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Authors whose works are in public domain in at least one jurisdiction

List of works by Juan Valle

18F-fluorodeoxyglucose positron emission tomography (18FDG-PET) for patients with biliary tract cancer: Systematic review and meta-analysis

scientific article published on 21 February 2019

A Systematic Review of the Burden of Pancreatic Cancer in Europe: Real-World Impact on Survival, Quality of Life and Costs.

scientific article published in September 2015

A comparison of diagnostic imaging modalities for colorectal liver metastases

scientific article published on 15 January 2014

A multicentre study of capecitabine, oxaliplatin plus bevacizumab as perioperative treatment of patients with poor-risk colorectal liver-only metastases not selected for upfront resection

scientific article published on 01 February 2011

A phase I and pharmacokinetic study of OSI-7904L, a liposomal thymidylate synthase inhibitor in combination with oxaliplatin in patients with advanced colorectal cancer

scientific article published on 23 May 2007

A phase I study of the safety and pharmacokinetics of the combination of pertuzumab (rhuMab 2C4) and capecitabine in patients with advanced solid tumors

scientific article published in May 2008

A phase II study of weekly cisplatin and gemcitabine in patients with advanced pancreatic cancer: is this a strategy still worth pursuing?

scientific article

A phase Ib/IIa trial to evaluate the CCK2 receptor antagonist Z-360 in combination with gemcitabine in patients with advanced pancreatic cancer

scientific article published on 14 December 2009

A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarker.

scientific article

A prospective observational study of chemotherapy-related nausea and vomiting in routine practice in a UK cancer centre

scientific article published on 10 October 2007

A systematic review of non-surgical treatments for pancreatic neuroendocrine tumours

scientific article published on 08 September 2013

Adjuvant chemotherapy with fluorouracil plus folinic acid vs gemcitabine following pancreatic cancer resection: a randomized controlled trial

scientific article

Adjuvant therapy for gastric cancer - has the standard changed?

scientific article published in April 2001

Advances in the treatment of metastatic or unresectable biliary tract cancer ⬇️

scientific article published on October 1, 2010

Analysis of circulating cell-free DNA identifies KRAS copy number gain and mutation as a novel prognostic marker in Pancreatic cancer

scientific article published on 12 August 2019

BINGO: targeted therapy for advanced biliary-tract cancer

scientific article published on 19 May 2014

Biliary Tract Cancer: State of the Art and potential role of DNA Damage Repair

scientific article published on 08 September 2018

Biliary tract cancers: current knowledge, clinical candidates and future challenges

scientific article published on 29 March 2019

Blockade of platelet-derived growth factor receptor-beta by CDP860, a humanized, PEGylated di-Fab', leads to fluid accumulation and is associated with increased tumor vascularized volume.

scientific article

Capecitabine and streptozocin ± cisplatin in advanced gastroenteropancreatic neuroendocrine tumours

scientific article published on 17 January 2014

Cediranib or placebo in combination with cisplatin and gemcitabine chemotherapy for patients with advanced biliary tract cancer (ABC-03): a randomised phase 2 trial

scientific article

Cetuximab Is Contraindicated in the Perioperative Treatment of Colorectal Liver Metastases

scientific article published in June 2015

Cholangiocarcinoma 2020: the next horizon in mechanisms and management

scientific article published on 30 June 2020

Circulating Tumor Cell Enumeration in a Phase II Trial of a Four-Drug Regimen in Advanced Colorectal Cancer

scientific article published on 31 December 2014

Circulating biomarkers during treatment in patients with advanced biliary tract cancer receiving cediranib in the UK ABC-03 trial

scientific article published on 21 June 2018

Cisplatin and gemcitabine for advanced biliary tract cancer: a meta-analysis of two randomised trials

scientific article published on 18 December 2013

Cisplatin and gemcitabine in patients with advanced biliary tract cancer (ABC) and persistent jaundice despite optimal stenting: Effective intervention in patients with luminal disease

scientific article

Citrobacter freundii and fatal neutropenic enterocolitis following adjuvant chemotherapy for breast cancer

scientific article published on January 1997

Combination therapy of 177Lu and 90Y Dotatate for treatment of neuroendocrine cancer

scientific article published on 01 June 2014

Concurrent irinotecan, oxaliplatin and UFT in first-line treatment of metastatic colorectal cancer: a phase I study

scientific article published on January 2007

Considerations for the treatment of pancreatic cancer during the COVID-19 pandemic: the UK consensus position

scientific article published on 08 July 2020

Contraceptive use by women receiving chemotherapy for breast cancer

Current and novel therapeutic opportunities for systemic therapy in biliary cancer

scientific article published on 22 July 2020

Current standards and future perspectives in adjuvant treatment for biliary tract cancers

scientific article published on 04 December 2019

Decline in CA19-9 during chemotherapy predicts survival in four independent cohorts of patients with inoperable bile duct cancer.

