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Authors whose works are in public domain in at least one jurisdiction

List of works by James A Irving

A Molecular Switch Governs the Interaction between the Human Complement Protease C1s and Its Substrate, Complement C4

scientific article

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

scientific article

A serpin in the cellulosome of the anaerobic fungus Piromyces sp. strain E2.

scientific article

A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity

scientific article

Aeropin from the extremophile Pyrobaculum aerophilum bypasses the serpin misfolding trap

scientific article

Altered native stability is the dominant basis for susceptibility of α1-antitrypsin mutants to polymerization

scientific article

An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein

scientific article published on May 2015

An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding

scientific article

Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population

scientific article published in PLoS ONE

Characterisation of serpin polymers in vitro and in vivo.

scientific article

Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody

scientific article

Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection.

scientific article

Computational analysis of evolution and conservation in a protein superfamily

scientific article

Conformational change in the chromatin remodelling protein MENT

scientific article

Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes

scientific article published on 04 March 2021

DNA accelerates the inhibition of human cathepsin V by serpins

scientific article

Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization

scientific article published on 19 June 2015

Evidence that serpin architecture intrinsically supports papain-like cysteine protease inhibition: engineering alpha(1)-antitrypsin to inhibit cathepsin proteases

scientific article

Functional insights from the distribution and role of homopeptide repeat-containing proteins

scientific article

High-resolution ex vivo NMR spectroscopy of human Z α<sub>1</sub>-antitrypsin

scientific article published on 11 December 2020

Human Ovalbumin Serpin Evolution: Phylogenic Analysis, Gene Organization, and Identification of New PI8-Related Genes Suggest That Two Interchromosomal and Several Intrachromosomal Duplications Generated the Gene Clusters at 18q21–q23 and 6p25

article

Human clade B serpins (ov-serpins) belong to a cohort of evolutionarily dispersed intracellular proteinase inhibitor clades that protect cells from promiscuous proteolysis.

scientific article published on February 2004

Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis

scientific article

Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation

scientific article

Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum

scientific article published on 14 September 2015

MUSTANG-MR structural sieving server: applications in protein structural analysis and crystallography

scientific article

Peptide mimotopes selected with HIV-1-blocking monoclonal antibodies against CCR5 represent motifs specific for HIV-1 entry

scientific article published on 3 July 2007

Phosphoproteins in stress-induced disease

scientific article published on January 2012

Phylogeny of the serpin superfamily: implications of patterns of amino acid conservation for structure and function.

scientific article

Probing the folding pathway of a consensus serpin using single tryptophan mutants

scientific article published in February 2018

Protein structural alignments and functional genomics

scientific article published on 01 February 2001

Reactive centre loop mutants of α-1-antitrypsin reveal position-specific effects on intermediate formation along the polymerization pathway

scientific article published on 25 June 2013

Requirement of multiple phage displayed peptide libraries for optimal mapping of a conformational antibody epitope on CCR5.

scientific article published in February 2005

Role of the alpha-helix 163-170 in factor Xa catalytic activity

scientific article published on 28 August 2007

Sequence, organization, chromosomal localization, and alternative splicing of the human serine protease inhibitor gene hurpin (PI13) which is upregulated in psoriasis

scientific article

Serpins in prokaryotes

scientific article

Serpins in the Caenorhabditis elegans genome

scientific article published on 01 July 1999

Serpins: finely balanced conformational traps

scientific article

Structural mechanisms of inactivation in scabies mite serine protease paralogues

scientific article

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

scientific article

Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity

scientific article

Targeting serpins in high-throughput and structure-based drug design

scientific article

The N terminus of the serpin, tengpin, functions to trap the metastable native state

scientific article

The evolution of enzyme specificity in Fasciola spp.

scientific article published in July 2003

The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition

scientific article

The high resolution crystal structure of the human tumor suppressor maspin reveals a novel conformational switch in the G-helix

scientific article

The molecular species responsible for α1 -antitrypsin deficiency are suppressed by a small molecule chaperone

scientific article published on 15 October 2020

The murine orthologue of human antichymotrypsin: a structural paradigm for clade A3 serpins

scientific article

The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization

scientific article

The serpin SQN-5 is a dual mechanistic-class inhibitor of serine and cysteine proteinases

scientific article published in March 2002

The serpinopathies studying serpin polymerization in vivo

scientific article

The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature

scientific article (publication date: 7 September 2001)

The structural basis for Z α1-antitrypsin polymerization in the liver

scientific article published on 21 October 2020

Unravelling the twists and turns of the serpinopathies.

scientific article published on 20 June 2011

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation

scientific article

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