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List of works by Rolf Marschalek

A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells

scientific article published in August 1999

A MLL-KIAA0284 fusion gene in a patient with secondary acute myeloid leukemia and t(11;14)(q23;q32).

scientific article

A complex 1;19;11 translocation involving the MLL gene in a patient with congenital acute monoblastic leukemia identified by molecular and cytogenetic techniques

article

A complex MLL rearrangement identified five years after initial MDS diagnosis results in out-of-frame fusions without progression to acute leukemia

scientific article published on 01 October 2011

A family of non-allelic tRNA(ValGUU) genes from the cellular slime mold Dictyostelium discoideum

scientific article

A highly specific and sensitive fluorescence in situ hybridization assay for the detection of t(4;11)(q21;q23) and concurrent submicroscopic deletions in acute leukaemias

scientific article published in March 2002

A new variant of KMT2A(MLL)-FLNA fusion transcript in acute myeloid leukemia with ins(X;11)(q28;q23q23)

scientific article published on 07 March 2015

A novel PML-ADAMTS17-RARA gene rearrangement in a patient with pregnancy-related acute promyelocytic leukemia

scientific article

A novel spliced fusion of MLL with CT45A2 in a pediatric biphenotypic acute leukemia. ⬇️

scientific article

A novel, negative selectable marker for gene disruption in Dictyostelium

article

A second case of secondary acute myeloblastic leukemia associated with the MLL-KIAA0284 fusion gene

scientific article published on 28 February 2009

A specific deletion in the breakpoint cluster region of the ALL-1 gene is associated with acute lymphoblastic T-cell leukemias

article

A three-way translocation of MLL, MLLT11, and the novel reciprocal partner gene MYO18A in a child with acute myeloid leukemia

scientific article published in May 2012

AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3

scientific article published on 27 July 2015

AF4 and AF4N protein complexes: recruitment of P-TEFb kinase, their interactome and potential functions

scientific article published on 15 June 2015

ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia

scientific article

Abl-interactor 2 (ABI2): a novel MLL translocation partner in acute myeloid leukemia

scientific article published in February 2012

Acute leukemias with ETV6/ABL1 (TEL/ABL) fusion: poor prognosis and prenatal origin.

scientific article published on October 2010

Acute monocytic leukaemia originating from MLL-MLLT3-positive pre-B cells

scientific article published on 20 May 2010

Acute promyelocytic leukemia with a rare PML exon 4/ RARA exon 3 fusion transcript variant

scientific article published on 5 June 2013

Acute promyelocytic leukemia with trisomy 8 showing normal PML-RARA FISH signal patterns: diagnostic application of long-distance polymerase chain reaction in molecularly discrepant leukemia cases

scientific article published on 9 March 2012

An Alu-mediated novel large deletion is the most frequent cause of type 3 von Willebrand disease in Hungary

article

An Interstitial Deletion at 3p21.3 Results in the Genetic Fusion of MLH1 and ITGA9 in a Lynch Syndrome Family

scientific article published on 01 February 2009

An alternative splice process renders the MLL protein either into a transcriptional activator or repressor

scientific article published in July 2013

Analyzing acute leukemia patients with complex MLL rearrangements by a sequential LDI-PCR approach.

scientific article published on 2 April 2013

BTBD18: A novel MLL partner gene in an infant with acute lymphoblastic leukemia and inv(11)(q13;q23).

scientific article

Backtracking to birth of the NUP98-HOXD13 gene fusion in an infant acute myeloid leukemia.

scientific article

Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL.

scientific article published in May 2001

Bioassays to monitor Taspase1 function for the identification of pharmacogenetic inhibitors

scientific article

Breakpoints of t(4;11) translocations in the human MLL and AF4 genes in ALL patients are preferentially clustered outside of high-affinity matrix attachment regions

scientific article published on January 2001

C/EBPbeta suppression by interruption of CUGBP1 resulting from a complex rearrangement of MLL.

scientific article published in September 2007

CASP8AP2 is a novel partner gene of MLL rearrangement with t(6;11)(q15;q23) in acute myeloid leukemia.

scientific article published in November 2009

CBLmutations do not frequently occur in paediatric acute myeloid leukaemia

article

Cell-based analysis of structure-function activity of threonine aspartase 1

scientific article published on 17 November 2010

Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells

scientific article

Characterisation of two novel large F8 deletions in patients with severe haemophilia A and factor VIII inhibitors.

scientific article

Characterization of transcripts from the Dictyostelium discoideum retrotransposable genetic element DRE.

scientific article published in December 1994

Childhood secondary ALL after ALL treatment.

scientific article

Clonal expansion of a new MLL rearrangement in the absence of leukemia

scientific article published on 01 May 2005

Clone-specific secondary aberrations are not detected in neonatal blood spots of children with ETV6-RUNX1-positive leukemia

scientific article published on September 2013

Combined effects of the two reciprocal t(4;11) fusion proteins MLL.AF4 and AF4.MLL confer resistance to apoptosis, cell cycling capacity and growth transformation.

scientific article published on 27 November 2006

Complex MLL rearrangement in non-infiltrated bone marrow in an infant with stage II precursor B-lymphoblastic lymphoma

scientific article published on 28 April 2014

Complex MLL rearrangements in t(4;11) leukemia patients with absent AF4·MLL fusion allele

scientific article published on 05 April 2007

Complex three-way translocation involving MLL, ELL, RREB1, and CMAHP genes in an infant with acute myeloid leukemia and t(6;19;11)(p22.2;p13.1;q23.3).

scientific article published on 30 May 2013

Covert preleukemia driven by MLL gene fusion

scientific article published in January 2009

Cryptic t(4;11) encoding MLL-AF4 due to insertion of 5' MLL sequences in chromosome 4.

scientific article published in April 2001

De novo acute myeloid leukemia associated with t(11;17)(q23;q25) and MLL-SEPT9 rearrangement in an elderly patient: a case study and review of the literature

scientific article published on 16 August 2011

Detection of EML4-ALK and other ALK fusion genes in lung cancer: a lesson from the leukemia fusion gene analysis and future application

scientific article published on 25 April 2012

Diagnostic usefulness of genomic breakpoint analysis of various gene rearrangements in acute leukemias: a perspective of long distance- or long distance inverse-PCR-based approaches.

scientific article published on 20 June 2012

Different organization of the tRNA-gene-associated repetitive element, DRE, in NC4-derived strains and in other wild-type Dictyostelium discoideum strains

scientific article

Do non-genomically encoded fusion transcripts cause recurrent chromosomal translocations?

scientific article published on 18 October 2012

ETV6/RUNX1-positive relapses evolve from an ancestral clone and frequently acquire deletions of genes implicated in glucocorticoid signaling

scientific article published on 11 January 2011

Editorial: Pharmazie in unserer Zeit 3/2012

scientific article published on 01 May 2012

Effective targeting of the P53-MDM2 axis in preclinical models of infant MLL-rearranged acute lymphoblastic leukemia

scientific article

Epigenetics and blood disorders

scientific article published on 20 June 2012

Establishment of a system for conditional gene expression using an inducible tRNA suppressor gene

scientific article published in September 1992

Etoposide-treatment and MLL rearrangements

scientific article

Evidence-based RT-PCR methods for the detection of the 8 most common MLL aberrations in acute leukemias

scientific article published on 29 November 2014

Evolution of AF6-RAS association and its implications in mixed-lineage leukemia.

scientific article

Exon/intron structure of the human AF‐4 gene, a member of the AF‐4/LAF‐4/FMR‐2 gene family coding for a nuclear protein with structural alterations in acute leukaemia ⬇️

scientific article (publication date: July 1997)

Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias

scientific article published on June 1996

FISH-negative cryptic PML-RARA rearrangement detected by long-distance polymerase chain reaction and sequencing analyses: a case study and review of the literature

scientific article published on December 2010

FLNA, a new partner gene fused toMLLin a patient with acute myelomonoblastic leukaemia

article

Fatal connections: when DNA ends meet on the nuclear matrix.

scientific article published in January 2000

Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation

scientific article published on December 1998

Formation of autocrine loops in human cerebral meningioma tissue by leukemia inhibitor factor, interleukin-6, and oncostatin M: inhibition of meningioma cell growth in vitro by recombinant oncostatin M.

scientific article published on March 1998

Functional analysis of the two reciprocal fusion genes MLL-NEBL and NEBL-MLL reveal their oncogenic potential.

scientific article

Functional characterisation of different MLL fusion proteins by using inducible Sleeping Beauty vectors

scientific article

Genetic and clinical characterization of 45 acute leukemia patients with MLL gene rearrangements from a single institution.

