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List of works by Philippe Ryvlin

5-HT(1A) receptor binding changes in patients with major depressive disorder before and after antidepressant treatment: a pilot [¹⁸F]MPPF positron emission tomography study.

scientific article published in July 2012

5-HT1A gene promoter polymorphism and [18F]MPPF binding potential in healthy subjects: a PET study

scientific article

5-HT1A receptor binding and intracerebral activity in temporal lobe epilepsy: an [18F]MPPF-PET study

scientific article published on 25 February 2004

A European survey on current practices in epilepsy monitoring units and implications for patients' safety

scientific article

A novel three base-pair LGI1 deletion leading to loss of function in a family with autosomal dominant lateral temporal epilepsy and migraine-like episodes

scientific article published on 5 March 2009

A phantom and animal study of temperature changes during fMRI with intracerebral depth electrodes.

scientific article published on 28 October 2013

A subset of genomic alterations detected in rolandic epilepsies contains candidate or known epilepsy genes including GRIN2A and PRRT2.

scientific article published on 24 December 2013

Accuracy of distinguishing between dysembryoplastic neuroepithelial tumors and other epileptogenic brain neoplasms with [¹¹C]methionine PET.

scientific article

Acute neurological deterioration in ovarioleukodystrophy related to EIF2B mutations: pregnancy with oocyte donation is a potentially precipitating factor

scientific article published on 14 November 2007

Adjunctive brivaracetam in adults with uncontrolled focal epilepsy: results from a double-blind, randomized, placebo-controlled trial.

scientific article published on 28 October 2013

Advanced [(18)F]FDG and [(11)C]flumazenil PET analysis for individual outcome prediction after temporal lobe epilepsy surgery for hippocampal sclerosis.

scientific article

Analysis of clinical patterns and underlying epileptogenic zones of hypermotor seizures

scientific article published on 21 May 2008

Apoptosis time course in the limbic system after myocardial infarction in the rat.

scientific article published on 18 April 2008

Association between triallelic polymorphism of the serotonin transporter and [18F]MPPF binding potential at 5-HT1A receptors in healthy subjects

scientific article

Association of prone position with sudden unexpected death in epilepsy

scientific article published on 01 September 2015

Automated Detection of Postictal Generalized EEG Suppression

scientific article published in February 2018

Behavioral and fMRI responses to fearful faces are altered in benign childhood epilepsy with centrotemporal spikes (BCECTS).

scientific article published on 31 July 2017

Beyond pharmacotherapy: surgical management.

scientific article

Big data in epilepsy: Clinical and research considerations. Report from the Epilepsy Big Data Task Force of the International League Against Epilepsy

scientific article published on 07 August 2020

Biomarkers of seizure severity derived from wearable devices

scientific article published on 10 June 2020

Brain glucose metabolism with [18F]-fluorodeoxyglucose and positron emission tomography before and after surgical resection of epileptogenic cavernous angiomas

scientific article published on 01 January 1997

Brain responses to success and failure: Direct recordings from human cerebral cortex

scientific article published in August 2010

Brainstem changes in 5-HT1A receptor availability during migraine attack.

scientific article published on 29 October 2010

Can we increase the yield of FDG-PET in the preoperative work-up for epilepsy surgery?

scientific article

Category-Specific Visual Responses: An Intracranial Study Comparing Gamma, Beta, Alpha, and ERP Response Selectivity

scientific article

Celecoxib after the onset of reperfusion reduces apoptosis in the amygdala

scientific journal article

Chirurgie des épilepsies de l’enfant : du fonctionnement en réseau à la création d’un centre d’expertise et de soins

scientific article published on 15 April 2008

Choosing the tumoral epilepsy surgery candidate.

scientific article

Clinical comparability of the new antiepileptic drugs in refractory partial epilepsy: reply to Costa et al

scientific article published on 01 November 2011

Clinical utility of flumazenil-PET versus [18F]fluorodeoxyglucose-PET and MRI in refractory partial epilepsy. A prospective study in 100 patients.

scientific article published in November 1998

Combination of PET and Magnetoencephalography in the Presurgical Assessment of MRI-Negative Epilepsy

scientific article

Comorbidity between temporal lobe epilepsy and depression: a [18F]MPPF PET study

scientific article published on 2 September 2008

Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy

scientific article published on 01 February 2007

Cortico-cortical and motor evoked potentials to single and paired-pulse stimuli: An exploratory transcranial magnetic and intracranial electric brain stimulation study.

scientific article published on 17 June 2016

Cost-effectiveness analysis of epilepsy surgery in a controlled cohort of adult patients with intractable partial epilepsy: A 5-year follow-up study.

scientific article published on 5 September 2016

Current practices in long-term video-EEG monitoring services: A survey among partners of the E-PILEPSY pilot network of reference for refractory epilepsy and epilepsy surgery.

scientific article

Current standards of neuropsychological assessment in epilepsy surgery centers across Europe.

scientific article published on 9 January 2017

Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe.

scientific article

Definition and diagnostic criteria of sleep-related hypermotor epilepsy

scientific article

Depression and epilepsy, pain and psychogenic non-epileptic seizures: clinical and therapeutic perspectives

scientific article published on June 2012

Depression and epilepsy: epidemiologic and neurobiologic perspectives that may explain their high comorbid occurrence.

scientific article

Diagnostic and prognostic value of noninvasive long-term video-electroencephalographic monitoring in epilepsy surgery: A systematic review and meta-analysis from the E-PILEPSY consortium

scientific article published on 22 November 2018

Diagnostic methods and treatment options for focal cortical dysplasia

scientific article

Dietary Measures to Prevent Sudden Unexpected Death in Epilepsy—Reply

scientific article published on 01 September 2018

Disengagement and inhibition of visual-spatial attention are differently impaired in children with rolandic epilepsy and Panayiotopoulos syndrome.

scientific article published on 15 July 2012

Disentangling the relationship between epilepsy and its behavioral comorbidities - the need for prospective studies in new-onset epilepsies

scientific article published on 13 December 2013

Does epilepsy surgery lower the mortality of drug-resistant epilepsy?

scientific article published on October 2003

Editorial

Effects of aripiprazole, risperidone, and olanzapine on 5-HT1A receptors in patients with schizophrenia.

scientific article

Efficacy and safety of adjunctive perampanel for the treatment of refractory partial seizures: a pooled analysis of three phase III studies.

scientific article published on 10 May 2013

Efficacy of naloxone in reducing postictal central respiratory dysfunction in patients with epilepsy: study protocol for a double-blind, randomized, placebo-controlled trial

scientific article

Epidemiology of epilepsy

scientific article

Epilepsia partialis continua with dystonic hand movement in a patient with a malformation of cortical development

scientific article

Epilepsy in the adult

scientific article published on December 20, 2010

Epilepsy surgery in children and adults.

scientific article

Epilepsy surgery: eligibility criteria and presurgical evaluation.

scientific article

Epilepsy, cognition, and neuropsychiatry (Epilepsy, Brain, and Mind, part 2)

scientific article published on 10 June 2013

Epilepsy: new advances

scientific article published on 24 September 2014

Erythropoietin receptor expression is concordant with erythropoietin but not with common beta chain expression in the rat brain throughout the life span

scientific journal article

European trends in epilepsy surgery

scientific article published on 13 June 2018

Evidence for corticofugal modulation of peripheral auditory activity in humans.

scientific article published on 8 September 2005

Evidence of peripheral auditory activity modulation by the auditory cortex in humans.

scientific article published in January 2001

Evoked potential study of hippocampal efferent projections in the human brain.

scientific article published on 12 June 2011

Exploratory Phase II Trial to Evaluate the Safety and the Antiepileptic Effect of Pitolisant (BF2.649) in Refractory Partial Seizures, Given as Adjunctive Treatment During 3 Months

scientific article

Facial pain as first manifestation of anti-Hu paraneoplastic syndrome.

scientific article

Factors determining response to antiepileptic drugs in randomized controlled trials. A systematic review and meta-analysis

scientific article published on 26 January 2011

Foreign language ictal speech automatisms in nondominant temporal lobe epilepsy

scientific article published in November 2008

From unwitnessed fatality to witnessed rescue: Pharmacologic intervention in sudden unexpected death in epilepsy

scientific article

Functional connectivity of insular efferences.

scientific article

Functional mapping of the insular cortex: clinical implication in temporal lobe epilepsy.

scientific article

Functional neuroimaging strategy in temporal lobe epilepsy: a comparative study of 18FDG-PET and 99mTc-HMPAO-SPECT.

scientific article published in June 1992

Functional significance of olfactory-induced oscillations in the human amygdala

scientific article published on 13 April 2005

GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction

scientific article published on 11 August 2013

Galanin pathogenic mutations in temporal lobe epilepsy

scientific article

Gamma oscillations in V1 are correlated with GABA(A) receptor density: A multi-modal MEG and Flumazenil-PET study.

scientific article

Generic substitution of antiepileptic drugs

scientific article published on December 2010

Greater response to placebo in children than in adults: a systematic review and meta-analysis in drug-resistant partial epilepsy

scientific article

High signal intensity on T2-weighted MRI correlates with hypoperfusion in temporal lobe epilepsy

scientific article published in January 1992

Hippocampal-orbitofrontal connectivity in human: an electrical stimulation study.

scientific article published in August 2005

Hypermotor seizures in lateral and mesial parietal epilepsy.

scientific article

Hypoxemia following generalized convulsive seizures: Risk factors and effect of oxygen therapy

scientific article published on 19 December 2018

Ictal changes in parasympathetic tone: Prediction of postictal oxygen desaturation.

scientific article

Impact of vagus nerve stimulation on sleep-related breathing disorders in adults with epilepsy.

scientific article published on 26 December 2017

Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study

scientific article published on 04 September 2013

Interictal brain 5-HT1A receptors binding in migraine without aura: a 18F-MPPF-PET study.

scientific article published on 22 August 2008

Interictal cerebral metabolism and epilepsy in cavernous angiomas.

scientific article published in June 1995

Intracerebral recordings of nocturnal hyperkinetic seizures: demonstration of a longer duration of the pre-seizure sleep spindle

scientific article published on 20 February 2007

Intrainsular functional connectivity in human

scientific article published on 12 September 2013

Introduction

scientific article published on 18 August 2017

Invasive Investigation of Insular Cortex Epilepsy

scientific article

Involvement of medial pulvinar thalamic nucleus in human temporal lobe seizures.

scientific article published in January 2006

Ipsilateral head deviation in frontal lobe seizures

scientific article published on 01 November 2005

Lateralization of olfactory processing: differential impact of right and left temporal lobe epilepsies

scientific article published on 20 July 2014

Linking structural and effective brain connectivity: structurally informed Parametric Empirical Bayes (si-PEB)

scientific article published on 09 October 2018

Long-lasting seizure-related anxiety in patients with temporal lobe epilepsy and comorbid psychiatric disorders.

scientific article published on 31 July 2015

Long-term outcome of gamma-knife surgery in temporal lobe epilepsy

scientific article published on 01 July 2008

Long-term surveillance of SUDEP in drug-resistant epilepsy patients treated with VNS therapy

scientific article published on 16 January 2018

MRI assessment of the anatomy of optic radiations after temporal lobe epilepsy surgery

scientific article published on 01 January 1999

Machine learning and wearable devices of the future

scientific article published on 26 July 2020

Magnetic resonance imaging in clinical trials.

scientific article

Measures for improving treatment outcomes for patients with epilepsy--results from a large multinational patient-physician survey

scientific article published on 02 April 2014

Medicoeconomic assessment of epilepsy surgery in adults with medically intractable partial epilepsy. Three-year outcomes from a multicenter French cohort

scientific article published on 28 April 2008

Mesio-temporal ictal semiology as an indicator for surgical treatment of epilepsies with large multilobar cerebral lesions.

scientific article published on 16 March 2013

Metabolic patterns associated with non-specific magnetic resonance imaging abnormalities in temporal lobe epilepsy

scientific article published in December 1991

More children with epilepsy are dying suddenly

scientific article published on 07 July 2014

NARP mitochondriopathy: an unusual cause of progressive myoclonic epilepsy

scientific article published on 01 April 2007

Neural Activity Elicited by a Cognitive Task can be Detected in Single-Trials with Simultaneous Intracerebral EEG-fMRI Recordings.

scientific article

Neurologist-patient communication about epilepsy in the United States, Spain, and Germany

scientific article published on 01 April 2018

Neurology

scientific article published in January 2018

Neurophysiological monitoring for epilepsy surgery: the Talairach SEEG method. StereoElectroEncephaloGraphy. Indications, results, complications and therapeutic applications in a series of 100 consecutive cases.

scientific article published in January 2001

Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus

scientific article

Nocturnal hypermotor seizures, suggesting frontal lobe epilepsy, can originate in the insula.

scientific article published on April 2006

Non-EEG seizure detection is here

scientific article published on 5 January 2018

Noninvasive detection of focal seizures in ambulatory patients

scientific article published on 02 June 2020

Novel mutations in EPM2A and NHLRC1 widen the spectrum of Lafora disease

scientific article published on 5 August 2010

Novel treatment and new drugs in epilepsy treatment

scientific article published on 24 October 2017

Odorants elicit evoked potentials in the human amygdala

scientific article published on July 2001

Olfaction and neurological diseases: a review of the literature

scientific article published in February 2007

Olfactory hypersensitivity in migraineurs: a H(2)(15)O-PET study

scientific article published on 22 August 2008

Olfactory short-term memory and related amygdala recordings in patients with temporal lobe epilepsy

scientific article published on 4 June 2003

On the origin of painful somatosensory seizures

scientific article published on February 2015

Once-daily lamotrigine extended release for epilepsy management.

scientific article published on February 2009

Opsoclonus-myoclonus as a manifestation of Lyme disease

scientific article (publication date: September 2006)

PET imaging of brain 5-HT1A receptors in the preoperative evaluation of temporal lobe epilepsy

scientific article published on 12 September 2008

Painful seizures with allodynia in an 11-year-old boy

scientific article published on 01 October 1999

Paroxysmal exercise-induced dyskinesia and epilepsy is due to mutations in SLC2A1, encoding the glucose transporter GLUT1.

scientific article

Patient and physician preferences: impact on treatment effectiveness*

scientific article published on September 1, 2012

Patients' safety in the epilepsy monitoring unit: time for revising practices

scientific article published on April 2014

Peri-ictal heart rate variability parameters as surrogate markers of seizure severity

scientific article published on 21 May 2020

Periventricular [(11)C]flumazenil binding for predicting postoperative outcome in individual patients with temporal lobe epilepsy and hippocampal sclerosis

scientific article published on 03 September 2013

Pharmacotherapy for tonic-clonic seizures

scientific article published on 06 May 2014

Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: reply to Beyenburg et al., 2009.

scientific article published in May 2010

Positron emission tomography with α-[11C]methyl-L-tryptophan in tuberous sclerosis complex-related epilepsy

scientific article published on 28 October 2013

Postconvulsive central apnea as a biomarker for sudden unexpected death in epilepsy (SUDEP)

scientific article published on 19 December 2018

Practical guidance and considerations for transitioning patients from oxcarbazepine or carbamazepine to eslicarbazepine acetate--Expert opinion

scientific article published on 23 June 2015

Practice Guideline Summary: Sudden Unexpected Death in Epilepsy Incidence Rates and Risk Factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Soci

scientific article

Predicting epilepsy surgery outcome.

scientific article published on 16 February 2016

Predictors of and attitudes toward counseling about SUDEP and other epilepsy risk factors among Austrian, German, and Swiss neurologists and neuropediatricians

scientific article published on 22 February 2016

Pregabalin for the management of partial epilepsy

scientific article published in December 2008

Pregabalin in partial seizures: a pragmatic 21-week, open-label study (PREPS).

scientific article published on 25 January 2010

Preventing Sudden Unexpected Death in Epilepsy

scientific article published on 01 May 2018

Prevention of generalized tonic-clonic seizures in refractory focal epilepsy: a meta-analysis

scientific article published on 02 September 2014

Principles of Stereotactic Electroencephalography in Epilepsy Surgery.

scientific article

Profile of perampanel and its potential in the treatment of partial onset seizures

scientific article published on 13 May 2013

Putting it all together: Options for intractable epilepsy: An updated algorithm on the use of epilepsy surgery and neurostimulation

scientific article published on 18 September 2018

Recommendations for the use of structural magnetic resonance imaging in the care of patients with epilepsy: A consensus report from the International League Against Epilepsy Neuroimaging Task Force

scientific article published on 28 May 2019

Recording the insula during ictal asystole

scientific article published on 08 September 2013

Refractory and super-refractory status epilepticus in adults: a 9-year cohort study

scientific article

Reply: Determinants of epilepsy surgery failure: aetiology matters.

scientific article published on 19 April 2016

Reply: Temporal plus epilepsy is a major determinant of temporal lobe surgery failures.

scientific article published on 10 March 2016

Representation of pain and somatic sensation in the human insula: a study of responses to direct electrical cortical stimulation

scientific article published in April 2002

Response to commentary on recommendations for the use of structural MRI in the care of patients with epilepsy: A consensus report from the ILAE Neuroimaging Task Force

scientific article published on 29 August 2019

Retigabine for partial onset seizures.

scientific article published on May 2012

Risk factors of postictal generalized EEG suppression in generalized convulsive seizures

scientific article published on 2 September 2015

Risk of sudden unexpected death in epilepsy in patients given adjunctive antiepileptic treatment for refractory seizures: a meta-analysis of placebo-controlled randomised trials

scientific article

SEEG-guided thermocoagulations: a palliative treatment of nonoperable partial epilepsies

scientific article published on 01 November 2008

Seizure detection and mobile health devices in epilepsy: Recent developments and future perspectives

scientific article published on 23 October 2020

Seizure detection and mobile health devices in epilepsy: Update and future developments

scientific article published on 01 June 2018

Seizure-related short-term plasticity of benzodiazepine receptors in partial epilepsy: a [11C]flumazenil-PET study

scientific article

Seizures Outcome After Stereoelectroencephalography-Guided Thermocoagulations in Malformations of Cortical Development Poorly Accessible to Surgical Resection

scientific article published on 01 July 2015

Severity and burden of partial-onset seizures in a phase III trial of eslicarbazepine acetate

scientific article published on 12 November 2015

Similar semiology of epileptic and psychogenic nonepileptic seizures recorded during stereo-EEG.

scientific article

Single and paired-pulse electrical stimulation during invasive EEG recordings

scientific article published on 15 March 2016

Spinal muscarinic and nicotinic subtypes activated by clonidine in postincisional pain

scientific article published in December 2005

Standards for testing and clinical validation of seizure detection devices

scientific article published on 01 June 2018

Statistical parametric mapping of 5-HT1A receptor binding in temporal lobe epilepsy with hippocampal ictal onset on intracranial EEG.

scientific article

Stereo electroencephalography-guided radiofrequency thermocoagulation (SEEG-guided RF-TC) in drug-resistant focal epilepsy: Results from a 10-year experience

scientific article published on 16 November 2016

Stereo-electro-encephalography-Guided Radiofrequency Thermocoagulation: From In Vitro and In Vivo Data to Technical Guidelines.

scientific article

Stereotactic Electroencephalography Is a Safe Procedure, Including for Insular Implantations

scientific article published on 18 December 2016

Structural and effective brain connectivity underlying biological motion detection

scientific article published on 04 December 2018

Subcontinuous epileptiform activity after failed hippocampal radiosurgery.

scientific article published on 10 June 2011

Sudden unexpected death in epilepsy (SUDEP): update and reflections.

scientific article

Sudden unexpected death in epilepsy patients is often misdiagnosed as sudden cardiac death

scientific article published on 02 August 2017

Sudden unexpected death in epilepsy: current knowledge and future directions

scientific article

Sudden unexpected death in epilepsy: from mechanisms to prevention.

scientific article

TMS combined with EEG in genetic generalized epilepsy: A phase II diagnostic accuracy study

scientific article published on 24 November 2016

Temporal plus epilepsy is a major determinant of temporal lobe surgery failures.

scientific article published on 22 December 2015

Temporo-mesial epilepsy surgery: outcome and complications in 100 consecutive adult patients

scientific article published on 7 November 2005

Test-retest reproducibility of 18F-MPPF PET in healthy humans: a reliability study

scientific article

Testing patients during seizures: A European consensus procedure developed by a joint taskforce of the ILAE - Commission on European Affairs and the European Epilepsy Monitoring Unit Association

scientific article published on 21 July 2016

The Human Brain Project-Synergy between neuroscience, computing, informatics, and brain-inspired technologies

scientific article published on 01 July 2019

The SKATE study: an open-label community-based study of levetiracetam as add-on therapy for adults with uncontrolled partial epilepsy

scientific article published on 6 August 2007

The Surgical Approach to the Anterior Nucleus of Thalamus in Patients With Refractory Epilepsy: Experience from the International Multicenter Registry (MORE)

scientific article published on 01 January 2019

The choice of antiepileptic drugs in newly diagnosed epilepsy: a national French survey

scientific article published in December 2004

The concept of temporal 'plus' epilepsy

scientific article

The hidden causes of surgery-resistant temporal lobe epilepsy: extratemporal or temporal plus?

scientific article

The long-term effect of vagus nerve stimulation on quality of life in patients with pharmacoresistant focal epilepsy: the PuLsE (Open Prospective Randomized Long-term Effectiveness) trial

scientific article

The role of sub-hippocampal versus hippocampal regions in bitemporal lobe epilepsies.

scientific article published in July 2016

The value of magnetoencephalography for seizure-onset zone localization in magnetic resonance imaging-negative partial epilepsy.

scientific article published on 06 September 2013

Third International Congress on Epilepsy, Brain, and Mind: Part 2.

scientific article published on 08 August 2015

Tolerability of adjunctive eslicarbazepine acetate according to concomitant lamotrigine or carbamazepine use: A subgroup analysis of three phase III trials in adults with focal (partial-onset) seizures

scientific article published on 29 August 2018

Topographical reliability of mesio-temporal sources of interictal spikes in temporal lobe epilepsy.

scientific article published in September 1998

Towards an optimal reference region in single-photon emission tomography difference images in epilepsy

scientific article published in February 2000

Towards source volume estimation of interictal spikes in focal epilepsy using magnetoencephalography

scientific article published on 21 October 2011

Transcranial Magnetic Stimulation Combined with EEG Reveals Covert States of Elevated Excitability in the Human Epileptic Brain

scientific article

Tumor necrosis factor-alpha participates in apoptosis in the limbic system after myocardial infarction

scientific article published in November 2009

Understanding the burden of focal epilepsy as a function of seizure frequency in the United States, Europe, and Brazil.

scientific article

Understanding the burden of idiopathic generalized epilepsy in the United States, Europe, and Brazil: An analysis from the National Health and Wellness Survey

scientific article

User-based evaluation of applicability and usability of a wearable accelerometer device for detecting bilateral tonic-clonic seizures: A field study

scientific article published on 01 June 2018

Vagus nerve stimulation (VNS) therapy update

scientific article published on 13 July 2018

Visual and auditory socio-cognitive perception in unilateral temporal lobe epilepsy in children and adolescents: a prospective controlled study

scientific article published in December 2014

Voxel-based analysis of asymmetry index maps increases the specificity of 18F-MPPF PET abnormalities for localizing the epileptogenic zone in temporal lobe epilepsies.

scientific article published in November 2010

Wearable devices for sudden unexpected death in epilepsy prevention

scientific article published on 01 June 2018

White matter development in children with benign childhood epilepsy with centro-temporal spikes

scientific article

[Does epilepsy surgery really lower mortality?].

scientific article

[Excess mortality and sudden unexpected death in epilepsy]

scientific article published on 25 January 2009

[In this era of value for money what is the place of epilepsy surgery in hospital practice]

scientific article published on 01 December 2007

[Long-term efficiency of vagus nerve stimulation (VNS) in non-surgical refractory epilepsies in adolescents and adults]

scientific article published on 01 December 2007

[Patients' and physicians' perceptions on participation in a clinical trial: results on a survey in a French hospital]

scientific article published on 01 November 2006

[Perceptions of patients and physicians involved in clinical trials: an overview of the literature]

scientific article published on 01 September 2006

[Polymorphism of epilepsy associated with the A3243G mutation of mitochondrial DNA (MELAS): reasons for delayed diagnosis]

scientific article published on 01 September 2004