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List of works by Daphne Merkus

'Integrative Physiology 2.0': integration of systems biology into physiology and its application to cardiovascular homeostasis.

scientific article published on 04 January 2011

A direct comparison of natural and acoustic-radiation-force-induced cardiac mechanical waves

scientific article published on 28 October 2020

A novel approach to assess hemorrhagic shock severity using the arterially determined left ventricular isovolumic contraction period

scientific article published on 15 December 2013

Activation of adenosine A2A but not A2B receptors is involved in uridine adenosine tetraphosphate-induced porcine coronary smooth muscle relaxation

scientific article published on 27 September 2019

Acute adaptations of the coronary circulation to exercise

scientific article

Alterations in endothelial control of the pulmonary circulation in exercising swine with secondary pulmonary hypertension after myocardial infarction

scientific article published in May 2007

Alterations in vasomotor control of coronary resistance vessels in remodelled myocardium of swine with a recent myocardial infarction

scientific article published in May 2008

Altered purinergic signaling in uridine adenosine tetraphosphate-induced coronary relaxation in swine with metabolic derangement.

scientific article published on 24 May 2017

Blunted coronary vasodilator response to uridine adenosine tetraphosphate in post-infarct remodeled myocardium is due to reduced P1 receptor activation

article

Both beta1- and beta2-adrenoceptors contribute to feedforward coronary resistance vessel dilation during exercise

scientific article published on 24 December 2009

Both male and female obese ZSF1 rats develop cardiac dysfunction in obesity-induced heart failure with preserved ejection fraction

scientific article published on 06 May 2020

Cardiac myocytes control release of endothelin-1 in coronary vasculature

scientific article published on 6 January 2005

Cardiac remodelling in a swine model of chronic thromboembolic pulmonary hypertension: comparison of right vs. left ventricle

scientific article published on 25 July 2019

Cardiovascular Function of Modern Pigs Does not Comply with Allometric Scaling Laws.

scientific article published on 15 January 2018

Cardiovascular performance of adult breeding sows fails to obey allometric scaling laws1

scientific article published in February 2011

Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement

scientific article published on 06 August 2020

Changes in the nitric oxide pathway of the pulmonary vasculature after exposure to hypoxia in swine model of neonatal pulmonary vascular disease

scientific article published on 01 October 2018

Chronic Kidney Disease as a Risk Factor for Heart Failure With Preserved Ejection Fraction: A Focus on Microcirculatory Factors and Therapeutic Targets

scientific article published on 04 September 2019

Chronic cardiac denervation affects the speed of coronary vascular regulation

scientific article published in December 1999

Contribution of KATP+ channels to coronary vasomotor tone regulation is enhanced in exercising swine with a recent myocardial infarction

scientific article published on 11 November 2004

Contribution of endothelin and its receptors to the regulation of vascular tone during exercise is different in the systemic, coronary and pulmonary circulation

scientific article published in September 2003

Contribution of endothelin to coronary vasomotor tone is abolished after myocardial infarction

scientific article published on 30 September 2004

Control of pulmonary vascular tone during exercise in health and pulmonary hypertension

scientific article published on 14 May 2008

Coronary blood flow regulation in exercising swine involves parallel rather than redundant vasodilator pathways

scientific article published on 13 March 2003

Coronary microvascular dysfunction after long-term diabetes and hypercholesterolemia.

scientific article published on 2 September 2016

Coronary vasoconstrictor influence of angiotensin II is reduced in remodeled myocardium after myocardial infarction

scientific article published in November 2006

Coronary-aortic interaction during ventricular isovolumic contraction.

scientific article

Cytochrome P-450 2C9 exerts a vasoconstrictor influence on coronary resistance vessels in swine at rest and during exercise

scientific article published on 03 February 2012

DNGR1-Cre-mediated Deletion of Tnfaip3/A20 in Conventional Dendritic Cells Induces Pulmonary Hypertension in Mice

scientific article published on 05 August 2020

Differential impact of severe familial hypercholesterolemia on regional skeletal muscle and organ blood flows during exercise: Effects of PDE5 inhibition

scientific article published on 26 March 2019

Disentangling the Gordian knot of local metabolic control of coronary blood flow

scientific article published on 08 November 2019

Does cardiovascular performance of modern fattening pigs obey allometric scaling laws?

