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List of works by Felix Beuschlein

A common hormonal imbalance with a wide clinical spectrum. When must hyperthyroidism be treated?

scientific article

A critical reappraisal of bilateral adrenalectomy for ACTH-dependent Cushing's syndrome

scientific article published on 20 May 2015

A microsphere-based duplex competitive immunoassay for the simultaneous measurements of aldosterone and testosterone in small sample volumes: validation in human and mouse plasma

scientific article published on 21 July 2010

ACTH 1-24 inhibits proliferation of adrenocortical tumors in vivo

scientific article published on September 2005

ACTH-Dependent Regulation of MicroRNA As Endogenous Modulators of Glucocorticoid Receptor Expression in the Adrenal Gland

AKT Is Highly Phosphorylated in Pheochromocytomas But Not in Benign Adrenocortical Tumors

ARMC5 Mutations in a Large Cohort of Primary Macronodular Adrenal Hyperplasia: Clinical and Functional Consequences

scientific article

Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice

scientific article

Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone

scientific article

Adrenal cortical insufficiency--a life threatening illness with multiple etiologies

scientific article published on December 2013

Adrenal function after adrenalectomy for subclinical hypercortisolism and Cushing's syndrome: a systematic review of the literature

scientific article published on 30 May 2014

Adrenal incidentalomas: presentation and clinical work-up

scientific article published on 10 December 2007

Adrenal vein sampling using rapid cortisol assays in primary aldosteronism is useful in centers with low success rates

scientific article published on 20 May 2011

Adrenal venous sampling: evaluation of the German Conn's registry

scientific article published on 7 March 2011

Adrenocortical carcinoma - towards genomics guided clinical care

scientific article published on 01 September 2019

Adrenocortical tumorigenesis

scientific article published on November 2006

Adrenomedullary function, obesity and permissive influences of catecholamines on body mass in patients with chromaffin cell tumours.

scientific article published on 3 March 2018

Age below 40 or a recently proposed clinical prediction score cannot bypass adrenal venous sampling in primary aldosteronism

scientific article published on 6 March 2014

Aged PROP1 deficient dwarf mice maintain ACTH production

scientific article

Aldosterone excess impairs first phase insulin secretion in primary aldosteronism

scientific article published on 28 March 2013

Analysis of plasma 3-methoxytyramine, normetanephrine and metanephrine by ultraperformance liquid chromatography-tandem mass spectrometry: utility for diagnosis of dopamine-producing metastatic phaeochromocytoma

scientific article published in March 2013

Animal models of adrenocortical tumorigenesis

scientific article published on 11 November 2011

Anti insulin-like growth factor I receptor immunoliposomes: a single formulation combining two anticancer treatments with enhanced therapeutic efficiency.

scientific article

Assessment of VAV2 Expression Refines Prognostic Prediction in Adrenocortical Carcinoma.

scientific article

Association of plasma aldosterone with the metabolic syndrome in two German populations

scientific article published on 28 February 2011

Automated Chemiluminescence-Immunoassay for Aldosterone during Dynamic Testing: Comparison to Radioimmunoassays with and without Extraction Steps

scientific article published on 20 July 2006

Biochemical Diagnosis of Chromaffin Cell Tumors in Patients at High and Low Risk of Disease: Plasma versus Urinary Free or Deconjugated O-Methylated Catecholamine Metabolites

scientific article published on 10 August 2018

Biochemical diagnosis of phaeochromocytoma using plasma-free normetanephrine, metanephrine and methoxytyramine: importance of supine sampling under fasting conditions

scientific article

Bone morphogenetic proteins 2 and 5 are down-regulated in adrenocortical carcinoma and modulate adrenal cell proliferation and steroidogenesis

scientific article

CBP/p300-interacting transactivator, with Glu/Asp-rich C-terminal domain, 2, and pre-B-cell leukemia transcription factor 1 in human adrenal development and disease

scientific article

CT characteristics of pheochromocytoma - Relevance for the evaluation of adrenal incidentaloma

scientific article published on 01 February 2019

Changes in Body Mass Index in Pheochromocytoma Patients Following Adrenalectomy

scientific article published on 21 February 2017

Characterization of an adrenocorticotropin (ACTH) receptor promoter polymorphism leading to decreased adrenal responsiveness to ACTH.

scientific article published on July 2004

Clinical Spectrum of Primary Adrenal Lymphoma: Results of a Multicenter Cohort Study

scientific article published on 01 June 2020

Clinical and molecular evidence for DAX-1 inhibition of steroidogenic factor-1-dependent ACTH receptor gene expression

scientific article published in May 2005

Clinical review: Outcome of bilateral adrenalectomy in Cushing's syndrome: a systematic review

scientific article published on 16 August 2013

Coexisting Prolactinoma and Primary Aldosteronism: Is There a Pathophysiological Link?

scientific article published on 15 July 2015

Combination chemotherapy in advanced adrenocortical carcinoma

scientific article published on 2 May 2012

Commentary on the Endocrine Society Practice Guidelines: Consequences of adjustment of antihypertensive medication in screening of primary aldosteronism

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

article

Comprehensive Characterization of Cancer Driver Genes and Mutations

article

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

scientific article

Comprehensive Pan-Genomic Characterization of Adrenocortical Carcinoma

article

Confirmatory testing in normokalaemic primary aldosteronism: the value of the saline infusion test and urinary aldosterone metabolites

scholarly article by Caroline Schirpenbach et al published June 2006 in European Journal of Endocrinology

Constitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome

scientific article published on 26 February 2014

Contemporary microsurgical concept for the treatment of Cushing’s disease: endocrine outcome in 83 consecutive patients

Cortisol Excess in Patients With Primary Aldosteronism Impacts Left Ventricular Hypertrophy

scientific article published on 01 December 2018

Cortisol-related metabolic alterations assessed by mass spectrometry assay in patients with Cushing's syndrome

scientific article published on 31 May 2017

Cushing's syndrome: a model for sarcopenic obesity

scientific article published on 12 July 2017

DNA Methylation Is an Independent Prognostic Marker of Survival in Adrenocortical Cancer.

scientific article

Decreased p44/42 mitogen-activated protein kinase phosphorylation in gender- or hormone-related but not during age-related adrenal gland growth in mice

scientific article published on 23 October 2008

Deficits in the management of patients with adrenocortical carcinoma in Germany

scientific article

Diagnosis of primary aldosteronism: value of different screening parameters and influence of antihypertensive medication

scientific article published in March 2004

Diagnosis: Novel molecular signatures for adrenocortical carcinoma

scientific article published in June 2009

Diastrophic dysplasia sulfate transporter (SLC26A2) is expressed in the adrenal cortex and regulates aldosterone secretion

scientific article published on 3 March 2014

Differential expression of the protein kinase A subunits in normal adrenal glands and adrenocortical adenomas.

scientific article published on 8 March 2017

EJE Prize 2013: Regulation of aldosterone secretion: from physiology to disease ⬇️

scientific article published on April 24, 2013

ERCC1 as predictive biomarker to platinum-based chemotherapy in adrenocortical carcinomas

scientific article published on 29 November 2017

Ectopic pro-opiomelanocortin syndrome

scientific article

Effectiveness of eplerenone or spironolactone treatment in preserving renal function in primary aldosteronism

scientific article

Evidence for two types of brown adipose tissue in humans.

scientific article published on 21 April 2013

Expression and spatio-temporal distribution of differentiation and proliferation markers during mouse adrenal development

scientific article published on 3 June 2006

Fabry disease genotype, phenotype, and migalastat amenability: Insights from a national cohort

scientific article published on 30 September 2019

Frequency and causes of adrenal crises over lifetime in patients with 21-hydroxylase deficiency

scientific article

Frequent incidental discovery of phaeochromocytoma: data from a German cohort of 201 phaeochromocytoma

scientific article

Gender differences in anxiety and depressive symptoms in patients with primary hyperaldosteronism: a cross-sectional study

scientific article published on 8 May 2012

Gender-, strain-, and inheritance-dependent variation in aldosterone secretion in mice

scientific article published on 26 September 2012

Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.

scientific article published on 7 July 2016

Genetic and potential autoimmune triggers of primary aldosteronism

scientific article published on 08 June 2015

Genetic influence of an ACTH receptor promoter polymorphism on adrenal androgen secretion

scientific article published in November 2005

Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma

scientific article published on 27 May 2014

Glucocorticoid excess in patients with pheochromocytoma compared to paraganglioma and other forms of hypertension

scientific article published on 01 July 2020

Gonadectomy in mice of the inbred strain CE/J induces proliferation of sub-capsular adrenal cells expressing gonadal marker genes.