scientific article published on 9 May 2015

Determination of the optimal echocardiographic scoring system to quantify carcinoid heart disease

scientific article published on 28 February 2014

Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial

scientific article

Efficacy and tolerability of limited field radiotherapy with concurrent capecitabine in locally advanced pancreatic cancer.

scientific article published on 21 July 2010

Evaluation of hypertension and proteinuria as markers of efficacy in antiangiogenic therapy for metastatic colorectal cancer

scientific article published in May 2014

Expert consensus for the management of advanced or metastatic pancreatic neuroendocrine and carcinoid tumors

scientific article

Gemcitabine and capecitabine with or without telomerase peptide vaccine GV1001 in patients with locally advanced or metastatic pancreatic cancer (TeloVac): an open-label, randomised, phase 3 trial

scientific article published on 19 June 2014

Guidelines for Management of Urgent Symptoms in Patients with Cholangiocarcinoma and Biliary Stents or Catheters using the Modified RAND/UCLA Delphi Process

scientific article published on 21 August 2020

Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs)

scientific article published on 3 November 2011

Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis

scientific article published on 17 December 2021

Identification of areas for improvement in the management of bone metastases in patients with neuroendocrine neoplasms

scientific article published on 22 October 2019

Impact of intensified chemotherapy in metastatic pancreatic ductal adenocarcinoma (PDAC) in clinical routine in Europe

scientific article published on 15 October 2018

Impact of laparotomy and liver resection on the peritoneal concentrations of fibroblast growth factor 2, vascular endothelial growth factor and hepatocyte growth factor

scientific article published on 26 October 2005

Impact of neuroendocrine morphology on cancer outcomes and stage at diagnosis: a UK nationwide cohort study 2013-2015

scientific article published on 25 October 2019

Impact of prior therapies on everolimus activity: an exploratory analysis of RADIANT-4.

scientific article

Intratumoural expression of deoxycytidylate deaminase or ribonuceotide reductase subunit M1 expression are not related to survival in patients with resected pancreatic cancer given adjuvant chemotherapy

scientific article published on 9 March 2018

Irinotecan with bolus and infusional 5-flurouracil and folinic acid for patients with advanced or metastatic colorectal cancer previously treated with 5-flurouracil: a possible alternative to single-agent irinotecan in a 'real-life' setting

scientific article published in December 2005

Irreversible Electroporation in pancreatic ductal adenocarcinoma: Is there a role in conjunction with conventional treatment?

scientific article published on 02 August 2018

Lessons from the comparison of two randomized clinical trials using gemcitabine and cisplatin for advanced biliary tract cancer

scientific article

Liver embolisation for patients with neuroendocrine neoplasms: systematic review

scientific article published on 13 March 2020

Metastatic colorectal cancer: current systemic treatment options.

scientific article published on January 2007

Methods for adjusting for bias due to crossover in oncology trials

scientific article published in June 2014

Molecular Profiling in Daily Clinical Practice: Practicalities in Advanced Cholangiocarcinoma and Other Biliary Tract Cancers

scientific article published on 03 September 2020

Multicentre phase II pharmacokinetic and pharmacodynamic study of OSI-7904L in previously untreated patients with advanced gastric or gastroesophageal junction adenocarcinoma.

scientific article

Observational Study to Assess Quality of Life in Patients with Pancreatic Neuroendocrine Tumors Receiving Treatment with Everolimus: The OBLIQUE Study (UK Phase IV Trial)

scientific article published on 30 January 2019

Optimal duration and timing of adjuvant chemotherapy after definitive surgery for ductal adenocarcinoma of the pancreas: ongoing lessons from the ESPAC-3 study

scientific article

Outcome of second-line chemotherapy for biliary tract cancer

scientific article published in April 2013

Outcomes in older patients with biliary tract cancer

scientific article published on 13 March 2020

Pancreatic cancer hENT1 expression and survival from gemcitabine in patients from the ESPAC-3 trial

scientific article

Patients with pancreatic cancer participating in clinical trials: are targets being met, and if not, why?

scientific article published on 01 March 2007

Pharmacokinetics of a hematoregulatory peptide (SK&F107647) in healthy male volunteers and in patients with colorectal or pancreatic adenocarcinoma not amenable to standard therapy

scientific article published on 01 April 2000

Phase I dose-escalation trial of irinotecan with continuous infusion 5-FU first line, in metastatic colorectal cancer

scientific article published on October 2004

Phase I evaluation of CDP791, a PEGylated di-Fab' conjugate that binds vascular endothelial growth factor receptor 2.

scientific article

Phase I evaluation of a fully human anti-alphav integrin monoclonal antibody (CNTO 95) in patients with advanced solid tumors.

