List of works - Patrick Kiser

"Set it and forget it": women's perceptions and opinions of long-acting topical vaginal gels

scientific article

A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis

scientific article

A Perspective on Progress and Gaps in HIV Prevention Science ⬇️

scientific article published on November 1, 2012

A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques

scientific article published on 21 February 2020

A hot-melt extruded intravaginal ring for the sustained delivery of the antiretroviral microbicide UC781.

scientific article published on 4 October 2011

A phase 1 randomized placebo-controlled safety and pharmacokinetic trial of a tenofovir disoproxil fumarate vaginal ring.

scientific article published on 24 November 2015

A synthetic mimic of the secretory granule for drug delivery

scientific article published in Nature

Activity and safety of synthetic lectins based on benzoboroxole-functionalized polymers for inhibition of HIV entry.

scientific article

Advances in microbicide vaginal rings

scientific article published on December 2010

An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV Transmission

scientific article published on 6 July 2015

Approaches to improve the stability of the antiviral agent UC781 in aqueous solutions

scientific article published on 25 May 2010

Are reduction potentials of antifungal agents relevant to activity?

scientific article published on 01 March 1990

Assessment of topical microbicides to prevent HIV-1 transmission: concepts, testing, lessons learned

scientific article published on 08 July 2013

Chemorheology of phenylboronate-salicylhydroxamate crosslinked hydrogel networks with a sulfonated polymer backbone

scientific article published on November 2008

Controlling the hydration rate of a hydrophilic matrix in the core of an intravaginal ring determines antiretroviral release

scientific article published on 23 December 2015

Design of a Drug-Eluting Subcutaneous Implant of the Antiretroviral Tenofovir Alafenamide Fumarate

scientific article published on 15 April 2020

Design of a semisolid vaginal microbicide gel by relating composition to properties and performance

scientific article published on 15 September 2010

Design of tenofovir-UC781 combination microbicide vaginal gels

scientific article published on 22 February 2012

Designing preclinical perceptibility measures to evaluate topical vaginal gel formulations: relating user sensory perceptions and experiences to formulation properties

scientific article published on 09 December 2013

Development of a Combination Microbicide Gel Formulation Containing IQP-0528 and Tenofovir for the Prevention of HIV Infection ⬇️

scientific article published on January 6, 2012

Differential Mechanisms of Tenofovir and Tenofovir Disoproxil Fumarate Cellular Transport and Implications for Topical Preexposure Prophylaxis.

scientific article published on 28 December 2015

Electrochemistry of Cu(I) bipyridyl complexes with alkene, alkyne, and nitrile ligands. Implications for plant hormone action of ethylene

scientific article published on 01 January 1991

Electrochemistry of anticonvulsants: electron transfer as a possible mode of action

scientific article published on 01 September 1992

Engineering a degradable polyurethane intravaginal ring for sustained delivery of dapivirine

scientific article published on 01 June 2011

Engineering a segmented dual-reservoir polyurethane intravaginal ring for simultaneous prevention of HIV transmission and unwanted pregnancy

scientific article (publication date: 2014)

Engineering and characterization of simplified vaginal and seminal fluid simulants.

scientific article published on 13 November 2015

Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles.

scientific article

Human cervicovaginal mucus contains an activity that hinders HIV-1 movement.

scientific article

Increases in Endogenous or Exogenous Progestins Promote Virus-Target Cell Interactions within the Non-human Primate Female Reproductive Tract

scientific article

Inhibition of the transport of HIV in vitro using a pH-responsive synthetic mucin-like polymer system

scientific article

Intravaginal flux controlled pump for sustained release of macromolecules

scientific article published on 2 May 2014

Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges

scientific article published on 16 September 2013

Lipid-coated microgels for the triggered release of doxorubicin

scientific article published in July 2000

Measuring macrodiffusion coefficients in microbicide hydrogels via postphotoactivation scanning

scientific article published on 15 January 2008

Modulation of Viscoelasticity and HIV Transport as a Function of pH in a Reversibly Crosslinked Hydrogel

scientific article

Multipurpose prevention technologies: products in development

scientific article

Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors.

scientific article

Novel preclinical models of topical PrEP pharmacodynamics provide rationale for combination of drugs with complementary properties

scientific article published on 24 October 2013

Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use.

scientific article

Pharmacokinetics of UC781-loaded intravaginal ring segments in rabbits: a comparison of polymer matrices

scientific article

Polyurethane intravaginal ring for controlled delivery of dapivirine, a nonnucleoside reverse transcriptase inhibitor of HIV-1.

scientific article published in October 2008

Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir.

scientific article published on 7 September 2012

Safe and sustained vaginal delivery of pyrimidinedione HIV-1 inhibitors from polyurethane intravaginal rings

scientific article published on 12 December 2011

Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir

scientific article published in December 2009

Site-specific cross-linking of proteins through tyrosine hexahistidine tags

scientific article

Specific covalent immobilization of proteins through dityrosine cross-links

scientific article published in December 2006

Spectroelectrochemical titrations and cyclic voltammetry of methyl pheophorbide in acid: Possible role of pheophytin enol iminium in the primary process of PS II

Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles

scientific article published on 01 March 2007

Tenofovir disoproxil fumarate intravaginal ring protects high-dose depot medroxyprogesterone acetate-treated macaques from multiple SHIV exposures.

scientific article

The Promise of Intravaginal Rings for Prevention: User Perceptions of Biomechanical Properties and Implications for Prevention Product Development

scientific article

The Vaginal Acquisition and Dissemination of HIV-1 Infection in a Novel Transgenic Mouse Model Is Facilitated by Coinfection with Herpes Simplex Virus 2 and Is Inhibited by Microbicide Treatment.

scientific article

Theoretical calculations on calcium channel drugs: is electron transfer involved mechanistically?

scientific article published on 01 January 1990

Vaginal microbicide gel for delivery of IQP-0528, a pyrimidinedione analog with a dual mechanism of action against HIV-1.

scientific article

Vaginally delivered tenofovir disoproxil fumarate provides greater protection than tenofovir against genital herpes in a murine model of efficacy and safety.

scientific article published on 09 December 2013

List of works by Patrick Kiser

"Set it and forget it": women's perceptions and opinions of long-acting topical vaginal gels

A 90-day tenofovir reservoir intravaginal ring for mucosal HIV prophylaxis

A Perspective on Progress and Gaps in HIV Prevention Science ⬇️

A Subcutaneous Implant of Tenofovir Alafenamide Fumarate Causes Local Inflammation and Tissue Necrosis in Rabbits and Macaques

A hot-melt extruded intravaginal ring for the sustained delivery of the antiretroviral microbicide UC781.

A phase 1 randomized placebo-controlled safety and pharmacokinetic trial of a tenofovir disoproxil fumarate vaginal ring.

A synthetic mimic of the secretory granule for drug delivery

Activity and safety of synthetic lectins based on benzoboroxole-functionalized polymers for inhibition of HIV entry.

Advances in microbicide vaginal rings

An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV Transmission

Approaches to improve the stability of the antiviral agent UC781 in aqueous solutions

Are reduction potentials of antifungal agents relevant to activity?

Assessment of topical microbicides to prevent HIV-1 transmission: concepts, testing, lessons learned

Chemorheology of phenylboronate-salicylhydroxamate crosslinked hydrogel networks with a sulfonated polymer backbone

Controlling the hydration rate of a hydrophilic matrix in the core of an intravaginal ring determines antiretroviral release

Design of a Drug-Eluting Subcutaneous Implant of the Antiretroviral Tenofovir Alafenamide Fumarate

Design of a semisolid vaginal microbicide gel by relating composition to properties and performance

Design of tenofovir-UC781 combination microbicide vaginal gels

Designing preclinical perceptibility measures to evaluate topical vaginal gel formulations: relating user sensory perceptions and experiences to formulation properties

Development of a Combination Microbicide Gel Formulation Containing IQP-0528 and Tenofovir for the Prevention of HIV Infection ⬇️

Differential Mechanisms of Tenofovir and Tenofovir Disoproxil Fumarate Cellular Transport and Implications for Topical Preexposure Prophylaxis.

Electrochemistry of Cu(I) bipyridyl complexes with alkene, alkyne, and nitrile ligands. Implications for plant hormone action of ethylene

Electrochemistry of anticonvulsants: electron transfer as a possible mode of action

Engineering a degradable polyurethane intravaginal ring for sustained delivery of dapivirine

Engineering a segmented dual-reservoir polyurethane intravaginal ring for simultaneous prevention of HIV transmission and unwanted pregnancy

Engineering and characterization of simplified vaginal and seminal fluid simulants.

Enzymatic triggered release of an HIV-1 entry inhibitor from prostate specific antigen degradable microparticles.

Human cervicovaginal mucus contains an activity that hinders HIV-1 movement.

Increases in Endogenous or Exogenous Progestins Promote Virus-Target Cell Interactions within the Non-human Primate Female Reproductive Tract

Inhibition of the transport of HIV in vitro using a pH-responsive synthetic mucin-like polymer system

Intravaginal flux controlled pump for sustained release of macromolecules

Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges

Lipid-coated microgels for the triggered release of doxorubicin

Measuring macrodiffusion coefficients in microbicide hydrogels via postphotoactivation scanning

Modulation of Viscoelasticity and HIV Transport as a Function of pH in a Reversibly Crosslinked Hydrogel

Multipurpose prevention technologies: products in development

Multivalent benzoboroxole functionalized polymers as gp120 glycan targeted microbicide entry inhibitors.

Novel preclinical models of topical PrEP pharmacodynamics provide rationale for combination of drugs with complementary properties

Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use.

Pharmacokinetics of UC781-loaded intravaginal ring segments in rabbits: a comparison of polymer matrices

Polyurethane intravaginal ring for controlled delivery of dapivirine, a nonnucleoside reverse transcriptase inhibitor of HIV-1.

Quantitative evaluation of a hydrophilic matrix intravaginal ring for the sustained delivery of tenofovir.

Safe and sustained vaginal delivery of pyrimidinedione HIV-1 inhibitors from polyurethane intravaginal rings

Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir

Site-specific cross-linking of proteins through tyrosine hexahistidine tags

Specific covalent immobilization of proteins through dityrosine cross-links

Spectroelectrochemical titrations and cyclic voltammetry of methyl pheophorbide in acid: Possible role of pheophytin enol iminium in the primary process of PS II

Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles

Tenofovir disoproxil fumarate intravaginal ring protects high-dose depot medroxyprogesterone acetate-treated macaques from multiple SHIV exposures.

The Promise of Intravaginal Rings for Prevention: User Perceptions of Biomechanical Properties and Implications for Prevention Product Development

The Vaginal Acquisition and Dissemination of HIV-1 Infection in a Novel Transgenic Mouse Model Is Facilitated by Coinfection with Herpes Simplex Virus 2 and Is Inhibited by Microbicide Treatment.

Theoretical calculations on calcium channel drugs: is electron transfer involved mechanistically?

Vaginal microbicide gel for delivery of IQP-0528, a pyrimidinedione analog with a dual mechanism of action against HIV-1.

Vaginally delivered tenofovir disoproxil fumarate provides greater protection than tenofovir against genital herpes in a murine model of efficacy and safety.