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Authors whose works are in public domain in at least one jurisdiction

List of works by Christian Hölscher

1-50 of 166 results

Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

scientific article

The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

scientific article published in April 2011

Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity.

scientific article published on July 1997

Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence

scientific article

Stimulation on the positive phase of hippocampal theta rhythm induces long-term potentiation that can Be depotentiated by stimulation on the negative phase in area CA1 in vivo

scientific article published in August 1997

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

scientific article published in December 2013

Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology

scientific article published on 8 January 2016

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease.

scientific article

Stress impairs performance in spatial water maze learning tasks

scientific article published in April 1999

Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease

scientific article published on 30 June 2009

Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system

scientific article published in August 2009

Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

scientific article published on 07 March 2014

Glucagon-like peptide-1 analogues enhance synaptic plasticity in the brain: a link between diabetes and Alzheimer's disease

scientific article published on 24 December 2009

Potential Role of Glucagon-Like Peptide-1 (GLP-1) in Neuroprotection

scientific article published on October 1, 2012

The selective neuronal NO synthase inhibitor 7-nitro-indazole blocks both long-term potentiation and depotentiation of field EPSPs in rat hippocampal CA1 in vivo.

scientific article published in January 1996

GSK3: a key target for the development of novel treatments for type 2 diabetes mellitus and Alzheimer disease

scientific article published on 21 December 2011

Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain

scientific article published on 10 January 2011

Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

scientific article

Investigation of the human brain metabolome to identify potential markers for early diagnosis and therapeutic targets of Alzheimer's disease

scientific article published on 8 January 2013

Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice

scientific article

Diabetes as a risk factor for Alzheimer's disease: insulin signalling impairment in the brain as an alternative model of Alzheimer's disease

scientific article published on August 1, 2011

Liraglutide protects against amyloid-β protein-induced impairment of spatial learning and memory in rats

scientific article

7-Nitro indazole, a selective neuronal nitric oxide synthase inhibitor in vivo, impairs spatial learning in the rat.

scientific article published in January 1996

An inhibitor of nitric oxide synthesis prevents memory formation in the chick

scientific article published in October 1992

Blockade of long-term potentiation by beta-amyloid peptides in the CA1 region of the rat hippocampus in vivo.

scientific article

Four weeks administration of Liraglutide improves memory and learning as well as glycaemic control in mice with high fat dietary-induced obesity and insulin resistance

scientific article published on October 2010

The effect of ageing on neurogenesis and oxidative stress in the APP(swe)/PS1(deltaE9) mouse model of Alzheimer's disease

scientific article published on 13 February 2012

Possible Causes of Alzheimer's Disease: Amyloid Fragments, Free Radicals, and Calcium Homeostasis

scientific article published on 18 September 2002

Inhibiting synthesis of the putative retrograde messenger nitric oxide results in amnesia in a passive avoidance task in the chick

scientific article published in August 1993

Reward modulates neuronal activity in the hippocampus of the rat.

scientific article published in June 2003

GLP-1 agonists facilitate hippocampal LTP and reverse the impairment of LTP induced by beta-amyloid

scientific article published on 29 March 2008

Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress

scientific article published on 28 October 2013

Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimer's disease.

scientific article published on June 2010

Val8-glucagon-like peptide-1 protects against Aβ1-40-induced impairment of hippocampal late-phase long-term potentiation and spatial learning in rats

scientific article published on 19 August 2010

Perirhinal cortex neuronal activity related to long-term familiarity memory in the macaque

scientific article

The incretin hormones glucagonlike peptide 1 and glucose‐dependent insulinotropic polypeptide are neuroprotective in mouse models of Alzheimer's disease

scientific article published on February 1, 2014

The diabetes drug liraglutide ameliorates aberrant insulin receptor localisation and signalling in parallel with decreasing both amyloid-β plaque and glial pathology in a mouse model of Alzheimer's disease.

scientific article

Lack of the metabotropic glutamate receptor subtype 7 selectively impairs short-term working memory but not long-term memory

scientific journal article

Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease

scientific article

Time, space and hippocampal functions.

scientific article published on January 2003

The Role of GLP-1 in Neuronal Activity and Neurodegeneration

scientific article published on January 1, 2010

New roles for insulin-like hormones in neuronal signalling and protection: new hopes for novel treatments of Alzheimer's disease?

scientific article published on 18 October 2008

Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet

scientific article published on 30 March 2010

Metabotropic glutamate receptor activation and blockade: their role in long-term potentiation, learning and neurotoxicity

scientific article published in January 1999

The type 2 diabetes drug liraglutide reduces chronic inflammation induced by irradiation in the mouse brain.

scientific article published on 28 December 2012

Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model

scientific article

Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

scientific article published on 8 August 2014

First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease

scientific article published on February 1, 2014

Neuroprotective effects of lixisenatide and liraglutide in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

scientific article published on 2 July 2015

Insulin, incretins and other growth factors as potential novel treatments for Alzheimer's and Parkinson's diseases

scientific article published on April 1, 2014