scientific article published on April 2007

Phase II Trial of Cetuximab and Conformal Radiotherapy Only in Locally Advanced Pancreatic Cancer with Concurrent Tissue Sampling Feasibility Study

scientific article published on February 2014

Phase II study of short-course capecitabine plus oxaliplatin (XELOX) followed by maintenance capecitabine in advanced colorectal cancer: XelQuali study

scientific article published on 30 July 2010

Phase III randomized comparison of gemcitabine versus gemcitabine plus capecitabine in patients with advanced pancreatic cancer

scientific article

Pneumoperitoneum following percutaneous biliary intervention: not necessarily a cause for alarm

scientific article published on 7 December 2007

Practical management of sunitinib toxicities in the treatment of pancreatic neuroendocrine tumors.

scientific article published on 16 September 2014

Prospective randomized trial comparing mitomycin, cisplatin, and protracted venous-infusion fluorouracil (PVI 5-FU) With epirubicin, cisplatin, and PVI 5-FU in advanced esophagogastric cancer

scientific article

Randomized, placebo-controlled, phase III study of oxaliplatin, fluorouracil, and leucovorin with or without PTK787/ZK 222584 in patients with previously treated metastatic colorectal adenocarcinoma

scientific article published on 04 April 2011

Reply 1: Call for NICE to review urgently their guidance concerning first-line chemotherapy for metastatic colorectal cancer

scientific article published in April 2003

Reply to Comment on "The UK consensus position on the treatment of pancreatic cancer during the COVID-19 pandemic"

scientific article published on 03 November 2020

Reply to the letter to the editor 'second-line chemotherapy in advanced biliary cancer: the present now will later be past' by Vivaldi et al

scientific article published on 19 August 2014

Reply: Guesstimates are not good enough for determining what is happening in routine care

scientific article

Review of recent trials of chemotherapy for advanced breast cancer: studies excluding taxanes

scientific article published on November 1997

Scheduling nab-paclitaxel combined with gemcitabine as first-line treatment for metastatic pancreatic adenocarcinoma

scientific article published on 30 April 2020

Second-line chemotherapy in advanced biliary cancer: a systematic review

scientific article published on 25 April 2014

Serial surveillance of carcinoid heart disease: factors associated with echocardiographic progression and mortality.

scientific article published on 11 September 2014

Somatostatin receptor expression in hepatocellular carcinoma: prognostic and therapeutic considerations.

scientific article

Sorafenib as first-line therapy in patients with advanced Child-Pugh B hepatocellular carcinoma-a meta-analysis

scientific article published on 29 October 2018

Spotlight on telotristat ethyl for the treatment of carcinoid syndrome diarrhea: patient selection and reported outcomes

scientific article published on 08 August 2019

Sunitinib for advanced pancreatic neuroendocrine tumors.

scientific article published on December 2011

Systemic Treatment Selection for Patients with Advanced Pancreatic Neuroendocrine Tumours (PanNETs)

scientific article published on 21 July 2020

Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial

scientific article published in May 2014

TG01/GM-CSF and adjuvant gemcitabine in patients with resected RAS-mutant adenocarcinoma of the pancreas (CT TG01-01): a single-arm, phase 1/2 trial

scientific article published on 17 February 2020

Telotristat etiprate for carcinoid syndrome: a single-arm, multicenter trial

scientific article published on 30 January 2015

Temozolomide-Capecitabine Chemotherapy for Neuroendocrine Neoplasms: The Dilemma of Treatment Duration

scientific article published on 17 September 2019

The association of a panel of biomarkers with the presence and severity of carcinoid heart disease: a cross-sectional study

scientific article

The effects of gemcitabine and capecitabine combination chemotherapy and of low-dose adjuvant GM-CSF on the levels of myeloid-derived suppressor cells in patients with advanced pancreatic cancer

scientific article

The role of adjuvant chemotherapy and radiotherapy for cholangiocarcinoma

scientific article published on 16 March 2015

Treatment of inoperable hepatocellular carcinoma with pegylated liposomal doxorubicin (PLD): results of a phase II study

scientific article published on February 2005

UGT1A1*28 genotype predicts gastrointestinal toxicity in patients treated with intermediate-dose irinotecan.

scientific article

Understanding chemotherapy treatment pathways of advanced colorectal cancer patients to inform an economic evaluation in the United Kingdom.

scientific article

Urgent need for consensus: international survey of clinical practice exploring use of platinum-etoposide chemotherapy for advanced extra-pulmonary high grade neuroendocrine carcinoma (EP-G3-NEC)

scientific article published on 30 November 2018

Vaccination of colorectal cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: a phase I/II trial

scientific article published on June 2006

Variation in Cardiac Screening and Management of Carcinoid Heart Disease in the UK and Republic of Ireland

scientific article published on 10 July 2015

Why hasn't the National Institute been 'NICE' to patients with colorectal cancer? National Institute of Clinical Excellence

scientific article published in June 2002

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