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List of works by Gilberto Schwartsmann

A gastrin-releasing peptide receptor antagonist blocks D-amphetamine-induced hyperlocomotion and increases hippocampal NGF and BDNF levels in rats

scientific article

A gastrin-releasing peptide receptor antagonist stimulates Neuro2a neuroblastoma cell growth: prevention by a histone deacetylase inhibitor.

scientific article published on 6 May 2009

A multicenter phase II study of XRP6258 administered as a 1-h i.v. infusion every 3 weeks in taxane-resistant metastatic breast cancer patients

scientific article published on 23 April 2008

A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer

scientific article

A phase I trial of the bombesin/gastrin-releasing peptide (BN/GRP) antagonist RC3095 in patients with advanced solid malignancies.

scientific article

A phosphodiesterase 4-controlled switch between memory extinction and strengthening in the hippocampus.

scientific article published on 17 March 2014

A progress report of a phase I study of interferon-gamma and interleukin-2 and some comments on the mechanism of the toxicity due to interleukin-2

scientific article published on 01 June 1989

A role for hippocampal gastrin-releasing peptide receptors in extinction of aversive memory

scientific article

A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris.

scientific article

Altered extracellular ATP, ADP and AMP catabolism in glioma cell lines

scientific article published in August 2003

Analysis of KIR gene frequencies and HLA class I genotypes in breast cancer and control group.

scientific article published on 18 June 2013

Analysis of KIR gene frequencies and HLA class I genotypes in prostate cancer and control group.

scientific article published on 10 April 2012

Anti-EGFR therapy combined with neuromedin B receptor blockade induces the death of DAOY medulloblastoma cells.

scientific article published on 3 October 2013

Anticancer drugs from nature

scientific article published on 01 July 2001

Antiproliferative activity of the dimeric phloroglucinol and benzophenone derivatives of Hypericum spp. native to southern Brazil

scientific article published on August 2013

Antitumor activity of three benzopyrans isolated from Hypericum polyanthemum.

scientific article published on March 2005

Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes

scientific article published on 16 May 2010

Asymptomatic babesiosis in a child with hepatoblastoma

scientific article published on 01 March 2004

BDNF and PDE4, but not the GRPR, regulate viability of human medulloblastoma cells

scientific article published on 30 July 2009

BDNF/TrkB content and interaction with gastrin-releasing peptide receptor blockade in colorectal cancer

scientific article published on January 2010

BDNF/TrkB signaling as an anti-tumor target

scientific article published in October 2011

BDNF/TrkB signaling protects HT-29 human colon cancer cells from EGFR inhibition.

scientific article

Basic fibroblast growth factor prevents the memory impairment induced by gastrin-releasing peptide receptor antagonism in area CA1 of the rat hippocampus

scientific article published on 4 April 2007

Bombesin protection against FK506 neurotoxicity

scientific article published on 01 April 2007

Bombesin/gastrin-releasing peptide receptors in the basolateral amygdala regulate memory consolidation.

scientific article published in February 2004

Breast cancer in Latin America: experts perceptions compared with medical care standards.

scientific article

CYP3A4*22 is related to increased plasma levels of 4-hydroxytamoxifen and partially compensates for reduced CYP2D6 activation of tamoxifen

scientific article published on 20 April 2015

Cancer chemotherapy and cognitive function in rodent models: memory impairment induced by cyclophosphamide in mice.

scientific article published in August 2006

Cancer stem cells and the biology of brain tumors.

scientific article published on December 2009

Carcinomatous meningitis as a clinical manifestation of pancreatic carcinoma

scientific article published on 01 December 2001

Cervical cancer screening in Porto Alegre, Brazil: alternative methods for detecting cancer precursors in a developing country

scientific article published on 01 January 2001

Clinical trials in advanced breast cancer

scientific article published on 01 June 1987

Comparative antitumour activity of vinblastine-isoleucinate and related vinca alkaloids in human tumour xenografts.

scientific article

Comparative genotoxic effect of vincristine, vinblastine, and vinorelbine in somatic cells of Drosophila melanogaster

scientific article published in August 2002

Current and emerging molecular targets in glioma

scientific article

DEFB1 gene 5′ untranslated region (UTR) polymorphisms are marginally involved in inflammatory bowel disease in south Brazilians

article

DUP 785 (NSC 368390): schedule-dependency of growth-inhibitory and antipyrimidine effects

scientific article published on 01 September 1988

Development, validation and clinical application of a HPLC-FL method for CYP2D6 phenotyping in South Brazilian breast cancer patients

scientific article published on 18 April 2014

Dexamethasone and gastrin-releasing peptide receptors in human lung cells

scientific article published on 01 October 2004

Dexamethasone reverses the memory impairment induced by antagonism of hippocampal gastrin-releasing peptide receptors

scientific article published on 18 January 2005

Disparities in cancer care: a worldwide perspective and roadmap for change

scientific article published on 01 May 2006

Double-minute chromatin bodies in HL-60 leukemia cells sensitive and resistant to differentiation inducing agents.

scientific article

EORTC New Drug Development Office coordinating and monitoring programme for phase I and II trials with new anticancer agents

scientific article published on 01 January 1991

Economic evaluation of strategies for managing women with equivocal cytological results in Brazil.

scientific article published on 12 November 2010

Effect of a gastrin-releasing peptide receptor antagonist and a proton pump inhibitor association in an animal model of gastritis.

scientific article

Effects of N-acetylcysteine/deferoxamine, taurine and RC-3095 on respiratory chain complexes and creatine kinase activities in rat brain after sepsis.

scientific article published in April 2010

Effects of a gastrin-releasing peptide receptor antagonist on D-amphetamine-induced oxidative stress in the rat brain

scientific article published on 4 February 2010

Effects of an antagonist of the bombesin/gastrin-releasing peptide receptor on complete Freund's adjuvant-induced arthritis in rats

scientific article

Effects of an antagonist of the gastrin-releasing peptide receptor in an animal model of uveitis.

scientific article

Effects of the gastrin-releasing peptide antagonist RC-3095 in a rat model of ulcerative colitis.

scientific article published on 6 November 2009

Effects of toxic doses of glutamate on Cu-Zn and Mn/superoxide dismutases activities in human glioma cell lines.

scientific article published on January 2005

Emerging therapeutic agents for cervical cancer.

scientific article

Epidemiologic correlates of antibody response to human papillomavirus among women at low risk of cervical cancer

article

Evaluation of antioxidant effect of extracts of Symphyopappus casarettoi

scientific article published on 07 February 2007

Evidence for an association of human papillomavirus infection and colorectal cancer

scientific article published on 22 February 2007

Expression of gastrin-releasing peptide receptor in epidermoid carcinoma of the anal canal

scientific article published on July 2014

Expression of gastrin-releasing peptide receptor in patients with cutaneous malignant melanoma

scientific article published on 12 April 2013

Extracellular nucleotides and nucleosides induce proliferation and increase nucleoside transport in human glioma cell lines

scientific article published in September 2003

Failure of anti-EGFR therapy in p16-positive head and neck cancer

scientific article published on 01 October 2013

Fractionated doses of oral etoposide in the treatment of patients with aids-related kaposi sarcoma: a clinical and pharmacologic study to improve therapeutic index.

scientific article

GRPR antagonists for prostate cancer--prospects and caveats.

scientific article published on 25 June 2013

Gastrin-Releasing Peptide Receptor Knockdown Induces Senescence in Glioblastoma Cells.

scientific article published on 16 January 2016

Gastrin-releasing peptide receptor (GRPR) mediates chemotaxis in neutrophils

scientific article published on 27 December 2011

Gastrin-releasing peptide receptor antagonism induces protection from lethal sepsis: involvement of toll-like receptor 4 signaling.

scientific article

Gastrin-releasing peptide receptor antagonist effects on an animal model of sepsis

scientific article

Gastrin-releasing peptide receptor antagonist or N-acetylcysteine combined with omeprazol protect against mitochondrial complex II inhibition in a rat model of gastritis

scientific article published on 8 December 2010

Gastrin-releasing peptide receptor as a molecular target for inflammatory diseases.

