List of works - Calum Sutherland

5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.

scientific article

A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin

scientific article published on 18 August 2012

A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration.

scientific article published on December 2005

A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression

article

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

scientific article

Activation of the Ras Mitogen-activated Protein Kinase-Ribosomal Protein Kinase Pathway Is Not Required for the Repression of Phosphoenolpyruvate Carboxykinase Gene Transcription by Insulin

scientific article published in Journal of Biological Chemistry

Anaesthesia generates neuronal insulin resistance by inducing hypothermia

scientific article published on 09 October 2008

Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3.

scientific article published on December 2005

Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin

scientific article published on July 1996

Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression

scientific article

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

scientific article

Bioinformatic prediction and confirmation of beta-adducin as a novel substrate of glycogen synthase kinase 3.

scientific article

Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

scientific article

CNP/cGMP signaling regulates axon branching and growth by modulating microtubule polymerization.

scientific article

CRMP2 hyperphosphorylation is characteristic of Alzheimer's disease and not a feature common to other neurodegenerative diseases

scientific article published in January 2011

Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

scientific article

Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression

scientific article

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

scientific article

Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells.

scientific article

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

scientific article published on February 2005

Different mechanisms are used by insulin to repress three genes that contain a homologous thymine-rich insulin response element

scientific article published in August 2003

Differential proteomics analysis of synaptic proteins identifies potential cellular targets and protein mediators of synaptic neuroprotection conferred by the slow Wallerian degeneration (Wlds) gene

scientific article

Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes

scientific article published on August 2012

Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo

scientific article

Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Clambda do not prevent insulin inhibition of phosphoenolpyruvate carboxykinase gene transcription

scientific article published on July 1999

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.

scientific article published on 03 August 2015

Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.

scientific article

Erratum to: A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin

scholarly article published in Diabetologia

Esterification and absorption of cholesterol: in vitro and in vivo observations in the rat

scientific article published on 01 June 1989

Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain

scientific article published on 5 October 2010

Filaggrin in the frontline: role in skin barrier function and disease

scientific article (publication date: May 2009)

Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226.

scientific article published on 6 April 2006

GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.

scientific article published on 5 October 2004

GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4.

scientific article published on April 2010

Generation, validation and humanisation of a novel insulin resistant cell model.

scientific article published on 23 June 2010

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

scientific article published on 27 June 2016

High fat feeding is associated with stimulation of the hypothalamic-pituitary-adrenal axis and reduced anxiety in the rat.

scientific article

High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task

scientific article published on 23 October 2010

Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats

scientific article published on 19 November 2014

Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation

scientific article

Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase

scientific article published on March 1993

Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology

scientific article

Insulin Regulation of Insulin-like Growth Factor-binding Protein-1 Gene Expression Is Dependent on the Mammalian Target of Rapamycin, but Independent of Ribosomal S6 Kinase Activity ⬇️

scientific article published on January 9, 2002

Insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTOR) signalling is impaired by the presence of hydrogen peroxide

scientific journal article

Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway

scientific article

Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo.

scientific article published on March 2009

Insulin resistance in the brain: an old-age or new-age problem?

scientific article published on 16 May 2012

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug

scientific article

Invited commentary

scientific article published on 01 July 2015

Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels

scientific article

Measuring GSK3 expression and activity in cells

scientific article

Models of dementia: an introductory overview

scientific article published in August 2011

Molecular connexions between dementia and diabetes.

scientific article published on 24 April 2007

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

scientific article

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.

scientific article

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

scientific article

Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase

scientific article

Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin

scientific article published in Journal of Biological Chemistry

Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis.

scientific article published on 10 November 2015

Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons

scientific article published on 13 October 2015

Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation.

scientific article published on 6 May 2008

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

scientific article

The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1

scientific article

The effect of dietary intervention on the metabolic and behavioural impairments generated by short term high fat feeding in the rat.

scientific article

The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis

scientific article published on May 2000

The role of ATM in response to metformin treatment and activation of AMPK.

scientific article

The α-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro

scientific article published on 01 January 1994

Tumour necrosis factor alpha decreases glucose-6-phosphatase gene expression by activation of nuclear factor kappaB.

scientific article published on September 2004

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

scientific article published on 08 August 2016

What Are the bona fide GSK3 Substrates?

scientific article

List of works by Calum Sutherland

5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.