scientific article published on 14 July 2012

Genetic basis of leukemia: Serious consequences of chromosomal translocations

scientific article published on May 1, 2012

Genomic DNA of leukemic patients: Target for clinical diagnosis ofMLL rearrangements

scientific article published on 01 June 2006

Genomic analysis of a four-way t(4;11;22;10) associated with MLL-AF4 in an adult acute lymphoblastic leukemia

scientific article published on 17 November 2011

Genomic breakpoints and clinical features of MLL-TET1 rearrangement in acute leukemias.

scientific article published on 25 October 2012

Glycosylation sites identified by detection of glycosylated amino acids released from Edman degradation: the identification of Xaa-Pro-Xaa-Xaa as a motif for Thr-O-glycosylation

scientific article published on August 1991

High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome

scientific article published on 23 September 2010

High IGSF4 expression in pediatric M5 acute myeloid leukemia with t(9;11)(p22;q23).

scientific article published on 2 November 2010

Hormonal dependency of cerebral meningiomas

scientific article

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions

scientific article published on 21 March 2019

Hydroxyurea for treatment of unresectable and recurrent meningiomas. I. Inhibition of primary human meningioma cells in culture and in meningioma transplants by induction of the apoptotic pathway

article

Hydroxyurea for treatment of unresectable and recurrent meningiomas. II. Decrease in the size of meningiomas in patients treated with hydroxyurea

scientific article published in May 1997

Hydroxyurea for treatment of unresectable meningiomas

scientific article published in The Lancet

Identification of MLL partner genes in 27 patients with acute leukemia from a single cytogenetic laboratory

scientific article published on 26 August 2011

Identification of a protein factor binding to the 5'-flanking region of a tRNA gene and being involved in modulation of tRNA gene transcription in vivo in Saccharomyces cerevisiae.

scientific article published on July 1988

Identification of aMLL–MLLT4fusion gene resulting from a t(6;11)(q27;q23) presenting as a del(11q) in a child with T-cell acute lymphoblastic leukemia

article

Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement.

scientific article published in February 2007

In vivo inducible reverse genetics in patients' tumors to identify individual therapeutic targets

scientific article published on 27 September 2021

Infant acute bilineal leukemia

scientific article published on 16 March 2009

Influence of different 5'-flanking sequences of tRNA genes on their in vivo transcription efficiencies in Saccharomyces cerevisiae

article

Inhibition of class I HDACs abrogates the dominant effect of MLL-AF4 by activation of wild-type MLL.

scientific article published on 17 November 2014

Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?

scientific article

Internally located and oppositely oriented polymerase II promoters direct convergent transcription of a LINE-like retroelement, the Dictyostelium repetitive element, from Dictyostelium discoideum.

scientific article published on May 1994

Inv(11)(q21q23) fuses MLL to the Notch co-activator mastermind-like 2 in secondary T-cell acute lymphoblastic leukemia

scientific article published on 13 March 2008

Involvement of the MLL gene in adult T-lymphoblastic leukemia

scientific article published on 25 August 2012

Isolation of two interleukin-6 response element binding proteins from acute phase rat livers.

scientific article published on July 1995

It takes two-to-leukemia: About addictions and requirements

scientific article published on 11 November 2010

KIAA1524: A novel MLL translocation partner in acute myeloid leukemia.

scientific article

LDI-PCR: identification of known and unknown gene fusions of the human MLL gene

scientific article published in January 2009

Leukämie

scientific article published on 01 May 2012

Ligand-independent FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform cord blood CD34+ cells

scientific article published on 18 November 2013

Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth

scientific article published on 2 January 2012

Long-term remission of therapy-related acute myeloid leukemia with a new t(11;18)(q23;q21.2) translocation and KMT2A-ME2 (MLL-ME2) fusion gene

article

Low frequency of clonotypic Ig and T-cell receptor gene rearrangements in t(4;11) infant acute lymphoblastic leukaemia and its implication for the detection of minimal residual disease

scientific article published in May 2002

MLL insertion with MLL-MLLT3 gene fusion in acute leukemia: case report and review of the literature

scientific article published on May 2008

MLL leukemia and future treatment strategies

scientific article

MLL partner genes in secondary acute lymphoblastic leukemia: report of a new partner PRRC1 and review of the literature

scientific article published on 29 August 2014

MLL-SEPT5 fusion transcript in infant acute myeloid leukemia with t(11;22)(q23;q11).

