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List of works by David M. Irwin

"Out of pollen" hypothesis for origin of new genes in flowering plants: study from Arabidopsis thaliana

scientific article

A novel element regulates expression of the proximal human proglucagon promoter in islet cells

scientific article published on 25 January 2007

A profound role for the expansion of trypsin-like serine protease family in the evolution of hematophagy in mosquito

scientific article published on 3 July 2009

A second insulin gene in fish genomes

scientific article

Aberrant regulation of human intestinal proglucagon gene expression in the NCI-H716 cell line

scientific article published on May 2003

Adaptation of gut microbiome and host metabolic systems to lignocellulosic degradation in bamboo rats

scientific article published on 14 May 2022

Adaptive Evolution of Feline Coronavirus Genes Based on Selection Analysis

scientific article published on 13 August 2020

Adaptive evolution of energy metabolism genes and the origin of flight in bats

scientific article

Adaptive evolution of the Hox gene family for development in bats and dolphins

scientific article (publication date: 2013)

Amphibian glucagon family peptides: potent metabolic regulators in fish hepatocytes

scientific article published in June 2001

An over expression APP model for anti-Alzheimer disease drug screening created by zinc finger nuclease technology

scientific article (publication date: 2013)

Ancient duplications of the human proglucagon gene

scientific article

Balancing selection on CDH2 may be related to the behavioral features of the Belgian Malinois

scientific article

Bats: Body mass index, forearm mass index, blood glucose levels and SLC2A2 genes for diabetes

scientific article

CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

scientific article

CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes

scientific article

Characterization of the cow stomach lysozyme genes: repetitive DNA and concerted evolution

scientific article published in October 1993

Chromosomal localization of the lysozyme gene cluster in river buffalo (Bubalus bubalis L.).

scientific article

Cloning of stanniocalcin (STC) cDNAs of divergent teleost species: Monomeric STC supports monophyly of the ancient teleosts, the osteoglossomorphs

scientific article

Comparison of glyburide and insulin in the management of gestational diabetes: A meta-analysis

scientific article

Complete mitochondrial genome of the Indian peafowl (Pavo cristatus), with phylogenetic analysis in phasianidae

scientific article published on 10 January 2014

Complete mtDNA genomes reveal similar penetrances of maternally inherited type 2 diabetes in two Chinese families

scientific article published on 3 December 2014

Contrasting Patterns in the Evolution of Vertebrate MLX Interacting Protein (MLXIP) and MLX Interacting Protein-Like (MLXIPL) Genes

scientific article

Correction: Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair

article

Correlated evolution among six gene families in Drosophila revealed by parallel change of gene numbers.

scientific article

DNA methylation signatures of long intergenic noncoding RNAs in porcine adipose and muscle tissues.

scientific article

De Novo Origin of Human Protein-Coding Genes ⬇️

scientific article published on November 10, 2011

Decreased CRH mRNA expression in the fetal guinea pig hypothalamus following maternal nutrient restriction

scientific article published in March 2001

Differences in Selection Drive Olfactory Receptor Genes in Different Directions in Dogs and Wolf ⬇️

scientific article published on June 7, 2012

Differential expression of Meis2, Mab21l2 and Tbx3 during limb development associated with diversification of limb morphology in mammals

scientific article

Differential expression of genes and changes in glucose metabolism in the liver of liver-specific glucokinase gene knockout mice.

scientific article published on 2 January 2013

Differential expression of genes associated with the progression of renal disease in the kidneys of liver-specific glucokinase gene knockout mice.

scientific article published on 21 March 2013

Direct regulation of the proglucagon gene by insulin, leptin, and cAMP in embryonic versus adult hypothalamic neurons.

scientific article

DoGSD: the dog and wolf genome SNP database

scientific article

Domestication genomics: evidence from animals

scientific article

Domestication of the dog from the wolf was promoted by enhanced excitatory synaptic plasticity: a hypothesis

scientific article

Draft genome sequence of the Tibetan antelope

scientific article published on January 2013

Evaluating the Roles of Energetic Functional Constraints on Teleost Mitochondrial-Encoded Protein Evolution

scientific article published on 5 October 2010

Evolution of New Hormone Function: Loss and Gain of a Receptor

scientific article published on 13 January 2005

Evolution of conserved secondary structures and their function in transcriptional regulation networks

scientific article

Evolution of cow nonstomach lysozyme genes

scientific article published in December 2004

Evolution of genes for incretin hormones and their receptors

scientific article published on January 2010

Evolution of glucose utilization: glucokinase and glucokinase regulator protein.

scientific article published on 25 September 2013

Evolution of hepatic glucose metabolism: liver-specific glucokinase deficiency explained by parallel loss of the gene for glucokinase regulatory protein (GCKR)

scientific article (publication date: 2013)

Evolution of receptors for peptides similar to glucagon

scientific article published on 17 March 2014

Evolution of receptors for proglucagon-derived peptides: isolation of frog glucagon receptors

scientific article

Evolution of rodent lysozymes: isolation and sequence of the rat lysozyme genes

scientific article published in March 1993

Evolution of stomach lysozyme: the pig lysozyme gene

scientific article published in April 1996

Evolution of the Vertebrate Resistin Gene Family

scientific article published on 15 June 2015

Evolution of the bovine lysozyme gene family: changes in gene expression and reversion of function

scientific article

Evolution of the mammalian lysozyme gene family

scientific article

Evolution of the vertebrate glucose-dependent insulinotropic polypeptide (GIP) gene

scientific article published in December 2006

Evolution of the vertebrate goose-type lysozyme gene family.

scientific article

Evolution of the vertebrate insulin receptor substrate (Irs) gene family

scientific article

Evolutionary and functional novelty of pancreatic ribonuclease: a study of Musteloidea (order Carnivora).

scientific article

Evolutionary genetics of ruminant lysozymes

scientific article published on January 1, 1992

Excessive Autophagy Activation and Increased Apoptosis Are Associated with Palmitic Acid-Induced Cardiomyocyte Insulin Resistance

scientific article published on 26 November 2017

Exposure of tumor-associated macrophages to apoptotic MCF-7 cells promotes breast cancer growth and metastasis

scientific article published on 26 May 2015

Expression of the Human Glucokinase Gene: Important Roles of the 5′ Flanking and Intron 1 Sequences ⬇️

scientific article published on September 20, 2012

Fish proglucagon genes have differing coding potential

scientific article published in February 2004

GdX/UBL4A specifically stabilizes the TC45/STAT3 association and promotes dephosphorylation of STAT3 to repress tumorigenesis.

scientific article

Genetic adaptation of the hypoxia-inducible factor pathway to oxygen pressure among eurasian human populations.

scientific article published on 23 May 2012

Genetic adaptations of the plateau zokor in high-elevation burrows

scientific article published on 25 November 2015

Genetic variations associated with six-white-point coat pigmentation in Diannan small-ear pigs

scientific article published on 08 June 2016

Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration

scientific article published on 27 May 2020

Genome-wide identification and characterization of teleost-specific microRNAs within zebrafish

scientific article published on 19 February 2015

Genome-wide identification of long intergenic noncoding RNA genes and their potential association with domestication in pigs.

scientific article published on 2 June 2014

Genome-wide scan for bats and dolphin to detect their genetic basis for new locomotive styles

scientific article

Genome-wide scans for candidate genes involved in the aquatic adaptation of dolphins.

scientific article

Genomic Analyses Reveal Potential Independent Adaptation to High Altitude in Tibetan Chickens

scientific article published on 18 March 2015

Genomic analysis of snub-nosed monkeys (Rhinopithecus) identifies genes and processes related to high-altitude adaptation

scientific article published on 11 July 2016

Genomic organization and evolution of ruminant lysozyme c genes ⬇️

scientific article

Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs

scientific article published in May 1999

Host genetics is associated with the gut microbial community membership rather than the structure

scientific article published on April 2016

Identification of HNF4A Mutation p.T130I and HNF1A Mutations p.I27L and p.S487N in a Han Chinese Family with Early-Onset Maternally Inherited Type 2 Diabetes.

scientific article published on 11 February 2016

In silico identification and Bayesian phylogenetic analysis of multiple new mammalian kallikrein gene families

scientific article published on 7 July 2006

Incretin hormones and the expanding families of glucagon-like sequences and their receptors

scientific article published on October 2011

Insights into the evolution of themotilin/ghrelin-associated family and their receptors

scientific article published on 23 December 2008

Insulin treatment and high-fat diet feeding reduces the expression of three Tcf genes in rodent pancreas

scientific article published on 30 July 2010

Integrating Genomic and Transcriptomic Data to Reveal Genetic Mechanisms Underlying Piao Chicken Rumpless Trait

scientific article published in 2021

Integrative analyses of RNA editing, alternative splicing, and expression of young genes in human brain transcriptome by deep RNA sequencing

scientific article published on 17 July 2015

Integrative analysis of young genes, positively selected genes and lncRNAs in the development of Drosophila melanogaster

scientific article

Introgression of mitochondrial DNA promoted by natural selection in the Japanese pipistrelle bat (Pipistrellus abramus).

scientific article published on 30 September 2014

Intron 1 sequences are required for pancreatic expression of the human proglucagon gene

scientific article published on 13 October 2005

Long term liver specific glucokinase gene defect induced diabetic cardiomyopathy by up regulating NADPH oxidase and down regulating insulin receptor and p-AMPK.

scientific article published on 22 January 2014

Long-term renal changes in the liver-specific glucokinase knockout mouse: implications for renal disease in maturity-onset diabetes of the young 2 ⬇️

scientific article published on December 13, 2010

Mitogenomic analyses propose positive selection in mitochondrial genes for high-altitude adaptation in galliform birds

scientific article published on 7 August 2014

Molecular Evolution of the Nuclear Factor (Erythroid-Derived 2)-Like 2 Gene Nrf2 in Old World Fruit Bats (Chiroptera: Pteropodidae)

scientific article

Molecular cloning of preproinsulin cDNAs from several osteoglossomorphs and a cyprinid

scientific article

Molecular evolution of mammalian incretin hormone genes

scientific article published on 15 April 2009

Molecular evolution of proglucagon.

scientific article

Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair

scientific article

Molecular evolution of the vertebrate hexokinase gene family: Identification of a conserved fifth vertebrate hexokinase gene.

scientific article

Molecular evolution of vertebrate goose-type lysozyme genes

scientific article

Molecular evolution. Who are the parents of eukaryotes?

scientific article

Molecular signatures and functional analysis of beige adipocytes induced from in vivo intra-abdominal adipocytes

scientific article published on 11 July 2018

Mosaic evolution of ruminant stomach lysozyme genes

scientific article published in December 1999

Multiple specialised goose-type lysozymes potentially compensate for an exceptional lack of chicken-type lysozymes in Atlantic cod.

scientific article published on 21 June 2016

Nocturnal to Diurnal Transition in the Common Ancestor of Haplorrhines: Evidence from Genomic-Scan for Positively Selected Genes

scientific article published in January 2015

Origin and convergent evolution of exendin genes.

scientific article

Out of southern East Asia: the natural history of domestic dogs across the world

scientific article published in January 2016

Parallel and convergent evolution of the dim-light vision gene RH1 in bats (Order: Chiroptera).

scientific article

Parallel evolution of the glycogen synthase 1 (muscle) gene Gys1 between Old World and New World fruit bats (Order: Chiroptera).

scientific article published on 8 July 2014

Phosphoenolpyruvate carboxykinase 1 gene (Pck1) displays parallel evolution between Old World and New World fruit bats

scientific article

Physical mapping of the lysozyme gene family in cattle

scientific article published in 1993

Polymorphism detected by multiple RENS in the human coagulation factor II (F2) gene

scientific article published on January 1991

Population Genomics Analysis Revealed Origin and High-altitude Adaptation of Tibetan Pigs

scientific article published on 07 August 2019

Population variation revealed high-altitude adaptation of Tibetan mastiffs

scientific article published on 11 February 2014

Positive Selection on the Gene RNASEL: Correlation between Patterns of Evolution and Function

scientific article published on 17 April 2012

Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication

scientific article published on April 2016

Proglucagon cDNAs from the Leopard Frog, Rana pipiens, encode two GLP-1-like peptides

scientific article published in April 2000

Proinsulin cDNAs from the leopard frog, Rana pipiens: evolution of proinsulin processing

scientific article published in March 2000

Prolonged treatment with 3-isobutyl-1-methylxanthine improves the efficiency of differentiating 3T3-L1 cells into adipocytes

scientific article

QcReads: an adapter and quality trimming tool for next-generation sequencing reads

scientific article published on 9 November 2013

Rapid Evolution of the Mammalian HILS1 Gene and the Nuclear Condensation Process during Mammalian Spermiogenesis

scientific article published in January 2013

Relaxed evolution in the tyrosine aminotransferase gene tat in old world fruit bats (Chiroptera: Pteropodidae)

scientific article (publication date: 2014)

Repetitive transpositions of mitochondrial DNA sequences to the nucleus during the radiation of horseshoe bats (Rhinolophus, Chiroptera).

scientific article published on 22 January 2016

Resistin and insulin resistance in hepatocytes: resistin disturbs glycogen metabolism at the protein level

scientific journal article

Resistin disrupts glycogen synthesis under high insulin and high glucose levels by down-regulating the hepatic levels of GSK3β.

scientific article published on 13 July 2013

Role of glucokinase in the subcellular localization of glucokinase regulatory protein

scientific article published on 2 April 2015

Selective constraints on the activation domain of transcription factor Pit-1.

scientific article published on September 1996

Signature of balancing selection at the MC1R gene in Kunming dog populations

scientific article

Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells (CD44(+)/CD24(-)) in MCF-7 by Upregulating Mucin1 and EpCAM.

scientific article

Stepwise loss of motilin and its specific receptor genes in rodents

scientific article published on 20 August 2009

Stomach lysozyme gene of the langur monkey: tests for convergence and positive selection

scientific article published on November 1991

Structure and evolution of the bovine prothrombin gene

scientific article published in March 1988

Structure and expression of the chicken proglucagon gene

scientific article published in January 2005

The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis.

scientific article published on 10 September 2012

The Xenopus proglucagon gene encodes novel GLP-1-like peptides with insulinotropic properties.

scientific article

The complete consensus sequence of coxsackievirus B6 and generation of infectious clones by long RT-PCR.

scientific article published on October 1999

The fish endocrine pancreas: review, new data, and future research directions in ontogeny and phylogeny.

scientific article published on 23 January 2006

The genomics of selection in dogs and the parallel evolution between dogs and humans

scientific article

The great roundleaf bat (Hipposideros armiger) as a good model for cold-induced browning of intra-abdominal white adipose tissue

scientific article

The motilin gene evolved a new function in kangaroo rats and kangaroo mice (Dipodomyinae).

scientific article published on October 2012

Two steps easier than one?

scientific article published in December 1993

Whole-genome sequence of the Tibetan frog Nanorana parkeri and the comparative evolution of tetrapod genomes

scientific article

Xinmailong mitigated epirubicin-induced cardiotoxicity via inhibiting autophagy

scientific article published on 29 August 2016

[40] Assays for copy number, differential expression, and recombination in lysozyme multigene family

scientific article published in 1993

cDNA Cloning of Proglucagon from the Stomach and Pancreas of the Dog

scientific article published in January 2001

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