List of works - Gunnar Schulte

19thActa Physiologicainternational symposium ‘WNT Signaling in Physiology and Disease’- a long way from developmental biology to physiology

A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine

scientific article published on 09 November 2019

A Nordic meeting on G-protein-coupled receptors: from molecular aspects to novel therapy

scientific article published on 01 May 2007

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

scientific article published in Nature Communications

Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells

scientific journal article

Adenosine A receptors are necessary for protection of the murine heart by remote, delayed adaptation to ischaemia

scientific article published in October 2004

Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC.

scientific article published on 04 July 2008

Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3'-kinase

scientific article published on January 2004

Adenosine increases LPS-induced nuclear factor kappa B activation in smooth muscle cells via an intracellular mechanism and modulates it via actions on adenosine receptors

scientific article published on 28 October 2013

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling

scientific article published on 9 August 2017

Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity

scientific article published on 27 May 2014

Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway.

scientific article

Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways

scientific article published on 24 October 2008

Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo.

scholarly article

Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneurons

scientific article published in September 2004

CX3CL1--a macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle.

scientific article published on 2 December 2015

Consequences of eliminating adenosine A1receptors in mice

Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene.

scientific article

Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6.

scientific article published on 5 February 2014

Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization

scientific article published in Journal of Biological Chemistry

Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins

scientific article published on 02 August 2016

Distribution of antinociceptive adenosine A1 receptors in the spinal cord dorsal horn, and relationship to primary afferents and neuronal subpopulations

scientific article published in January 2003

Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists

scientific article published in February 2002

Effects of sciatic nerve injuries on delta -opioid receptor and substance P immunoreactivities in the superficial dorsal horn of the rat.

scientific article published in June 1999

Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3

scientific journal article

Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor

scholarly article

Evidence for functional adenosine A3 receptors in microglia cells

scientific article published in August 2003

FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis.

scientific article published on 23 January 2017

FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs

scientific article published on 04 December 2018

Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain

scientific article published on 10 November 2021

Frizzleds and WNT/β-catenin signaling--The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics

scientific article published on 20 May 2015

Frizzleds as GPCRs - More Conventional Than We Thought!

scientific article published on 23 July 2018

Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment

scientific article published on 20 September 2018

Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation

scientific article

High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes

scientific article published on 25 October 2015

Human adenosine A(1), A(2A), A(2B), and A(3) receptors expressed in Chinese hamster ovary cells all mediate the phosphorylation of extracellular-regulated kinase 1/2

scientific article published on 01 September 2000

Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation.

scientific article

International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors ⬇️

scientific article published on December 1, 2010

Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.

scientific article

Modulation of glial cell functions by adenosine receptors.

scientific article published on 21 May 2007

Molecular Pharmacology of Class F Receptor Activation

scientific article published on 07 October 2019

Molecular reorganization of endocannabinoid signalling in Alzheimer's disease

scientific article

Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia.

scientific article

Novel aspects of G-protein-coupled receptor signalling--different ways to achieve specificity.

scientific article published on May 2007

PKC 412 sensitizes U1810 non-small cell lung cancer cells to DNA damage

scientific article

Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice.

scientific article published on 3 August 2010

Pertussis toxin-sensitive heterotrimeric G(αi/o) proteins mediate WNT/β-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A

scientific article published on 22 December 2012

Prolonged attenuation of acetylcholine-induced phosphorylation of extracellular signal-regulated kinase 1/2 following sevoflurane exposure

scientific article

Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation

scientific journal article

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine

scientific article published on 01 September 2021

Recombinant WNTs differentially activate β-catenin-dependent and -independent signalling in mouse microglia-like cells

scientific article published on 20 June 2011

Residue 6.43 defines receptor function in class F GPCRs

scientific article published on 24 June 2021

Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases.

scientific article

Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2.

scientific article published in November 2002

Structural insight into Class F receptors - What have we learnt regarding agonist-induced activation?

scientific article published on 29 March 2019

Structural insight into small molecule action on Frizzleds

scientific article published on 21 January 2020

Structure and function of adenosine receptors and their genes.

scientific article

Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs.

scientific article

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors ⬇️

journal article from 'British Journal of Pharmacology' published in 2021

The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38.

scientific article published in October 2003

The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesia

scientific article published on December 2010

The tyrosine Y2502.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled.

scientific article published on 28 June 2017

Vang-like protein 2 and Rac1 interact to regulate adherens junctions

scientific article

WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13.

scientific article published on 25 July 2016

WNT signaling in activated microglia is proinflammatory.

scientific article

WNT signaling in microglia and the glioma microenvironment

scientific article published on 12 June 2015

WNT signalling: mechanisms and therapeutic opportunities.

scientific article published in December 2017

WNT-3A and WNT-5A counteract lipopolysaccharide-induced pro-inflammatory changes in mouse primary microglia

scientific article published on 22 April 2013

WNT-3A-induced β-catenin signaling does not require signaling through heterotrimeric G proteins

scientific article published on 24 June 2019

WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.

scientific article published on 8 November 2010

WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3

scientific article published on March 2014

Wnt-3a Induces Cytokine Release in Human Mast Cells

scientific article published on 01 November 2019

Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin

scientific journal article

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

scientific journal article

beta-Arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

scientific article

eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled

scientific article published on 07 May 2020

β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.

scientific article published on 21 November 2013

List of works by Gunnar Schulte

19thActa Physiologicainternational symposium ‘WNT Signaling in Physiology and Disease’- a long way from developmental biology to physiology

A NanoBRET-Based Binding Assay for Smoothened Allows Real-time Analysis of Ligand Binding and Distinction of Two Binding Sites for BODIPY-cyclopamine

A Nordic meeting on G-protein-coupled receptors: from molecular aspects to novel therapy

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

Adenosine A 2B receptors modulate cAMP levels and induce CREB but not ERK1/2 and p38 phosphorylation in rat skeletal muscle cells

Adenosine A receptors are necessary for protection of the murine heart by remote, delayed adaptation to ischaemia

Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC.

Adenosine A3 receptor-mediated regulation of p38 and extracellular-regulated kinase ERK1/2 via phosphatidylinositol-3'-kinase

Adenosine increases LPS-induced nuclear factor kappa B activation in smooth muscle cells via an intracellular mechanism and modulates it via actions on adenosine receptors

Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling

Assessment of Frizzled 6 membrane mobility by FRAP supports G protein coupling and reveals WNT-Frizzled selectivity

Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway.

Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways

Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo.

Brain-derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast-spiking GABAergic interneurons

CX3CL1--a macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle.

Consequences of eliminating adenosine A1receptors in mice

Decreased hippocampal volume and increased anxiety in a transgenic mouse model expressing the human CYP2C19 gene.

Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6.

Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization

Dishevelled is a NEK2 kinase substrate controlling dynamics of centrosomal linker proteins

Distribution of antinociceptive adenosine A1 receptors in the spinal cord dorsal horn, and relationship to primary afferents and neuronal subpopulations

Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists

Effects of sciatic nerve injuries on delta -opioid receptor and substance P immunoreactivities in the superficial dorsal horn of the rat.

Endocannabinoid-independent retrograde signaling at inhibitory synapses in layer 2/3 of neocortex: involvement of vesicular glutamate transporter 3

Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor

Evidence for functional adenosine A3 receptors in microglia cells

FZD10-Gα13 signalling axis points to a role of FZD10 in CNS angiogenesis.

FZD5 is a Gαq-coupled receptor that exhibits the functional hallmarks of prototypical GPCRs

Frizzled BRET sensors based on bioorthogonal labeling of unnatural amino acids reveal WNT-induced dynamics of the cysteine-rich domain

Frizzleds and WNT/β-catenin signaling--The black box of ligand-receptor selectivity, complex stoichiometry and activation kinetics

Frizzleds as GPCRs - More Conventional Than We Thought!

Functional dissection of the N-terminal extracellular domains of Frizzled 6 reveals their roles for receptor localization and Dishevelled recruitment

Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation

High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes

Human adenosine A(1), A(2A), A(2B), and A(3) receptors expressed in Chinese hamster ovary cells all mediate the phosphorylation of extracellular-regulated kinase 1/2

Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation.

International Union of Basic and Clinical Pharmacology. LXXX. The Class Frizzled Receptors ⬇️

Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.

Modulation of glial cell functions by adenosine receptors.

Molecular Pharmacology of Class F Receptor Activation

Molecular reorganization of endocannabinoid signalling in Alzheimer's disease

Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia.

Novel aspects of G-protein-coupled receptor signalling--different ways to achieve specificity.

PKC 412 sensitizes U1810 non-small cell lung cancer cells to DNA damage

Peripheral adenosine A2A receptors are involved in carrageenan-induced mechanical hyperalgesia in mice.

Pertussis toxin-sensitive heterotrimeric G(αi/o) proteins mediate WNT/β-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A

Prolonged attenuation of acetylcholine-induced phosphorylation of extracellular signal-regulated kinase 1/2 following sevoflurane exposure

Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation

Rare genetic variability in human drug target genes modulates drug response and can guide precision medicine

Recombinant WNTs differentially activate β-catenin-dependent and -independent signalling in mouse microglia-like cells

Residue 6.43 defines receptor function in class F GPCRs

Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases.

Signaling pathway from the human adenosine A(3) receptor expressed in Chinese hamster ovary cells to the extracellular signal-regulated kinase 1/2.

Structural insight into Class F receptors - What have we learnt regarding agonist-induced activation?

Structural insight into small molecule action on Frizzleds

Structure and function of adenosine receptors and their genes.

Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors ⬇️

The G(s)-coupled adenosine A(2B) receptor recruits divergent pathways to regulate ERK1/2 and p38.

The human carotid body: expression of oxygen sensing and signaling genes of relevance for anesthesia

The tyrosine Y2502.39 in Frizzled 4 defines a conserved motif important for structural integrity of the receptor and recruitment of Disheveled.

Vang-like protein 2 and Rac1 interact to regulate adherens junctions

WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13.

WNT signaling in activated microglia is proinflammatory.

WNT signaling in microglia and the glioma microenvironment

WNT signalling: mechanisms and therapeutic opportunities.

WNT-3A and WNT-5A counteract lipopolysaccharide-induced pro-inflammatory changes in mouse primary microglia

WNT-3A-induced β-catenin signaling does not require signaling through heterotrimeric G proteins

WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.

WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3

Wnt-3a Induces Cytokine Release in Human Mast Cells

Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

beta-Arrestins - scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

eGFP-tagged Wnt-3a enables functional analysis of Wnt trafficking and signaling and kinetic assessment of Wnt binding to full-length Frizzled

β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.