List of works - Masayasu Okochi

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

scientific article

Abnormal gel-electrophoretic behavior of presenilin 1 and it's fragment

scientific article published on September 1996

Absolute quantitation of low abundance plasma APL1β peptides at sub-fmol/mL Level by SRM/MRM without immunoaffinity enrichment

scientific article published on 26 December 2013

Altered localization of amyloid precursor protein under endoplasmic reticulum stress

scientific article published on 5 April 2006

Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients

scientific article

Apolipoprotein E and central nervous system disorders: reviews of clinical findings

scientific article published on December 2010

Association study of KIBRA gene with memory performance in a Japanese population

scientific article published in October 2010

Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study

scientific article published on 23 February 2009

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

scientific article (publication date: 7 January 2000)

Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor

scientific article

Development of new screening system for Alzheimer disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils

scientific article published on 20 February 2006

Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs

scientific article

Difficulty identifying spinocerebellar ataxia 17 from preceding psychiatric symptoms

scientific article published on 01 October 2008

Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain

scientific article

FAD-linked presenilin-1 mutants impede translation regulation under ER stress.

scientific article

Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor

scientific article

Glial tau-positive structures lack the sequence encoded by exon 3 of the tau protein gene

scientific article published in March 1997

Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex

scientific article

Identification and characterization of presenilin I-467, I-463 and I-374.

scientific article

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

scientific article published on 5 December 2002

Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia.

scientific article published on 26 August 2008

Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation

scientific article

Involvement of endoplasmic reticulum stress in tauopathy

scientific article

KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.

scientific article published on 25 September 2010

Laughter and humor as complementary and alternative medicines for dementia patients.

scientific article

New drugs for Alzheimer's disease in Japan.

scientific article published in August 2011

Non-pharmacological intervention for dementia patients

scientific article published on 01 February 2012

Presenilin 1 cleavage is a universal event in human organs

scientific article

Presenilin-1 exists in the axoplasm fraction in the brains of aged Down's syndrome subjects and non-demented individuals

scientific article

Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.

scientific article

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

scientific article (publication date: 22 November 2002)

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

scientific article published on October 2002

Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death

scientific article published on June 2011

Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations

scientific article

Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1

scientific article

Relative ratio and level of amyloid-β 42 surrogate in cerebrospinal fluid of familial Alzheimer disease patients with presenilin 1 mutations

scientific article published on 30 October 2013

Secretion of the Notch-1 Abeta-like peptide during Notch signaling

scientific article published on 23 January 2006

Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

scientific article published in May 2001

Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress

scientific article published on 3 November 2011

Subcellular distribution and turnover of presenilins in transfected cells

scientific article published on 01 May 1998

TATA box-binding protein gene is associated with risk for schizophrenia, age at onset and prefrontal function

scientific article

The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system

scientific article

The AKT1 gene is associated with attention and brain morphology in schizophrenia.

scientific article

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

scientific article

The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis

scientific article published on 3 January 2010

The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.

scientific article published in September 2010

γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment

scientific article published on 28 December 2013

List of works by Masayasu Okochi

A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells

Abnormal gel-electrophoretic behavior of presenilin 1 and it's fragment

Absolute quantitation of low abundance plasma APL1β peptides at sub-fmol/mL Level by SRM/MRM without immunoaffinity enrichment

Altered localization of amyloid precursor protein under endoplasmic reticulum stress

Analysis of APL1beta28, a surrogate marker for Alzheimer Abeta42, indicates altered precision of gamma-cleavage in the brains of Alzheimer disease patients

Apolipoprotein E and central nervous system disorders: reviews of clinical findings

Association study of KIBRA gene with memory performance in a Japanese population

Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study

Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein

Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor

Development of new screening system for Alzheimer disease, in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils

Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs

Difficulty identifying spinocerebellar ataxia 17 from preceding psychiatric symptoms

Effect of valine on the efficiency and precision at S4 cleavage of the Notch-1 transmembrane domain

FAD-linked presenilin-1 mutants impede translation regulation under ER stress.

Fluvoxamine alleviates ER stress via induction of Sigma-1 receptor

Glial tau-positive structures lack the sequence encoded by exon 3 of the tau protein gene

Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex

Identification and characterization of presenilin I-467, I-463 and I-374.

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation

Impaired prepulse inhibition and habituation of acoustic startle response in Japanese patients with schizophrenia.

Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation

Involvement of endoplasmic reticulum stress in tauopathy

KIBRA genetic polymorphism influences episodic memory in Alzheimer's disease, but does not show association with disease in a Japanese cohort.

Laughter and humor as complementary and alternative medicines for dementia patients.

New drugs for Alzheimer's disease in Japan.

Non-pharmacological intervention for dementia patients

Presenilin 1 cleavage is a universal event in human organs

Presenilin-1 exists in the axoplasm fraction in the brains of aged Down's syndrome subjects and non-demented individuals

Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

Protein kinase C stabilizes X-linked inhibitor of apoptosis protein (XIAP) through phosphorylation at Ser(87) to suppress apoptotic cell death

Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations

Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1

Relative ratio and level of amyloid-β 42 surrogate in cerebrospinal fluid of familial Alzheimer disease patients with presenilin 1 mutations

Secretion of the Notch-1 Abeta-like peptide during Notch signaling

Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice

Sigma-1Rs are upregulated via PERK/eIF2α/ATF4 pathway and execute protective function in ER stress

Subcellular distribution and turnover of presenilins in transfected cells

TATA box-binding protein gene is associated with risk for schizophrenia, age at onset and prefrontal function

The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system

The AKT1 gene is associated with attention and brain morphology in schizophrenia.

The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.

The chitinase 3-like 1 gene and schizophrenia: evidence from a multi-center case-control study and meta-analysis

The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.

γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment