List of works - Armin Giese

11 C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to α-Synuclein Fibrils in vitro and Crosses the Blood-Brain Barrier

scientific article published on 09 January 2020

A refined method for molecular typing reveals that co-occurrence of PrP(Sc) types in Creutzfeldt-Jakob disease is not the rule

scientific article published on 24 September 2007

AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers

scientific article published on 26 April 2011

Adjunctive N-acetyl-L-cysteine in treatment of murine pneumococcal meningitis

scientific article published on 22 July 2013

Agent strain variation in human prion disease: insights from a molecular and pathological review of the National Institutes of Health series of experimentally transmitted disease

scientific article

An unusual case of ectopic ACTH syndrome

scientific article published on 20 December 2011

Analyses of protease resistance and aggregation state of abnormal prion protein across the spectrum of human prions

scientific article published on 29 July 2013

Analysis of Conformational Stability of Abnormal Prion Protein Aggregates across the Spectrum of Creutzfeldt-Jakob Disease Prions

scientific article

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease

scientific article

Autocatalytic self-propagation of misfolded prion protein

scholarly article

Automated PrPres amplification using indirect sonication

scientific article published in June 2005

Biological tumour volumes of gliomas in early and standard 20-40 min 18F-FET PET images differ according to IDH mutation status.

scientific article

Breakage of PrP aggregates is essential for efficient autocatalytic propagation of misfolded prion protein

scientific article

CADASIL mutations enhance spontaneous multimerization of NOTCH3.

scientific article published on 5 May 2009

Cell-free formation of misfolded prion protein with authentic prion infectivity

scholarly article

Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers

scientific article published in September 2006

Characterization of truncated forms of abnormal prion protein in Creutzfeldt-Jakob disease

scientific article published on 27 August 2008

Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression

scientific article published on 15 November 2017

Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects

Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria

scientific article published on 3 May 2017

Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis

scientific article published on 30 May 2011

Consensus classification of human prion disease histotypes allows reliable identification of molecular subtypes: an inter-rater study among surveillance centres in Europe and USA

scientific article published on 30 June 2012

Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron

scientific article

Correction to: Biological tumour volumes of gliomas in early and standard 20-40 min 18F-FET PET images differ according to IDH mutation status

scientific article published on 01 June 2018

Cysteine-sparing CADASIL mutations in NOTCH3 show proaggregatory properties in vitro

scientific article published on 20 January 2015

Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein

scholarly article

Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease

scientific article (publication date: 2013)

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

scientific article published in August 2007

Differential effects of prion particle size on infectivity in vivo and in vitro

scientific article published on 5 March 2008

Diffuse leukoencephalopathy with spheroids: biopsy findings and a novel mutation.

scientific article published on 4 May 2014

Diphenylpyrazole-derived compounds increase survival time of mice after prion infection.

scientific article

Divergent molecular effects of desmin mutations on protein assembly in myofibrillar myopathy

scientific article

Dynamic 18F-FET PET in suspected WHO grade II gliomas defines distinct biological subgroups with different clinical courses.

scientific article

Effect of metal ions on de novo aggregation of full-length prion protein

scientific article published on 01 August 2004

Effects of different experimental conditions on the PrPSc core generated by protease digestion: implications for strain typing and molecular classification of CJD.

scientific article published on 29 January 2004

Elevated levels of methylmalonate and homocysteine in Parkinson's disease, progressive supranuclear palsy and amyotrophic lateral sclerosis

scientific article published on 3 July 2010

Erratum to: The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach

scientific article published on 25 August 2016

Establishing quantitative real-time quaking-induced conversion (qRT-QuIC) for highly sensitive detection and quantification of PrPSc in prion-infected tissues.

scientific article published on 02 August 2013

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

scientific article

Generation of ferric iron links oxidative stress to α-synuclein oligomer formation

scientific article published in January 2011

Generation of genuine prion infectivity by serial PMCA.