scientific article

Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment

scientific article

High Diagnostic and Prognostic Value of Steroidogenic Factor-1 Expression in Adrenal Tumors

scientific article published on 21 July 2010

High incidence of adrenal crisis in educated patients with chronic adrenal insufficiency: a prospective study

scientific article published on 24 November 2014

High prevalence of reduced fecundity in men with congenital adrenal hyperplasia

scientific article published on 3 March 2009

Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series

scientific article

IGF1-R inhibition and liposomal doxorubicin: Progress in preclinical evaluation for the treatment of adrenocortical carcinoma

scientific article

Identification of adrenal genes regulated in a potassium-dependent manner

scientific article published on 20 July 2010

Identification of glucocorticoid-related molecular signature by whole blood methylome analysis

scientific article published on 13 January 2022

Improved survival in patients with stage II adrenocortical carcinoma followed up prospectively by specialized centers

scientific article published on 28 July 2010

Increased prevalence of diabetes mellitus and the metabolic syndrome in patients with primary aldosteronism of the German Conn's Registry

scientific article published on 26 August 2015

Integrated genomic characterization of adrenocortical carcinoma

scientific article published on 20 April 2014

Interaction between Dax-1 and steroidogenic factor-1 in vivo: increased adrenal responsiveness to ACTH in the absence of Dax-1

scientific journal article

Intraoperative haemodynamic stability in patients with phaeochromocytoma ? minimally invasive vs conventional open surgery

Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats

scientific article

KCNJ5 Mutations in European Families With Nonglucocorticoid Remediable Familial Hyperaldosteronism

scientific article published on 27 December 2011

Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency

scientific article

Lack of influence of somatic mutations on steroid gradients during adrenal vein sampling in aldosterone-producing adenoma patients

scientific article published in October 2013

Lack of utility of SDHB mutation testing in adrenergic metastatic phaeochromocytoma

scientific article published on 01 February 2015

Levodopa therapy in Parkinson's disease: influence on liquid chromatographic tandem mass spectrometric-based measurements of plasma and urinary normetanephrine, metanephrine and methoxytyramine

scientific article published on 19 July 2013

Limited prognostic value of the 2004 International Union Against Cancer staging classification for adrenocortical carcinoma

Linear and volumetric evaluation of the adrenal gland--MDCT-based measurements of the adrenals

scientific article published in November 2014

Liposomal doxorubicin for active targeting: surface modification of the nanocarrier evaluated in vitro and in vivo: challenges and prospects

scientific article published on 20 October 2015

Liposomal doxorubicin-based treatment in a preclinical model of adrenocortical carcinoma

scientific article

Liposomal polychemotherapy improves adrenocortical carcinoma treatment in a preclinical rodent model

article

Long-term outcome of primary bilateral macronodular adrenocortical hyperplasia after unilateral adrenalectomy

scientific article published on 07 March 2019

MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma

scientific article published on 27 March 2012

Major prognostic role of Ki67 in localized adrenocortical carcinoma after complete resection.

scientific article published on 5 January 2015

Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression

scientific article published on 10 October 2008

Mechanistic Roles of Inhibin as a Tumor Suppressor in the Adrenal Cortex

scientific article published on 01 November 2004

Metabolic impact of pheochromocytoma/paraganglioma: targeted metabolomics in patients before and after tumor removal

scientific article published on 01 December 2019

Missed clinical clues in patients with pheochromocytoma/paraganglioma discovered by imaging

scientific article published on 01 September 2018

Mitotane Therapy in Adrenocortical Cancer Induces CYP3A4 and Inhibits 5α-Reductase, Explaining the Need for Personalized Glucocorticoid and Androgen Replacement

scientific article published on 16 November 2012

Mitotane monotherapy in patients with advanced adrenocortical carcinoma

scientific article published on 14 February 2018

Mouse models of adrenal tumorigenesis

scientific article published on December 2010

Mutations in the deubiquitinase gene USP8 cause Cushing's disease

scientific article published on 8 December 2014

Neuroendocrine tumor recurrence: diagnosis with 68Ga-DOTATATE PET/CT.

scientific article

Novel genes in primary aldosteronism

scientific article published on June 2014

Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study

scientific article published on 24 July 2014

OR29-2 Mild Autonomous Cortisol Excess (MACE) in Adrenal Incidentalomas - Metabolic Risk Profile and Urinary Steroid Metabolome Analysis in 1208 Prospectively Recruited Patients