scientific article published in June 2009

Early detection of left ventricular diastolic dysfunction using conventional and speckle tracking echocardiography in a large animal model of metabolic dysfunction

scientific article published on 12 December 2017

Echocardiographic-Derived Strain-Area Loop of the Right Ventricle is Related to Pulmonary Vascular Resistance in Pulmonary Arterial Hypertension.

scientific article

Endothelial dysfunction enhances the pulmonary and systemic vasodilator effects of phosphodiesterase-5 inhibition in awake swine at rest and during treadmill exercise

scientific article published in February 2012

Endothelin-1 Regulation of Exercise-Induced Changes in Flow: Dynamic Regulation of Vascular Tone

scientific article published on 24 October 2017

Enhanced myofilament responsiveness upon β-adrenergic stimulation in post-infarct remodeled myocardium

scientific article published on 13 December 2010

Erratum to: Exercise training in adverse cardiac remodeling

scientific article published on 01 February 2016

Exercise Facilitates Early Recognition of Cardiac and Vascular Remodeling in Chronic Thrombo-Embolic Pulmonary Hypertension in a Novel CTEPH Swine Model.

scientific article published on 22 November 2017

Exercise hyperaemia in the heart: the search for the dilator mechanism.

scientific article published on 7 June 2007

Exercise limits the production of endothelin in the coronary vasculature

scientific article

Exercise training in adverse cardiac remodeling

scientific article published on 27 February 2014

Exercise unmasks autonomic dysfunction in swine with a recent myocardial infarction

scientific article published in March 2005

Experimental animal models of coronary microvascular dysfunction

scientific article published on 01 March 2020

Familial hypercholesterolemia impairs exercise-induced systemic vasodilation due to reduced NO bioavailability.

scientific article published on 24 October 2013

Farnesylation of RhoB: the cancer hypothesis of pulmonary hypertension revisited

scientific article published on 01 March 2017

Functional and Structural Adaptations of Coronary Microvessels Distal to a Chronic Coronary Artery Stenosis

scientific article published on 11 April 2008

Gene reprogramming in exercise-induced cardiac hypertrophy in swine: A transcriptional genomics approach.

scientific article published on 22 October 2014

Guiding the failing heart to exercise.

scientific article

Human Placental Vascular Reactivity in Health and Disease: Implications for the Treatment of Pre-eclampsia

scientific article published on 01 January 2019

Hybrid contact force ablation: best of both worlds?

scientific article published on 17 July 2015

In vivo role of heme oxygenase in ischemic coronary vasodilation

scientific article published in June 2004

Initiation of ventricular contraction as reflected in the aortic pressure waveform

scientific article published on 14 March 2012

Integrated control of pulmonary vascular tone by endothelin and angiotensin II in exercising swine depends on gender

scientific article published on 26 March 2010

Integrative control of coronary resistance vessel tone by endothelin and angiotensin II is altered in swine with a recent myocardial infarction

scientific article

Interaction between prostanoids and nitric oxide in regulation of systemic, pulmonary, and coronary vascular tone in exercising swine ⬇️

scientific article published on October 16, 2003

Intermittent pacing therapy favorably modulates infarct remodeling

scientific article published on 6 April 2017

Intervening with the Nitric Oxide Pathway to Alleviate Pulmonary Hypertension in Pulmonary Vein Stenosis

scientific article published on 12 August 2019

KCa+ channels contribute to exercise-induced coronary vasodilation in swine

scientific article published in November 2006

Left ventricular remodeling in swine after myocardial infarction: a transcriptional genomics approach.

scientific article published on 5 November 2011

Limitation of Infarct Size and No-Reflow by Intracoronary Adenosine Depends Critically on Dose and Duration.

scientific article published in December 2015

Low pulmonary vascular resistance breaks the two-hour marathon limit

scientific article published in January 2011

Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension

scientific article published on 25 April 2020

Measures of subclinical cardiac dysfunction and increased filling pressures associate with pulmonary arterial pressure in the general population: results from the population-based Rotterdam Study

scientific article published on 13 December 2017

Metabolic communication from cardiac myocytes to vascular endothelial cells

scientific article

Metabolic regulation of coronary vascular tone: role of endothelin-1.

