List of works - Laura Sanz

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

scientific article published in Nature Communications

ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy

scientific article published on 27 September 2017

Bacterial secretion of soluble and functional trivalent scFv-based N-terminal trimerbodies.

scientific article published on 4 August 2015

Balanced secretion of anti-CEA × anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity

scientific article

Basement membrane-rich organoids with functional human blood vessels are permissive niches for human breast cancer metastasis

scientific article

EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination

scientific article

Efficient production of single-chain fragment variable-based N-terminal trimerbodies in Pichia pastoris

scientific article published on 12 August 2014

Engineered human tumor xenografts with functional human vascular networks.

scientific article published on 8 October 2010

Engineering human cells for in vivo secretion of antibody and non-antibody therapeutic proteins

scientific article published on 22 March 2011

Factory neovessels: engineered human blood vessels secreting therapeutic proteins as a new drug delivery system.

scientific article published on 25 March 2010

Functional comparison of single-chain and two-chain anti-CD3-based bispecific antibodies in gene immunotherapy applications

scientific article published on 23 May 2014

Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab.

scientific article

Generation and characterization of monospecific and bispecific hexavalent trimerbodies

scientific article published on 5 December 2012

Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity

scientific article

Immunotherapeutic organoids: a new approach to cancer treatment

scientific article

Improved stability of multivalent antibodies containing the human collagen XV trimerization domain.

scientific article published on March 2012

In vivo secretion of anti-CD3 × anti-tumor bispecific antibodies by gene-modified cells: over a decade of T-cell engagement.

scientific article published on April 2015

Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains

scientific article

Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes

scientific article published on 4 December 2013

Microencapsulation of therapeutic bispecific antibodies producing cells: immunotherapeutic organoids for cancer management

scientific article published on 22 October 2014

Non-hematopoietic stem cells as factories for in vivo therapeutic protein production.

scientific article published on 12 May 2011

Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies

scientific article

Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation

scientific article

Selection strategies for anticancer antibody discovery: searching off the beaten path

scientific article published on 26 March 2015

TGF-β-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion

scientific article published on 07 August 2020

The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis.

scientific article published on 14 December 2011

The coming of age of engineered multivalent antibodies.

scientific article

The heterotrimeric laminin coiled-coil domain exerts anti-adhesive effects and induces a pro-invasive phenotype

scientific article

The therapeutic potential of engineered human neovessels for cell-based gene therapy ⬇️

scientific article published on November 17, 2010

Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer

scientific article published on 07 February 2022

List of works by Laura Sanz

A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

ATTACK, a novel bispecific T cell-recruiting antibody with trivalent EGFR binding and monovalent CD3 binding for cancer immunotherapy

Bacterial secretion of soluble and functional trivalent scFv-based N-terminal trimerbodies.

Balanced secretion of anti-CEA × anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity

Basement membrane-rich organoids with functional human blood vessels are permissive niches for human breast cancer metastasis

EFNA3 long noncoding RNAs induced by hypoxia promote metastatic dissemination

Efficient production of single-chain fragment variable-based N-terminal trimerbodies in Pichia pastoris

Engineered human tumor xenografts with functional human vascular networks.

Engineering human cells for in vivo secretion of antibody and non-antibody therapeutic proteins

Factory neovessels: engineered human blood vessels secreting therapeutic proteins as a new drug delivery system.

Functional comparison of single-chain and two-chain anti-CD3-based bispecific antibodies in gene immunotherapy applications

Gene expression profiling identifies EPHB4 as a potential predictive biomarker in colorectal cancer patients treated with bevacizumab.

Generation and characterization of monospecific and bispecific hexavalent trimerbodies

Immune Regulation by Pericytes: Modulating Innate and Adaptive Immunity

Immunotherapeutic organoids: a new approach to cancer treatment

Improved stability of multivalent antibodies containing the human collagen XV trimerization domain.

In vivo secretion of anti-CD3 × anti-tumor bispecific antibodies by gene-modified cells: over a decade of T-cell engagement.

Intramolecular trimerization, a novel strategy for making multispecific antibodies with controlled orientation of the antigen binding domains

Lipopolysaccharide activates Toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway and proinflammatory response in human pericytes

Microencapsulation of therapeutic bispecific antibodies producing cells: immunotherapeutic organoids for cancer management

Non-hematopoietic stem cells as factories for in vivo therapeutic protein production.

Proteasome activator complex PA28 identified as an accessible target in prostate cancer by in vivo selection of human antibodies

Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation

Selection strategies for anticancer antibody discovery: searching off the beaten path

TGF-β-induced IGFBP-3 is a key paracrine factor from activated pericytes that promotes colorectal cancer cell migration and invasion

The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis.

The coming of age of engineered multivalent antibodies.

The heterotrimeric laminin coiled-coil domain exerts anti-adhesive effects and induces a pro-invasive phenotype

The therapeutic potential of engineered human neovessels for cell-based gene therapy ⬇️

Trispecific T-cell engagers for dual tumor-targeting of colorectal cancer