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List of works by Wayne A. Phillips

A central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma.

scientific article

A simple micro-assay for neutrophil bactericidal activity ⬇️

scientific article published on January 1, 1979

A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition

scientific article published in December 2006

APR-246 potently inhibits tumour growth and overcomes chemoresistance in preclinical models of oesophageal adenocarcinoma

scientific article published on 17 July 2015

Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia

scientific article

Activating BRAF and PIK3CA mutations cooperate to promote anaplastic thyroid carcinogenesis

scientific article

Activation and proliferation signals in murine macrophages: Relationships among c-fos and c-myc expression, phosphoinositide hydrolysis, superoxide formation, and DNA synthesis

scientific article published in December 1989

Activation of protein kinase C augments butyrate-induced differentiation and turnover in human colonic epithelial cells in vitro

scientific article published in June 1999

Activation of the macrophage respiratory burst by phorbol myristate acetate: evidence for both tyrosine-kinase-dependent and -independent pathways

scientific article published on 01 June 1994

Activation of the respiratory burst in macrophages. Phosphorylation specifically associated with Fc receptor-mediated stimulation ⬇️

scientific article published on September 1, 1988

Advances in understanding the pathogenesis of Barrett's esophagus

scientific article

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

scientific article published on 3 January 2012

Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells

scientific article published on April 2014

Autophosphorylation of serine 608 in the p85 regulatory subunit of wild type or cancer-associated mutants of phosphoinositide 3-kinase does not affect its lipid kinase activity

scientific article published on 27 December 2012

Barrett's esophagus

article

Barrett's esophagus: cancer and molecular biology.

scientific article published on October 2013

Changes in the incorporation of free fatty acids upon the stimulation of human polymorphonuclear leukocytes

scientific article published on 01 March 1986

Characterization of a novel tumorigenic esophageal adenocarcinoma cell line: OANC1.

scientific article published on January 2014

Colony stimulating factor-1 is a negative regulator of the macrophage respiratory burst.

scientific article

Combined CDK4/6 and PI3Kα Inhibition Is Synergistic and Immunogenic in Triple-Negative Breast Cancer

scientific article

Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo.

scientific article

Copper as a target for prostate cancer therapeutics: copper-ionophore pharmacology and altering systemic copper distribution.

scientific article published on 09 May 2016

Correlations between histopathological diagnosis of chemotherapy-induced hepatic injury, clinical features, and perioperative morbidity

scientific article

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers

scientific article

Developing a Quantitative In Vivo Tissue Reconstitution Assay to Assess the Relative Potency of Candidate Populations of Mouse Oesophageal Epithelial Cells ⬇️

scientific article published on January 1, 2012

Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma.

scientific article

Differential hypermethylation of SOCS genes in ovarian and breast carcinomas.

scientific article

Effect of ammonium chloride treatment on human polymorphonuclear leucocyte iodination

scientific article published on July 1983

Elevation of fatty acid desaturase 2 in esophageal adenocarcinoma increases polyunsaturated lipids and may exacerbate bile acid-induced DNA damage ⬇️

scientific article published on 01 May 2022

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

scientific article published in 2022

Esophageal stem cells and genetics/epigenetics in esophageal cancer

scientific article published on 01 September 2014

Esophageal stem cells--a review of their identification and characterization

scientific article published on 05 August 2008

Evaluation of Serum Glycoprotein Biomarker Candidates for Detection of Esophageal Adenocarcinoma and Surveillance of Barrett's Esophagus

scientific article published on 10 August 2018

Expression of Wnt genes in human colon cancers

scientific article published on May 2001

Expression of interleukin-6, leukemia inhibitory factor and their receptors by colonic epithelium and pericryptal fibroblasts

scientific article published on 01 September 2001

Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth

scientific article

Functional abnormalities in protein tyrosine phosphatase epsilon-deficient macrophages

scientific article published in August 2001

Gene expression profiling of esophageal cancer: comparative analysis of Barrett's esophagus, adenocarcinoma, and squamous cell carcinoma

scientific article published on May 2007

Genetic and epigenetic analysis of the putative tumor suppressor km23 in primary ovarian, breast, and colorectal cancers.

scientific article

Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.

scientific article

HOXA13 in etiology and oncogenic potential of Barrett’s esophagus

scientific article published on 7 June 2021

Haematopoietic colony stimulating factors CSF-1 and GM-CSF increase phosphatidylinositol 3-kinase activity in murine bone marrow-derived macrophages

scientific article published on January 1994

Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects

scientific article published on 7 May 2015

Human perforin mutations and susceptibility to multiple primary cancers

scientific article

Id2 is a target of the beta-catenin/T cell factor pathway in colon carcinoma

scientific article

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth

scientific article published on 26 March 2018

Identification of candidate murine esophageal stem cells using a combination of cell kinetic studies and cell surface markers

scientific article

Identification of microRNA Biomarkers of Response to Neoadjuvant Chemoradiotherapy in Esophageal Adenocarcinoma Using Next Generation Sequencing

scientific article published on 09 July 2018

Identification of the CIMP-like subtype and aberrant methylation of members of the chromosomal segregation and spindle assembly pathways in esophageal adenocarcinoma

scientific article published on 10 February 2016

Inhibiting system xC- and glutathione biosynthesis - a potential Achilles' heel in mutant-p53 cancers.

scientific article published on 5 July 2017

Inhibiting the system xC-/glutathione axis selectively targets cancers with mutant-p53 accumulation

scientific article published on 28 March 2017

Intramuscular Transplantation Improves Engraftment Rates for Esophageal Patient-Derived Tumor Xenografts

scientific article published on 18 February 2015

Lipopolysaccharide- and interferon-gamma-induced expression of hck and lyn tyrosine kinases in murine bone marrow-derived macrophages

scientific article published on April 1992

Lipopolysaccharide-induced priming of the human neutrophil is not associated with a change in phosphotyrosine phosphatase activity

scientific article published on 01 May 1999

Loss of SMAD4 Is Sufficient to Promote Tumorigenesis in a Model of Dysplastic Barrett's Esophagus

scientific article published on 25 March 2021

Methylation of exon 2 of p16 is associated with late stage oesophageal cancer

scientific article published on 01 March 2000

Microsatellite instability in gastrointestinal tract tumours.

scientific article

Molecular biology of anal squamous cell carcinoma: implications for future research and clinical intervention.

scientific article published on December 2015

Molecular changes in the phosphatidylinositide 3-kinase (PI3K) pathway are common in gastric cancer.

scientific article published on 28 June 2013

Molecular epidemiology of and genetic susceptibility to esophageal cancer.

scientific article published in September 2014

Mouse Models for Exploring the Biological Consequences and Clinical Significance of PIK3CA Mutations

scientific article published on 23 April 2019

Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus

scientific article published on 01 May 2006

Mutation of the PIK3CA gene in ovarian and breast cancer

scientific article published on 01 November 2004

Mutationally activated PIK3CA(H1047R) cooperates with BRAF(V600E) to promote lung cancer progression.

scientific article published on 09 September 2013

Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers

scientific article published on December 2006

Novel metastatic models of esophageal adenocarcinoma derived from FLO-1 cells highlight the importance of E-cadherin in cancer metastasis

scientific article

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

scientific article

PI3'-kinase inhibition forestalls the onset of MEK1/2 inhibitor resistance in BRAF-mutated melanoma.

scientific article

PI3K Activation in Neural Stem Cells Drives Tumorigenesis which can be Ameliorated by Targeting the cAMP Response Element Binding (CREB) Protein.

scientific article

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer

scientific article

PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical data

scientific article (publication date: 23 January 2014)

PIK3CA mutations in ovarian cancer.

scientific article

Phorbol ester-stimulated superoxide production by murine bone marrow-derived macrophages requires preexposure to cytokines

scientific article

Phosphotyrosine phosphatase activity in the macrophage is enhanced by lipopolysaccharide, tumor necrosis factor alpha, and granulocyte/macrophage-colony stimulating factor: correlation with priming of the respiratory burst

scientific article published on 01 March 1997

Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice.

scientific article

Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors

scientific article (publication date: 2012)

Predicting pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a systematic review

scientific article

Pretreatment gene expression profiles can be used to predict response to neoadjuvant chemoradiotherapy in esophageal cancer.

scientific article

Pretreatment transcriptional profiling for predicting response to neoadjuvant chemoradiotherapy in rectal adenocarcinoma

scientific article published on 11 January 2011

Protein kinase C has both stimulatory and suppressive effects on macrophage superoxide production

scientific article published in July 1992

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.

scientific article

Reconstitution of stratified murine and human oesophageal epithelia in an in vivo transplant culture system

scientific article published on January 2008

Recurrent and persistent infections in related Weimaraner dogs

scientific article published on 01 August 1984

Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.

scientific article published on February 2004

Removal of contaminating erythrocytes from human polymorphonuclear leucocyte preparations

scientific article published on 01 November 1983

Role of YopD in the virulence of Yersinia enterocolitica

scientific article published on January 1995

Role of YopH in the suppression of tyrosine phosphorylation and respiratory burst activity in murine macrophages infected with Yersinia enterocolitica

scientific article published on June 1995

ST7-mediated suppression of tumorigenicity of prostate cancer cells is characterized by remodeling of the extracellular matrix

scientific journal article

Salvage Surgery for Locoregional Failure in Anal Squamous Cell Carcinoma

scientific article published in February 2018

Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferation

scientific article

Selective inhibition of proliferation in colorectal carcinoma cell lines expressing mutant APC or activated B-Raf

scientific article

Separation and detection of nitroblue tetrazolium-reducing enzymes from human polymorphonuclear leukocytes

scientific article published on 01 October 1982

Short-chain fatty acids reduce expression of specific protein kinase C isoforms in human colonic epithelial cells

scientific article

Signaling pathways in the molecular pathogenesis of adenocarcinomas of the esophagus and gastroesophageal junction

scientific article

Single-step direct PCR amplification from solid tissues ⬇️

scientific article

Sodium butyrate-induced differentiation of human LIM2537 colon cancer cells decreases GSK-3beta activity and increases levels of both membrane-bound and Apc/axin/GSK-3beta complex-associated pools of beta-catenin

scientific article published on January 2000

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans

scientific article published on March 2016

Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett's esophagus.

scientific article published on 11 October 2012

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

scientific article published on 3 September 2013

Targeting PI3 kinase/AKT/mTOR signaling in cancer.

scientific article published on January 2012

The Genetics of Barrett's Esophagus: A Familial and Population-Based Perspective

scientific article published on 12 March 2016

The developing clinical problem of chemotherapy-induced hepatic injury

scientific article published on 17 May 2011

The effect of interleukin-4 on the macrophage respiratory burst is species dependent

scientific article published in January 1992

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis

scientific article

The ras/mitogen-activated protein kinase pathway inhibitor and likely tumor suppressor proteins, sprouty 1 and sprouty 2 are deregulated in breast cancer.

scientific article published on September 2004

Translational research on Barrett's esophagus.

scientific article published in September 2014

Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly.

scientific article

Using gene expression profiling to predict response and prognosis in gastrointestinal cancers-the promise and the perils

scientific article

Zymosan-triggered tyrosine phosphorylation in mouse bone-marrow-derived macrophages is enhanced by respiratory-burst priming agents ⬇️

scientific article published on December 1, 1992

mRNA gene expression correlates with histologically diagnosed chemotherapy-induced hepatic injury

scientific article published on 2 August 2011

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