List of works by Axel Imhof

"Chromatomics" the analysis of the chromatome

scientific article published on 17 June 2005

A Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling

scientific article published on 01 August 2019

A Focus on Chromatin Proteomics

scientific article published on 01 February 2016

A Quantitative Proteomic Analysis of In Vitro Assembled Chromatin

scientific article published on 25 January 2016

A combination of different mass spectroscopic techniques for the analysis of dynamic changes of histone modifications.

scientific article

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b

scientific article

A multi-adenylate cyclase regulator at the flagellar tip controls African trypanosome transmission

scientific article published in 2022

A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation

scientific article published on 17 March 2020

A pair of centromeric proteins mediates reproductive isolation in Drosophila species

scientific article

A systemic cell cycle block impacts stage-specific histone modification profiles during Xenopus embryogenesis

scientific article published on 07 September 2021

ATM induces MacroD2 nuclear export upon DNA damage

scientific article published on 7 October 2016

Acetylation of general transcription factors by histone acetyltransferases

scientific article published on September 1997

Acf1, the largest subunit of CHRAC, regulates ISWI-induced nucleosome remodelling

scientific article published on July 2001

Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a

scientific journal article

Adrenergic Signaling Strengthens Cardiac Myocyte Cohesion

scientific article published on 13 March 2017

Altered Localization of Hybrid Incompatibility Proteins in Drosophila

scientific article published on 01 August 2019

Analysis of Histone Modifications by Mass Spectrometry

article published in 2018

Analysis of histone modifications by mass spectrometry

scientific article

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation

scientific article

Author Correction: Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1.

scientific article published on 25 February 2020

Bioinformatic analysis of proteomics data

scientific article

Biomarker discovery from body fluids using mass spectrometry

scientific article

Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly

scientific article

Cbp3?Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly

scientific article

Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells

scientific article

Characterization of the insertase for β-barrel proteins of the outer mitochondrial membrane

scientific article

Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum

scientific article published on 20 March 2020

Circadian acetylome reveals regulation of mitochondrial metabolic pathways

scientific article published on 22 January 2013

Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1.

scientific article published on 14 January 2014

Clonal analysis of Inquilinus limosus isolates from six cystic fibrosis patients and specific serum antibody response.

scientific article

Combinatorial Histone Acetylation Patterns Are Generated by Motif-Specific Reactions

scientific article

Connecting threads: epigenetics and metabolism

scientific article published in January 2012

Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity.

scientific article published on 14 June 2017

Cross-talk between type three secretion system and metabolism in Yersinia

scientific article published on 25 February 2009

DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex

scientific journal article

DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

scientific article published on 12 June 2015

DOT1A-dependent H3K76 methylation is required for replication regulation in Trypanosoma brucei

scientific article published on 31 August 2012

Data on the kinetics of in vitro assembled chromatin

scientific article

Detection of Histone Modification Dynamics during the Cell Cycle by MS-Based Proteomics

Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster

scientific article published on 3 November 2011

Df31 Protein and snoRNAs Maintain Accessible Higher-Order Structures of Chromatin

scientific article (publication date: November 2012)

Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse

scientific article published on 03 May 2022

Distinct CoREST complexes act in a cell-type-specific manner

scientific article published on 01 December 2019

Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase.

scientific article published in January 1998

Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc.

scientific article

Dynamics of adaptive microevolution of hypermutable Pseudomonas aeruginosa during chronic pulmonary infection in patients with cystic fibrosis.

scientific article

ESC, ESCL and their roles in Polycomb Group mechanisms

scientific article published on 12 January 2008

Epigenetic regulators and histone modification

scientific article published on 2 September 2006

Epigenetic reprogramming of cortical neurons through alteration of dopaminergic circuits.

scientific article

Epstein-Barr virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation

scientific article published on 3 October 2013

Establishment of histone modifications after chromatin assembly

scientific article published on 18 June 2009

Every methyl counts--epigenetic calculus

scientific article

Fast signals and slow marks: the dynamics of histone modifications

scientific article published on 03 August 2010

Fine mapping of posttranslational modifications of the linker histone H1 from Drosophila melanogaster

scientific article

From HDACi to KDACi: we need to revisit non-epigenetic pathways affected by inhibiting lysine deacetylases in therapy

scientific article

Global and specific responses of the histone acetylome to systematic perturbation

scientific article

H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation

scientific article

H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

scientific article published on 22 June 2016

HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors

scientific article published on 13 November 2006

Harmonization of quality metrics and power calculation in multi-omic studies

scientific article published on 18 June 2020

Heptad-Specific Phosphorylation of RNA Polymerase II CTD.

scientific article published in January 2016

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate.

scientific article published on 31 March 2014

Histone Modification Analysis Using Mass Spectrometry

Histone Modifications:Methods and Techniques

Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1.

scientific article published on 9 October 2002

Histone modifications--marks for gene expression?

scientific article published on January 2003

Histone modifications: an assembly line for active chromatin?

scientific article

Identification of Drosophila centromere associated proteins by quantitative affinity purification-mass spectrometry

scientific article published on 26 July 2015

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

scientific article published on 17 July 2005

Identification of novel Drosophila centromere-associated proteins

scientific article published on 14 July 2014

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

scientific article

In situ detection of histone variants and modifications in mouse brain using imaging mass spectrometry

scientific article published on 23 November 2015

Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression

scientific article

Intricate structure of the interphase chromocenter revealed by the analysis of a factor involved in species formation

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells

scientific article published on 06 May 2019

Kinetics of histone modifications during in vitro chromatin assembly

scientific article

Life span extension by targeting a link between metabolism and histone acetylation in Drosophila

scientific article published on 18 January 2016

Lipids join the post-genomic era

scientific article published on 31 October 2006

Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila

scientific article

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

scientific article

MALDI imaging mass spectrometry as a novel tool for detecting histone modifications in clinical tissue samples

scientific article published on 25 January 2016

MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility

scientific article published on 06 January 2021

MSL2 combines sensor and effector functions in homeostatic control of the Drosophila dosage compensation machinery.

scientific article published on 18 October 2012

MacroH2A histone variants maintain nuclear organization and heterochromatin architecture

scientific article

Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1.

scientific article published on 21 January 2020

Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice

scientific article published in 2021

Methylation of histone H3 lysine 9 occurs during translation.

scientific article published on 24 September 2015

Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX.

scientific article published on 13 February 2014

Modifications of the histone N-terminal domains. Evidence for an "epigenetic code"?

scientific article

Monomethylation of lysine 20 on histone H4 facilitates chromatin maturation

scientific article

Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation

scientific article published on 14 October 2021

Mouse cytomegalovirus egress protein pM50 interacts with cellular endophilin-A2

Multi-reference spectral library yields almost complete coverage of heterogeneous LC-MS/MS data sets

scholarly article published 26 August 2017

Myb-binding protein 1a (Mybbp1a) regulates levels and processing of pre-ribosomal RNA.

scientific article published on 29 May 2012

NO Augments Endothelial Reactivity by Reducing Myoendothelial Calcium Signal Spreading: A Novel Role for Cx37 (Connexin 37) and the Protein Tyrosine Phosphatase SHP-2.

scientific article published on 12 October 2017

New Approaches for Absolute Quantification of Stable-Isotope-Labeled Peptide Standards for Targeted Proteomics based on a UV Active Tag

scientific article published on 08 April 2020

Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma

scientific article published on 29 March 2019

OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria

scientific article

PP32 and SET/TAF-Iβ proteins regulate the acetylation of newly synthesized histone H4.

scientific article published on 30 August 2017

PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells

scientific article published on December 2014

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation

scientific article

PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state

scientific article

PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex

scientific article published in Nature Communications

Phosphorylation of SU(VAR)3-9 by the chromosomal kinase JIL-1.

scientific article

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4

scientific article

Physical and functional association of SU(VAR)3-9 and HDAC1 in Drosophila

scientific article

Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry

scientific article published on 13 December 2011

Proteins at the polypeptide tunnel exit of the yeast mitochondrial ribosome

scientific article

Proteome analysis of mitochondrial outer membrane from Neurospora crassa

scientific article

Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination

scientific article published on 14 January 2021

Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signalling

scientific article

RNA-interference components are dispensable for transcriptional silencing of the drosophila bithorax-complex

scientific article

Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation

scientific article published on 06 November 2014

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

scientific article published on 16 February 2007

Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC.

scientific article published on 14 March 2018

Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin

scientific article

Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin

scientific article published on 17 March 2010

Replication Stress Interferes with Histone Recycling and Predeposition Marking of New Histones

Reply to "Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases"

article published in 2013

Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria

scientific article

S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling

scientific article published on 16 December 2020

SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres

scientific article published on 08 May 2019

STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse

scientific article published on 31 October 2019

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

scientific article

Sequential establishment of marks on soluble histones H3 and H4.

scientific article published on 29 March 2011

Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability

scientific article published on 12 November 2018

Site-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II

scientific article published on 13 November 2015

Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progression

scientific article published on 6 June 2016

Spt6 is a maintenance factor for centromeric CENP-A

scientific article published on 10 June 2020

Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome

scientific article

Stepwise evolution of essential centromere function in a Drosophila neogene

scientific article

Structural Architecture of the Nucleosome Remodeler ISWI Determined from Cross-Linking, Mass Spectrometry, SAXS, and Modeling

scientific article published on 26 January 2018

Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction.

scientific article

The Drosophila G9a gene encodes a multi-catalytic histone methyltransferase required for normal development

scientific article

The Drosophila speciation factor HMR localizes to genomic insulator sites.

scientific article

The Epoxyeicosatrienoic Acid Pathway Enhances Hepatic Insulin Signaling and is Repressed in Insulin-Resistant Mouse Liver

scientific article

The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin

scientific article

The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila

scientific article published on 23 August 2021

The Metabolic Impact on Histone Acetylation and Transcription in Ageing

scientific article

The N-terminus of Drosophila SU(VAR)3-9 mediates dimerization and regulates its methyltransferase activity

scientific article published in March 2004

The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster

scientific article

The analysis of histone modifications

scientific article published on 26 August 2006

The complete murine cDNA sequence of the transcription factor AP-2

scientific article published on October 1993

The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization

scientific article published on May 2002

The genomic structure of the human AP-2 transcription factor

scientific article

The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases.

scientific article

The histone variant H2A.Bbd is enriched at sites of DNA synthesis

scientific article

The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase.

scientific article

The prion curing agent guanidinium chloride specifically inhibits ATP hydrolysis by Hsp104.

scientific article published on 10 December 2003

The sounds of silence--histone deacetylation meets histone methylation

scientific article

The use of mass spectrometry for the analysis of histone modifications.

scientific article published in January 2004

Transcription: gene control by targeted histone acetylation

scientific article published in June 1998

Transcriptional regulation of the AP-2alpha promoter by BTEB-1 and AP-2rep, a novel wt-1/egr-related zinc finger repressor

scientific article

Trnp1 organizes diverse nuclear membrane-less compartments in neural stem cells

scientific article published on 06 July 2020

Two distinct modes for propagation of histone PTMs across the cell cycle

scientific article

Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals

scientific article published in January 2018

Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells

scientific article

Yersinia protein kinase YopO is activated by a novel G-actin binding process

scientific article published on 22 November 2006

dMi-2 and ISWI chromatin remodelling factors have distinct nucleosome binding and mobilization properties

scientific article

hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells

scientific article

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