scientific article published on 20 August 2013

MLL-mediated transcriptional gene regulation investigated by gene expression profiling

scientific article published in June 2003

MLL–ELLfusion gene in two infants with acute monoblastic leukemia and myeloid sarcoma

article

Mechanisms of leukemogenesis by MLL fusion proteins

scientific article published on December 2010

Mixed lineage leukemia-rearranged childhood pro-B and CD10-negative pre-B acute lymphoblastic leukemia constitute a distinct clinical entity

scientific article published in May 2006

Molecular analysis of the chromosomal breakpoint and fusion transcripts in the acute lymphoblastic SEM cell line with chromosomal translocation t(4;11).

scientific article published on June 1995

Molecular characterization and clinical course of MLL-ACTN4 rearrangement in therapy-related hematologic malignancies

scientific article published on 21 February 2014

Molecular characterization and clinical impact of t(11;15)(q23;q14-15) MLL-CASC5 rearrangement.

scientific article published on January 2014

Molecular dissection of t(11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants

article

Molecular identification of a new splicing variant of the MLL - MLLT11 fusion transcript in an adult with acute myeloid leukemia and t(1;11)(q21;q23).

scientific article published on August 2012

Molecular methods for genomic analyses of variantPML-RARAor otherRARA-related chromosomal translocations in acute promyelocytic leukemia ⬇️

scientific article published on December 24, 2012

Molecular monitoring of minimal residual disease in two patients with MLL-rearranged acute myeloid leukemia and haploidentical transplantation after relapse.

scientific article

Molecular studies reveal a MLL-MLLT3 gene fusion displaced in a case of childhood acute lymphoblastic leukemia with complex karyotype

article

Monitoring minimal residual disease by quantification of genomic chromosomal breakpoint sequences in acute leukemias with MLL aberrations

scientific article published in March 2006

Multidimensional gas chromatography-mass spectrometry for tracer studies of fatty acid metabolism via stable isotopes in cultured human trophoblast cells

scientific article published on July 2003

NQO1 C609T polymorphism in distinct entities of pediatric hematologic neoplasms.

scientific article published in December 2004

NRIP3: a novel translocation partner of MLL detected in a pediatric acute myeloid leukemia with complex chromosome 11 rearrangements

scientific article published on 19 May 2009

Nebulette is the second member of the nebulin family fused to the MLL gene in infant leukemia

article

Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain

scientific article

New insights to the MLL recombinome of acute leukemias

scientific article

Nuclear factors which bind to Dictyostelium discoideum transfer RNA genes

article

Nucleotide sequence of a Dictyostelium discoideum gene encoding a protein homologous to the yeast ribosomal protein S31.

scientific article published in January 1993

Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

scientific article published on 20 March 2011

Optimized Sleeping Beauty transposons rapidly generate stable transgenic cell lines

scientific article published on 2 March 2015

Premature transcript termination, trans-splicing and DNA repair: a vicious path to cancer.

scientific article published on 7 April 2011

Prenatal origin of childhood AML occurs less frequently than in childhood ALL.

scientific article published on 21 April 2006

Presence of N regions in the clonotypic DJ rearrangements of the immunoglobulin heavy-chain genes indicates an exquisitely short latency in t(4;11)-positive infant acute lymphoblastic leukemia

scientific article published in October 2001

Presence of clone-specific antigen receptor gene rearrangements at birth indicates an in utero origin of diverse types of early childhood acute lymphoblastic leukemia

scientific article published in April 2000

Prognostic factors in adult patients up to 60 years old with acute myeloid leukemia and translocations of chromosome band 11q23: individual patient data-based meta-analysis of the German Acute Myeloid Leukemia Intergroup

scientific article

Prognostic significance of minimal residual disease in infants with acute lymphoblastic leukemia treated within the Interfant-99 protocol.

scientific article published on 12 February 2009

RNA polymerase III catalysed transcription can be regulated in Saccharomyces cerevisiae by the bacterial tetracycline repressor-operator system

scientific article published on April 1992

Rapid isolation of chromosomal breakpoints from patients with t(4;11) acute lymphoblastic leukemia: implications for basic and clinical research.

