List of works - Elissa K. Deenick

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

scientific article published on 01 November 2019

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

scientific article published on 01 June 2018

Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation, function and EBV immunity.

scientific article

Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4+ T cells

scientific article published on 06 February 2019

B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects

scientific article published on 20 February 2019

B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

scientific article

B cells: we need them now more than ever

scientific article published on 01 July 2020

B-cell-specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome.

scientific article published on 11 June 2016

Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies.

scientific article

Decision criteria for resolving isotype switching conflicts by B cells

scientific article published in October 2005

Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency

scientific article published on 20 August 2018

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

scientific article

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

scientific article

Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

scientific article published in September 2009

Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome

scientific article published on 13 May 2016

Erratum: The circulating life of a memory T-follicular helper cell

scientific article published on 26 May 2017

Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

scientific article

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

scientific article

Generation and characterization of B7-H4/B7S1/B7x-deficient mice

scientific journal article

Germline-activating mutations in PIK3CD compromise B cell development and function

scientific article published on 17 July 2018

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

scientific article published on 01 December 2018

Human T follicular helper (Tfh) cells and disease

scientific article published on 22 October 2013

Human Th9 cells: inflammatory cytokines modulate IL-9 production through the induction of IL-21

scientific article published on 08 June 2010

IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

scientific article

Immune Dysregulation and Disease Pathogenesis due to Activating Mutations in PIK3CD-the Goldilocks' Effect

scientific article published on 01 February 2019

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

scientific article (publication date: 26 September 2014)

Immunology: Helpful T cells are sticky

scientific article published in Nature

Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP ⬇️

scientific article published on November 1, 2011

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

scientific article published on 07 July 2015

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.

scientific article

Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells

scientific article

Regulation of T follicular helper cell formation and function by antigen presenting cells.

scientific article

STAT3 is a central regulator of lymphocyte differentiation and function.

scientific article published on 06 March 2014

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

scientific article published on 4 May 2015

Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses

scientific article published on 7 February 2018

Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.

scientific article published on 04 July 2013

T cell-B cell interactions in primary immunodeficiencies

scientific article published on 30 January 2012

T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses.

scientific article published on 31 March 2015

TCR affinity and negative regulation limit autoimmunity

article

The TORC that Gets the GC Cycling.

scientific article published in June 2017

The good, the bad and the ugly - TFH cells in human health and disease

scientific article published on 17 May 2013

The origins, function, and regulation of T follicular helper cells ⬇️

scientific article published on July 2, 2012

The regulation and role of T follicular helper cells in immunity ⬇️

scientific article published on December 1, 2011

The role of SAP and SLAM family molecules in the humoral immune response ⬇️

scientific article published on November 22, 2010

The sound of silence: modulating anergy in T lymphocytes.

scientific article

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.

scientific article published on 11 July 2016

c-Rel but not NF-κB1 is important for T regulatory cell development

scientific article published on 01 March 2010

c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance.

scientific article

List of works by Elissa K. Deenick

A divergent transcriptional landscape underpins the development and functional branching of MAIT cells

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

Activating PIK3CD mutations impair human cytotoxic lymphocyte differentiation, function and EBV immunity.

Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4+ T cells

B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects

B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans

B cells: we need them now more than ever

B-cell-specific STAT3 deficiency: Insight into the molecular basis of autosomal-dominant hyper-IgE syndrome.

Cytokine-Mediated Regulation of Human Lymphocyte Development and Function: Insights from Primary Immunodeficiencies.

Decision criteria for resolving isotype switching conflicts by B cells

Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12.

Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome

Erratum: The circulating life of a memory T-follicular helper cell

Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling.

Functional STAT3 deficiency compromises the generation of human T follicular helper cells.

Generation and characterization of B7-H4/B7S1/B7x-deficient mice

Germline-activating mutations in PIK3CD compromise B cell development and function

Human IFN-γ immunity to mycobacteria is governed by both IL-12 and IL-23

Human T follicular helper (Tfh) cells and disease

Human Th9 cells: inflammatory cytokines modulate IL-9 production through the induction of IL-21

IMMUNODEFICIENCIES. Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

Immune Dysregulation and Disease Pathogenesis due to Activating Mutations in PIK3CD-the Goldilocks' Effect

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

Immunology: Helpful T cells are sticky

Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP ⬇️

Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies

Naive and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells.

Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells

Regulation of T follicular helper cell formation and function by antigen presenting cells.

STAT3 is a central regulator of lymphocyte differentiation and function.

STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function

Signal Transducer and Activator of Transcription 3 Control of Human T and B Cell Responses

Signal transducer and activator of transcription 3 (STAT3) mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8(+) T-cell memory formation and function.

T cell-B cell interactions in primary immunodeficiencies

T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses.

TCR affinity and negative regulation limit autoimmunity

The TORC that Gets the GC Cycling.

The good, the bad and the ugly - TFH cells in human health and disease

The origins, function, and regulation of T follicular helper cells ⬇️

The regulation and role of T follicular helper cells in immunity ⬇️

The role of SAP and SLAM family molecules in the humoral immune response ⬇️

The sound of silence: modulating anergy in T lymphocytes.

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets.

c-Rel but not NF-κB1 is important for T regulatory cell development

c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance.