List of works - Hui-Wen Lo

A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion

scientific article

Akt destabilizes p57 (Kip2) : Akt at the converging crossroad?

scientific article published on 7 March 2013

Cancer-specific gene therapy.

scientific article

Co-regulation of B-Myb expression by E2F1 and EGF receptor

scientific article

Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis

scientific article published on 14 September 2020

Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators

scientific article published on October 2008

Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation

scientific article

Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes

scientific article

Dacomitinib, an emerging HER-targeted therapy for non-small cell lung cancer

scientific article published on December 2012

EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity.

scientific article

EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis

scientific article published on 9 March 2011

EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization.

scientific article

Emerging therapeutic targets and agents for glioblastoma therapy--part II.

scientific article

Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression

scientific article published on October 2007

Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance.

scientific article published on 6 August 2007

Genomic Cloning of hGSTP1*C, an Allelic Human Pi Class Glutathione S-Transferase Gene Variant and Functional Characterization of Its Retinoic Acid Response Elements ⬇️

scientific article published on December 26, 1997

Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2

scientific article published on 28 September 2020

Identification, functional characterization, and pathobiological significance of GLI1 isoforms in human cancers

scientific article

Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations ⬇️

scientific article published on January 17, 2012

M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer

scientific article

Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival.

scientific article

Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

scientific article published on June 2005

Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1.

scientific article published on August 2006

STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3

scientific article

Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy

scientific article published on March 2004

Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line

scientific article published on April 1998

The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and Diseases

scientific article published on June 2010

The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells.

scientific article

Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells.

scientific article

List of works by Hui-Wen Lo

A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion

Akt destabilizes p57 (Kip2) : Akt at the converging crossroad?

Cancer-specific gene therapy.

Co-regulation of B-Myb expression by E2F1 and EGF receptor

Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis

Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators

Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation

Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes

Dacomitinib, an emerging HER-targeted therapy for non-small cell lung cancer

EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity.

EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis

EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization.

Emerging therapeutic targets and agents for glioblastoma therapy--part II.

Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression

Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance.

Genomic Cloning of hGSTP1*C, an Allelic Human Pi Class Glutathione S-Transferase Gene Variant and Functional Characterization of Its Retinoic Acid Response Elements ⬇️

Her2 promotes early dissemination of breast cancer by suppressing the p38 pathway through Skp2-mediated proteasomal degradation of Tpl2

Identification, functional characterization, and pathobiological significance of GLI1 isoforms in human cancers

Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations ⬇️

M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer

Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival.

Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1.

STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3

Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy

Structure of the human allelic glutathione S-transferase-pi gene variant, hGSTP1 C, cloned from a glioblastoma multiforme cell line

The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and Diseases

The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells.

Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells.