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List of works by John W Upham

A Charter to Improve Patient Care in Severe Asthma

scientific article published on 04 September 2018

Activated human dendritic cells express inducible cyclo-oxygenase and synthesize prostaglandin E2 but not prostaglandin D2.

scientific article published in February 2004

Acute exercise is associated with reduced exhaled nitric oxide in physically inactive adults with asthma

scientific article published on 29 April 2015

Adaptive immunity to rhinoviruses: sex and age matter

scientific article

Adenovirus species C is associated with chronic suppurative lung diseases in children

scientific article

Aeroallergen-induced IL-33 predisposes to respiratory virus-induced asthma by dampening antiviral immunity

scientific article published on 25 April 2016

Airway cells from protracted bacterial bronchitis and bronchiectasis share similar gene expression profiles.

scientific article published on 24 March 2018

Airway dendritic cells: co-ordinators of immunological homeostasis and immunity in the respiratory tract

scientific article

Airway dysbiosis: Haemophilus influenzae and Tropheryma in poorly controlled asthma.

scientific article published on 2 December 2015

Airway epithelial cells condition dendritic cells to express multiple immune surveillance genes

scientific article

Airway epithelial cells regulate the functional phenotype of locally differentiating dendritic cells: implications for the pathogenesis of infectious and allergic airway disease.

scientific article

Allergen-enhanced thrombomodulin (blood dendritic cell antigen 3, CD141) expression on dendritic cells is associated with a TH2-skewed immune response

article

Altered sputum granzyme B and granzyme B/proteinase inhibitor-9 in patients with non-eosinophilic asthma.

scientific article published on 23 December 2013

Alveolar macrophages and CC chemokines are increased in children with cystic fibrosis.

scientific article published on 22 April 2009

Alveolar macrophages from humans and rodents selectively inhibit T-cell proliferation but permit T-cell activation and cytokine secretion

scientific article published on 01 January 1995

An immunodiagnostic assay for quantitation of specific IgE to the major pollen allergen component, Pas n 1, of the subtropical Bahia grass

scientific article published on 01 January 2014

Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β.

scientific article

Are rhinoviral proteinases responsible for mixed T(H)1 and T(H)2 immunity in chronic obstructive pulmonary disease?

scientific article published on 14 August 2010

Asthma is associated with multiple alterations in anti-viral innate signalling pathways

scientific article

Basic science funding in Australia: lessons from the EU

scientific article published on 01 October 2002

Biogeographical variation in specific IgE recognition of temperate and subtropical grass pollen allergens in allergic rhinitis patients

scientific article published on 03 February 2020

Blood cytotoxic/inflammatory mediators in non-eosinophilic asthma.

scientific article

Bronchiectasis in Children: Current Concepts in Immunology and Microbiology

scientific article

Bronchoscopy contributes to the clinical management of indigenous children newly diagnosed with bronchiectasis.

scientific article published on 19 March 2012

Budesonide and formoterol reduce early innate anti-viral immune responses in vitro

scientific article

CLEC4C gene expression can be used to quantify circulating plasmacytoid dendritic cells

article

Can biomarkers help us hit targets in difficult-to-treat asthma?

scientific article published on March 2017

Children with chronic suppurative lung disease have a reduced capacity to synthesize interferon-gamma in vitro in response to non-typeable Haemophilus influenzae.

scientific article

Chronic IL-33 expression predisposes to viral-induced exacerbations of asthma by increasing type-2 inflammation and dampening antiviral immunity

scientific article published on 22 September 2017

Clinical factors associated with the humoral immune response to influenza vaccination in chronic obstructive pulmonary disease

scientific article published on 24 December 2013

Contemporaneous maturation of immunologic and respiratory functions during early childhood: implications for development of asthma prevention strategies

scientific article

Contemporary Concise Review 2018: Asthma and chronic obstructive pulmonary disease

scientific article published on 03 April 2019

Critical Role of Plasmacytoid Dendritic Cells in Regulating Gene Expression and Innate Immune Responses to Human Rhinovirus-16.

scientific article published on 25 October 2017

Cytokine responses to two common respiratory pathogens in children are dependent on interleukin-1β.

