired Ig locus contraction and decreased bone marrow output

scientific article

Induction of IgG2 and IgG4 B-cell memory following sublingual immunotherapy for ryegrass pollen allergy

scientific article published on 06 October 2019

Inferred Allelic Variants of Immunoglobulin Receptor Genes: A System for Their Evaluation, Documentation, and Naming

article

Influenza-specific IgG1+ memory B-cell numbers increase upon booster vaccination in healthy adults but not in patients with predominantly antibody deficiency

scientific article published on 16 October 2020

Is there a pathogenic role for IgE in psoriasis?

scientific article published in July 2016

Mutations in Bruton's tyrosine kinase impair IgA responses

scientific article published on 15 January 2015

New frontiers of primary antibody deficiencies.

scientific article

New insights into human immune memory from SARS‐CoV‐2 infection and vaccination

scientific article published in 2022

No Interactive Effects of Sex and Persistent Cytomegalovirus on Immune Phenotypes in Young Children: The Generation R Study

scientific article published on March 2017

Nomenclature of CD molecules from the Tenth Human Leucocyte Differentiation Antigen Workshop.

scientific article published on 22 January 2016

Novel mutations in TNFRSF7/CD27: Clinical, immunologic, and genetic characterization of human CD27 deficiency

scientific article published on 02 April 2015

Novel mutations in a Japanese patient with CD19 deficiency

article

Nuclear positioning rather than contraction controls ordered rearrangements of immunoglobulin loci.

scientific article published on 17 September 2015

PID comes full circle: applications of V(D)J recombination excision circles in research, diagnostics and newborn screening of primary immunodeficiency disorders.

scientific article published on 4 May 2011

Perigranuloma localization and abnormal maturation of B cells: emerging key players in sarcoidosis?

scientific article

Persistent polyclonal B-cell lymphocytosis: extensively proliferated CD27+IgM+IgD+ memory B cells with a distinctive immunophenotype.

scientific article

Persistent subclinical immune defects in HIV-1-infected children treated with antiretroviral therapy

scientific article published on September 2015

Pre-B cell receptor signaling induces immunoglobulin κ locus accessibility by functional redistribution of enhancer-mediated chromatin interactions

scientific article

Quantification of T-Cell and B-Cell Replication History in Aging, Immunodeficiency, and Newborn Screening

scientific article published on 29 August 2019

Real-time quantitative (RQ-)PCR approach to quantify the contribution of proliferation to B lymphocyte homeostasis.

scientific article published in January 2013

Recent developments and highlights in immune monitoring of allergen immunotherapy

scientific article published on 08 November 2019

Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion

scientific article

Reply

scientific article published on 10 January 2018

Review article: short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders

scientific article published on 03 May 2018

Rôle de la molécule CD81 dans le fonctionnement des lymphocytes B chez l’homme

scientific article published on 01 January 2011

Studies into the mechanism of measles-associated immune suppression during a measles outbreak in the Netherlands

scientific article published in Nature Communications

Studying the Replication History of Human B Lymphocytes by Real-Time Quantitative (RQ-)PCR

scientific article published on 01 January 2019

Studying the replication history of human B lymphocytes by real-time quantitative (RQ)-PCR.

scientific article

Successful elevation of circulating acetate and propionate by dietary modulation does not alter T-regulatory cell or cytokine profiles in healthy humans: a pilot study

scientific article published on 24 October 2019

Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data

scientific article published on 27 August 2019

Systemic B-cell abnormalities in patients with atopic dermatitis?

scientific article published on 08 April 2016

T and B Cell Markers in Dried Blood Spots of Neonates with Congenital Cytomegalovirus Infection: B Cell Numbers at Birth Are Associated with Long-Term Outcomes.

scientific article published on 30 November 2016

The 3D structure of the immunoglobulin heavy-chain locus: implications for long-range genomic interactions.

scientific article published on April 2008

The EuroFlow PID Orientation Tube for Flow Cytometric Diagnostic Screening of Primary Immunodeficiencies of the Lymphoid System

scientific article published on 04 March 2019

The Human Thymus Is Enriched for Autoreactive B Cells.

scientific article published on 3 June 2016

The activation of the adaptive immune system: cross-talk between antigen-presenting cells, T cells and B cells

scientific article published on 16 October 2014

The forkhead transcription factor FOXP1 represses human plasma cell differentiation

scientific article published on 19 August 2015

The identification of celiac disease in asymptomatic children: the Generation R Study

scientific article published on 6 June 2017

The influence of Epstein-Barr virus and cytomegalovirus on childhood respiratory health: A population-based prospective cohort study

scientific article published on 27 February 2020

The nature of circulating CD27+CD43+ B cells.

scientific article published in December 2011

The role of vitamin D on circulating memory T cells in children: The Generation R study

scientific article published on 7 July 2017

Transient reduction in IgA+ and IgG+ memory B cell numbers in young EBV-seropositive children: the Generation R Study.

scientific article published on 7 November 2016

Treatment for moderate to severe atopic dermatitis at alpine and moderate maritime climates differentially affect helper T cells and memory B cells in children.

scientific article published on 25 March 2018

Vaccines and allergic reactions: The past, the current COVID‐19 pandemic, and future perspectives

scientific article published in 2021

Wiskott-Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans

scientific article

Paulina is supported by:

About Paulina

Help