A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin

A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration.

A temporal switch in the insulin-signalling pathway that regulates hepatic IGF-binding protein-1 gene expression

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

Activation of the Ras Mitogen-activated Protein Kinase-Ribosomal Protein Kinase Pathway Is Not Required for the Repression of Phosphoenolpyruvate Carboxykinase Gene Transcription by Insulin

Anaesthesia generates neuronal insulin resistance by inducing hypothermia

Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3.

Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin

Antagonistic effects of phorbol esters on insulin regulation of insulin-like growth factor-binding protein-1 (IGFBP-1) but not glucose-6-phosphatase gene expression

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

Bioinformatic prediction and confirmation of beta-adducin as a novel substrate of glycogen synthase kinase 3.

Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status

CNP/cGMP signaling regulates axon branching and growth by modulating microtubule polymerization.

CRMP2 hyperphosphorylation is characteristic of Alzheimer's disease and not a feature common to other neurodegenerative diseases

Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells.

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

Different mechanisms are used by insulin to repress three genes that contain a homologous thymine-rich insulin response element

Differential proteomics analysis of synaptic proteins identifies potential cellular targets and protein mediators of synaptic neuroprotection conferred by the slow Wallerian degeneration (Wlds) gene

Disordered insulin secretion in the development of insulin resistance and Type 2 diabetes

Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo

Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Clambda do not prevent insulin inhibition of phosphoenolpyruvate carboxykinase gene transcription

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3.

Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles.

Erratum to: A high-fat-diet-induced cognitive deficit in rats that is not prevented by improving insulin sensitivity with metformin

Esterification and absorption of cholesterol: in vitro and in vivo observations in the rat

Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain

Filaggrin in the frontline: role in skin barrier function and disease

Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226.

GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.

GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4.

Generation, validation and humanisation of a novel insulin resistant cell model.

Heat Shock Factor 1 Is a Substrate for p38 Mitogen-Activated Protein Kinases

High fat feeding is associated with stimulation of the hypothalamic-pituitary-adrenal axis and reduced anxiety in the rat.

High fat feeding promotes simultaneous decline in insulin sensitivity and cognitive performance in a delayed matching and non-matching to position task

Hypertension fails to disrupt white matter integrity in young or aged Fisher (F44) Cyp1a1Ren2 transgenic rats

Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation

Identification of insulin-stimulated protein kinase-1 as the rabbit equivalent of rskmo-2. Identification of two threonines phosphorylated during activation by mitogen-activated protein kinase

Implications of genome wide association studies for the understanding of type 2 diabetes pathophysiology

Insulin Regulation of Insulin-like Growth Factor-binding Protein-1 Gene Expression Is Dependent on the Mammalian Target of Rapamycin, but Independent of Ribosomal S6 Kinase Activity ⬇️

Insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTOR) signalling is impaired by the presence of hydrogen peroxide

Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway

Insulin resistance in polycystic ovary syndrome is associated with defective regulation of ERK1/2 by insulin in skeletal muscle in vivo.

Insulin resistance in the brain: an old-age or new-age problem?

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug

Invited commentary

Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels

Measuring GSK3 expression and activity in cells

Models of dementia: an introductory overview

Molecular connexions between dementia and diabetes.

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2.

Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

Obesity-induced insulin resistance in human skeletal muscle is characterised by defective activation of p42/p44 MAP kinase

Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin

Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis.

Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons

Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation.

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1

The effect of dietary intervention on the metabolic and behavioural impairments generated by short term high fat feeding in the rat.

The molecular physiology of hepatic nuclear factor 3 in the regulation of gluconeogenesis

The role of ATM in response to metformin treatment and activation of AMPK.

The α-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro

Tumour necrosis factor alpha decreases glucose-6-phosphatase gene expression by activation of nuclear factor kappaB.

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

What Are the bona fide GSK3 Substrates?