scientific article published on 2 October 2017

Cytosine-phosphate-guanine motifs fail to promote T-helper type 1-polarized responses in human neonatal mononuclear cells

article

Dendritic Cells in Human Lung Disease: Recent Advances

scientific article

Dendritic cell immaturity during infancy restricts the capacity to express vaccine-specific T-cell memory

scientific article

Dendritic cell maturation and IL-12 synthesis induced by the synthetic immune-response modifier S-28463

scientific article published on 01 November 2002

Dendritic cells infected with a vaccinia virus interleukin-2 vector secrete high levels of IL-2 and can become efficient antigen presenting cells that secrete high levels of the immunostimulatory cytokine IL-12.

scientific article published in August 2003

Development of interleukin-12-producing capacity throughout childhood

scientific article

Direct oral anticoagulants for cancer associated venous thromboembolisms: a systematic review and network meta-analysis

scientific article published on 08 September 2020

Dystonic reaction to metoclopramide

scientific article published on 01 January 1983

Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial.

scientific article

Effectiveness and response predictors of omalizumab in a severe allergic asthma population with a high prevalence of comorbidities: the Australian Xolair Registry.

scientific article published on 28 June 2016

Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: A test-negative case control study

article

Effects of interleukin-6 receptor blockade on allergen-induced airway responses in mild asthmatics.

scientific article

Environment and development of atopy

scientific article

Environmental exposures and innate immunity in the lung

scientific article published on January 2014

Epithelial-dendritic cell interactions in allergic disorders

scientific article

Full blood count parameters for the detection of asthma inflammatory phenotypes.

scientific article published in September 2014

Functional analysis of human bronchial mucosal T cells extracted with interleukin-2.

scientific article published in June 1994

Functional immunoglobulin E cross-reactivity between Pas n 1 of Bahia grass pollen and other group 1 grass pollen allergens

scientific article published on 01 February 2011

Functional maturation of CD4+CD25+CTLA4+CD45RA+ T regulatory cells in human neonatal T cell responses to environmental antigens/allergens.

scientific article published in September 2004

HLA-DR expression on neonatal monocytes is associated with allergen-specific immune responses

scientific article published on 01 November 2004

HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling

scientific article published on 13 July 2020

High Pulmonary Levels of IL-6 and IL-1β in Children with Chronic Suppurative Lung Disease Are Associated with Low Systemic IFN-γ Production in Response to Non-Typeable Haemophilus influenzae.

scientific article published on 12 June 2015

Higher prostaglandin e2 production by dendritic cells from subjects with asthma compared with normal subjects

scientific article

Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma

scientific article published on October 2016

IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice

scientific article published on 13 April 2014

IgE+ B cells are scarce, but allergen-specific B cells with a memory phenotype circulate in patients with allergic rhinitis.

scientific article published on 2 February 2015

Impaired macrophage phagocytosis in non-eosinophilic asthma.

scientific article published in January 2013

Improving immunity to Haemophilus influenzae in children with chronic suppurative lung disease.

scientific article published on 22 November 2014

Increased Peripheral Blood Pro-Inflammatory/Cytotoxic Lymphocytes in Children with Bronchiectasis

scientific article published on 10 August 2015

Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology.

scientific article published on 4 May 2017

Influenza epidemiology in patients admitted to sentinel Australian hospitals in 2015: the Influenza Complications Alert Network.

scientific article

Influenza epidemiology, vaccine coverage and vaccine effectiveness in children admitted to sentinel Australian hospitals in 2014: the Influenza Complications Alert Network (FluCAN).

scientific article published on July 2016

Influenza epidemiology, vaccine coverage and vaccine effectiveness in sentinel Australian hospitals in 2012: the Influenza Complications Alert Network (FluCAN).

scientific article published on 30 September 2013

Influenza epidemiology, vaccine coverage and vaccine effectiveness in sentinel Australian hospitals in 2013: the Influenza Complications Alert Network.

