List of works - Ingebrigt Sylte

1,2,3-triazole analogs of combretastatin A-4 as potential microtubule-binding agents

scientific article published on 17 July 2010

1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin

scientific article

A combined simulation with ab initio MO and classical vibrational analysis on the specific interactions between thermolysin and dipeptide ligands

A homology model of SERT based on the LeuTAa template

scientific article published on 17 August 2006

A linear combination of pharmacophore hypotheses as a new tool in search of new active compounds--an application for 5-HT1A receptor ligands

scientific article (publication date: 2013)

A molecular model of a putative substrate releasing conformation of multidrug resistance protein 5 (MRP5).

scientific article published on 25 January 2008

A short update on the structure of drug binding sites on neurotransmitter transporters.

scientific article

An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity

scientific article

Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor

scientific article published in February 2005

Binding Modes and Pharmacophore Modelling of Thermolysin Inhibitors ⬇️

scientific article published on June 1, 2012

Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure

scientific article published on 04 September 2009

Bioinformatics and receptor mechanisms of psychotropic drugs

scientific article published on January 1, 2001

Bioinformatics: from genome to drug targets

scientific article published on 01 January 2002

Comparative Molecular Dynamics of Mesophilic and Psychrophilic Protein Homologues Studied by 1.2 ns Simulations

scientific article published on 01 December 1999

Comparative molecular dynamic simulations of wild type and Thr114Val mutated Scaptodrosophila lebanonensis alcohol dehydrogenase

scientific article published on 25 March 2013

Comparative molecular dynamics simulations of mitogen-activated protein kinase-activated protein kinase 5.

scientific article published on 19 March 2014

Comparative sequence and structure analysis reveal features of cold adaptation of an enzyme in the thermolysin family

scientific article published in February 2006

Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs

scientific article published on 01 March 2005

Determinants for psychrophilic and thermophilic features of metallopeptidases of the M4 family.

scientific article published in January 2009

Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models

scientific article published on 11 January 2014

Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin

scientific article

Dipeptide inhibitors of thermolysin and angiotensin I-converting enzyme

scientific article published in January 2012

Discovery of potent thermolysin inhibitors using structure based virtual screening and binding assays

scientific article

Effect of the glutathione/glutathione disulfide redox couple on thiopurine methyltransferase

scientific article

Environmental Chemicals Modulate Polar Bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and Adipogenesis in Vitro

scientific article published on 7 September 2016

From Homology Models to a Set of Predictive Binding Pockets-a 5-HT1A Receptor Case Study

scientific article published on 05 January 2017

From genomics to drug targets

scientific article published on July 2006

Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands

scientific article (publication date: 2015)

High-level expression of pseudolysin, the extracellular elastase of Pseudomonas aeruginosa, in Escherichia coli and its purification

scientific article

Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5).

scientific article

Homology modeling of human γ-butyric acid transporters and the binding of pro-drugs 5-aminolevulinic acid and methyl aminolevulinic acid used in photodynamic therapy

scientific article

Homology modeling of transporter proteins (carriers and ion channels).

scientific article published on January 2012

Homology modelling of metabotropic glutamate receptor 2.

scientific article published on 19 April 2011

Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases

scientific article published on 29 April 2010

Identification of novel serotonin transporter compounds by virtual screening

scientific article published on 26 February 2014

In Silico Methods for the Discovery of Orthosteric GABA Receptor Compounds

In Vitro and In Silico Competitive Binding of Brominated Polyphenyl Ether Contaminants With Human and Gull Thyroid Hormone Transport Proteins.

scientific article

Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.

scientific article published on 18 October 2014

Interaction of 1,2,4-substituted piperazines, new serotonin receptor ligands, with 5-HT1A and 5-HT2A receptors

scientific article

Intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-HT(1A) receptors.

scientific article

Ligand induced conformational states of the 5-HT(1A) receptor

scientific article

Ligand-directed trafficking of receptor stimulus

scientific article

Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor

scientific article

Ligand-induced stabilization and activation of peroxisome proliferator-activated receptor gamma

scientific article published on 11 June 2008

Mapping the suramin-binding sites of human neutrophil elastase: investigation by fluorescence resonance energy transfer and molecular modeling.

scientific article published in December 1997

Mass-spectrometric studies of new 6-nitroquipazines-serotonin transporter inhibitors

scientific article published on October 2011

Membrane Transporters: Structure, Function and Targets for Drug Design

Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer

scientific article published on 12 June 2020

Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues.

