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List of works by Hinrich Gronemeyer

9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists

scientific article published in December 2004

A DNA methyltransferase modulator inspired by peyssonenyne natural product structures.

scientific article

A canonical structure for the ligand-binding domain of nuclear receptors

scientific article published on 01 January 1996

A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors

scholarly article

A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers ⬇️

scientific article published on September 15, 1997

A new era of cancer therapy: cancer cell targeted therapies are coming of age.

scientific article published on 21 September 2007

A quality control system for profiles obtained by ChIP sequencing.

scientific article published on 14 September 2013

A reappraisal of ecdysteroid binding in drosophila

scientific article published on 01 October 1983

A single amino acid that determines the sensitivity of progesterone receptors to RU486.

scientific article

A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor

scientific article

About the variability, quality and reproducibility of ChIP-seq data

Action mechanism of retinoid-synergistic dibenzodiazepines

scientific article published on April 1997

Activation Function 2 in the Human Androgen Receptor Ligand Binding Domain Mediates Interdomain Communication with the NH2-terminal Domain

scientific article published in Journal of Biological Chemistry

Acute myeloid leukemia: therapeutic impact of epigenetic drugs

scientific article

Affinity labelling of steroid hormone receptors

scientific article

Allosteric Effects Govern Nuclear Receptor Action: DNA Appears as a Player

scientific article published on 02 June 2009

An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist.

scientific article published on May 2015

Antibody performance in ChIP-sequencing assays: From quality scores of public data sets to quantitative certification.

scientific article

Aronia melanocarpa juice induces a redox-sensitive p73-related caspase 3-dependent apoptosis in human leukemia cells

scientific article

Assessing quality standards for ChIP-seq and related massive parallel sequencing-generated datasets: When rating goes beyond avoiding the crisis

scientific article

Autonomous rexinoid death signaling is suppressed by converging signaling pathways in immature leukemia cells

scientific article

C3 halogen and c8'' substituents on stilbene arotinoids modulate retinoic Acid receptor subtype function

scientific article published in October 2009

CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity

scientific article published in Scientific Reports

Characterising ChIP-seq binding patterns by model-based peak shape deconvolution.

scientific article

Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies

scientific article published on 4 November 2004

Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family

scientific journal article

Co-regulator recruitment and the mechanism of retinoic acid receptor synergy

scientific article published in January 2002

Co-resistance to retinoic acid and TRAIL by insertion mutagenesis into RAM.

scientific article published on 30 January 2006

Conformational adaptation of agonists to the human nuclear receptor RAR gamma

scientific article

Critical role of retinoid/rexinoid signaling in mediating transformation and therapeutic response of NUP98-RARG leukemia.

scientific article published on 16 December 2014

Cross-talk of vitamin D and glucocorticoids in hippocampal cells

scientific article published on 29 November 2005

Crystal structure of a heterodimeric complex of RAR and RXR ligand-binding domains

scientific article

Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid

scientific article

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha

scientific article

DAXX, FLASH, and FAF-1 modulate mineralocorticoid and glucocorticoid receptor-mediated transcription in hippocampal cells--toward a basis for the opposite actions elicited by two nuclear receptors?

scientific article

Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008

article

Decryption of the retinoid death code in leukemia

scientific article

Design and stereoselective synthesis of retinoids with ferrocene or N-butylcarbazole pharmacophores that induce post-differentiation apoptosis in acute promyelocytic leukemia cells

scientific article published on 19 April 2011

Design of selective nuclear receptor modulators: RAR and RXR as a case study

scientific article published on October 2007

Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists

scientific article

Discovery of novel transcriptional and epigenetic targets in APL by global ChIP analyses: Emerging opportunity and challenge

scientific article

Disila-analogues of the synthetic retinoids EC23 and TTNN: synthesis, structure and biological evaluation

scientific article published on 20 July 2012

Dissecting the retinoid-induced differentiation of F9 embryonal stem cells by integrative genomics

scientific article published on 11 October 2011

Dual RXR Agonists and RAR Antagonists Based on the Stilbene Retinoid Scaffold

scientific article

Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells

scientific article published on 31 August 2017

Enantioselective apoptosis induction in histiocytic lymphoma cells and acute promyelocytic leukemia cells

scientific article published on 26 September 2012

Epigenetic multiple modulators

scientific article

Epigenetic profiling of the antitumor natural product psammaplin A and its analogues

scientific article published on 15 December 2010

Epimetheus - a multi-profile normalizer for epigenomic sequencing data

scientific article

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Evidence for two structurally related progesterone receptors in chick oviduct cytosol

article

Fingering modulators of retinoic acid signaling identifies new prognostic marker for neuroblastoma

scientific article

Functions, therapeutic applications, and synthesis of retinoids and carotenoids

scientific article

Genome-wide studies of nuclear receptors in cell fate decisions

scientific article published on 02 August 2013

Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO.

scientific article

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway

scientific article published on 15 March 2007

HDACs class II-selective inhibition alters nuclear receptor-dependent differentiation

scientific article published on 16 July 2010

Heterodimeric Complex of RAR and RXR Nuclear Receptor Ligand-Binding Domains: Purification, Crystallization, and Preliminary X-Ray Diffraction Analysis

scientific article published on 01 July 2000

Highly potent naphthofuran-based retinoic acid receptor agonists

scientific article published on May 2009

How to finger DNA

scientific article published in Nature

Human cells contain natural double-stranded RNAs with potential regulatory functions

scientific article published on 15 December 2014

In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries

scientific article published on September 1996

Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities

scientific article

Insights into the mechanism of the site-selective sequential palladium-catalyzed cross-coupling reactions of dibromothiophenes/dibromothiazoles and arylboronic acids. Synthesis of PPARβ/δ agonists

scientific article published on 13 November 2006

Integrative genomics to dissect retinoid functions.

scientific article published on January 2014

International Union of Pharmacology. LX. Retinoic acid receptors

scientific article

International Union of Pharmacology. LXIII. Retinoid X receptors

scientific article

Inverse agonists and antagonists of retinoid receptors

scientific article published on January 2010

LOGIQA: a database dedicated to long-range genome interactions quality assessment.

scientific article

Leukemia: beneficial actions of retinoids and rexinoids

scientific article published on February 2004

Leukemic transformation by the APL fusion protein PRKAR1A-RAR{alpha} critically depends on recruitment of RXR{alpha}.

scientific article published on 17 November 2009

Ligand- and DNA-induced dissociation of RXR tetramers 1 1Edited by M. Yaniv

scientific article published on 01 January 1998

Localization of ecdysterone on polytene chromosomes of Drosophila melanogaster.

scientific article

Mechanism of nuclear receptor action: Structure and function

Mechanisms of antihormone action

scientific article

Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin

scientific article

Modeling gene-regulatory networks to describe cell fate transitions and predict master regulators

article

Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers

scientific article

Modulation of RXR function through ligand design

scientific article published on 16 April 2011

Modulation of Retinoic Acid Receptor Subtypes by 5- and 8-Substituted (Naphthalen-2-yl)-based Arotinoids

scientific article published on 26 May 2015

Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function

scientific article

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

Monitoring ligand-mediated nuclear receptor-coregulator interactions by noncovalent mass spectrometry

scientific article published in December 2004

Multivalent DR5 peptides activate the TRAIL death pathway and exert tumoricidal activity

scientific article

Mutation of isoleucine 747 by a threonine alters the ligand responsiveness of the human glucocorticoid receptor

scientific article published on 01 October 1996

NGS-QC Generator: A Quality Control System for ChIP-Seq and Related Deep Sequencing-Generated Datasets

scientific article published in January 2016

Neofunctionalization in vertebrates: the example of retinoic acid receptors

scientific article

New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists

scientific article

Nuclear receptor superfamily: Principles of signaling

Nuclear receptors in cell life and death.

scientific article

PIAS3 (protein inhibitor of activated STAT-3) modulates the transcriptional activation mediated by the nuclear receptor coactivator TIF2

scientific article (publication date: 28 August 2002)

POLYPHEMUS: R package for comparative analysis of RNA polymerase II ChIP-seq profiles by non-linear normalization

scientific article published on 7 December 2011

Patient-matched analysis identifies deregulated networks in prostate cancer to guide personalized therapeutic intervention

scientific article published on 15 November 2021

Peptide sequencing of the chick oviduct progesterone receptor form B

scientific article published on 01 August 1987

Photoaffinity labelling of steroid hormone binding sites

Photoinduced bonding of endogenous ecdysterone to salivary gland chromosomes of Chironomus tentans

scientific article published on 01 January 1981

Plasminogen activator urokinase expression reveals TRAIL responsiveness and supports fractional survival of cancer cells

scientific article

Principles for modulation of the nuclear receptor superfamily

scientific article

Purification of the human RARgamma ligand-binding domain and crystallization of its complex with all-trans retinoic acid.

scientific article published on January 1997

Purification, Functional Characterization, and Crystallization of the Ligand Binding Domain of the Retinoid X Receptor

scientific article published on 01 October 1995

Pyrazine arotinoids with inverse agonist activities on the retinoid and rexinoid receptors

scientific article

Quality indicators increase the reliability of microarray data

scientific article

RAR and RXR modulation in cancer and metabolic disease

scientific article published on October 2007

RAR-RXR selectivity and biological activity of new retinoic acid analogues with heterocyclic or polycyclic aromatic systems

scientific article published in July 2002

RAR-independent RXR signaling induces t(15;17) leukemia cell maturation

scientific article published on December 1999

RARbeta ligand-binding domain bound to an SRC-1 co-activator peptide: purification, crystallization and preliminary X-ray diffraction analysis

scientific article published on 20 October 2004

Rational design of RAR-selective ligands revealed by RARbeta crystal structure

scientific article

Reappraisal of the Role of Heat Shock Proteins as Regulators of Steroid Receptor Activity

scientific article published on 01 January 1998

Reconstructed cell fate-regulatory programs in stem cells reveal hierarchies and key factors of neurogenesis.

scientific article published on 20 September 2016

Reconstruction of gene regulatory networks reveals chromatin remodelers and key transcription factors in tumorigenesis.

scientific article published on 19 May 2016

Recruitment of RXR by Homotetrameric RARα Fusion Proteins Is Essential for Transformation

scientific article published on 01 July 2007

Regulation of Retinoidal Actions by Diazepinylbenzoic Acids.1Retinoid Synergists Which Activate the RXR−RAR Heterodimers

scientific article published on 01 December 1997

Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation

scientific article

Retinoic acid analogues inhibit human herpesvirus 8 replication

scientific article

Retinoic acid determines life span of leukemic cells by inducing antagonistic apoptosis-regulatory programs

scientific article published on 25 April 2005

Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms

scientific article

Retinoic acid receptor modulators: a perspective on recent advances and promises

scientific article

Retinoic acid via RARalpha inhibits the expression of 24-hydroxylase in human prostate stromal cells

scientific article published on 7 November 2005

Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL.

scientific article

Retinoid X receptor alpha forms tetramers in solution

scientific article

Retinoid receptor subtype-selective modulators through synthetic modifications of RARgamma agonists.

scientific article published on 18 May 2009

Retinoid receptors and therapeutic applications of RAR/RXR modulators

scientific article published on January 2012

Retinoids and TRAIL: two cooperating actors to fight against cancer

scientific article published on January 2004

Retinoids: potential in cancer prevention and therapy.

scientific article

Rexinoid-triggered differentiation and tumor-selective apoptosis of acute myeloid leukemia by protein kinase A-mediated desubordination of retinoid X receptor

scientific article

Role of Ligand in Retinoid Signaling. 9-cis-Retinoic Acid Modulates the Oligomeric State of the Retinoid X Receptor

scientific article published on 01 October 1995

Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity of HDAC-MEF2 complexes ⬇️

scientific article

Senescence-associated reprogramming promotes cancer stemness.

scientific article published on 20 December 2017

Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis

scientific article

Separation of retinoid X receptor homo- and heterodimerization functions

scientific article

Sequences in the ligand-binding domains of the human androgen and progesterone receptors which determine their distinct ligand identities

scientific article published on 01 April 1997

Silicon analogues of the RXR-selective retinoid agonist SR11237 (BMS649): chemistry and biology

scientific article

Silicon analogues of the retinoid agonists TTNPB and 3-methyl-TTNPB, disila-TTNPB and disila-3-methyl-TTNPB: chemistry and biology

scientific article published on September 2007

Single-tube linear DNA amplification (LinDA) for robust ChIP-seq.

scientific article published on 5 June 2011

Single-tube linear DNA amplification for genome-wide studies using a few thousand cells.

scientific article published on 26 January 2012

Steroid hormone receptors compete for factors that mediate their enhancer function

scientific article published on 01 May 1989

Structural basis for engineering of retinoic acid receptor isotype-selective agonists and antagonists

scientific article

Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor

scientific article published on 22 February 2007

Structure-activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells

scientific article published on August 2004

Suppression of tumorigenicity in T-cell lymphoma hybrids is correlated with changes in myc expression and DNA replication of the myc chromosomal domain

scientific article published on 01 January 1988

Surface‐enhanced Raman scattering and fluorescence spectroscopy reveal molecular interactions of all‐trans retinoic acid and RARγ ligand‐binding domain

Switching agonistic, antagonistic, and mixed transcriptional responses to 11 beta-substituted progestins by mutation of the progesterone receptor

scientific article published on December 1992

Synthesis and pharmacological characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, silicon analogues of the RARalpha-selective retinoid agonists AM80 (Tamibarotene) and AM580.

scientific article published in November 2009

Synthesis of a radiolabelled retinoid X receptor (RXR) specific ligand

Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs

scientific article published on 18 October 2005

Synthesis, Crystal Structure Analysis, and Pharmacological Characterization of Disila-bexarotene, a Disila-Analogue of the RXR-Selective Retinoid Agonist Bexarotene

scholarly article by Jürgen O. Daiss et al published June 2005 in Organometallics

Synthetic Glucocorticoids That Dissociate Transactivation and AP-1 Transrepression Exhibit Antiinflammatory Activityin Vivo ⬇️

scientific article published on August 1, 1997

TARDIS, a targeted RNA directional sequencing method for rare RNA discovery

scientific article published on 29 October 2015

TIF2 mediates the synergy between RARalpha 1 activation functions AF-1 and AF-2.

scientific article published on 30 July 2002

TRAIL: at the center of drugable anti-tumor pathways

scientific article

Targeted expression of tumor necrosis factor-related apoptosis-inducing ligand TRAIL in skin protects mice against chemical carcinogenesis

scientific article

The DNA binding pattern of the retinoid X receptor is regulated by ligand-dependent modulation of its oligomeric state

scientific article published on May 1997

The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation

scientific article

The N-terminal region of the chicken progesterone receptor specifies target gene activation

scientific article

The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways

scientific article published in January 1998

The contribution of the N- and C-terminal regions of steroid receptors to activation of transcription is both receptor and cell-specific.

scientific article

The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP.

scientific article

The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer

scientific article

The nuclear receptor ligand-binding domain: structure and function

scientific article published in June 1998

The promise of retinoids to fight against cancer.

scientific article

The retinoic acid signaling pathway regulates anterior/posterior patterning in the nerve cord and pharynx of amphioxus, a chordate lacking neural crest.

scientific article published in June 2002

Thioether analogues of disulfide-bridged cyclic peptides targeting death receptor 5: conformational analysis, dimerisation and consequences for receptor activation

scientific article published on 8 December 2014

Total synthesis of the proposed structures of the DNA methyl transferase inhibitors peyssonenynes, and structural revision of peyssonenyne B

article

Towards novel paradigms for cancer therapy.

scientific article published on 11 October 2010

Transcription activation by estrogen and progesterone receptors ⬇️

scientific article published on January 1, 1991

Transcription activation by nuclear receptors

scientific article

Transformation-dependent silencing of tumor-selective apoptosis-inducing TRAIL by DNA hypermethylation is antagonized by decitabine

scientific article published on 22 June 2011

Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL

scientific article

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

scientific article published on 26 December 2004

Twenty years of nuclear receptors: Conference on Nuclear Receptors: from Chromatin to Disease

scientific article

Two distinct actions of retinoid-receptor ligands

scientific article published in Nature

Type II antagonists impair the DNA binding of steroid hormone receptors without affecting dimerization

scientific article published on 01 April 1993

Versatile Copurification Procedure for Rapid Isolation of Homogeneous RAR-RXR Heterodimers

scientific article published on 01 July 1999

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