Observational study mortality in treated primary aldosteronism: the German Conn's registry.

scientific article published on 23 July 2012

Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort

scientific article published on 30 May 2017

PBX1 is dispensable for neural commitment of RA-treated murine ES cells

scientific article

PKA catalytic subunit mutations in adrenocortical Cushing's adenoma impair association with the regulatory subunit.

scientific article

Performance of LC-MS/MS and immunoassay based 24-h urine free cortisol in the diagnosis of Cushing's syndrome

scientific article published on 05 April 2019

Peripheral administration of the N-terminal pro-opiomelanocortin fragment 1-28 to Pomc-/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production

scientific article published on August 2006

Peroxisome proliferator-activated receptor-gamma agonists suppress adrenocortical tumor cell proliferation and induce differentiation

scientific article

Persistence of myopathy in Cushing's syndrome: evaluation of the German Cushing's Registry

scientific article published on 21 March 2017

Pheochromocytoma and paraganglioma: clinical feature-based disease probability in relation to catecholamine biochemistry and reason for disease suspicion

scientific article published on 01 October 2019

Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma

scientific article

Plasma methoxytyramine: clinical utility with metanephrines for diagnosis of pheochromocytoma and paraganglioma

scientific article

Post-saline infusion test aldosterone levels indicate severity and outcome in primary aldosteronism

scientific article published on 28 January 2015

Potent antitumor activity of the novel HSP90 inhibitors AUY922 and HSP990 in neuroendocrine carcinoid cells

scientific article published on 4 October 2013

Pre-B-cell transcription factor 1 and steroidogenic factor 1 synergistically regulate adrenocortical growth and steroidogenesis

scientific article published on 2 November 2006

Preclinical progress and first translational steps for a liposomal chemotherapy protocol against adrenocortical carcinoma

scientific article published on 22 August 2016

Presence of brown adipocytes in retroperitoneal fat from patients with benign adrenal tumors: relationship with outdoor temperature

scientific article published on 6 June 2013

Prevalence, clinical, and molecular correlates of KCNJ5 mutations in primary aldosteronism.

scientific article published on 23 January 2012

Primary Aldosteronism: Key Characteristics at Diagnosis - a Trend towards Milder Forms

scientific article published on 10 April 2018

Prolonged zona glomerulosa insufficiency causing hyperkalemia in primary aldosteronism after adrenalectomy

scientific article published on 14 August 2012

Quality of life in patients with primary aldosteronism: gender differences in untreated and long-term treated patients and associations with treatment and aldosterone

scientific article published on 25 September 2012

Quality of life is less impaired in adults with congenital adrenal hyperplasia because of 21-hydroxylase deficiency than in patients with primary adrenal insufficiency

scientific article

Response Letter to the Editor from Sweeney AT: "CT Characteristics of Pheochromocytoma: Relevance for the Evaluation of Adrenal Incidentaloma"

scientific article published on 20 July 2020

Risk factors associated with a low glomerular filtration rate in primary aldosteronism

scientific article

Role of bone morphogenetic proteins in adrenal physiology and disease

scientific article published on 04 February 2010

SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T).

scientific article published on 27 February 2015

Short term regulation of aldosterone secretion after stimulation and suppression experiments in mice

scientific article

Side population does not define stem cell-like cancer cells in the adrenocortical carcinoma cell line NCI h295R.

scientific article

Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R.

scientific article

Simultaneous liquid chromatography tandem mass spectrometric determination of urinary free metanephrines and catecholamines, with comparisons of free and deconjugated metabolites

scientific article published on 9 January 2013

Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation

scientific article published on 27 January 2021

Sleep-EEG in patients with primary aldosteronism in comparison to healthy controls and patients with depression

scientific article published on 23 February 2019

Somatic ATP1A1, ATP2B3, and KCNJ5 mutations in aldosterone-producing adenomas

scientific article

Somatic RET mutation in a patient with pigmented adrenal pheochromocytoma

scientific article published on 18 January 2016

Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension

scientific article

Spontaneous remission of idiopathic aldosteronism after long-term treatment with spironolactone: results from the German Conn's Registry

scientific article published on April 2012

Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism

scientific article

Steroidogenic acute regulatory (StAR)-directed immunotherapy protects against tumor growth of StAR-expressing Sp2-0 cells in a rodent adrenocortical carcinoma model

scientific article published on 8 January 2004

Steroidogenic factor-1 is essential for compensatory adrenal growth following unilateral adrenalectomy

scientific article

Stress-inducible-stem cells: a new view on endocrine, metabolic and mental disease?

scientific article published on 21 September 2018

Subclinical hypercortisolism: a state, a syndrome, or a disease?

scientific article (publication date: October 2015)

TNF alpha signaling is associated with therapeutic responsiveness to vascular disrupting agents in endocrine tumors

scientific article published on 5 January 2016

Targeting CXCR4 (CXC Chemokine Receptor Type 4) for Molecular Imaging of Aldosterone-Producing Adenoma

scientific article published on 26 December 2017

Targeting heterogeneity of adrenocortical carcinoma: Evaluation and extension of preclinical tumor models to improve clinical translation

scientific article published on 15 October 2016

Testicular adrenal rest tumors develop independently of long-term disease control: a longitudinal analysis of 50 adult men with congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency

scientific article published on 22 August 2013

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

article

The Gene of the Ubiquitin-Specific Protease 8 Is Frequently Mutated in Adenomas Causing Cushing's Disease

scientific article published on 5 May 2015

The cardiovascular markers copeptin and high-sensitive C-reactive protein decrease following specific therapy for primary aldosteronism

scientific article published on 19 July 2016

The diagnosis and treatment of primary hyperaldosteronism in Germany: results on 555 patients from the German Conn Registry

scientific article published on May 2009

The impact of Connshing's syndrome - mild cortisol excess in primary aldosteronism drives diabetes risk

scientific article published on 01 December 2017

The metabolic phenotype of patients with primary aldosteronism: impact of subtype and sex – a multicenter-study of 3566 Caucasian and Asian subjects

scientific article published in 2022

The role of surgery in the management of recurrent adrenocortical carcinoma

scientific article published on 12 November 2012

The side population phenomenon enriches for designated adrenocortical progenitor cells in mice

scholarly article by Urs Lichtenauer et al published 5 October 2012 in Journal of Endocrinology

The tumor stem cell concept-implications for endocrine tumors?

scientific article

Thyroid Hormone Replacement for Central Hypothyroidism: A Randomized Controlled Trial Comparing Two Doses of Thyroxine (T4) with a Combination of T4and Triiodothyronine

article by Marc Slawik et al published November 2007 in The Journal of Clinical Endocrinology and Metabolism

Thyroid nodules--Indication for surgery?

scientific article

Timelines in the management of adrenal crisis - targets, limits and reality

scientific article published on 06 November 2014

Total adrenal volume but not testicular adrenal rest tumor volume is associated with hormonal control in patients with 21-hydroxylase deficiency

scientific article published on 26 February 2010

Treatment of Primary Aldosteronism With mTORC1 Inhibitors

scientific article published on 01 October 2019

Treatment of Refractory Adrenocortical Carcinoma with Thalidomide: Analysis of 27 Patients from the European Network for the Study of Adrenal Tumours Registry

scientific article published on 14 November 2018

Urine Steroid Metabolomics as a Novel Tool for Detection of Recurrent Adrenocortical Carcinoma

scientific article published on 01 March 2020

Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study

scientific article published on 23 July 2020

Urocortin-dependent effects on adrenal morphology, growth, and expression of steroidogenic enzymes in vivo

scholarly article by Anna Riester published in February 2012

Use of Steroid Profiling Combined With Machine Learning for Identification and Subtype Classification in Primary Aldosteronism

scientific article published on 01 September 2020

Utilization of a mutagenesis screen to generate mouse models of hyperaldosteronism

scientific article

Value of Molecular Classification for Prognostic Assessment of Adrenocortical Carcinoma

scientific article published on 11 July 2019

Virilization of a young girl caused by concomitant ectopic and intra-adrenal adenomas of the adrenal cortex

scientific article

Worsening of lipid metabolism after successful treatment of primary aldosteronism

scientific article

Xenograft models for adrenocortical carcinoma

scientific article published on 29 May 2015

[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes

scientific article published on 8 April 2008

[Arterial hypertension and subclinical Cushing's syndrome]

scientific article published on 01 February 2010

[Every eighth case of hypertension originates in the adrenal gland. For whom is it worthwhile to screen for an endocrine cause?]

scientific article published on 01 February 2010

cAMP signaling in cortisol-producing adrenal adenoma

scientific article published on 02 July 2015

β-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis

scientific article published on 03 April 2020

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