scientific article

Re: Acute myeloid leukemia associated with FGFR1 abnormalities

scientific article published on 7 June 2013

Recombination at chromosomal sequences involved in leukaemogenic rearrangements is differentially regulated by p53.

scientific article published on 23 January 2004

Refinement of IKZF1 recombination hotspots in pediatric BCP-ALL patients

scientific article published on 5 May 2013

Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia

scientific article

Secondary acute monocytic leukemia positive for 11q23 rearrangement in Nijmegen breakage syndrome

scientific article published on 11 March 2014

Secondary mutations in t(4;11) leukemia patients

scientific article published on 14 December 2012

Spliced MLL fusions: a novel mechanism to generate functional chimeric MLL-MLLT1 transcripts in t(11;19)(q23;p13.3) leukemia.

scientific article

Structure of DRE, a retrotransposable element which integrates with position specificity upstream of Dictyostelium discoideum tRNA genes

scientific article published on January 1992

Structure of the promoter region of the gene encoding cytochrome c oxidase subunit V in Dictyostelium.

scientific article published on February 1993

Subclonality and prenatal origin ofRASmutations inKMT2A (MLL)-rearranged infant acute lymphoblastic leukaemia

scientific article published on 22 January 2015

Submicroscopic deletion of FGFR1 gene is recurrently detected in myeloid and lymphoid neoplasms associated with ZMYM2-FGFR1 rearrangements: a case study

scientific article

TEL/AML1-positive patients lacking TEL exon 5 resemble canonical TEL/AML1 cases.

scientific article

TOP3A, a new partner gene fused to MLL in an adult patient with de novo acute myeloid leukaemia

article

Temperature sensitive synthesis of transfer RNAs in vivo in Saccharomyces cerevisiae

scientific article

The AF4.MLL fusion protein is capable of inducing ALL in mice without requirement of MLL.AF4.

scientific article

The Dictyostelium discoideum 5S rDNA is organized in the same transcriptional orientation as the other rDNAs

scientific article published in March 1993

The MLL recombinome of acute leukemias

scientific article published on 01 May 2006

The MLL recombinome of acute leukemias in 2013.

scientific article

The MLL recombinome of acute leukemias in 2017.

scientific article published on 13 July 2017

The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group

scientific article published on 14 January 2009

The acute lymphoblastic leukaemia cell line SEM with t(4;11) chromosomal rearrangement is biphenotypic and responsive to interleukin-7.

scientific article published on February 1994

The distribution of MLL breakpoints correlates with outcome in infant acute leukaemia.

scientific article published on 21 February 2013

The heterodimerization domains of MLL-FYRN and FYRC--are potential target structures in t(4;11) leukemia

scientific article published on 14 January 2011

The human ALL-1/MLL/HRX antigen is predominantly localized in the nucleus of resting and proliferating peripheral blood mononuclear cells.

scientific article

The leukemogenic AF4-MLL fusion protein causes P-TEFb kinase activation and altered epigenetic signatures.

scientific article

The role of reciprocal fusions in MLL-r acute leukemia: studying the chromosomal translocation t(4;11)

scientific article published on 06 September 2021

The structure of the human ALL-1/MLL/HRX gene.

scientific article

Therapy-related acute myeloid leukemia with t(2;11)(q37;q23) after treatment for osteosarcoma.

scientific article

Three-way translocation involving MLL, MLLT1, and a novel third partner, NRXN1, in a patient with acute lymphoblastic leukemia and t(2;19;11) (p12;p13.3;q23).

scientific article published in February 2010

Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells.

scientific article

Transfer RNA genes from Dictyostelium discoideum are frequently associated with repetitive elements and contain consensus boxes in their 5' and 3'-flanking regions

scientific article

Transfer RNA genes: landmarks for integration of mobile genetic elements in Dictyostelium discoideum

scientific article

Translokationen des MLL-Gens

scientific article published on 01 May 2012

Two distinct subforms of the retrotransposable DRE element in NC4 strains of Dictyostelium discoideum

scientific article published on December 1992

Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients.

scientific article published on 25 June 2009

Unique BHLHB3 overexpression in pediatric acute myeloid leukemia with t(6;11)(q27;q23).

scientific article published on 24 February 2014

Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4-MLL Fusion Protein

scientific article

tRNAGlu(GAA) genes from the cellular slime mold Dictyostelium discoideum

scientific article

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