scientific article published in November 2001

Molecular dynamics of NPY Y 1 receptor activation

scientific article published on 01 December 1999

Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors

scientific article

Molecular dynamics of serotonin and ritanserin interacting with the 5-HT2 receptor

scientific article

Molecular dynamics of the 5-HT1a receptor and ligands.

scientific article published in September 1993

Molecular insight into pseudolysin inhibition using the MM-PBSA and LIE methods.

scientific article published on 5 December 2005

Molecular mechanism of citalopram and cocaine interactions with neurotransmitter transporters

scientific article

Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol

scientific article

Molecular model of the Escherichia coli Na1/H1 antiporter NhaA.

scientific article published in January 2001

Molecular model of the neural dopamine transporter

scientific article published in May 2003

Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)

scientific article

Molecular modeling of neurotransmitter receptors and ligands

scientific article published on 01 January 1993

Molecular modelling of UH-301 and 5-HTla receptor interactions

scientific article published on 01 February 1996

Molecular modelling of drug targets: the past, the present and the future.

scientific article

Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha

scientific article published on 29 April 2008

Molecular recognition of long chain fatty acids by peroxisome proliferator-activated receptor α

Molecular structure and dynamics of cis(Z)-and trans(E)-flupenthixol and clopenthixol

scientific article published in April 1991

Molecular structure and dynamics of dopamine, serotonin and the D2, 5-HT2 and 5-HT1A receptors

scholarly article by S.G Dahl et al published September 1991 in European Neuropsychopharmacology

Multivariate Linear Regression Models Based on ADME Descriptors and Predictions of ADMET Profile for Structurally Diverse Thermolysin Inhibitors

scholarly article by Mahmud Khan & Ingebrigt Sylte published 1 September 2009 in Letters in drug design & discovery

New techniques for optimization of thiopurine therapy in leukemia and transplantation

scientific article published in April 2002

Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2.

scientific article published on 16 July 2009

PAC-1 and isatin derivatives are weak matrix metalloproteinase inhibitors

scientific article published on 18 July 2014

Pancreatic trypsin activates human promatrix metalloproteinase-2.

scientific article published in July 2005

Predictive QSAR modeling for the successful predictions of the ADMET properties of candidate drug molecules

scientific article published on October 2007

Protein binding site analysis by means of structural interaction fingerprint patterns

scientific article published on 14 September 2011

Putative drug binding conformations of monoamine transporters

scientific article

Receptor-binding and pharmacokinetic properties of dopaminergic agonists

scientific article published on January 2008

Regulation of liver X receptor target genes by 22-functionalized oxysterols. Synthesis, in silico and in vitro evaluations

scientific article published on 20 December 2016

Regulation of matrix metalloproteinase activity in health and disease

scientific article

Serotonin transporter and receptor ligands with antidepressant activity as neuroprotective and proapoptotic agents

scientific article published on 22 January 2017

Specific interactions and binding energies between thermolysin and potent inhibitors: Molecular simulations based on ab initio molecular orbital method

scientific article published on 02 November 2011

Specific interactions and binding free energies between thermolysin and dipeptides: Molecular simulations combined with Ab initio molecular orbital and classical vibrational analysis

scientific article published on 03 August 2011

Specific interactions between zinc metalloproteinase and its inhibitors: Ab initio fragment molecular orbital calculations

scientific article published on 8 June 2017

Stereochemical activity of lone pairs. The crystal and molecular structure of a complex of 18-crown-6 (1,4,7,10,13,16-hexaoxacyclooctadecane) with bismuth(III) chloride

Structure and localisation of drug binding sites on neurotransmitter transporters.

scientific article published on 24 February 2009

Structures and models of transporter proteins

scientific article published on 26 February 2004

Studies of synthetic chalcone derivatives as potential inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and pro-inflammatory cytokines

scientific article published on 16 September 2014

Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations.

scientific article published on 14 June 2011

Synthesis and initial biological evaluation of new mimics of the LXR-modulator 22(S)-hydroxycholesterol

scientific article published on 5 November 2013

Synthesis, Biological Evaluation and Molecular Modeling of GW 501516 Analogues

scientific article published on 01 November 2010

Synthesis, antidepressant evaluation and docking studies of long-chain alkylnitroquipazines as serotonin transporter inhibitors

scientific article published on 11 April 2013

Synthesis, biological evaluation and molecular modeling of new analogs of the anti-cancer agent 2-methoxyestradiol: potent inhibitors of angiogenesis

scholarly article in RSC Advances, vol. 5 no. 41, 2015

Synthesis, biological evaluation and molecular modeling studies of the PPARβ/δ antagonist CC618

scientific article published on 05 March 2015

Synthesis, experimental evaluation and molecular modelling of hydroxamate derivatives as zinc metalloproteinase inhibitors

scientific article

Synthesis, in vitro and in vivo biological evaluation of new oxysterols as modulators of the liver X receptors

scientific article published on 25 July 2016

Synthesis, in vitro binding studies and docking of long-chain arylpiperazine nitroquipazine analogues, as potential serotonin transporter inhibitors

scientific article

Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol.

scientific article

Synthesis, molecular modeling studies and biological evaluation of fluorine substituted analogs of GW 501516

article

Templates and models of monoamine transporter proteins.

scientific article

The GABAB Receptor-Structure, Ligand Binding and Drug Development

scientific article published on 07 July 2020

The catalytic triad in Drosophila alcohol dehydrogenase: pH, temperature and molecular modelling studies

scientific article published in November 1999

The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT(7)R antagonists

scientific article published on 6 March 2010

The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor

scientific journal article

The ligand binding site of NPY at the rat Y1 receptor investigated by site-directed mutagenesis and molecular modeling

scientific article

The ligand-binding site of buspirone analogues at the 5-HT1A receptor.

scientific article

The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism

scientific article

The molecular interactions of buspirone analogues with the serotonin transporter

scientific article published on 5 September 2008

The protein-protein interactions between SMPI and thermolysin studied by molecular dynamics and MM/PBSA calculations.

scientific article published in April 2005

The selectivity of galardin and an azasugar-based hydroxamate compound for human matrix metalloproteases and bacterial metalloproteases

scientific article published in PLoS ONE

The thermolysin family (M4) of enzymes: therapeutic and biotechnological potential

scientific article published on January 2009

Theoretical calculations of the catalytic triad in short-chain alcohol dehydrogenases/reductases

scientific article published on 2 November 2007

Theoretical models of interactions between buspirone analogues and 5-HT1A and 5-HT2A serotonin receptor subtypes

scholarly article by A Bronowska et al published November 2000 in Acta Poloniae Pharmaceutica: drug research

Three-dimensional structure and molecular dynamics of cis(Z)- and trans(E)-chlorprothixene

scientific article

List of works by Ingebrigt Sylte

1,2,3-triazole analogs of combretastatin A-4 as potential microtubule-binding agents

1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin

A combined simulation with ab initio MO and classical vibrational analysis on the specific interactions between thermolysin and dipeptide ligands

A homology model of SERT based on the LeuTAa template

A linear combination of pharmacophore hypotheses as a new tool in search of new active compounds--an application for 5-HT1A receptor ligands

A molecular model of a putative substrate releasing conformation of multidrug resistance protein 5 (MRP5).

A short update on the structure of drug binding sites on neurotransmitter transporters.

An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity

Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor

Binding Modes and Pharmacophore Modelling of Thermolysin Inhibitors ⬇️

Binding site of ABC transporter homology models confirmed by ABCB1 crystal structure

Bioinformatics and receptor mechanisms of psychotropic drugs

Bioinformatics: from genome to drug targets

Comparative Molecular Dynamics of Mesophilic and Psychrophilic Protein Homologues Studied by 1.2 ns Simulations

Comparative molecular dynamic simulations of wild type and Thr114Val mutated Scaptodrosophila lebanonensis alcohol dehydrogenase

Comparative molecular dynamics simulations of mitogen-activated protein kinase-activated protein kinase 5.

Comparative sequence and structure analysis reveal features of cold adaptation of an enzyme in the thermolysin family

Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs

Determinants for psychrophilic and thermophilic features of metallopeptidases of the M4 family.

Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models

Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin

Dipeptide inhibitors of thermolysin and angiotensin I-converting enzyme

Discovery of potent thermolysin inhibitors using structure based virtual screening and binding assays

Effect of the glutathione/glutathione disulfide redox couple on thiopurine methyltransferase

Environmental Chemicals Modulate Polar Bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and Adipogenesis in Vitro

From Homology Models to a Set of Predictive Binding Pockets-a 5-HT1A Receptor Case Study

From genomics to drug targets

Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands

High-level expression of pseudolysin, the extracellular elastase of Pseudomonas aeruginosa, in Escherichia coli and its purification

Homology modeling and ligand docking of Mitogen-activated protein kinase-activated protein kinase 5 (MK5).

