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List of works by Stefan Marciniak

A novel monoclonal antibody to characterize pathogenic polymers in liver disease associated with alpha1-antitrypsin deficiency.

scientific article

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity

scientific article

A solution scan of societal options to reduce transmission and spread of respiratory viruses: SARS-CoV-2 as a case study

scientific article published in December 2021

Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation

scientific article

Activation-dependent substrate recruitment by the eukaryotic translation initiation factor 2 kinase PERK.

scientific article

Alpha1-antitrypsin deficiency and autophagy

scientific article published on November 2010

An Optical Technique for Mapping Microviscosity Dynamics in Cellular Organelles

scientific article published on 18 April 2018

Association of nucleoside diphosphate kinase with pancreatic zymogen granules: effects of local GTP generation on granule membrane characteristics

scientific article published on May 1996

Autism-associated R451C mutation in neuroligin3 leads to activation of the unfolded protein response in a PC12 Tet-On inducible system

scientific article published on 30 November 2015

Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression

scientific article published on December 2005

Biological basis for novel mesothelioma therapies

publication published on 05 July 2021

C/EBP homologous protein is necessary for normal osteoblastic function.

scientific article published in February 2006

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

scientific journal article

Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 2. Protein misfolding and ER stress

scientific article published on 15 October 2014

Characterisation of serpin polymers in vitro and in vivo.

scientific article

Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody

scientific article

Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation

scientific article published on 27 February 2013

Circulating polymers in 1-antitrypsin deficiency

scientific article published on 06 March 2014

Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development

scientific article published on 15 February 2013

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

scientific article

Diabetes as a disease of endoplasmic reticulum stress

scientific article published on 03 October 2010

Endoplasmic reticulum dysfunction in neurological disease

scientific article published on January 2013

Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1-antitrypsin deficiency

scientific article published on 14 March 2013

Endoplasmic reticulum stress in lung disease

scientific article published on 28 June 2017

Endoplasmic reticulum stress in malignancy

scientific article

Endoplasmic reticulum stress: a key player in human disease

scientific article published on 01 January 2019

Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins

scientific article

Evaluation of secondary spontaneous pneumothorax with multidetector CT.

scientific article published on 05 December 2012

Exploring High Aspect Ratio Gold Nanotubes as Cytosolic Agents: Structural Engineering and Uptake into Mesothelioma Cells

scientific article published on 25 October 2020

Familial pneumothorax: towards precision medicine

scientific article

Function of monocytes and monocyte-derived macrophages in α1-antitrypsin deficiency

scientific article

G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases

scientific article

Genetic susceptibility

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response

scientific article

Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice

scholarly article by Vruti Patel et al published 27 February 2019 in Scientific Reports

Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin

scientific article published on 4 October 2013

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum

scientific article published on 14 September 2015

Intracellular serpins, firewalls and tissue necrosis

scientific article published on 22 January 2008

Involvement of a phosphoprotein on the zymogen granule membrane in the control of regulated exocytosis in the exocrine pancreas

scientific article published on 01 October 1993

Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation

scientific article

Linker length affects photostability of protein-targeted sensor of cellular microviscosity

scientific article published on 10 October 2019

Localization of immunoreactive endothelin and proendothelin in the human lung

scientific article

Measuring the effects of α1 -antitrypsin polymerisation on the structure and biophysical properties of the endoplasmic reticulum

scientific article published on 10 September 2018

MesobanK UK: an international mesothelioma bioresource

scientific article published on 14 October 2015

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells.

scientific article

Modeling serpin conformational diseases in Drosophila melanogaster

scientific article published in January 2011

Molecular mechanisms in exocytosis

scientific article published on July 1995

Neurology for the MRCP Part II

Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response.

scientific article published on 07 May 2009

New Concepts in Alpha-1 Antitrypsin Deficiency Disease Mechanisms

scientific article

Noninterventional statistical comparison of BTS and CHEST guidelines for size and severity in primary pneumothorax.

scientific article published on 18 March 2015

PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.

scientific article published on 27 April 2017

Palliative treatment for symptomatic malignant pericardial effusion†.

scientific article

Pancreatic plasma membranes: promiscuous partners in membrane fusion

scientific article published on March 1994

Paneth cells as a site of origin for intestinal inflammation.

scientific article

Phosphoproteins in stress-induced disease

scientific article published on January 2012

Pneumothorax and the biology of Birt-Hogg-Dubé syndrome

scientific article published on 01 June 2020

Polymers of Z α1-antitrypsin are secreted in cell models of disease.

scientific article published on 4 February 2016

Pulmonary endoplasmic reticulum stress-scars, smoke, and suffocation

scientific article published on 11 January 2018

Recurrent pneumothorax

scientific article published on 01 May 2011

Role of unfolded proteins in lung disease

scientific article published on 19 October 2020

Single particle trajectories reveal active endoplasmic reticulum luminal flow

scientific article published on 17 September 2018

Spontaneous pneumothorax can be associated with TGFBR2 mutation.

scientific article

Sterol metabolism regulates neuroserpin polymer degradation in the absence of the unfolded protein response in the dementia FENIB.

scientific article published on 28 June 2013

Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity

scientific article

Susceptibility to cellular stress in PS1 mutant N2a cells is associated with mitochondrial defects and altered calcium homeostasis

scientific article published on 15 April 2020

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

scientific article

The Genetics of Pneumothorax

scientific article published on 01 June 2019

The TRiC/CCT chaperone is implicated in Alzheimer's disease based on patient GWAS and an RNAi screen in Aβ-expressing Caenorhabditis elegans.

scientific article

The effect of lung biopsy on lung function in diffuse lung disease.

scientific article

The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin

scientific article published on 06 September 2016

The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma.

scientific article published on 14 February 2013

The integrated stress response in lung disease

scientific article published on June 2014

The integrated stress response regulates BMP signalling through effects on translation

scientific article published on 3 April 2018

The serpinopathies studying serpin polymerization in vivo

scientific article

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress.

scientific article published on 28 April 2014

Time Is of the Essence: A Young Man with Recurrent Pneumothorax and Cavitating Lung Lesions

scientific article published on 01 August 2018

Unravelling the story of protein misfolding in diabetes mellitus

scientific article published on July 2011

Unravelling the twists and turns of the serpinopathies.

scientific article published on 20 June 2011

Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells

scientific article published on 17 June 2015

What can naturally occurring mutations tell us about the pathogenesis of COPD?

scientific article published on April 2009

alpha1-Antitrypsin deficiency, chronic obstructive pulmonary disease and the serpinopathies

scientific article published on 14 May 2009

p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress

scientific article published on 22 January 2013

α(1)-antitrypsin deficiency and inflammation

scientific article published on March 2011

α1-Antitrypsin deficiency.

scientific article published on 28 July 2016

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