scientific article published on December 2007

Gastrin-releasing peptide receptor content in human glioma and normal brain

scientific article

Gastrin-releasing peptide receptor expression in cervical cancer

scientific article published on 01 January 2007

Gastrin-releasing peptide receptor expression in lung cancer.

scientific article published on January 2014

Gastrin-releasing peptide receptor signaling in the integration of stress and memory.

scientific article published on 31 August 2013

Gastrin-releasing peptide receptor: a potential target in treatment of IBD?

scientific article published on 01 March 2009

Gastrin-releasing peptide receptors in the central nervous system: role in brain function and as a drug target.

scientific article

Gastrin-releasing peptide receptors regulate proliferation of C6 Glioma cells through a phosphatidylinositol 3-kinase-dependent mechanism

scientific article

Gemcitabine administered as a short infusion versus a fixed dose rate in combination with cisplatin for the treatment of patients with advanced non-small cell lung cancer

scientific article published on 22 June 2007

Glioma revisited: from neurogenesis and cancer stem cells to the epigenetic regulation of the niche ⬇️

scientific article

Growth inhibitory effects of 5-aza-2'-deoxycytidine in HL-60 promyelocytic leukemia cells resistant to differentiation induction.

scientific article

HER2 as a cancer stem-cell target.

scientific article published in March 2010

High-dose chemotherapy and autologous peripheral blood stem cell rescue in a patient with pleuropulmonary blastoma

scientific article published on January 2003

Histone deacetylase inhibition prevents the impairing effects of hippocampal gastrin-releasing peptide receptor antagonism on memory consolidation and extinction.

scientific article published on 26 March 2016

Hsp70 response to 5-fluorouracil treatment in human colon cancer cell lines

scientific article published on 28 March 2007

Impairments of social behavior and memory after neonatal gastrin-releasing peptide receptor blockade in rats: Implications for an animal model of neurodevelopmental disorders

scientific journal article

Improved determination of uracil and dihydrouracil in plasma after a loading oral dose of uracil using high-performance liquid chromatography with photodiode array detection and porous graphitic carbon stationary phase

scientific article published in May 2015

In reference to Fu et al. (neuro-Oncology 2008:10139-152)

scientific article published on 25 November 2008

Influence of CYP2D6 and CYP3A4 Phenotypes, Drug Interactions, and Vitamin D Status on Tamoxifen Biotransformation

scientific article published on 4 April 2015

Influence of purple grape juice in cyclosporine bioavailability

scientific article published on 19 March 2010

Inhibitory activities of trichostatin a in U87 glioblastoma cells and tumorsphere-derived cells.

scientific article published on 25 January 2014

International scientific collaboration in HIV and HPV: a network analysis

scientific article

Intrahippocampal infusion of the bombesin/gastrin-releasing peptide antagonist RC-3095 impairs inhibitory avoidance retention

scientific article published in July 2003

Long-term behavioral effects of neonatal blockade of gastrin-releasing peptide receptors in rats: similarities to autism spectrum disorders.

scientific article

Low cytotoxicity of ecteinascidin 743 in yeast lacking the major endonucleolytic enzymes of base and nucleotide excision repair pathways

scientific article published in July 2005

Lymph node retrieval after preoperative chemoradiotherapy for rectal cancer

scientific article published on 23 May 2012

MAPK pathway activation in colorectal cancer: a therapeutic opportunity for GRP receptor antagonists

scientific article published on 01 July 2005

Mangiferin, a naturally occurring glucoxilxanthone improves long-term object recognition memory in rats.

scientific article published on 19 March 2010

Metastatic renal cell carcinoma involving the rectum

scientific article published in September 2002

Modulation of oxidative stress in response to gamma-radiation in human glioma cell lines

scientific article published in January 2003

Molecular mechanisms mediating gastrin-releasing peptide receptor modulation of memory consolidation in the hippocampus.

scientific article

Multidrug resistance gene expression during the murine ontogeny

scientific article published on 01 March 2001

Musical hallucinations following insular glioma resection

scientific article

Natural products in anticancer therapy.

scientific article

Neonatal gastrin-releasing peptide receptor blockade reduces maternal odor preference in rats

scientific article

Neuropeptides and anxiety disorders: bombesin receptors as novel therapeutic targets.

scientific article

Non-associative learning and anxiety in rats treated with a single systemic administration of the gastrin-releasing peptide receptor antagonist RC-3095.

scientific article published on 14 July 2005

Opposite effects of low and high doses of the gastrin-releasing peptide receptor antagonist RC-3095 on memory consolidation in the hippocampus: possible involvement of the GABAergic system.

scientific article published on 2 May 2006

Overview of Breast Health Care Guidelines for Countries with Limited Resources ⬇️

scientific article published on May 1, 2003

PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines

scientific article published on 20 May 2014

Pharmacokinetics of Brequinar sodium (NSC 368390) in patients with solid tumors during a phase I study

scientific article published on 01 December 1989

Pharmacokinetics of Brequinar sodium (NSC 368390; DUP 785) in cerebrospinal fluid

scientific article published on 01 December 1988

Phase I study of Brequinar sodium (NSC 368390) in patients with solid malignancies

scientific article published on 01 January 1990

Phase II study of teniposide in patients with AIDS-related Kaposi's sarcoma ⬇️

scientific article published on January 1, 1991

Phase II study of thalidomide in patients with metastatic malignant melanoma.

scientific article published on December 2004

Phase II trial and pharmacokinetic study of thalidomide in patients with metastatic colorectal cancer.

scientific article published on August 2003

Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix

scientific article published in October 2002

Phase II trial of paclitaxel and ifosfamide as a salvage treatment in metastatic breast cancer

scientific article published on August 1997

Phenotype modulation of cellular UV-sensitivity

scientific article published on 01 October 1999

Phosphodiesterase-4 inhibition and brain tumor growth

scientific article published in May 2009

Phosphoinositide 3-kinase is required for bombesin-induced enhancement of fear memory consolidation in the hippocampus

scientific article

Planning cancer control in Latin America and the Caribbean

scientific article

Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas

scientific article

Prevalence of vascular-endothelial growth factor, matrix metalloproteinases and tissue inhibitors of metalloproteinases in primary breast cancer

scientific article published on 04 September 2009

Protective effect of RC-3095, an antagonist of the gastrin-releasing peptide receptor, in experimental arthritis

scientific article published on 01 October 2011

Protective effect of gastrin-releasing peptide receptor antagonist in carrageenan-induced pleural inflammation in rats

scientific article published on 3 April 2010

Protein kinase C-mediated in vitro invasion of human glioma cells through extracellular-signal-regulated kinase and ornithine decarboxylase.

scientific article published in May 2000

Quantification of the bombesin/gastrin releasing peptide antagonist RC-3095 by liquid chromatography-tandem mass spectrometry.

scientific article published in February 2005

RC-3095, a bombesin/gastrin-releasing peptide receptor antagonist, impairs aversive but not recognition memory in rats.

scientific article published in February 2004

RC-3095, a selective gastrin-releasing peptide receptor antagonist, does not protect the lungs in an experimental model of lung ischemia-reperfusion injury.

scientific article published on 29 March 2015

RNA expression of the molecular signature genes for metastasis in colorectal cancer.

scientific article published on 04 March 2011

Reduced NGF Secretion by HT-29 Human Colon Cancer Cells Treated with a GRPR Antagonist

scientific article published on 01 January 2009

Regulation of E-cadherin expression by growth factor receptors in cancer cells

scientific article published on 28 February 2011

Rescue of social behavior impairment by clozapine and alterations in the expression of neuronal receptors in a rat model of neurodevelopmental impairment induced by GRPR blockade

scientific article published on 17 August 2011

Resistance of HL-60 promyelocytic leukemia cells to induction of differentiation and its reversal by combination treatment.

scientific article

Reversal by interleukin-2 of alopecia universalis, mucocutaneous candidiasis, and sexual impotence in a patient with malignant thymoma

scientific article published on 01 April 1993

Screening for antiproliferative activity of six southern Brazilian species of Hypericum.

scientific article published on January 2005

Sentinel lymph node identification and sampling in women with early breast cancer using 99m Tc labelled dextran 500 and patent blue V dye.

scientific article published in October 2001

Sentinel lymph node in carcinoma of the anal canal: a review.

scientific article

Sentinel lymph node procedure in patients with epidermoid carcinoma of the anal canal: early experience

scientific article published in August 2003

Sequence-dependent growth inhibition and DNA damage formation by the irinotecan-5-fluorouracil combination in human colon carcinoma cell lines

scientific article published on 01 December 1999

Serum Hsp70 as an early predictor of fatal outcome after severe traumatic brain injury in males

scientific article

Sodium butyrate enhances the cytotoxic effect of antineoplastic drugs in human lymphoblastic T-cells.

scientific article published on 9 August 2008

Stimulation of proliferation of U138-MG glioblastoma cells by gastrin-releasing peptide in combination with agents that enhance cAMP signaling.

scientific article

Study of killer immunoglobulin-like receptor genes and human leukocyte antigens class I ligands in a Caucasian Brazilian population with Crohn's disease and ulcerative colitis.

scientific article published on 8 January 2010

Synergistic effect of three benzopyrans isolated from Hypericum polyanthemum in U-373 MG glioblastoma cell line.

scientific article

Systemic administration of doxorubicin impairs aversively motivated memory in rats.

scientific article published in 2009

Tamoxifen inhibits particulate-associated protein kinase C activity, and sensitises cultured human glioblastoma cells not to etoposide but to gamma-radiation and BCNU.

scientific article published on May 1999

Targeting the bombesin/gastrin-releasing peptide receptor to treat sepsis.

scientific article

Targeting the epidermal growth factor receptor in colorectal cancer: a potential therapeutic role for gastrin-releasing peptide receptor antagonists

scientific article published on 21 December 2007

The bombesin/gastrin releasing peptide receptor antagonist RC-3095 blocks apomorphine but not MK-801-induced stereotypy in mice.

scientific article

The effects of sample size on the outcome of ovarian tissue cryopreservation

scientific article

The egos and the goals of reporting results

scientific article published on 01 March 2007

The gastrin-releasing peptide receptor as a marker of dysplastic alterations in cervical epithelial cells.

scientific article published on 9 February 2012

The gastrin-releasing peptide receptor as a therapeutic target in central nervous system disorders.

scientific article published on June 2007

The histone deacetylase inhibitor sodium butyrate in combination with brain-derived neurotrophic factor reduces the viability of DAOY human medulloblastoma cells.

scientific article published on 6 April 2011

The histone deacetylase inhibitor sodium butyrate promotes cell death and differentiation and reduces neurosphere formation in human medulloblastoma cells.

scientific article published on 21 March 2013

The irinotecan/5-fluorouracil combination induces apoptosis and enhances manganese superoxide dismutase activity in HT-29 human colon carcinoma cells.

scientific article

The main steps in the development of anticancer agents

scientific article published on August 1988

Transient disruption of fear-related memory by post-retrieval inactivation of gastrin-releasing peptide or N-methyl-D-aspartate receptors in the hippocampus

scientific article

Treatment of breast cancer in countries with limited resources.

scientific article published in May 2003

Tumor size as a surrogate end point for the detection of early breast cancer: a 30-year (1972-2002), single-center experience in southern Brazil

scientific article published in September 2007

Ultra-high performance liquid chromatography tandem mass spectrometric method for the determination of tamoxifen, N-desmethyltamoxifen, 4-hydroxytamoxifen and endoxifen in dried blood spots--development, validation and clinical application during br

scientific article published on 29 October 2014

Viability of D283 medulloblastoma cells treated with a histone deacetylase inhibitor combined with bombesin receptor antagonists.

scientific article published on 20 November 2015

Von Willebrand factor in colorectal cancer

scientific article published on 01 January 2002

When drugs are worth more than gold!

scientific article published on 01 December 2007

[Complementary and alternative medicine: a common practice among patients with cancer]

scientific article published on 01 November 2008

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