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List of works by Ruben Nogueiras

A Functional Link between AMPK and Orexin Mediates the Effect of BMP8B on Energy Balance.

scientific article published on 10 August 2016

A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis

scientific article

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

scientific article

A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat

scientific journal article

A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans.

scientific article

ANGPTL-4 is Associated with Obesity and Lipid Profile in Children and Adolescents

scientific article published on 14 June 2019

Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.

scientific article

Action of obestatin in skeletal muscle repair: stem cell expansion, muscle growth, and microenvironment remodeling.

scientific article published on 12 March 2015

Action profile of the antiobesity drug candidate oleoyl-estrone in rats

scientific article published on 25 March 2010

Acute but not chronic activation of brain glucagon-like peptide-1 receptors enhances glucose-stimulated insulin secretion in mice

scientific article published on 11 May 2015

Acute stimulation of brain mu opioid receptors inhibits glucose-stimulated insulin secretion via sympathetic innervation

scientific article

Adiponectin receptor 2 is regulated by nutritional status, leptin and pregnancy in a tissue-specific manner.

scientific article published in January 2010

Angiopoietin-like protein 8/betatrophin as a new determinant of type 2 diabetes remission after bariatric surgery.

scientific article published on 9 March 2017

Antiobesity efficacy of GLP-1 receptor agonist liraglutide is associated with peripheral tissue-specific modulation of lipid metabolic regulators

scientific article published on 23 May 2016

Biomedicine. Separation of conjoined hormones yields appetite rivals

scientific article published in November 2005

Brain-derived neurotrophic factor is expressed in rat and human placenta and its serum levels are similarly regulated throughout pregnancy in both species.

scientific article published on 17 January 2014

Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability

scientific article

CNS leptin action modulates immune response and survival in sepsis.

scientific article

Cellular distribution and regulation of ghrelin messenger ribonucleic acid in the rat pituitary gland

scientific article published on 7 August 2003

Central GLP-1 actions on energy metabolism

scientific article published on January 2010

Central administration of resistin promotes short-term satiety in rats

scientific article published in September 2005

Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance

scientific article published on 02 October 2014

Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion

scientific article

Central manipulation of dopamine receptors attenuates the orexigenic action of ghrelin

scientific article published on 28 April 2013

Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways

scientific article published on 6 November 2012

Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle

scientific article

Central nervous system regulation of adipocyte metabolism

scientific article published on April 2008

Central nervous system regulation of energy metabolism: ghrelin versus leptin

scientific article

Central nicotine induces browning through hypothalamic κ opioid receptor

scientific article published on 06 September 2019

Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion

scientific article published on 22 May 2008

Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition

scientific article published on 2 June 2005

Characterization of the Potent Luteinizing Hormone-Releasing Activity of KiSS-1 Peptide, the Natural Ligand of GPR54

scientific article published on 16 September 2004

Chronic inflammation modulates ghrelin levels in humans and rats

scientific article published on 17 November 2003

Chronic sympathoexcitation through loss of Vav3, a Rac1 activator, results in divergent effects on metabolic syndrome and obesity depending on diet

scientific article published in August 2013

Circulating Betatrophin Levels Are Increased in Anorexia and Decreased in Morbidly Obese Women

scientific article published on 14 July 2015

Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty

scientific article published in Scientific Reports

Circulating hormones and hypothalamic energy balance: regulatory gene expression in the Lou/C and Wistar rats

scientific article published on September 2006

Come to Where Insulin Resistance Is, Come to AMPK Country.

scientific article

Contribution of adaptive thermogenesis to the hypothalamic regulation of energy balance.

scientific article published on November 2016

Cooperative role of the glucagon-like peptide-1 receptor and β3-adrenergic-mediated signalling on fat mass reduction through the downregulation of PKA/AKT/AMPK signalling in the adipose tissue and muscle of rats

scientific article published on 28 November 2017

Corrigendum: Hepatic p63 regulates steatosis via IKKβ/ER stress.

scientific article published on 16 June 2017

Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis

scientific article

Current Understanding of the Hypothalamic Ghrelin Pathways Inducing Appetite and Adiposity.

scientific article published on 17 January 2017

Decreased glucose tolerance and plasma adiponectin:resistin ratio in a mouse model of post-traumatic stress disorder

article

Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice

scientific article published on 27 May 2008

Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity

scientific article published in May 2009

Distinct phosphorylation sites on the ghrelin receptor, GHSR1a, establish a code that determines the functions of ß-arrestins

scientific article published on 3 March 2016

Dual action of adiponectin on insulin secretion in insulin-resistant mice

scientific article published in August 2004

Effect of food restriction on ghrelin in normal-cycling female rats and in pregnancy

scientific article published in July 2002

Effects of obestatin on energy balance and growth hormone secretion in rodents

scientific article published on 28 September 2006

EndoG Knockout Mice Show Increased Brown Adipocyte Recruitment in White Adipose Tissue and Improved Glucose Homeostasis.

scientific article published on 22 August 2016

Endocrine control of energy homeostasis

scientific article published in December 2015

Endocrine-disrupting chemicals and the regulation of energy balance

scientific article

Energy balance regulation by thyroid hormones at central level

scientific article published on 23 May 2013

Estradiol regulates brown adipose tissue thermogenesis via hypothalamic AMPK

scientific article

Exciting advances in GPCR-based drugs discovery for treating metabolic disease and future perspectives

scientific article published on 01 March 2019

Expression and regulation of adiponectin and receptor in human and rat placenta

scientific journal article

Expression and regulation of chemerin during rat pregnancy

scientific article published on 25 February 2012

Expression of ghrelin in the cyclic and pregnant rat ovary

scientific article published in April 2003

Female Nur77-deficient mice show increased susceptibility to diet-induced obesity.

scientific article

Firing Up Brown Fat with Brain Amylin ⬇️

scientific article published on July 1, 2013

Functional identity of hypothalamic melanocortin neurons depends on Tbx3

scientific article published on 28 January 2019

GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK.

scientific article published on 10 June 2014

GLP-1: The Oracle for Gastric Bypass?

scientific article published on 01 February 2014

GOAT: a stomach enzyme that whets our appetite.

scientific article published on 23 June 2008

GOAT: the master switch for the ghrelin system?

scientific article published on 26 April 2010

GPR55 and the regulation of glucose homeostasis.

scientific article

GPR55: a new promising target for metabolism?

scientific article published on 14 February 2017

Gastrointestinal signalling peptides in obesity

Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake

article

Ghrelin

Ghrelin action in the brain controls adipocyte metabolism

scientific article

Ghrelin and LEAP-2: Rivals in Energy Metabolism

scholarly article by Omar Al-Massadi et al published August 2018 in Trends in Pharmacological Sciences

Ghrelin and lipid metabolism: key partners in energy balance

scientific article published on 15 February 2011

Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender

scientific article published on 24 March 2010

Ghrelin localization in rat and human thyroid and parathyroid glands and tumours.

scientific article

Ghrelin plasmatic levels in patients with fibromyalgia

scientific article

Ghrelin requires p53 to stimulate lipid storage in fat and liver

scientific article published on 5 July 2013

Ghrelin, Lipid Metabolism, and Metabolic Syndrome

Ghrelin, obesity and diabetes

scientific article published on October 2007

Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity

scientific article published on 28 April 2011

Ghrelin.

scientific article

Ghrelin: new molecular pathways modulating appetite and adiposity.

scientific article published on 04 October 2010

Glucagon Control on Food Intake and Energy Balance

scientific article published on 11 August 2019

Glucagon-Like Peptide 1 Analogs and their Effects on Pancreatic Islets

scientific article published on 6 April 2016

Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolism

scientific article

Hepatic p63 regulates steatosis via IKKβ/ER stress

scientific article

Heterozygous deficiency of endoglin decreases insulin and hepatic triglyceride levels during high fat diet

scientific article

Hyperthyroidism differentially regulates neuropeptide S system in the rat brain

scientific article published on 18 February 2012

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

scientific article

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

scientific article

Hypothalamic AMPK: a canonical regulator of whole-body energy balance

scientific article published on 20 May 2016

Hypothalamic CaMKKβ mediates glucagon anorectic effect and its diet-induced resistance.

scientific article published on 22 October 2015

Hypothalamic GLP-1: the control of BAT thermogenesis and browning of white fat.

scientific article published on 7 January 2015

Hypothalamic KLF4 mediates leptin's effects on food intake via AgRP

scientific article

Hypothalamic Lipids: Key Regulators of Whole Body Energy Balance.

scientific article

Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortins

scientific article published on 17 May 2011

Hypothalamic effects of thyroid hormones on metabolism.

scientific article published on 25 April 2014

Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone-induced liver damage through inflammation and endoplasmic reticulum stress.

scientific article published on 7 July 2016

Hypothalamic lipotoxicity and the metabolic syndrome

scientific article published on 29 September 2009

Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism.

scientific article published on 17 February 2012

Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin

scientific article

Hypothalamic mTOR: the rookie energy sensor.

scientific article published on January 2014

Hypothalamic pathways regulate the anorectic action of p-chloro-diphenyl diselenide in rats

scientific article published on 21 September 2017

Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin

scientific article

Hypothalamic-autonomic control of energy homeostasis

scientific article published on 19 June 2015

Hypothalamus and thermogenesis: Heating the BAT, browning the WAT.

scientific article

Insulinotropic Actions of GLP-1: How Much in the Brain and How Much in the Periphery?

scientific article published in July 2017

Irisin levels during pregnancy and changes associated with the development of preeclampsia

scientific article published on 14 March 2014

Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression.

scientific article

Lack of Ovarian Secretions Reverts the Anabolic Action of Olanzapine in Female Rats

scientific article published on 14 August 2017

Leptin and fasting regulate rat gastric glucose-regulated protein 58.

scientific article

Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function

scientific article published on 02 August 2021

Leptin receptor gene expression and number in the brain are regulated by leptin level and nutritional status

scientific article

Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats

scientific article published on 6 May 2008

Longitudinal analysis of maternal serum Follistatin concentration in normal pregnancy and preeclampsia

article published in 2015

MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance

scientific article published on 16 September 2019

MKK6 controls T3-mediated browning of white adipose tissue

scientific article published on 11 October 2017

Maternal Serum Meteorin Levels and the Risk of Preeclampsia

scientific article published on 29 June 2015

Maternal serum omentin-1 profile is similar in humans and in the rat animal model

scientific article published on 2 July 2015

Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake.

scientific article published on 27 November 2017

Melanocortin signaling in the CNS directly regulates circulating cholesterol

scientific article

Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice.

scientific article published on 31 July 2009

Mice lacking δ-opioid receptors resist the development of diet-induced obesity

scientific article

Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.

scientific article published on June 2017

Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance.

scientific article published on September 2013

Mu opioid receptor: from pain to glucose metabolism

scientific article published on 26 December 2016

Negative energy balance and leptin regulate neuromedin-U expression in the rat pars tuberalis

scientific article published on August 2006

New insights in ghrelin orexigenic effect

scientific article published on 05 July 2010

Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats

scientific article published on 11 February 2014

Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase

scientific article published on 7 February 2012

Novel expression and direct effects of adiponectin in the rat testis.

scientific article

Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors

scientific article

Novel role of 26RFa, a hypothalamic RFamide orexigenic peptide, as putative regulator of the gonadotropic axis.

scientific article

Obesity- and gender-dependent role of endogenous somatostatin and cortistatin in the regulation of endocrine and metabolic homeostasis in mice

scientific article

Obestatin controls skeletal muscle fiber-type determination

scientific article published on 18 May 2017

Olanzapine-induced hyperphagia and weight gain associate with orexigenic hypothalamic neuropeptide signaling without concomitant AMPK phosphorylation

scientific article

Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat.

scientific article published on 23 October 2013

Orexin-A regulates growth hormone-releasing hormone mRNA content in a nucleus-specific manner and somatostatin mRNA content in a growth hormone-dependent fashion in the rat hypothalamus

scientific article

Our evolving understanding of the interaction between leptin and dopamine system to regulate ingestive behaviors

scientific article published on 10 August 2012

PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance

scientific article

Perinatal overfeeding in rats results in increased levels of plasma leptin but unchanged cerebrospinal leptin in adulthood

scientific article published on 27 June 2006

Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats

scientific article published on 20 August 2008

Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice

scientific article published on 16 May 2016

Pharmacological inhibition of cannabinoid receptor 1 stimulates gastric release of nesfatin-1 via the mTOR pathway

scientific article published on September 2017

Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis.

scientific article published on 15 December 2017

Phytochemical Composition, Anti-Inflammatory and ER Stress-Reducing Potential of Sambucus ebulus L. Fruit Extract

scientific article published in 2021

Plasma ANGPTL-4 is Associated With Obesity and Glucose Tolerance: Cross-Sectional and Longitudinal Findings.

scientific article published on 14 March 2018

Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-CoA and the thermogenic effect of hypothalamic AMPK inhibition in female rats

scientific article

Preproghrelin expression is a key target for insulin action on adipogenesis

scientific article published on 20 June 2011

Reduction of Hypothalamic Endoplasmic Reticulum Stress Activates Browning of White Fat and Ameliorates Obesity

scientific article

Regulation of Chemerin and CMKLR1 Expression by Nutritional Status, Postnatal Development, and Gender

scientific article published on 25 September 2018

Regulation of GPR55 in rat white adipose tissue and serum LPI by nutritional status, gestation, gender and pituitary factors.

scientific article published on 27 December 2013

Regulation of NR4A by nutritional status, gender, postnatal development and hormonal deficiency

scientific article published on 03 March 2014

Regulation of NucB2/Nesfatin-1 throughout rat pregnancy

scientific article published on 4 June 2014

Regulation of PRL release by cytokines and immunomodifiers: Interrelationships between leptin and prolactin secretion. Functional implications

Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin

scientific article published in October 2004

Regulation of lipid metabolism by energy availability: a role for the central nervous system.

scientific article published on 21 October 2009

Regulation of lipin1 by nutritional status, adiponectin, sex and pituitary function in rat white adipose tissue

scientific article published on 25 October 2011

Regulation of peptide YY levels by age, hormonal, and nutritional status

scientific article published in December 2004

Regulation of peroxisome proliferator activated receptor-gamma in rat pituitary

scientific article published in May 2005

Regulation of resistin by gonadal, thyroid hormone, and nutritional status

scientific article

Regulation of visceral adipose tissue-derived serine protease inhibitor by nutritional status, metformin, gender and pituitary factors in rat white adipose tissue.

scientific article published on 26 May 2009

Resistin is expressed in different rat tissues and is regulated in a tissue- and gender-specific manner

scientific article published in July 2003

Resistin: regulation of food intake, glucose homeostasis and lipid metabolism

scientific article

Review of novel aspects of the regulation of ghrelin secretion

scientific article published on January 2014

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

scientific article published in Nature Communications

Sensing the fat: fatty acid metabolism in the hypothalamus and the melanocortin system

scientific article

Sequential Exposure to Obesogenic Factors in Females Rats: From Physiological Changes to Lipid Metabolism in Liver and Mesenteric Adipose Tissue

scientific article published on 07 April 2017

Serum Adipsin Levels throughout Normal Pregnancy and Preeclampsia.

scientific article published on February 2016

Serum Galanin Levels in Young Healthy Lean and Obese Non-Diabetic Men during an Oral Glucose Tolerance Test

scientific article published on 23 August 2016

Serum chemerin levels during normal human pregnancy

scientific article published on 08 January 2013

Sex-Biased Physiological Roles of NPFF1R, the Canonical Receptor of RFRP-3, in Food Intake and Metabolic Homeostasis Revealed by its Congenital Ablation in mice

scholarly article by Silvia Leon et al published October 2018 in Metabolism

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism

scientific article

The Central Nervous System in Metabolic Syndrome

The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism

scientific article published on 28 October 2011

The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity

scientific article published on 16 December 2011

The MST3/STK24 kinase mediates impaired fasting blood glucose after a high-fat diet

scientific article published on 27 September 2017

The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system

scientific article published on 7 September 2011

The atypical cannabinoid O-1602 stimulates food intake and adiposity in rats.

scientific article

The brain and brown fat

scientific article

The brain: a new organ for the metabolic actions of SIRT1.

scientific article published on 15 August 2013

The cannabinoid receptor 2 is critical for the host response to sepsis

scientific article published on 12 June 2009

The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin

scientific article

The central melanocortin system directly controls peripheral lipid metabolism

scientific article

The endocannabinoid system and the control of glucose homeostasis.

scientific article published on May 2008

The endocannabinoid system: role in glucose and energy metabolism

scientific article published on 14 April 2009

The melanocortin-3 receptor is required for entrainment to meal intake

scientific journal article

The obestatin/GPR39 system is up-regulated by muscle injury and functions as an autocrine regenerative system

scientific article

The opioid system and food intake: homeostatic and hedonic mechanisms

scientific article published on 19 April 2012

The orexigenic effect of orexin-A revisited: dependence of an intact growth hormone axis.

scientific article published on 16 July 2013

Thyroid hormones induce browning of white fat ⬇️

scientific article published on 02 December 2016

Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway

scientific article

Urogualylin: a new actor in the energy balance movie

scientific article published on 4 December 2017

Uroguanylin Action in the Brain Reduces Weight Gain in Obese Mice via Different Efferent Autonomic Pathways

scientific article

Uroguanylin levels in intestine and plasma are regulated by nutritional status in a leptin-dependent manner.

scientific article published on 06 March 2015

Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional status.

scientific article published in August 2009

Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis

scientific article published on 16 November 2020

What is the real relevance of endogenous ghrelin?

scientific article published on 20 May 2015

dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe

scientific article published in 2024

kappa-Opioid receptors control the metabolic response to a high-energy diet in mice

scientific article

mTOR signaling in the arcuate nucleus of the hypothalamus mediates the anorectic action of estradiol

scientific article published on 18 June 2018

p38α blocks brown adipose tissue thermogenesis through p38δ inhibition

scientific article published on 06 July 2018

p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.

scientific article published on 3 February 2016

p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1

scientific article published in Nature Communications

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