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List of works by Andrea Bertotti

A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.

scientific article published on 3 October 2017

A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells

scientific article

A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors.

scientific article published on 30 September 2016

A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

scientific article

A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors.

scientific article published on 30 May 2011

A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth

scientific article

Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition.

scientific article

Adaptive mutability of colorectal cancers in response to targeted therapies

scientific article published on 07 November 2019

Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer

scientific article

Animal research: Temper Italy's strict lab-animal law.

scientific article published in September 2013

Anti-cancer effect and gene modulation of ET-743 in human biliary tract carcinoma preclinical models

scientific article

Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth

scientific article

Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis

scientific article published on December 2005

Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell-like phenotype

scientific article published on 01 August 2020

Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models

scientific article published on 04 June 2019

Compensatory pathways in oncogenic kinase signaling and resistance to targeted therapies: six degrees of separation

scientific article published on 01 October 2012

Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts

scientific article published on 07 January 2021

Corrigendum: Stromal contribution to the colorectal cancer transcriptome.

scientific article published in September 2016

Cytokine-induced killer cells eradicate bone and soft-tissue sarcomas.

scientific article published on 19 December 2013

Discovery of molecular determinants of response to targeted therapies in colorectal cancer using patient-derived xenografts (‘xenopatients’).

scientific article published on 4 April 2013

Dual-targeted therapy with trastuzumab and lapatinib in treatment-refractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-of-concept, multicentre, open-label, phase 2 trial

scientific article

EGFR blockade reverts resistance to KRAS G12C inhibition in colorectal cancer

scientific article published on 19 May 2020

Efficacy of NEDD8 Pathway Inhibition in Preclinical Models of Poorly Differentiated, Clinically Aggressive Colorectal Cancer

scientific article

Evolving neoantigen profiles in colorectal cancers with DNA repair defects

scientific article published on 28 June 2019

From bench to bedside: does preclinical practice in translational oncology need some rebuilding?

scientific article published on 19 September 2013

Genetic and Expression Analysis of MET, MACC1, and HGF in Metastatic Colorectal Cancer: Response to Met Inhibition in Patient Xenografts and Pathologic Correlations

article

HER2 activating mutations are targets for colorectal cancer treatment

scientific article

IGF2 is an actionable target that identifies a distinct subpopulation of colorectal cancer patients with marginal response to anti-EGFR therapies.

scientific article published on January 2015

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases

scientific article published on 12 April 2019

INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases

scientific article published on 24 May 2019

Immunogenomics of Colorectal Tumors: Facts and Hypotheses on an Evolving Saga

scientific article published on 06 November 2019

Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

scientific article published on 14 October 2020

Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas

scientific article

Inhibition of Src impairs the growth of met-addicted gastric tumors.

scientific article published on 13 July 2010

Interrogating open issues in cancer medicine with patient-derived xenografts

scientific article published on 15 September 2017

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

scientific article published on 20 January 2017

Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.

scientific article

LAS: A Software Platform to Support Oncological Data Management ⬇️

scientific article published on November 2, 2012

MACC1 mRNA levels predict cancer recurrence after resection of colorectal cancer liver metastases.

scientific article published in June 2013

MEK plus PI3K/mTORC1/2 Therapeutic Efficacy Is Impacted by TP53 Mutation in Preclinical Models of Colorectal Cancer.

scientific article published on 13 August 2015

MET dysregulation is a hallmark of aggressive disease in multiple myeloma patients

scientific article published on 23 January 2014

MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors.

scientific article

MET signalling: principles and functions in development, organ regeneration and cancer

scientific article published on December 2010

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations.

scientific article published on February 2016

Met signaling regulates growth, repopulating potential and basal cell-fate commitment of mammary luminal progenitors: implications for basal-like breast cancer.

scientific article

Met-driven invasive growth involves transcriptional regulation of Arhgap12.

scientific article

Microenvironment-derived HGF overcomes genetically determined sensitivity to anti-MET drugs.

scientific article published on 12 September 2014

Molecular Pathways: Sensitivity and Resistance to Anti-EGFR Antibodies.

scientific article published on 12 June 2015

NOTCH3 signaling regulates MUSASHI-1 expression in metastatic colorectal cancer cells

scientific article published on 13 February 2014

One tool to find them all: a case of data integration and querying in a distributed LIMS platform

scientific article published on 01 January 2019

Only a Subset of Met-Activated Pathways Are Required to Sustain Oncogene Addiction

scientific article published on 08 December 2009

Only a subset of Met-activated pathways are required to sustain oncogene addiction

scientific article

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.

scientific article published in November 2017

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

scientific article published on 02 August 2019

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens

scientific article published on 10 April 2019

RET rearrangements define a new and rare molecular subtype of metastatic colorectal cancer (mCRC)

scientific article published on 01 June 2017

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

scientific article published on 01 July 2018

Rituximab Treatment Prevents Lymphoma Onset in Gastric Cancer Patient-Derived Xenografts.

scientific article published on 22 March 2018

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

scientific article published on 31 May 2017

Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

scientific article

Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research

scientific article published in January 2019

Stromal contribution to the colorectal cancer transcriptome.

scientific article

Sustained Inhibition of HER3 and EGFR Is Necessary to Induce Regression of HER2-Amplified Gastrointestinal Carcinomas.

scientific article published on 21 August 2015

Systems analysis of protein signatures predicting Cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenografts models of metastatic colorectal cancer

scientific article published on 23 July 2020

Tankyrase inhibition impairs directional migration and invasion of lung cancer cells by affecting microtubule dynamics and polarity signals.

scientific article

The genomic landscape of response to EGFR blockade in colorectal cancer.

scientific article published on 30 September 2015

The tetraspanin CD151 is required for Met-dependent signaling and tumor cell growth

scientific article

Tyrosine kinase signal specificity: lessons from the HGF receptor ⬇️

scientific article published on October 1, 2003

Vertical suppression of the EGFR pathway prevents onset of resistance in colorectal cancers.

scientific article published on 22 September 2015

Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer

scientific article published on 14 March 2020

met oncogene activation qualifies spontaneous canine osteosarcoma as a suitable pre-clinical model of human osteosarcoma.

scientific article published on July 2009

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