Search filters

List of works by Robert K Hills

A comparative assessment of the curative potential of reduced intensity allografts in acute myeloid leukaemia

scientific article published on 07 November 2014

A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment

scientific article published on 01 March 2007

A functional variant in the core promoter of the CD95 cell death receptor gene predicts prognosis in acute promyelocytic leukemia.

scientific article

A randomised comparison of the novel nucleoside analogue sapacitabine with low-dose cytarabine in older patients with acute myeloid leukaemia

scientific article

A randomised-controlled trial in England of a postnatal midwifery intervention on breast-feeding duration

scientific article published on 27 December 2005

A randomized comparison of daunorubicin 90 mg/m2 vs 60 mg/m2 in AML induction: results from the UK NCRI AML17 trial in 1206 patients

scientific article published in April 2015

ASXL1 mutations are infrequent in young patients with primary acute myeloid leukemia and their detection has a limited role in therapeutic risk stratification

scientific article published on 9 October 2013

Addition of gemtuzumab ozogamicin to induction chemotherapy improves survival in older patients with acute myeloid leukemia

scientific article published on 30 July 2012

Addition of gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia: a meta-analysis of individual patient data from randomised controlled trials

scientific article

Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study.

scientific article

An immunophenotypic pre-treatment predictor for poor response to induction chemotherapy in older acute myeloid leukaemia patients: blood frequency of CD34+ CD38 low blasts

scientific article published on 14 April 2015

Analysis of the clinical impact of NPM1 mutant allele burden in a large cohort of younger adult patients with acute myeloid leukaemia

scientific article published on 08 October 2019

Analysis of the interaction of induction regimens with p-glycoprotein expression in patients with acute myeloid leukaemia: results from the MRC AML15 trial.

scientific article published on 17 June 2011

Anything in modulation?

scientific article published in September 2003

Applicability of a "Pick a Winner" trial design to acute myeloid leukemia

scientific article published on 6 July 2011

Arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial

scientific article published on 14 September 2015

Aspirin in Alzheimer's disease (AD2000): a randomised open-label trial

scientific article

Assessing new interventions in women's health.

scientific article

Assessing the prognostic value of preoperative carcinoembryonic antigen-specific T-cell responses in colorectal cancer

scientific article

Assessment of Minimal Residual Disease in Standard-Risk AML.

scientific article

Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group

scientific article

Attempts to optimize induction and consolidation treatment in acute myeloid leukemia: results of the MRC AML12 trial

scientific article published on 28 December 2009

Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia

scientific article

Balancing treatment allocations by clinician or center in randomized trials allows unacceptable levels of treatment prediction.

scientific article

CD200 as a prognostic factor in acute myeloid leukaemia.

scientific article published on 25 January 2007

CD200 expression suppresses natural killer cell function and directly inhibits patient anti-tumor response in acute myeloid leukemia

scientific article

CD49d is an independent prognostic marker that is associated with CXCR4 expression in CLL.

scientific article published on 18 November 2010

Can we say farewell to monitoring minimal residual disease in acute promyelocytic leukaemia?

scientific article

Can we trust the results of trials that are stopped early?

scientific article published on July 2006

Clofarabine doubles the response rate in older patients with acute myeloid leukemia but does not improve survival

scientific article published on 9 July 2013

Combination of a mitogen-activated protein kinase inhibitor with the tyrosine kinase inhibitor pacritinib combats cell adhesion-based residual disease and prevents re-expansion of FLT3-ITD acute myeloid leukaemia

scientific article published on 11 May 2020

Conflicting data on the prognostic significance of FLT3/TKD mutations in acute myeloid leukemia might be related to the incidence of biallelic disease

scientific article published in July 2008

Continuous versus interrupted perineal repair with standard or rapidly absorbed sutures after spontaneous vaginal birth: a randomised controlled trial

scientific article published on 01 June 2002

Continuous versus interrupted sutures for repair of episiotomy or second degree tears

scientific article

Cord Blood-Derived Quiescent CD34+ Cells Are More Transcriptionally Matched to AML Blasts Than Cytokine-Induced Normal Human Hematopoietic CD34+ Cells

scientific article published on January 2015

Corner cutting compromises clinical trials: the inherent problems with up-front randomisation and a common standard arm.

scientific article

Curability of patients with acute myeloid leukemia who did not undergo transplantation in first remission

scientific article published on 25 February 2013

Cytogenetics of childhood acute myeloid leukemia: United Kingdom Medical Research Council Treatment trials AML 10 and 12.

scientific article

Defining the dose of gemtuzumab ozogamicin in combination with induction chemotherapy in acute myeloid leukemia: a comparison of 3 mg/m2 with 6 mg/m2 in the NCRI AML17 Trial

scientific article

Defining the prognosis of early stage chronic lymphocytic leukaemia patients

scientific article published on 15 December 2011

Disease evolution and outcomes in familial AML with germline CEBPA mutations

scientific article published on 10 July 2015

Does BCR/ABL1 positive acute myeloid leukaemia exist?