scientific article

Histopathology and clinical course of MOG-antibody-associated encephalomyelitis

scientific article

Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model

scientific article

Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ₄₂ aggregates

scientific article published on 01 January 2011

Identification of time-to-peak on dynamic 18F-FET-PET as a prognostic marker specifically in IDH1/2 mutant diffuse astrocytoma

scientific article published on 14 August 2017

Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification

scientific article published on 29 August 2009

Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases

scientific article

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

scientific article

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

scientific article published on 14 September 2010

K27M midline gliomas display malignant progression by imaging and histology

scientific article published on 01 August 2017

Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer's disease tau

scientific article published on 01 August 2019

Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation

scientific article published on 6 August 2012

Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols ⬇️

scientific article published on June 28, 2013

Modelling Ser129 phosphorylation inhibits membrane binding of pore-forming alpha-synuclein oligomers

scientific article

Molecular dynamics simulations indicate a possible role of parallel beta-helices in seeded aggregation of poly-Gln

scientific article published on 21 January 2005

Molecular stereotactic biopsy technique improves diagnostic accuracy and enables personalized treatment strategies in glioma patients

scientific article published on 3 May 2014

Neuronal cell death in scrapie-infected mice is due to apoptosis

scientific article published on July 1995

Next-generation sequencing reveals regional differences of the α-synuclein methylation state independent of Lewy body disease

scientific article published on 01 November 2011

Phenotypic variability of sporadic human prion disease and its molecular basis: past, present, and future

scientific article

Photo-induced crosslinking of prion protein oligomers and prions

scientific article published in June 2006

Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo

scientific article

Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis.

scientific article

Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro

scientific article published on 23 May 2012

Presence of phosphodiesterase type 5 in the spinal cord and its involvement in bladder outflow obstruction related bladder overactivity

scientific article published on 29 March 2013

Prion protein as copper-binding protein at the synapse

scientific article

Prion-related peripheral neuropathy in sporadic Creutzfeldt-Jakob disease

scientific article published on 24 October 2018

Quantifying prion disease penetrance using large population control cohorts

scientific article published on January 2016

Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis

scientific article published on 24 January 2011

Regional pattern of microgliosis in sporadic Creutzfeldt-Jakob disease in relation to phenotypic variants and disease progression

scientific article published on 18 January 2018

Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial

scientific article published on 02 July 2019

Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortex

scientific article

Single particle analysis of manganese-induced prion protein aggregates

scientific article

Single particle analysis of tau oligomer formation induced by metal ions and organic solvents

scientific article published on 24 June 2011

Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes

scientific article

Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level

scientific article

Synthesis of benzamide derivatives and their evaluation as antiprion agents

scientific article

Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets

scientific article

The German FFI Cases ⬇️

scientific article published on July 1, 1998

The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach

scientific article published on 25 January 2016

The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset.

scientific article published on 11 March 2014

Two different binding modes of α-synuclein to lipid vesicles depending on its aggregation state

scientific article published on 3 April 2012

Typing prion isoforms.

scientific article published in March 1997

α-Internexin in the diagnosis of oligodendroglial tumors and association with 1p/19q status

scientific article published in November 2011

List of works by Armin Giese

11 C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to α-Synuclein Fibrils in vitro and Crosses the Blood-Brain Barrier

A refined method for molecular typing reveals that co-occurrence of PrP(Sc) types in Creutzfeldt-Jakob disease is not the rule

AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced α-synuclein oligomers

Adjunctive N-acetyl-L-cysteine in treatment of murine pneumococcal meningitis

Agent strain variation in human prion disease: insights from a molecular and pathological review of the National Institutes of Health series of experimentally transmitted disease

An unusual case of ectopic ACTH syndrome

Analyses of protease resistance and aggregation state of abnormal prion protein across the spectrum of human prions

Analysis of Conformational Stability of Abnormal Prion Protein Aggregates across the Spectrum of Creutzfeldt-Jakob Disease Prions

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease

Autocatalytic self-propagation of misfolded prion protein

Automated PrPres amplification using indirect sonication

Biological tumour volumes of gliomas in early and standard 20-40 min 18F-FET PET images differ according to IDH mutation status.

Breakage of PrP aggregates is essential for efficient autocatalytic propagation of misfolded prion protein

CADASIL mutations enhance spontaneous multimerization of NOTCH3.

Cell-free formation of misfolded prion protein with authentic prion infectivity

Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers

Characterization of truncated forms of abnormal prion protein in Creutzfeldt-Jakob disease

Chitotriosidase (CHIT1) is increased in microglia and macrophages in spinal cord of amyotrophic lateral sclerosis and cerebrospinal fluid levels correlate with disease severity and progression

Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects

Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria

Co-aggregate formation of CADASIL-mutant NOTCH3: a single-particle analysis

Consensus classification of human prion disease histotypes allows reliable identification of molecular subtypes: an inter-rater study among surveillance centres in Europe and USA

Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron

Correction to: Biological tumour volumes of gliomas in early and standard 20-40 min 18F-FET PET images differ according to IDH mutation status

Cysteine-sparing CADASIL mutations in NOTCH3 show proaggregatory properties in vitro

Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein

Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

Differential effects of prion particle size on infectivity in vivo and in vitro

Diffuse leukoencephalopathy with spheroids: biopsy findings and a novel mutation.

Diphenylpyrazole-derived compounds increase survival time of mice after prion infection.

Divergent molecular effects of desmin mutations on protein assembly in myofibrillar myopathy

Dynamic 18F-FET PET in suspected WHO grade II gliomas defines distinct biological subgroups with different clinical courses.

Effect of metal ions on de novo aggregation of full-length prion protein

Effects of different experimental conditions on the PrPSc core generated by protease digestion: implications for strain typing and molecular classification of CJD.

Elevated levels of methylmalonate and homocysteine in Parkinson's disease, progressive supranuclear palsy and amyotrophic lateral sclerosis

Erratum to: The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach

Establishing quantitative real-time quaking-induced conversion (qRT-QuIC) for highly sensitive detection and quantification of PrPSc in prion-infected tissues.

Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation

Generation of ferric iron links oxidative stress to α-synuclein oligomer formation

Generation of genuine prion infectivity by serial PMCA.

Histopathology and clinical course of MOG-antibody-associated encephalomyelitis

Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model

Identification of polyphenolic compounds and black tea extract as potent inhibitors of lipid membrane destabilization by Aβ₄₂ aggregates

Identification of time-to-peak on dynamic 18F-FET-PET as a prognostic marker specifically in IDH1/2 mutant diffuse astrocytoma

Incidence and spectrum of sporadic Creutzfeldt-Jakob disease variants with mixed phenotype and co-occurrence of PrPSc types: an updated classification

Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases

Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1.

K27M midline gliomas display malignant progression by imaging and histology

Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer's disease tau

Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation

Mitochondrial membrane permeabilisation by amyloid aggregates and protection by polyphenols ⬇️

Modelling Ser129 phosphorylation inhibits membrane binding of pore-forming alpha-synuclein oligomers

Molecular dynamics simulations indicate a possible role of parallel beta-helices in seeded aggregation of poly-Gln

Molecular stereotactic biopsy technique improves diagnostic accuracy and enables personalized treatment strategies in glioma patients

Neuronal cell death in scrapie-infected mice is due to apoptosis

Next-generation sequencing reveals regional differences of the α-synuclein methylation state independent of Lewy body disease

Phenotypic variability of sporadic human prion disease and its molecular basis: past, present, and future

Photo-induced crosslinking of prion protein oligomers and prions

Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo

Plasminogen activator inhibitor-1 influences cerebrovascular complications and death in pneumococcal meningitis.

Polyphenolic compounds are novel protective agents against lipid membrane damage by α-synuclein aggregates in vitro

Presence of phosphodiesterase type 5 in the spinal cord and its involvement in bladder outflow obstruction related bladder overactivity

Prion protein as copper-binding protein at the synapse

Prion-related peripheral neuropathy in sporadic Creutzfeldt-Jakob disease

Quantifying prion disease penetrance using large population control cohorts

Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis

Regional pattern of microgliosis in sporadic Creutzfeldt-Jakob disease in relation to phenotypic variants and disease progression

Safety and efficacy of epigallocatechin gallate in multiple system atrophy (PROMESA): a randomised, double-blind, placebo-controlled trial

Seeding and transgenic overexpression of alpha-synuclein triggers dendritic spine pathology in the neocortex

Single particle analysis of manganese-induced prion protein aggregates

Single particle analysis of tau oligomer formation induced by metal ions and organic solvents

Single-channel electrophysiology reveals a distinct and uniform pore complex formed by α-synuclein oligomers in lipid membranes

Synergistic influence of phosphorylation and metal ions on tau oligomer formation and coaggregation with α-synuclein at the single molecule level

Synthesis of benzamide derivatives and their evaluation as antiprion agents

Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets

The German FFI Cases ⬇️

The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach