List of works - Birthe B. Kragelund

(S)Pinning down protein interactions by NMR.

scientific article published on 26 December 2016

1H, 13C, and 15N assignments of un-myristoylated Ca2+-frequenin, a synaptic efficacy modulator

scientific article published on 01 January 2000

A Residue Quartet in the Extracellular Domain of the Prolactin Receptor Selectively Controls Mitogen-activated Protein Kinase Signaling

scientific article published on 17 March 2015

A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast ⬇️

scientific article

A combined computational and structural model of the full-length human prolactin receptor

scientific article

A de Novo-Designed Monomeric, Compact Three-Helix-Bundle Protein on a Carbohydrate Template

scientific article published on 6 July 2015

A highly compliant protein native state with a spontaneous-like mechanical unfolding pathway

scientific article published in 2012

A loop of coagulation factor VIIa influencing macromolecular substrate specificity

scientific article published on 11 December 2006

Acyl-CoA binding proteins; structural and functional conservation over 2000 MYA

scientific article published on 01 May 2007

Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells

scientific article published on March 2008

Acyl-coenzyme A binding protein (ACBP).

scientific article

An efficient arabinoxylan-debranching α-L-arabinofuranosidase of family GH62 from Aspergillus nidulans contains a secondary carbohydrate binding site

scientific article

Analyzing Temperature-Induced Transitions in Disordered Proteins by NMR Spectroscopy and Secondary Chemical Shift Analyses

scientific article published on 01 January 2012

Barley lipid-transfer protein complexed with palmitoyl CoA: the structure reveals a hydrophobic binding site that can expand to fit both large and small lipid-like ligands

scientific article

Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif

scientific article published on 15 July 2006

Cold Denaturation of the HIV-1 Protease Monomer.

scientific article published on 7 February 2017

Crystal Structure of an Affinity-matured Prolactin Complexed to Its Dimerized Receptor Reveals the Topology of Hormone Binding Site 2

scientific article

DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2

scientific article published in 2024

DSS1/Sem1, a Multifunctional and Intrinsically Disordered Protein

scientific article

Development of prolactin receptor antagonists with reduced pH-dependence of receptor binding

article

Different secondary structure elements as scaffolds for protein folding transition states of two homologous four-helix bundles

scientific article published on 01 April 2005

Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1

scientific article

Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry

scientific article published on 16 September 2020

Dss1 is a 26S proteasome ubiquitin receptor

scientific article published on 9 October 2014

Dynamical Oligomerisation of Histidine Rich Intrinsically Disordered ProteinS Is Regulated through Zinc-Histidine Interactions.

scientific article

Early kinetic intermediate in the folding of acyl-CoA binding protein detected by fluorescence labeling and ultrarapid mixing

scientific article

Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa

scientific article

Evolutionary conservation of the intrinsic disorder-based Radical-Induced Cell Death1 hub interactome

scientific article published on 12 December 2019

Exploiting hydrophobicity for efficient production of transmembrane helices for structure determination by NMR spectroscopy

scientific article published on 26 August 2015

Exploring the Minimally Frustrated Energy Landscape of Unfolded ACBP

scientific article published on 07 November 2013

Fast and One-step Folding of Closely and Distantly Related Homologous Proteins of a Four-helix Bundle Family

scientific article published on 01 February 1996

Fluorescently labelled bovine acyl-CoA-binding protein acting as an acyl-CoA sensor: interaction with CoA and acyl-CoA esters and its use in measuring free acyl-CoA esters and non-esterified fatty acids

scientific article published on July 2002

Folding of a four-helix bundle: studies of acyl-coenzyme A binding protein

scientific article published on 01 May 1995

Formation of hydrogen bonds precedes the rate-limiting formation of persistent structure in the folding of ACBP.

scientific article published in September 2000

Functional aspects of protein flexibility.

scientific article

Functional characterization of a conserved archaeal viral operon revealing single-stranded DNA binding, annealing and nuclease activities

scientific article published on 29 March 2015

Gentamicin Binds to the Megalin Receptor as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats: INSIGHT FROM THE NMR STRUCTURE OF THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE AND IN COMPLEX WITH GENTAMICIN

scientific article

Globular and disordered-the non-identical twins in protein-protein interactions

scientific article published on 9 July 2015

Hydrophobic core substitutions in calbindin D9k: effects on Ca2+ binding and dissociation

scientific article published in June 1998

Hydroxylation of the herbicide isoproturon by fungi isolated from agricultural soil

scientific article published on December 2005

IDDomainSpotter: Compositional bias reveals domains in long disordered protein regions-Insights from transcription factors

scientific article published on 11 November 2019

Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes

scientific article

Local perturbations by ligand binding of hydrogen deuterium exchange kinetics in a four-helix bundle protein, acyl coenzyme A binding protein (ACBP).

scientific article

Mapping the lifetimes of local opening events in a native state protein

scientific article

Mechanism of the Ca2+-induced Enhancement of the Intrinsic Factor VIIa Activity

scientific article

Metabolites of the phenylurea herbicides chlorotoluron, diuron, isoproturon and linuron produced by the soil fungus Mortierella sp.

scientific article

Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin

scientific article published on 02 August 2019

New horizons for lipoprotein receptors: communication by β-propellers

scientific article published on 23 July 2013

Orchestration of signaling by structural disorder in class 1 cytokine receptors

scientific article published on 24 August 2020

Order by disorder in plant signaling

scientific article published on 20 July 2012

Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis

scientific article published on 29 April 2020

Phosphate selective uranyl photo-affinity cleavage of proteins. Determination of phosphorylation sites

scientific article

Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes

scientific article published on 12 November 2020

Prolactin Signaling Stimulates Invasion via Na(+)/H(+) Exchanger NHE1 in T47D Human Breast Cancer Cells

scientific article

Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins

scientific article

Protein intrinsic disorder in Arabidopsis NAC transcription factors: transcriptional activation by ANAC013 and ANAC046 and their interactions with RCD1.

scientific article

Protein stability, flexibility and function ⬇️

scientific article published on November 19, 2010

Random coil chemical shifts for serine, threonine and tyrosine phosphorylation over a broad pH range

scientific article published on 09 October 2019

Regulation of ribonucleotide reductase by Spd1 involves multiple mechanisms

scientific article published on June 2010

Residue 146 regulates prolactin receptor folding, basal activity and ligand-responsiveness: potential implications in breast tumorigenesis

scientific article published on 15 December 2014

Reversible dimerization of acid-denatured ACBP controlled by helix A4.

scientific article published in February 2005

Senescence-associated barley NAC (NAM, ATAF1,2, CUC) transcription factor interacts with radical-induced cell death 1 through a disordered regulatory domain

scientific article

Single methyl groups can act as toggle switches to specify transmembrane Protein-protein interactions.

scientific article published on 4 September 2017

Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing

scientific article

Single-molecule folding mechanism of an EF-hand neuronal calcium sensor

article by Pétur O Heidarsson et al published 8 October 2013 in Structure

Single-molecule folding mechanisms of the apo- and Mg(2+)-bound states of human neuronal calcium sensor-1

scientific article published on July 2015

Solution Structure of Human Prolactin

scientific article published on 01 August 2005

Solution properties of the archaeal CRISPR DNA repeat-binding homeodomain protein Cbp2.

scientific article published on 15 January 2013

Spd2 assists Spd1 in the modulation of ribonucleotide reductase architecture but does not regulate deoxynucleotide pools.

scientific article published on 20 March 2014

Specificity of MYB interactions relies on motifs in ordered and disordered contexts

scientific article published on 01 October 2019

Strains of the soil fungus Mortierella show different degradation potentials for the phenylurea herbicide diuron

scientific article

Streptococcal pyogenic exotoxin B (SpeB) boosts the contact system via binding of α-1 antitrypsin

scientific article published in February 2011

Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL

scientific article

Structural dynamics and regulation of the mammalian SLC9A family of Na⁺/H⁺ exchangers

scientific article

Structure and biochemical function of a prototypical Arabidopsis U-box domain

scientific article published on 30 June 2004

Structure and dynamic properties of membrane proteins using NMR.

scientific article

Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase

scientific article

Structure of the mature Streptococcal cysteine protease exotoxin mSpeB in its active dimeric form

scientific article

Structure, dynamics, and stability of the globular domain of human linker histone H1.0 and the role of positive charges

scientific article published on 23 February 2022

Structure--activity study of the antibacterial peptide fallaxin

scientific article

Structures and Short Linear Motif of Disordered Transcription Factor Regions Provide Clues to the Interactome of the Cellular Hub Protein Radical-induced Cell Death1.

scientific article published on 23 November 2016

Temperature-Induced Transitions in Disordered Proteins Probed by NMR Spectroscopy

scientific article published on 01 January 2012

Temperature-dependent structural changes in intrinsically disordered proteins: formation of alpha-helices or loss of polyproline II?

scientific article published on August 2010

The C-terminal tail of human neuronal calcium sensor 1 regulates the conformational stability of the Ca²⁺₋ activated state

scientific article

The Ku70/80 ring in Non-Homologous End-Joining: easy to slip on, hard to remove.

scientific article published on January 2016

The Non-Fibrillating N-Terminal of α-Synuclein Binds and Co-Fibrillates with Heparin

scientific article published on 16 August 2020

The PCNA interaction motifs revisited: thinking outside the PIP-box

scientific article published on 27 May 2019

The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation: insight from structures of the prolactin receptor

scientific article

The formation of a native-like structure containing eight conserved hydrophobic residues is rate limiting in two-state protein folding of ACBP

scientific article published on 01 June 1999

The human Na(+)/H(+) exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2

scientific article

The intracellular distal tail of the Na+/H+ exchanger NHE1 is intrinsically disordered: implications for NHE1 trafficking

scientific article published on 8 April 2011

The intracellular lipid-binding domain of human Na<sup>+</sup>/H<sup>+</sup> exchanger 1 forms a lipid-protein co-structure essential for activity

scientific article published on 03 December 2020

The intrinsically disordered RNR inhibitor Sml1 is a dynamic dimer

scientific article published on December 2008

The transcriptional repressor domain of Gli3 is intrinsically disordered

scientific article

Transient intermediary states with high and low folding probabilities in the apparent two-state folding equilibrium of ACBP at low pH.

scientific article

Transient structure formation in unfolded acyl-coenzyme A-binding protein observed by site-directed spin labelling

scientific article published in November 2002

Understanding single-pass transmembrane receptor signaling from a structural viewpoint-what are we missing?

scientific article

Who climbs the tryptophan ladder? On the structure and function of the WSXWS motif in cytokine receptors and thrombospondin repeats

scientific article published on 09 May 2014

αα-hub domains and intrinsically disordered proteins - a decisive combo

scientific article published on 22 December 2020

β-Microseminoprotein endows post coital seminal plasma with potent candidacidal activity by a calcium- and pH-dependent mechanism

scientific article

List of works by Birthe B. Kragelund

(S)Pinning down protein interactions by NMR.

1H, 13C, and 15N assignments of un-myristoylated Ca2+-frequenin, a synaptic efficacy modulator

A Residue Quartet in the Extracellular Domain of the Prolactin Receptor Selectively Controls Mitogen-activated Protein Kinase Signaling

A Two-step Protein Quality Control Pathway for a Misfolded DJ-1 Variant in Fission Yeast ⬇️

A combined computational and structural model of the full-length human prolactin receptor

A de Novo-Designed Monomeric, Compact Three-Helix-Bundle Protein on a Carbohydrate Template

A highly compliant protein native state with a spontaneous-like mechanical unfolding pathway

A loop of coagulation factor VIIa influencing macromolecular substrate specificity

Acyl-CoA binding proteins; structural and functional conservation over 2000 MYA

Acyl-CoA-binding protein (ACBP) localizes to the endoplasmic reticulum and Golgi in a ligand-dependent manner in mammalian cells

Acyl-coenzyme A binding protein (ACBP).

An efficient arabinoxylan-debranching α-L-arabinofuranosidase of family GH62 from Aspergillus nidulans contains a secondary carbohydrate binding site

Analyzing Temperature-Induced Transitions in Disordered Proteins by NMR Spectroscopy and Secondary Chemical Shift Analyses

Barley lipid-transfer protein complexed with palmitoyl CoA: the structure reveals a hydrophobic binding site that can expand to fit both large and small lipid-like ligands

Binding site structure of one LRP-RAP complex: implications for a common ligand-receptor binding motif

Cold Denaturation of the HIV-1 Protease Monomer.

Crystal Structure of an Affinity-matured Prolactin Complexed to Its Dimerized Receptor Reveals the Topology of Hormone Binding Site 2

DNA binding redistributes activation domain ensemble and accessibility in pioneer factor Sox2

DSS1/Sem1, a Multifunctional and Intrinsically Disordered Protein

Development of prolactin receptor antagonists with reduced pH-dependence of receptor binding

Different secondary structure elements as scaffolds for protein folding transition states of two homologous four-helix bundles

Direct single-molecule observation of calcium-dependent misfolding in human neuronal calcium sensor-1

Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry

Dss1 is a 26S proteasome ubiquitin receptor

Dynamical Oligomerisation of Histidine Rich Intrinsically Disordered ProteinS Is Regulated through Zinc-Histidine Interactions.

Early kinetic intermediate in the folding of acyl-CoA binding protein detected by fluorescence labeling and ultrarapid mixing

Engineering the substrate and inhibitor specificities of human coagulation Factor VIIa

Evolutionary conservation of the intrinsic disorder-based Radical-Induced Cell Death1 hub interactome

Exploiting hydrophobicity for efficient production of transmembrane helices for structure determination by NMR spectroscopy

Exploring the Minimally Frustrated Energy Landscape of Unfolded ACBP

Fast and One-step Folding of Closely and Distantly Related Homologous Proteins of a Four-helix Bundle Family

Fluorescently labelled bovine acyl-CoA-binding protein acting as an acyl-CoA sensor: interaction with CoA and acyl-CoA esters and its use in measuring free acyl-CoA esters and non-esterified fatty acids

Folding of a four-helix bundle: studies of acyl-coenzyme A binding protein

Formation of hydrogen bonds precedes the rate-limiting formation of persistent structure in the folding of ACBP.

Functional aspects of protein flexibility.

Functional characterization of a conserved archaeal viral operon revealing single-stranded DNA binding, annealing and nuclease activities

Gentamicin Binds to the Megalin Receptor as a Competitive Inhibitor Using the Common Ligand Binding Motif of Complement Type Repeats: INSIGHT FROM THE NMR STRUCTURE OF THE 10TH COMPLEMENT TYPE REPEAT DOMAIN ALONE AND IN COMPLEX WITH GENTAMICIN

Globular and disordered-the non-identical twins in protein-protein interactions

Hydrophobic core substitutions in calbindin D9k: effects on Ca2+ binding and dissociation

Hydroxylation of the herbicide isoproturon by fungi isolated from agricultural soil

IDDomainSpotter: Compositional bias reveals domains in long disordered protein regions-Insights from transcription factors

Intrinsically disordered cytoplasmic domains of two cytokine receptors mediate conserved interactions with membranes

Local perturbations by ligand binding of hydrogen deuterium exchange kinetics in a four-helix bundle protein, acyl coenzyme A binding protein (ACBP).

Mapping the lifetimes of local opening events in a native state protein

Mechanism of the Ca2+-induced Enhancement of the Intrinsic Factor VIIa Activity

Metabolites of the phenylurea herbicides chlorotoluron, diuron, isoproturon and linuron produced by the soil fungus Mortierella sp.

Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin

New horizons for lipoprotein receptors: communication by β-propellers

Orchestration of signaling by structural disorder in class 1 cytokine receptors

Order by disorder in plant signaling

Peptides containing the PCNA interacting motif APIM bind to the β-clamp and inhibit bacterial growth and mutagenesis

Phosphate selective uranyl photo-affinity cleavage of proteins. Determination of phosphorylation sites

Polyelectrolyte interactions enable rapid association and dissociation in high-affinity disordered protein complexes

Prolactin Signaling Stimulates Invasion via Na(+)/H(+) Exchanger NHE1 in T47D Human Breast Cancer Cells

Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins

Protein intrinsic disorder in Arabidopsis NAC transcription factors: transcriptional activation by ANAC013 and ANAC046 and their interactions with RCD1.

Protein stability, flexibility and function ⬇️

Random coil chemical shifts for serine, threonine and tyrosine phosphorylation over a broad pH range

Regulation of ribonucleotide reductase by Spd1 involves multiple mechanisms

Residue 146 regulates prolactin receptor folding, basal activity and ligand-responsiveness: potential implications in breast tumorigenesis

Reversible dimerization of acid-denatured ACBP controlled by helix A4.

Senescence-associated barley NAC (NAM, ATAF1,2, CUC) transcription factor interacts with radical-induced cell death 1 through a disordered regulatory domain

Single methyl groups can act as toggle switches to specify transmembrane Protein-protein interactions.

Single site suppressors of a fission yeast temperature-sensitive mutant in cdc48 identified by whole genome sequencing

Single-molecule folding mechanism of an EF-hand neuronal calcium sensor

Single-molecule folding mechanisms of the apo- and Mg(2+)-bound states of human neuronal calcium sensor-1

Solution Structure of Human Prolactin

Solution properties of the archaeal CRISPR DNA repeat-binding homeodomain protein Cbp2.

Spd2 assists Spd1 in the modulation of ribonucleotide reductase architecture but does not regulate deoxynucleotide pools.

Specificity of MYB interactions relies on motifs in ordered and disordered contexts

Strains of the soil fungus Mortierella show different degradation potentials for the phenylurea herbicide diuron

Streptococcal pyogenic exotoxin B (SpeB) boosts the contact system via binding of α-1 antitrypsin

Structural and thermodynamic bases for the design of pure prolactin receptor antagonists: X-ray structure of Del1-9-G129R-hPRL

Structural dynamics and regulation of the mammalian SLC9A family of Na⁺/H⁺ exchangers

Structure and biochemical function of a prototypical Arabidopsis U-box domain

Structure and dynamic properties of membrane proteins using NMR.

Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase

Structure of the mature Streptococcal cysteine protease exotoxin mSpeB in its active dimeric form

Structure, dynamics, and stability of the globular domain of human linker histone H1.0 and the role of positive charges