scientific article published in November 2002

Metabolism of Tryptophan in the Healthy and Preeclamptic Human Placenta

scholarly article

Mitochondrial adaptations within chronically ischemic swine myocardium

scientific article

Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening.

scientific article published on 8 February 2018

Myofilament dysfunction in cardiac disease from mice to men.

scientific article published on January 2008

NO and prostanoids blunt endothelin-mediated coronary vasoconstrictor influence in exercising swine

scientific article published in November 2006

Nitric oxide blunts the endothelin-mediated pulmonary vasoconstriction in exercising swine

scientific article published on 4 August 2005

Nitric oxide production is maintained in exercising swine with chronic left ventricular dysfunction

scientific article

Nitroso-redox balance in control of coronary vasomotor tone.

scientific article

Normal and high eNOS levels are detrimental in both mild and severe cardiac pressure-overload

scientific article published on 2 October 2015

Normalization of hemoglobin-based oxygen carrier-201 induced vasoconstriction: targeting nitric oxide and endothelin

scientific article

Nuclear protein extraction from frozen porcine myocardium

scientific article published on 9 November 2010

Oxidative injury of the pulmonary circulation in the perinatal period: Short- and long-term consequences for the human cardiopulmonary system

scientific article

Peripheral circulation

scientific article published on January 2012

Perturbations in myocardial perfusion and oxygen balance in swine with multiple risk factors: a novel model of ischemia and no obstructive coronary artery disease

scientific article published on 25 February 2020

Phosphodiesterase 5 inhibition-induced coronary vasodilation is reduced after myocardial infarction

scientific article

Phosphodiesterase-5 activity exerts a coronary vasoconstrictor influence in awake swine that is mediated in part via an increase in endothelin production.

scientific article published on 24 January 2014

Placental effects and transfer of sildenafil in healthy and preeclamptic conditions

scientific article published in July 2019

Porcine models for studying complications and organ crosstalk in diabetes mellitus

scientific article published on 13 January 2020

Prevention of myofilament dysfunction by beta-blocker therapy in postinfarct remodeling

scientific article published on 25 March 2009

Prostanoids suppress the coronary vasoconstrictor influence of endothelin after myocardial infarction

scientific article published in September 2011

Protease-activated receptor 1 as potential therapeutic target in pulmonary arterial hypertension

scientific article published on 01 July 2019

Protection against skeletal muscle hypoperfusion by adenosine and nitric oxide: together alone?

scientific article published in May 2011

Pulmonary arteriovenous malformations: haemodynamics and shunt closure

scientific article published on August 2014

Pulmonary blood flow and its distribution in highly trained endurance athletes and healthy control subjects

scientific article

Pulmonary microvascular remodeling in chronic thrombo-embolic pulmonary hypertension

scientific article published on 27 September 2018

Pulmonary vasoconstrictor influence of endothelin in exercising swine depends critically on phosphodiesterase 5 activity.

scientific article published on 10 January 2014

Pulmonary vasodilation by phosphodiesterase 5 inhibition is enhanced and nitric oxide independent in early pulmonary hypertension after myocardial infarction.

scientific article published on 6 October 2017

Purinergic Dysfunction in Pulmonary Arterial Hypertension

scientific article published on 01 September 2020

Quantification of myocardial blood flow by adenosine-stress CT perfusion imaging in pigs during various degrees of stenosis correlates well with coronary artery blood flow and fractional flow reserve.

scientific article published on 26 July 2012

Quantitative analysis of exercise-induced enhancement of early- and late-systolic retrograde coronary blood flow

scientific article

Quantitative analysis of myofilament protein phosphorylation in small cardiac biopsies

article

ROCK as a molecular bond connecting coronary microvascular and cardiac remodelling.

scientific article published in September 2017

Reactive Oxygen Species: Radical Factors in the Evolution of Animal Life: A molecular timescale from Earth's earliest history to the rise of complex life

scientific article published on 7 February 2018

Reactive oxygen species and the cardiovascular system

scientific article published on 22 April 2013

Reduced contribution of endothelin to the regulation of systemic and pulmonary vascular tone in severe familial hypercholesterolaemia

scientific article published on 15 April 2014

Regulation of Coronary Microvascular Resistance in Health and Disease

scientific article published in 2008

Regulation of coronary blood flow in health and ischemic heart disease

scientific article

Regulation of coronary resistance vessel tone in response to exercise

scientific article published on 15 October 2011

Right ventricular oxygen delivery as a determinant of right ventricular functional reserve during exercise in juvenile swine with chronic pulmonary hypertension

scientific article published on 09 August 2019

Right ventricular phenotype, function, and failure: a journey from evolution to clinics

scientific article published on 17 June 2020

Role of endothelin receptor activation in secondary pulmonary hypertension in awake swine after myocardial infarction

scientific article published on 15 July 2006

Sarcomeric dysfunction in heart failure.

scientific article published on 30 November 2007

Say NO to hypoperfusion!

scientific article published in December 2009

Serially measured circulating microRNAs and adverse clinical outcomes in patients with acute heart failure

scientific article published on 25 September 2017

Severe familial hypercholesterolemia impairs the regulation of coronary blood flow and oxygen supply during exercise

scientific article

Sex differences in pulmonary vascular control: focus on the nitric oxide pathway

scientific article

Stress myocardial perfusion: imaging with multidetector CT.

scientific article published on January 2014

Structural and functional changes of the pulmonary vasculature after hypoxia exposure in the neonatal period - a new swine model of pulmonary vascular disease.

scientific article published on 10 November 2017

Sunitinib-Induced Systemic Vasoconstriction in Swine Is Endothelin Mediated and Does Not Involve Nitric Oxide or Oxidative Stress

scientific article published on 28 November 2011

Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine.

scientific article published on 9 February 2016

Sympathetic coronary vasomotor control: are women really the weaker sex?

scientific article

The Left Heart, Systemic Circulation and Bronchopulmonary Dysplasia: Relevance to Pathophysiology and Therapeutics

scientific article published on 14 June 2020

The microcirculation: a key player in obesity-associated cardiovascular disease.

scientific article published on 8 May 2017

Time course of VCAM-1 expression in reperfused myocardial infarction in swine and its relation to retention of intracoronary administered bone marrow-derived mononuclear cells

scientific article

Transition from post-capillary pulmonary hypertension to combined pre- and post-capillary pulmonary hypertension in swine: a key role for endothelin

scientific article published on 21 June 2018

Transmural heterogeneity of myofilament function and sarcomeric protein phosphorylation in remodeled myocardium of pigs with a recent myocardial infarction

scientific article published on 24 November 2011

UM206, a selective Frizzled antagonist, attenuates adverse remodeling after myocardial infarction in swine

scientific article published on 14 December 2015

Uridine Adenosine Tetraphosphate-Induced Coronary Relaxation Is Blunted in Swine With Pressure Overload: A Role for Vasoconstrictor Prostanoids.

scientific article published on 26 March 2018

Uridine adenosine tetraphosphate acts as a proangiogenic factor in vitro through purinergic P2Y receptors

scientific article published on 27 May 2016

Uridine adenosine tetraphosphate and purinergic signaling in cardiovascular system: An update

scientific article published on 13 December 2018

Uridine adenosine tetraphosphate is a novel vasodilator in the coronary microcirculation which acts through purinergic P1 but not P2 receptors

scientific article published on 9 October 2012

Vagal nerve stimulation started just prior to reperfusion limits infarct size and no-reflow

scientific article

Validation of 4D flow CMR against simultaneous invasive hemodynamic measurements: a swine study

scientific article published on 08 April 2019

Vasomotor control in mice overexpressing human endothelial nitric oxide synthase

scientific article published in August 2007

What can we learn about treating heart failure from the heart's response to acute exercise? Focus on the coronary microcirculation

scientific article

l-Tryptophan-Induced Vasodilation Is Enhanced in Preeclampsia: Studies on Its Uptake and Metabolism in the Human Placenta

scientific article published on 01 June 2020

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