scientific article published on 30 June 2014

Influenza vaccine effectiveness against hospitalisation with confirmed influenza in the 2010-11 seasons: a test-negative observational study

scientific article

Inhalant allergen-specific T-cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum-free medium

article

Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis

scientific article (publication date: 27 January 2016)

Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis

scientific article

Innate IFNs and plasmacytoid dendritic cells constrain Th2 cytokine responses to rhinovirus: a regulatory mechanism with relevance to asthma

scientific article published on 18 May 2012

Innate interferons inhibit allergen and microbial specific T(H)2 responses

scientific article published on 24 July 2012

Interactions between airway epithelial cells and dendritic cells: implications for the regulation of airway inflammation

scientific article

Interferon alpha and doxorubicin in malignant mesothelioma: a phase II study

scientific article published on 01 December 1993

Interleukin 33 Selectively Augments Rhinovirus-Induced Type 2 Immune Responses in Asthmatic but not Healthy People

article

Investigation of pleural effusion: the role of bronchoscopy

scientific article published on 01 February 1992

Is Alveolar Macrophage Phagocytic Dysfunction in Children With Protracted Bacterial Bronchitis a Forerunner to Bronchiectasis?

scientific article

Long-Term Azithromycin Reduces Haemophilus influenzae and Increases Antibiotic Resistance in Severe Asthma

scientific article published on 01 August 2019

Management of hypoxaemic respiratory failure in a Respiratory High-dependency Unit.

scientific article published on 22 February 2017

Managing patients with severe asthma in Australia: Current challenges with the existing models of care

scientific article published on 01 December 2018

Maternal reactivity to fetal alloantigens is related to newborn immune responses and subsequent allergic disease

scientific article published on 01 April 2005

Mediators of neutrophil function in children with protracted bacterial bronchitis

scientific article published in October 2014

Monocytes from children with clinically stable cystic fibrosis show enhanced expression of Toll-like receptor 4

article

Neonatal interleukin-12 capacity is associated with variations in allergen-specific immune responses in the neonatal and postnatal periods

article

Optimising treatment for severe asthma

scientific article published on 01 July 2018

PBB: definition, mechanisms, and treatment.

scientific article published on 18 August 2015

PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production

scientific article

Periostin levels and eosinophilic inflammation in poorly-controlled asthma

scientific article

Plasmacytoid dendritic cells during infancy are inversely associated with childhood respiratory tract infections and wheezing

article

Plasmacytoid dendritic cells protect from viral bronchiolitis and asthma through semaphorin 4a-mediated T reg expansion

scientific article published on 22 December 2017

Postnatal Development of Monocyte Cytokine Responses to Bacterial Lipopolysaccharide

article

Presence of atopy increases the risk of asthma relapse

scientific article published on 11 October 2017

Prospective characterization of protracted bacterial bronchitis in children.

scientific article published on June 2014

Protracted Bacterial Bronchitis in Children: Natural History and Risk Factors for Bronchiectasis.

scientific article published on 8 July 2016

Protracted bacterial bronchitis: The last decade and the road ahead

scientific article

Pulmonary innate immunity in children with protracted bacterial bronchitis

scientific article published on 9 May 2012

RAGE deficiency predisposes mice to virus-induced paucigranulocytic asthma

scientific article published on 18 January 2017

Rapid dendritic cell recruitment to the bronchial mucosa of patients with atopic asthma in response to local allergen challenge

scientific article published on November 2001

Rapid response of circulating myeloid dendritic cells to inhaled allergen in asthmatic subjects

scientific article published in June 2002

Rational oral corticosteroid use in adult severe asthma: A narrative review

scientific article published on 12 November 2019

Real-life effectiveness of omalizumab in severe allergic asthma above the recommended dosing range criteria.

scientific article published on 5 July 2016

Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids

scientific article published on 24 December 2015

Reduced expression of hemopoietic cytokine receptors on cord blood progenitor cells in neonates at risk for atopy

scientific article published on 01 August 1999

Reduced rhinovirus-specific antibodies are associated with acute exacerbations of chronic obstructive pulmonary disease requiring hospitalisation

scientific article

Reduced soluble receptor for advanced glycation end-products in COPD

scientific article published on 01 July 2010

Regulation of IL-5 and IL-5 receptor expression in the bone marrow of allergic asthmatics

scientific article

Regulation of IL-5 receptor on eosinophil progenitors in allergic inflammation: role of retinoic acid.

scientific article published in January 2001

Regulation of urokinase receptor expression: interpreting data in the absence of statistics

scientific article published on 01 September 2009

Remission of asthma: The next therapeutic frontier? ⬇️

scientific article published on January 11, 2011

Respiratory virus detection in nasopharyngeal aspirate versus bronchoalveolar lavage is dependent on virus type in children with chronic respiratory symptoms

scientific article published on 23 September 2013

Response

Retinoic acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cells

scientific article (publication date: February 2002)

Rhinovirus stimulated IFN-α production: how important are plasmacytoid DCs, monocytes and endosomal pH?

scientific article

Selective inhibition of T cell proliferation but not expression of effector function by human alveolar macrophages ⬇️

scientific article published on September 1, 1997

Severe Asthma Assessment, Management and the Organisation of Care in Australia and New Zealand: Expert Forum Roundtable Meetings

scientific article published on 27 February 2020

Severe asthma: Current management, targeted therapies and future directions-A roundtable report

scientific article published on 30 November 2016

Sex hormones and systemic inflammation are modulators of the obese-asthma phenotype.

scientific article published on 23 March 2016

Simplified quantitation of myeloid dendritic cells in peripheral blood using flow cytometry

scientific article published in May 2000

Soluble receptor for advanced glycation end products (sRAGE) is present at high concentrations in the lungs of children and varies with age and the pattern of lung inflammation.

scientific article published on July 2012

Sputum cytology during late-phase responses to inhalation challenge with different allergens

scientific article published on 16 January 2018

Subtropical grass pollen allergens are important for allergic respiratory diseases in subtropical regions

scientific article published on 5 March 2012

T-cell "priming" against environmental allergens in human neonates: sequential deletion of food antigen reactivity during infancy with concomitant expansion of responses to ubiquitous inhalant allergens

article

TLR3 and RIG-I gene variants: associations with functional effects on receptor expression and responses to measles virus and vaccine in vaccinated infants.

scientific article published on 12 April 2012

The Bronchial Epithelial Secretory IgA System in Asthma

scientific article published on 01 November 2018

The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population.

scientific article published on March 2005

The development of models for the evaluation of pulmonary drug disposition

scientific article published on 08 January 2013

The dominant 55 kDa allergen of the subtropical Bahia grass (Paspalum notatum) pollen is a group 13 pollen allergen, Pas n 13.

scientific article published on 26 January 2011

The plasmacytoid dendritic cell: at the cross-roads in asthma

scientific article published on 21 February 2013

The role of dendritic cells in asthma

scientific article published on February 2004

The role of dendritic cells in immune regulation and allergic airway inflammation.

scientific article

Toll-like receptor 2 ligands inhibit TH2 responses to mite allergen.

scientific article published in May 2006

Toll-like receptor 7 and 8 polymorphisms: associations with functional effects and cellular and antibody responses to measles virus and vaccine

scientific article published on 23 September 2011

Toll-like receptor 7 function is reduced in adolescents with asthma.

scientific article published on 30 July 2009

Toward making inroads in reducing the disparity of lung health in Australian indigenous and new zealand māori children

scientific article

Treatable traits can be identified in a severe asthma registry and predict future exacerbations

scientific article published on 19 September 2018

T‐cell proliferative responses to mite allergens are detectable in most individuals regardless of atopic status and age ⬇️

scientific article published on 01 June 1997

Utility of squamous cell carcinoma antigen (SCC Ag) as a tumour marker in pulmonary malignancy

scientific article published on 01 May 1992

Vitamin D in Asthma. Is the Golden Bullet Losing Its Luster?

scientific article published on March 2016

Why are dendritic cells important in allergic diseases of the respiratory tract?

scientific article published on October 2003

Working while unwell: Workplace impairment in people with severe asthma

scientific article published on 17 May 2018

Year-in-review 2009: Asthma, COPD and airway biology

scientific article published on February 2010

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