Homology modeling of human γ-butyric acid transporters and the binding of pro-drugs 5-aminolevulinic acid and methyl aminolevulinic acid used in photodynamic therapy

Homology modeling of transporter proteins (carriers and ion channels).

Homology modelling of metabotropic glutamate receptor 2.

Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases

Identification of novel serotonin transporter compounds by virtual screening

In Silico Methods for the Discovery of Orthosteric GABA Receptor Compounds

In Vitro and In Silico Competitive Binding of Brominated Polyphenyl Ether Contaminants With Human and Gull Thyroid Hormone Transport Proteins.

Inhibition of pseudolysin and thermolysin by hydroxamate-based MMP inhibitors.

Interaction of 1,2,4-substituted piperazines, new serotonin receptor ligands, with 5-HT1A and 5-HT2A receptors

Intrinsic activity and comparative molecular dynamics of buspirone analogues at the 5-HT(1A) receptors.

Ligand induced conformational states of the 5-HT(1A) receptor

Ligand-directed trafficking of receptor stimulus

Ligand-guided homology modelling of the GABAB2 subunit of the GABAB receptor

Ligand-induced stabilization and activation of peroxisome proliferator-activated receptor gamma

Mapping the suramin-binding sites of human neutrophil elastase: investigation by fluorescence resonance energy transfer and molecular modeling.

Mass-spectrometric studies of new 6-nitroquipazines-serotonin transporter inhibitors

Membrane Transporters: Structure, Function and Targets for Drug Design

Molecular Interactions Stabilizing the Promatrix Metalloprotease-9·Serglycin Heteromer

Molecular dynamics of 5-HT1A and 5-HT2A serotonin receptors with methylated buspirone analogues.

Molecular dynamics of NPY Y 1 receptor activation

Molecular dynamics of buspirone analogues interacting with the 5-HT1A and 5-HT2A serotonin receptors

Molecular dynamics of serotonin and ritanserin interacting with the 5-HT2 receptor

Molecular dynamics of the 5-HT1a receptor and ligands.

Molecular insight into pseudolysin inhibition using the MM-PBSA and LIE methods.

Molecular mechanism of citalopram and cocaine interactions with neurotransmitter transporters

Molecular mechanism of serotonin transporter inhibition elucidated by a new flexible docking protocol

Molecular model of the Escherichia coli Na1/H1 antiporter NhaA.

Molecular model of the neural dopamine transporter

Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5)

Molecular modeling of neurotransmitter receptors and ligands

Molecular modelling of UH-301 and 5-HTla receptor interactions

Molecular modelling of drug targets: the past, the present and the future.

Molecular recognition of docosahexaenoic acid by peroxisome proliferator-activated receptors and retinoid-X receptor alpha

Molecular recognition of long chain fatty acids by peroxisome proliferator-activated receptor α

Molecular structure and dynamics of cis(Z)-and trans(E)-flupenthixol and clopenthixol

Molecular structure and dynamics of dopamine, serotonin and the D2, 5-HT2 and 5-HT1A receptors

Multivariate Linear Regression Models Based on ADME Descriptors and Predictions of ADMET Profile for Structurally Diverse Thermolysin Inhibitors

New techniques for optimization of thiopurine therapy in leukemia and transplantation

Novel 4-aryl-pyrido[1,2-c]pyrimidines with dual SSRI and 5-HT1A activity: part 2.

PAC-1 and isatin derivatives are weak matrix metalloproteinase inhibitors

Pancreatic trypsin activates human promatrix metalloproteinase-2.

Predictive QSAR modeling for the successful predictions of the ADMET properties of candidate drug molecules

Protein binding site analysis by means of structural interaction fingerprint patterns

Putative drug binding conformations of monoamine transporters

Receptor-binding and pharmacokinetic properties of dopaminergic agonists

Regulation of liver X receptor target genes by 22-functionalized oxysterols. Synthesis, in silico and in vitro evaluations

Regulation of matrix metalloproteinase activity in health and disease

Serotonin transporter and receptor ligands with antidepressant activity as neuroprotective and proapoptotic agents

Specific interactions and binding energies between thermolysin and potent inhibitors: Molecular simulations based on ab initio molecular orbital method