scientific article published on 25 March 2013

Donepezil and memantine for moderate-to-severe Alzheimer's disease.

scientific article

EZH2 mutations are frequent and represent an early event in follicular lymphoma

scientific article published on 19 September 2013

Establishing the Evidence Bar for Molecular Diagnostics in Personalised Cancer Care

scientific article published on 11 November 2015

European development of clofarabine as treatment for older patients with acute myeloid leukemia considered unsuitable for intensive chemotherapy

scientific article published on 12 April 2010

Evaluating drug treatments for Parkinson's disease: how good are the trials?

scientific article

Evaluating sixty years of UK trials research in acute myeloid leukaemia: lessons for trial design, past, present and future

scientific article published on 12 December 2019

Expression of CD200 on AML blasts directly suppresses memory T-cell function.

scientific article published on 20 March 2012

FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia

scientific article published on 24 April 2007

Factors predisposing women to chronic pelvic pain: systematic review

scientific article published on 16 February 2006

GATA2 mutations in sporadic and familial acute myeloid leukaemia patients with CEBPA mutations

scientific article published on 5 April 2013

Genetic variation in XPD predicts treatment outcome and risk of acute myeloid leukemia following chemotherapy.

scientific article published on 31 August 2004

Group cognitive behavioural treatment for low-back pain in primary care: a randomised controlled trial and cost-effectiveness analysis

scientific article published on 25 February 2010

Hyperdiploidy with 49–65 chromosomes represents a heterogeneous cytogenetic subgroup of acute myeloid leukemia with differential outcome

scientific article published on 01 July 2013

Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML15 trial

scientific article published on 20 December 2010

Impact of FLT3(ITD) mutant allele level on relapse risk in intermediate-risk acute myeloid leukemia.

scientific article

Inappropriate reporting and interpretation of subgroups in the AML-BFM 93 study.

scientific article published in November 2001

Incidence and prognostic significance of C-MPL expression in acute myeloid leukemia

scientific article published on 01 September 2003

Inclusion of chemotherapy in addition to anthracycline in the treatment of acute promyelocytic leukaemia does not improve outcomes: results of the MRC AML15 trial

scientific article published on 10 December 2012

Increased CD200 expression in acute myeloid leukemia is linked with an increased frequency of FoxP3+ regulatory T cells.

scientific article published on 20 March 2012

Increased frequency of CD4+ PD-1+ HLA-DR+ T cells is associated with disease progression in CLL

scientific article published on 08 November 2019

Independent prognostic variables in acute myeloid leukaemia

scientific article

Individual patient data meta-analysis of randomized evidence to assess the effectiveness of laparoscopic uterosacral nerve ablation in chronic pelvic pain.

scientific article

International randomized phase III study of elacytarabine versus investigator choice in patients with relapsed/refractory acute myeloid leukemia

scientific article published on 19 May 2014

Intrapartum tests for group B streptococcus: accuracy and acceptability of screening

scientific article published on 13 October 2010

Laparoscopic uterosacral nerve ablation for alleviating chronic pelvic pain: a randomized controlled trial

scientific article published in September 2009

Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial.

scientific article

Long-term results of the MRC AML10 trial.

scientific article published in June 2006

Mcl-1 expression has in vitro and in vivo significance in chronic lymphocytic leukemia and is associated with other poor prognostic markers.

scientific article published on 3 July 2008

Measurement of beliefs about effectiveness of laparoscopic uterosacral nerve ablation

scientific article published on 01 February 2005

Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: results of the United Kingdom MRC AML-15 trial

scientific article published on 08 August 2012

Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party

scientific article

No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials.

scientific article

Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses.

scientific article published on 26 October 2015

OGG1 is a novel prognostic indicator in acute myeloid leukaemia

scientific article published on 21 December 2009

Optimization of chemotherapy for younger patients with acute myeloid leukemia: results of the medical research council AML15 trial

scientific article published on 12 August 2013

Overproduction of NOX-derived ROS in AML promotes proliferation and is associated with defective oxidative stress signaling

scientific article

PErineal Assessment and Repair Longitudinal Study (PEARLS): protocol for a matched pair cluster trial

scientific article

PROSPER: a randomised comparison of surgical treatments for rectal prolapse

scientific article published in July 2013

Problems with up-front randomization in clinical trials

scientific article published on 01 December 2006

Prognostic and therapeutic relevance of c-FLIP in acute myeloid leukaemia

scientific article published on 20 November 2012

Prognostic relevance of treatment response measured by flow cytometric residual disease detection in older patients with acute myeloid leukemia

scientific article published on 23 September 2013

Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations

scientific article published on 3 May 2010

Prognostic value of monitoring a candidate immunophenotypic leukaemic stem/progenitor cell population in patients allografted for acute myeloid leukaemia

scientific article

Prospective minimal residual disease monitoring to predict relapse of acute promyelocytic leukemia and to direct pre-emptive arsenic trioxide therapy.

scientific article

RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years

scientific article

Real world data and the art of maintenance therapy

scientific article published on 27 December 2018

Real-time quantitative polymerase chain reaction detection of minimal residual disease by standardized WT1 assay to enhance risk stratification in acute myeloid leukemia: a European LeukemiaNet study.

scientific article

Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.

scientific article published on 12 April 2010

Rel a is an independent biomarker of clinical outcome in chronic lymphocytic leukemia

scientific article published on 5 January 2009

Relationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia

scientific article published on 16 August 2005

Relationship between event-free survival and overall survival in acute myeloid leukemia: a report from SWOG, HOVON/SAKK, and MRC/NCRI.

scientific article published on 24 March 2016

Reply to D. Przepiorka et al and M.K. Jensen

scientific article published in May 2013

Resistance prediction in AML: analysis of 4601 patients from MRC/NCRI, HOVON/SAKK, SWOG and MD Anderson Cancer Center.

scientific article

Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia.

scientific article published on 11 May 2015

Studying a disease with no home--lessons in trial recruitment from the PATCH II study

scientific article

Surgery for Parkinson's disease: lack of reliable clinical trial evidence.

scientific article

TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis

scientific article published on 3 July 2008

Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease

scientific article published on 3 July 2014

Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients

scientific article published on 25 February 2015

The HSP90 inhibitor ganetespib: A potential effective agent for Acute Myeloid Leukemia in combination with cytarabine

scientific article published on 30 March 2015

The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts.

scientific article published on 13 December 2013

The addition of arsenic trioxide to low-dose Ara-C in older patients with AML does not improve outcome.

scientific article published on 8 April 2011

The addition of gemtuzumab ozogamicin to low-dose Ara-C improves remission rate but does not significantly prolong survival in older patients with acute myeloid leukaemia: results from the LRF AML14 and NCRI AML16 pick-a-winner comparison

scientific article

The addition of the farnesyl transferase inhibitor, tipifarnib, to low dose cytarabine does not improve outcome for older patients with AML.

scientific article published on 29 May 2012

The clinical impact of mutant DNMT3A R882 variant allele frequency in acute myeloid leukaemia

scientific article published on 31 January 2020

The contribution of randomized trials to the cure of haematological disorders from Bradford Hill onwards ⬇️

scientific article published on July 5, 2012

The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia

scientific article

The impact of dose escalation and resistance modulation in older patients with acute myeloid leukaemia and high risk myelodysplastic syndrome: the results of the LRF AML14 trial

scientific article

The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with nonacute promyelocytic acute myeloid leukemia: ...

scientific article from 2010

The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia

scientific article published on 20 June 2013

The paradox of NKp46+ natural killer cells: drivers of severe hepatitis C virus-induced pathology but in-vivo resistance to interferon α treatment.

scientific article published on 11 May 2013

The prognostic relevance of flt3 and npm1 mutations on older patients treated intensively or non-intensively: a study of 1312 patients in the UK NCRI AML16 trial

scientific article published on 27 February 2014

The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status

scientific article published on 22 July 2010

The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias

scientific article

The value of molecular stratification for CEBPA(DM) and NPM1(MUT) FLT3(WT) genotypes in older patients with acute myeloid leukaemia

scientific article published on 21 December 2015

Treatment for myeloid leukaemia of Down syndrome: population-based experience in the UK and results from the Medical Research Council AML 10 and AML 12 trials.

scientific article published on March 2006

Treatment strategy and long-term results in paediatric patients treated in consecutive UK AML trials

scientific article published on 01 December 2005

Twenty five years of UK trials in acute myeloid leukaemia: what have we learned?

scientific article published on 11 December 2019

Utility of a clinical risk score to identify high-risk patients with de novo acute myeloid leukaemia in first remission after high-dose cytarabine (HiDAC) based induction chemotherapy

scientific article published on 24 December 2012

Variation in practice of laparoscopic uterosacral nerve ablation: a European survey

scientific article published on 01 August 2004

Vosaroxin and vosaroxin plus low-dose Ara-C (LDAC) vs low-dose Ara-C alone in older patients with acute myeloid leukemia.

scientific article

Who is an "older" patient with acute myeloid leukaemia (AML)? An investigation of two NCRI/AML trials

scientific article published on 23 December 2013

Who should be transplanted in first remission of acute myeloid leukaemia?

scientific article published in December 2011

Paulina is supported by:

About Paulina

Help