List of works by Timo T. Myöhänen

A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease

scientific article published on June 2012

Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry

scientific article

Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent

scientific article published on 02 December 2019

Association of prolyl oligopeptidase with conventional neurotransmitters in the brain.

scientific article published on May 2011

Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease

scientific article published on 22 November 2019

Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain

scientific article published on 16 April 2013

Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters

scientific article published in April 2008

Comparison of motor performance, brain biochemistry and histology of two A30P α-synuclein transgenic mouse strains.

scientific article

Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine

scientific article published on 12 October 2017

Different interactions of prolyl oligopeptidase and neurotensin in dopaminergic function of the rat nigrostriatal and mesolimbic pathways

scientific article published on 23 June 2012

Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture?

scientific article published on January 2010

Distribution of immunoreactive prolyl oligopeptidase in human and rat brain

scientific article published on 31 March 2007

Distribution of prolyl oligopeptidase in human peripheral tissues and in ovarian and colorectal tumors

scientific article

Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues.

scientific article published on 11 July 2008

Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice

scientific article

Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain

scientific article

Inhibition of prolyl oligopeptidase increases the survival of alpha-synuclein overexpressing cells after rotenone exposure by reducing alpha-synuclein oligomers

scientific article published on 20 September 2014

Localization of prolyl oligopeptidase in the thalamic and cortical projection neurons: a retrograde neurotracing study in the rat brain.

scientific article published on 21 November 2008

Mice deficient in transmembrane prostatic acid phosphatase display increased GABAergic transmission and neurological alterations.

scientific article

New tricks of prolyl oligopeptidase inhibitors - A common drug therapy for several neurodegenerative diseases

scientific article published on 17 January 2019

Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson's disease in young and adult mouse

scientific article published on 24 April 2017

Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse.

scientific article published on 13 December 2016

Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson's and Alzheimer's diseases.

scientific article

Prolyl oligopeptidase enhances α-synuclein dimerization via direct protein-protein interaction

scientific article

Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner.

scientific article

Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A

scientific article published on 20 November 2019

Prolyl oligopeptidase inhibition attenuates the toxicity of a proteasomal inhibitor, lactacystin, in the alpha-synuclein overexpressing cell culture

scientific article published on 3 November 2016

Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington's disease

scientific article published on 29 September 2019

Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice

scientific article

Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo

scientific article published on 24 January 2018

Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model

scientific article published in 2022

Sequential expression, activity and nuclear localization of prolyl oligopeptidase protein in the developing rat brain.

scientific article published on 14 December 2010

Spatial association of prolyl oligopeptidase, inositol 1,4,5-triphosphate type 1 receptor, substance P and its neurokinin-1 receptor in the rat brain: an immunohistochemical colocalization study.

scientific article published on 4 March 2008

Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors

scientific article published on 11 November 2019

The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse.

scientific article published on 16 April 2014

Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis.

scientific article published on 05 June 2013

Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo.

scientific article

Paulina is supported by:

About Paulina

Help